AC T01804
AS T00157.
XX
ID T01804
XX
DT 13.05.1996 (created); dbo.
DT 24.12.2015 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA NF-YA
XX
SY CAAT-box DNA binding protein subunit A; CP1B; HAP2; HAP2 (yeast); NF-YA; NFYA; Nuclear Factor Y.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004104 NFYA; HGNC: NFYA.
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CL C0075; heteromer-CCAAT; 4.2.1.0.1.
XX
SF subunit of a trimeric DNA binding complex NF-YA:NF-YB:NF-YC, see T00150;
SF physical interaction (in vitro and in vivo) with ZHX1 T04355 [8];
XX
CP (cell lines:) HeLa; lymphocytes [13].
XX
FF as a subunit of the NF-Y complex, interacts directly with two subunits of the RFX complex, RFX5 T01672 and RFXANK T05441 [10];
XX
IN T04074 brca1; human, Homo sapiens.
IN T00105 C/EBPalpha; human, Homo sapiens.
IN T01488 Cdk2; human, Homo sapiens.
IN T01487 cyclinA; human, Homo sapiens.
IN T09117 E2F-1; human, Homo sapiens.
IN T14606 E2F-3; human, Homo sapiens.
IN T02997 E2F-6; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T01263 hap3; fission yeast, Schizosaccharomyces pombe.
IN T00350 Hap3p; yeast, Saccharomyces cerevisiae.
IN T00351 Hap4p; yeast, Saccharomyces cerevisiae.
IN T00087 NF-YB; rat, Rattus norvegicus.
IN T00154 NF-YB; human, Homo sapiens.
IN T00616 NF-YB; mouse, Mus musculus.
IN T02478 NF-YC-isoform3; human, Homo sapiens.
IN T10617 NF-YC; human, Homo sapiens.
IN T00545 POU2F1; human, Homo sapiens.
IN T01672 rfx5; human, Homo sapiens.
IN T05441 RFXANK; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
IN T01560 SREBP-2; human, Homo sapiens.
IN T04355 zhx1; human, Homo sapiens.
XX
MX M04683 V$NFYA_02.
MX M07222 V$NFYA_03.
MX M02106 V$NFYA_Q5.
MX M00209 V$NFY_C.
MX M07302 V$NFY_Q3.
MX M00185 V$NFY_Q6.
MX M00775 V$NFY_Q6_01.
XX
BS R00990.
BS R33105.
BS R30338.
BS R56818.
BS R61579.
BS R61581.
BS R25973.
BS R19647.
BS R19650.
BS R19652.
BS R21155.
BS R36461.
BS R70781.
BS R73959.
BS R36457.
BS R36458.
BS R36459.
BS R04344.
BS R12441.
BS R68780.
BS R37757.
BS R31586.
BS R21585.
BS R20182.
BS R04358.
BS R22899.
BS R21524.
BS R16911.
BS R33104.
BS R20409.
BS R58704.
BS R61147.
BS R31381.
BS R62799.
BS R62825.
BS R23531.
BS R25570.
BS R24495.
BS R33077.
BS R36773.
BS R22907.
BS R72851.
BS R28321.
BS R01088.
BS R04736.
BS R63383.
BS R63423.
BS R63454.
BS R39352.
BS R33601.
BS R33057.
BS R16941.
BS R38994.
BS R41150.
BS R21389.
BS R21390.
BS R42481.
BS R25638.
BS R71077.
BS R71078.
BS R21354.
BS R31845.
BS R37756.
BS R37764.
BS R36031.
BS R16969.
BS R22397.
BS R22398.
BS R22400.
BS R33173.
BS R38376.
BS R38377.
BS R38378.
BS R39904.
BS R16955.
BS R25045.
BS R31959.
BS R62609.
BS R22610.
BS R22905.
BS R37048.
BS R71579.
BS R20616.
BS R20617.
BS R24778.
BS R30918.
BS R59545.
BS R58346.
BS R58351.
BS R16987.
BS R22902.
BS R22768.
BS R59750.
BS R13352.
BS R13353.
BS R22901.
BS R21203.
BS R34317.
BS R22609.
BS R29981.
BS R22137.
BS R29980.
BS R28124.
XX
DR TRANSPATH: MO000025939.
DR TRANSCOMPEL: C00180.
DR TRANSCOMPEL: C00190.
DR TRANSCOMPEL: C00206.
DR TRANSCOMPEL: C00207.
DR TRANSCOMPEL: C00210.
DR TRANSCOMPEL: C00211.
DR TRANSCOMPEL: C00284.
DR TRANSCOMPEL: C00378.
DR TRANSCOMPEL: C00382.
DR TRANSCOMPEL: C00383.
DR TRANSCOMPEL: C00439.
DR TRANSCOMPEL: C00452.
DR TRANSCOMPEL: C00639.
DR UniProtKB: P23511;
XX
RN [1]; RE0000036.
RX PUBMED: 3349524.
RA Chodosh L. A., Baldwin jr A. S., Carthew R. W., Sharp P. A.
RT Human CCAAT-Binding Proteins Have Heterologous Subunits
RL Cell 53:11-24 (1988).
RN [2]; RE0000037.
RX PUBMED: 3280141.
RA Chodosh L. A., Olesen J., Hahn S., Baldwin jr A. S., Guarente L., Sharp P. A.
RT A Yeast and a Human CCAAT-Binding Protein Have Heterologous Subunits That Are Functionally Interchangeable
RL Cell 53:25-35 (1988).
RN [3]; RE0000110.
RX PUBMED: 3476205.
RA Dorn A., Bollekens J., Staub A., Benoist C., Mathis D.
RT A Multiplicity of CCAAT Box-Binding Proteins
RL Cell 50:863-872 (1987).
RN [4]; RE0000447.
RX PUBMED: 1698608.
RA Hooft van Huijsduijnen R., Li X. Y., Black D., Matthes H., Benoist C., Mathis D.
RT Co-evolution from yeast to mouse: cDNA cloning of the two NF-Y (CP-1/CBF) subunits
RL EMBO J. 9:3119-3127 (1990).
RN [5]; RE0000618.
RX PUBMED: 2159932.
RA Dutta A., Stoeckle M. Y., Hanafusa H.
RT Serum and v-src increase the level of a CCAAT-binding factor required for transcription from a retroviral long terminal repeat
RL Genes Dev. 4:243-254 (1990).
RN [6]; RE0002454.
RX PUBMED: 2000400.
RA Becker D. M., Fikes J. D., Guarente L.
RT A cDNA encoding a human CCAAT-binding protein cloned by functional complementation in yeast
RL Proc. Natl. Acad. Sci. USA 88:1968-1972 (1991).
RN [7]; RE0004117.
RX PUBMED: 7556094.
RA Zwicker J., Lucibello F. C., Wolfraim L. A., Gross C., Truss M., Engeland K., Mueller R.
RT Cell cycle regulation of the cyclin A, cdc25C and cdc2 genes is based on a common mechanism of transcriptional repression
RL EMBO J. 14:4514-4522 (1995).
RN [8]; RE0015796.
RX PUBMED: 10441475.
RA Yamada K., Printz R. L., Osawa H., Granner D. K.
RT Human ZHX1: cloning, chromosomal location, and interaction withtranscription factor NF-Y
RL Biochem. Biophys. Res. Commun. 261:614-621 (1999).
RN [9]; RE0017971.
RX PUBMED: 9662544.
RA Edwards D., Murray J. A., Smith A. G.
RT Multiple genes encoding the conserved CCAAT-box transcription factor complex are expressed in Arabidopsis.
RL Plant Physiol. 117:1015-1022 (1998).
RN [10]; RE0022593.
RX PUBMED: 12101253.
RA Jabrane-Ferrat N., Nekrep N., Tosi G., Esserman L. J., Peterlin B. M.
RT Major histocompatibility complex class II transcriptional platform: assembly of nuclear factor Y and regulatory factor X (RFX) on DNA requires RFX5 dimers.
RL Mol. Cell. Biol. 22:5616-5625 (2002).
RN [11]; RE0023108.
RX PUBMED: 12857729.
RA Yun J., Chae H. D., Choi T. S., Kim E. H., Bang Y. J., Chung J. K., Choi K. S., Mantovani R., Shin D. Y.
RT Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway.
RL J. Biol. Chem. 278:36966-36972 (2003).
RN [12]; RE0047410.
RX PUBMED: 11459781.
RA Farsetti A., Narducci M., Moretti F., Nanni S., Mantovani R., Sacchi A., Pontecorvi A.
RT Inhibition of ERalpha-mediated trans-activation of human coagulation factor XII gene by heteromeric transcription factor NF-Y.
RL Endocrinology 142:3380-3388 (2001).
RN [13]; RE0047491.
RX PUBMED: 16343534.
RA Bannwarth S., Laine S., Daher A., Grandvaux N., Clerzius G., Leblanc A. C., Hiscott J., Gatignol A.
RT Cell-specific regulation of TRBP1 promoter by NF-Y transcription factor in lymphocytes and astrocytes.
RL J. Mol. Biol. 355:898-910 (2006).
RN [14]; RE0047945.
RX PUBMED: 11777930.
RA Fan W., Jin S., Tong T., Zhao H., Fan F., Antinore M. J., Rajasekaran B., Wu M., Zhan Q.
RT BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs.
RL J. Biol. Chem. 277:8061-8067 (2002).
RN [15]; RE0066824.
RX PUBMED: 20450493.
RA Ishimoto K., Tachibana K., Hanano I., Yamasaki D., Nakamura H., Kawai M., Urano Y., Tanaka T., Hamakubo T., Sakai J., Kodama T., Doi T.
RT Sterol regulatory element-binding protein 2 and nuclear factor Y controls human farnesyl diphosphate synthase expression and affects cell proliferation in hepatoblastoma cells.
RL Biochem. J. 429:347-357 (2010).
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