AC T00261
XX
ID T00261
XX
DT 15.10.1992 (created); ewi.
DT 25.08.2015 (updated); sup.
CO Copyright (C), QIAGEN.
XX
FA ER-alpha
XX
SY ER; ER alpha; ESR1; estradiol receptor; estrogen receptor; estrogen receptor alpha; NR3A1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G003925 ESR1; HGNC: ESR1.
XX
CL C0002; CC (rec); 2.1.1.2.1.
XX
SF 1 estrogen-inducible NLS (nuclear localization signal) within region E [3];
SF AF-1 (activating function, previously designated TAF-1): constitutive, independently active [2] [25];
SF in yeast, 3 independent subdomains are active (1-62, 80-113, 118-149) [25];
SF activating subdomains of AF-1 which are active in animal cells (51-93, 102-149) independently synergize with AF-2 [25];
SF AF-2: hormone inducible (within HBD);
SF 1H NMR: 2 zinc ions coordinated by 4 Cys within each zinc finger;
SF 2 perpendicular alpha-helices [11] [22];
SF can bind DNA as a homodimer or heterodimer T05702 with ER-beta T04651 [36];
XX
CP MCF-7, T47D, 21PT [65]; MCF-7+E2 [67]; MCF-7 cells [73]; MCF-7 + E2 [76].
EX muscles,,,adult; detectable; Northern blot; RNA (undefined); [97].
EX ovary (right and left),,,adult; detectable; Northern blot; RNA (undefined); [97].
EX prostate gland,,,adult; detectable; Northern blot; RNA (undefined); [97].
EX testis (right and left),,,adult; detectable; Northern blot; RNA (undefined); [97].
XX
FF N-terminal region and DNA binding domain are involved in the repression of Cyclin G2 promoter G018993 [68];
FF Oligoamines treatment down-regulates the protein level in MCF-7 and T47D cells [78];
FF IGF-1 potentiates nuclear transport [67];
FF ICI182,780 and TSA treatment decreases the expression [69];
FF The repression of TNF-alpha gene G000400 is mediated through the Ligand binding Domain;
FF site-specific activator [26];
FF may function as a co-activator, that is enhance transcription without direct binding to DNA [33] [34];
FF as a co-activator, enhances binding of Sp1 to GC-boxes [33] [34];
FF inducible NLS also inducible by hydroxy-tamoxifen, not by ICI 164,384 [3];
FF discrimination over GRE-binding through first zinc finger: E-203, G-204, A-206;
FF TAF-1 is constitutive, but cell-specific (active in CEF, poorly active in HeLa) [12];
FF estrogen-dependent binding and inhibition of GATA-1 T00305 causes suppression of erythropoiesis [27];
FF estrogen-bound ER induces apoptosis in MEL cells, not via binding to target gene promoters but probably due to inhibition of the erythroid transcription factor GATA-1 T00305 [28];
FF directly interacts with ERR1 [35];
XX
IN T05038 ADA3; human, Homo sapiens.
IN T01795 AhR; human, Homo sapiens.
IN T30262 alpha-actinin-4-isoform3; human, Homo sapiens.
IN T08796 ASC-2; human, Homo sapiens.
IN T05452 BAF155; human, Homo sapiens.
IN T22424 BAF57; human, Homo sapiens.
IN T27166 BAF57; mouse, Mus musculus.
IN T08887 brca1-isoform1; human, Homo sapiens.
IN T04074 brca1; human, Homo sapiens.
IN T15204 brca1; Mammalia.
IN T05451 BRG1; human, Homo sapiens.
IN T01261 Brm; human, Homo sapiens.
IN T00133 c-Jun; human, Homo sapiens.
IN T00581 C/EBPbeta; human, Homo sapiens.
IN T18378 CBP; human, Homo sapiens.
IN T01488 Cdk2; human, Homo sapiens.
IN T10259 Clock-L; mouse, Mus musculus.
IN T04891 CLOCK; human, Homo sapiens.
IN T00149 COUP-TF1; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T09637 ER-alpha; Mammalia.
IN T04651 ER-beta-isoform1; human, Homo sapiens.
IN T34781 ErbB1; human, Homo sapiens.
IN T02936 FOXO1A; human, Homo sapiens.
IN T02938 FOXO3a; human, Homo sapiens.
IN T00305 GATA-1; mouse, Mus musculus.
IN T17995 GATA-2; Mammalia.
IN T05076 GR; human, Homo sapiens.
IN T04106 HDAC1; human, Homo sapiens.
IN T01043 HSF2; human, Homo sapiens.
IN T00992 Hsp90; human, Homo sapiens.
IN T06375 ING1b; human, Homo sapiens.
IN T10510 JunB; Mammalia.
IN T09447 JunD; Mammalia.
IN T05110 Ku70; human, Homo sapiens.
IN T05111 Ku80; human, Homo sapiens.
IN T04453 LXR-beta; human, Homo sapiens.
IN T02187 MAT1; human, Homo sapiens.
IN T18783 MRF1; human, Homo sapiens.
IN T10759 MTA-1; human, Homo sapiens.
IN T00593 NF-kappaB1-p50; human, Homo sapiens.
IN T01804 NF-YA; human, Homo sapiens.
IN T00154 NF-YB; human, Homo sapiens.
IN T10617 NF-YC; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T34674 prohibitin-2; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T08711 RelA-p65; human, Homo sapiens.
IN T04597 SKIP; human, Homo sapiens.
IN T24830 Smad2; Mammalia.
IN T09538 Smad3; Mammalia.
IN T10378 Smad3; human, Homo sapiens.
IN T13998 Smad4; Mammalia.
IN T04642 SnoN; human, Homo sapiens.
IN T08326 Sp1; Mammalia.
IN T04632 SRC-1; human, Homo sapiens.
IN T21552 SRC-1; Mammalia.
IN T22417 SRC-1E; human, Homo sapiens.
IN T04640 SRC3; human, Homo sapiens.
IN T01574 STAT3; mouse, Mus musculus.
IN T22561 STAT3{p}; human, Homo sapiens.
IN T02118 TAFII30; human, Homo sapiens.
IN T02143 TIF1; mouse, Mus musculus.
IN T02482 TIF2; mouse, Mus musculus.
IN T02483 TIF2; human, Homo sapiens.
IN T19142 TR2; human, Homo sapiens.
IN T08700 XBP-1S; human, Homo sapiens.
IN T08699 XBP-1U; human, Homo sapiens.
IN T05150 ZAC-1b; mouse, Mus musculus.
IN T05129 ZER6 p52; human, Homo sapiens.
IN T20365 ZNF131; human, Homo sapiens.
XX
MX M01801 V$ERALPHA_01.
MX M07283 V$ERALPHA_Q4.
MX M03547 V$ERALPHA_Q6_01.
MX M03820 V$ERALPHA_Q6_02.
MX M00191 V$ER_Q6.
MX M00959 V$ER_Q6_02.
MX M02261 V$ESR1_01.
MX M04738 V$ESR1_04.
MX M04881 V$ESR1_05.
XX
BS R30301.
BS R02150.
BS R03564.
BS R13349.
BS R14257.
BS R24845.
BS R24995.
BS R25111.
BS R18719.
BS R03565.
BS R19794.
BS R34977.
BS R71317.
BS R63929.
BS R63936.
BS R62268.
BS R22139.
BS R25013.
BS R62297.
BS R62976.
BS R62978.
BS R62979.
BS R62980.
BS R14229.
BS R14230.
BS R24713.
BS R24989.
BS R24726.
BS R24764.
BS R66181.
BS R61708.
BS R14231.
BS R20451.
BS R20452.
BS R20453.
BS R60809.
BS R60818.
BS R60819.
BS R65856.
BS R35117.
BS R36830.
BS R19775.
BS R35028.
BS R32284.
BS R35021.
BS R30024.
BS R24844.
BS R14232.
BS R56393.
BS R56394.
BS R61460.
BS R68791.
BS R68792.
BS R68793.
BS R34965.
BS R62265.
BS R62266.
BS R27889.
BS R03958.
BS R39441.
BS R39444.
BS R39445.
BS R57087.
BS R35119.
BS R62743.
BS R18539.
BS R63534.
BS R63538.
BS R63539.
BS R69368.
BS R69373.
BS R69374.
BS R69375.
BS R69376.
BS R33451.
BS R33453.
BS R33454.
BS R14217.
BS R66984.
BS R30109.
BS R66986.
BS R62508.
BS R35940.
BS R67006.
BS R67007.
BS R67008.
BS R67009.
BS R25022.
BS R24877.
BS R57585.
BS R64788.
BS R64789.
BS R64790.
BS R36148.
BS R36153.
BS R36155.
BS R25127.
BS R62998.
BS R62999.
BS R63000.
BS R63001.
BS R71377.
BS R62992.
BS R62994.
BS R62995.
BS R62996.
BS R24669.
BS R24670.
BS R24671.
BS R24673.
BS R24674.
BS R24675.
BS R62347.
BS R28709.
BS R35118.
BS R16684.
BS R66182.
BS R42482.
BS R42484.
BS R67952.
BS R14211.
BS R25049.
BS R23769.
BS R32689.
BS R32690.
BS R32691.
BS R64630.
BS R30911.
BS R37749.
BS R30368.
BS R30572.
BS R25135.
BS R14194.
BS R24725.
BS R35215.
BS R35216.
BS R65841.
BS R72617.
BS R72618.
BS R72619.
BS R64082.
BS R62640.
BS R25188.
BS R68291.
BS R58554.
BS R59544.
BS R35040.
BS R28285.
BS R28286.
BS R24912.
BS R33051.
BS R25176.
BS R63782.
BS R35090.
BS R35091.
BS R35092.
BS R30089.
BS R35144.
BS R35227.
BS R03563.
BS R35094.
BS R22514.
BS R14214.
BS R56355.
BS R30481.
BS R01267.
BS R63073.
BS R01906.
BS R28284.
BS R35121.
XX
DR TRANSPATH: MO000019431.
DR TRANSCOMPEL: C00363.
DR TRANSCOMPEL: C00398.
DR TRANSCOMPEL: C00399.
DR TRANSCOMPEL: C00400.
DR TRANSCOMPEL: C00401.
DR TRANSCOMPEL: C00402.
DR TRANSCOMPEL: C00403.
DR TRANSCOMPEL: C00404.
DR TRANSCOMPEL: C00598.
DR PATHODB: MT010568.
DR PATHODB: MT010573.
DR PATHODB: MT010574.
DR PATHODB: MT010577.
DR PATHODB: MT010578.
DR PATHODB: MT010579.
DR PATHODB: MT010580.
DR PATHODB: MT010591.
DR PATHODB: MT010592.
DR PATHODB: MT010603.
DR PATHODB: MT010604.
DR PATHODB: MT010605.
DR UniProtKB: P03372;
XX
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