AC T01560
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ID T01560
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DT 14.09.1995 (created); ewi.
DT 06.12.2015 (updated); sup.
CO Copyright (C), QIAGEN.
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FA SREBP-2
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SY SREBP2-precursor form; Sterol Regulatory Element Binding Protein 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002349 SREBF2; HGNC: SREBF2.
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CL C0012; bHLH-ZIP; 1.2.6.3.2.
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SF SREBP-2 binds to the same DNA sequence as SREBP-1 [1];
SF there are no hints on splice variants [1];
SF because of its very similar structure, it is most likely subjected to the same control mechanisms as SREBP-1;
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CP ubiquitous (fetal and adult) [1].
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FF Yin Yang 1 protein (YY1) inhibits the SREBP-mediated activation of the low density lipoprotein receptor (LDLR) in a sensitive and dose-dependent manner. [12];
FF Its expression is enhanced by dexamethasone, and this enhancement is further augmented by PGC-1alpha T05295 [5];
FF androgen treatment caused an increase in expression [10];
FF suppressed basal vascular endothelial growth factor (VEGF) promoter activities [11];
FF SREBP-2 directly interact with HNF-4alpha, both together synergistically activated the SI gene [13];
FF transcriptional activator, acting through sterol regulatory elements (SRE) [1];
FF cleavage of the large precursor protein produces a 65-kDa membrane-bound C-terminal protein and a 68-kDa nuclear N-terminus [3];
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IN T08562 CREB1; human, Homo sapiens.
IN T00241 Egr-1; human, Homo sapiens.
IN T18011 ESET; human, Homo sapiens.
IN T27167 GATAD2B; human, Homo sapiens.
IN T03828 HNF-4alpha; human, Homo sapiens.
IN T20017 MGA; human, Homo sapiens.
IN T01804 NF-YA; human, Homo sapiens.
IN T00154 NF-YB; human, Homo sapiens.
IN T10617 NF-YC; human, Homo sapiens.
IN T09538 Smad3; Mammalia.
IN T28756 SMC-3; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
IN T19539 ZASC1; human, Homo sapiens.
IN T27281 ZNF737; human, Homo sapiens.
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MX M07406 V$SREBF2_02.
MX M01177 V$SREBP2_Q6.
MX M03852 V$SREBP2_Q6_01.
MX M00776 V$SREBP_Q3.
MX M01168 V$SREBP_Q6.
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BS R68806.
BS R68808.
BS R31366.
BS R31441.
BS R31642.
BS R30370.
BS R31245.
BS R31277.
BS R41721.
BS R41725.
BS R70834.
BS R70836.
BS R70837.
BS R70838.
BS R70839.
BS R70840.
BS R70841.
BS R70842.
BS R31229.
BS R31590.
BS R41749.
BS R13175.
BS R13177.
BS R33173.
BS R71264.
BS R19664.
BS R19665.
BS R69835.
BS R04432.
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DR TRANSPATH: MO000025765.
DR TRANSCOMPEL: C00206.
DR TRANSCOMPEL: C00210.
DR UniProtKB: Q12772;
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RN [1]; RE0003436.
RX PUBMED: 7903453.
RA Hua X., Yokoyama C., Wu J., Briggs M. R., Brown M. S., Goldstein J., Wang X.
RT SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element
RL Proc. Natl. Acad. Sci. USA 90:11603-11607 (1993).
RN [2]; RE0005535.
RX PUBMED: 7629113.
RA Wang X., Pai J., Wiedenfeld E. A., Medina J. C., Slaughter C. A., Goldstein J. L., Brown M. S.
RT Purification of an interleukin-1 beta converting enzyme-related cysteine protease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembran domains
RL J. Biol. Chem. 270:18044-18050 (1995).
RN [3]; RE0005825.
RX PUBMED: 7493979.
RA Hua X., Sakai J., Ho Y. K., Goldstein J. L., Brown M. S.
RT Hairpin orientation of sterol regulatory element-binding protein-2 in cell membrans as determined by protease protection
RL J. Biol. Chem. 270:29422-29427 (1995).
RN [4]; RE0047886.
RX PUBMED: 15527767.
RA Grimsby S., Jaensson H., Dubrovska A., Lomnytska M., Hellman U., Souchelnytskyi S.
RT Proteomics-based identification of proteins interacting with Smad3: SREBP-2 forms a complex with Smad3 and inhibits its transcriptional activity.
RL FEBS Lett. 577:93-100 (2004).
RN [5]; RE0048535.
RX PUBMED: 16282353.
RA Oberkofler H., Klein K., Felder T. K., Krempler F., Patsch W.
RT Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells.
RL Endocrinology 147:966-976 (2006).
RN [6]; RE0051058.
RX PUBMED: 16415294.
RA Schmidt R. J., Ficorilli J. V., Zhang Y., Bramlett K. S., Beyer T. P., Borchert K., Dowless M. S., Houck K. A., Burris T. P., Eacho P. I., Liang G., Guo L. W., Wilson W. K., Michael L. F., Cao G.
RT A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity.
RL J. Lipid Res. 47:1037-1044 (2006).
RN [7]; RE0052304.
RX PUBMED: 9139737.
RA Duncan E. A., Brown M. S., Goldstein J. L., Sakai J.
RT Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.
RL J. Biol. Chem. 272:12778-12785 (1997).
RN [8]; RE0066824.
RX PUBMED: 20450493.
RA Ishimoto K., Tachibana K., Hanano I., Yamasaki D., Nakamura H., Kawai M., Urano Y., Tanaka T., Hamakubo T., Sakai J., Kodama T., Doi T.
RT Sterol regulatory element-binding protein 2 and nuclear factor Y controls human farnesyl diphosphate synthase expression and affects cell proliferation in hepatoblastoma cells.
RL Biochem. J. 429:347-357 (2010).
RN [9]; RE0070393.
RX PUBMED: 16251441.
RA Valenza M., Rigamonti D., Goffredo D., Zuccato C., Fenu S., Jamot L., Strand A., Tarditi A., Woodman B., Racchi M., Mariotti C., Di Donato S., Corsini A., Bates G., Pruss R., Olson J. M., Sipione S., Tartari M., Cattaneo E.
RT Dysfunction of the cholesterol biosynthetic pathway in Huntington's disease.
RL J. Neurosci. 25:9932-9939 (2005).
RN [10]; RE0028949.
RX PUBMED: 11579213.
RA Heemers H., Maes B., Foufelle F., Heyns W., Verhoeven G., Swinnen J. V.
RT Androgens stimulate lipogenic gene expression in prostate cancer cells by activation of the sterol regulatory element-binding protein cleavage activating protein/sterol regulatory element-binding protein pathway.
RL Mol. Endocrinol. 15:1817-28 (2001).
RN [11]; RE0047696.
RX PUBMED: 16480961.
RA Motoyama K., Fukumoto S., Koyama H., Emoto M., Shimano H., Maemura K., Nishizawa Y.
RT SREBP inhibits VEGF expression in human smooth muscle cells.
RL Biochem. Biophys. Res. Commun. 342:354-360 (2006).
RN [12]; RE0047713.
RX PUBMED: 10224053.
RA Bennett M. K., Ngo T. T., Athanikar J. N., Rosenfeld J. M., Osborne T. F.
RT Co-stimulation of promoter for low density lipoprotein receptor gene by sterol regulatory element-binding protein and Sp1 is specifically disrupted by the yin yang 1 protein.
RL J. Biol. Chem. 274:13025-13032 (1999).
RN [13]; RE0038571.
RX PUBMED: 12855700.
RA Misawa K., Horiba T., Arimura N., Hirano Y., Inoue J., Emoto N., Shimano H., Shimizu M., Sato R.
RT Sterol regulatory element-binding protein-2 interacts with hepatocyte nuclear factor-4 to enhance sterol isomerase gene expression in hepatocytes
RL J. Biol. Chem. 278:36176-82 (2003).
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