TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00261 XX ID T00261 XX DT 15.10.1992 (created); ewi. DT 25.08.2015 (updated); sup. CO Copyright (C), QIAGEN. XX FA ER-alpha XX SY ER; ER alpha; ESR1; estradiol receptor; estrogen receptor; estrogen receptor alpha; NR3A1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003925 ESR1; HGNC: ESR1. XX CL C0002; CC (rec); XX SF 1 estrogen-inducible NLS (nuclear localization signal) within region E [3]; SF AF-1 (activating function, previously designated TAF-1): constitutive, independently active [2] [25]; SF in yeast, 3 independent subdomains are active (1-62, 80-113, 118-149) [25]; SF activating subdomains of AF-1 which are active in animal cells (51-93, 102-149) independently synergize with AF-2 [25]; SF AF-2: hormone inducible (within HBD); SF 1H NMR: 2 zinc ions coordinated by 4 Cys within each zinc finger; SF 2 perpendicular alpha-helices [11] [22]; SF can bind DNA as a homodimer or heterodimer T05702 with ER-beta T04651 [36]; XX CP MCF-7, T47D, 21PT [65]; MCF-7+E2 [67]; MCF-7 cells [73]; MCF-7 + E2 [76]. EX muscles,,,adult; detectable; Northern blot; RNA (undefined); [97]. EX ovary (right and left),,,adult; detectable; Northern blot; RNA (undefined); [97]. EX prostate gland,,,adult; detectable; Northern blot; RNA (undefined); [97]. EX testis (right and left),,,adult; detectable; Northern blot; RNA (undefined); [97]. XX FF N-terminal region and DNA binding domain are involved in the repression of Cyclin G2 promoter G018993 [68]; FF Oligoamines treatment down-regulates the protein level in MCF-7 and T47D cells [78]; FF IGF-1 potentiates nuclear transport [67]; FF ICI182,780 and TSA treatment decreases the expression [69]; FF The repression of TNF-alpha gene G000400 is mediated through the Ligand binding Domain; FF site-specific activator [26]; FF may function as a co-activator, that is enhance transcription without direct binding to DNA [33] [34]; FF as a co-activator, enhances binding of Sp1 to GC-boxes [33] [34]; FF inducible NLS also inducible by hydroxy-tamoxifen, not by ICI 164,384 [3]; FF discrimination over GRE-binding through first zinc finger: E-203, G-204, A-206; FF TAF-1 is constitutive, but cell-specific (active in CEF, poorly active in HeLa) [12]; FF estrogen-dependent binding and inhibition of GATA-1 T00305 causes suppression of erythropoiesis [27]; FF estrogen-bound ER induces apoptosis in MEL cells, not via binding to target gene promoters but probably due to inhibition of the erythroid transcription factor GATA-1 T00305 [28]; FF directly interacts with ERR1 [35]; XX IN T05038 ADA3; human, Homo sapiens. IN T01795 AhR; human, Homo sapiens. IN T30262 alpha-actinin-4-isoform3; human, Homo sapiens. IN T08796 ASC-2; human, Homo sapiens. IN T05452 BAF155; human, Homo sapiens. IN T22424 BAF57; human, Homo sapiens. IN T27166 BAF57; mouse, Mus musculus. IN T08887 brca1-isoform1; human, Homo sapiens. IN T04074 brca1; human, Homo sapiens. IN T15204 brca1; Mammalia. IN T05451 BRG1; human, Homo sapiens. IN T01261 Brm; human, Homo sapiens. IN T00133 c-Jun; human, Homo sapiens. IN T00581 C/EBPbeta; human, Homo sapiens. IN T18378 CBP; human, Homo sapiens. IN T01488 Cdk2; human, Homo sapiens. IN T10259 Clock-L; mouse, Mus musculus. IN T04891 CLOCK; human, Homo sapiens. IN T00149 COUP-TF1; human, Homo sapiens. IN T00261 ER-alpha; human, Homo sapiens. IN T09637 ER-alpha; Mammalia. IN T04651 ER-beta-isoform1; human, Homo sapiens. IN T34781 ErbB1; human, Homo sapiens. IN T02936 FOXO1A; human, Homo sapiens. IN T02938 FOXO3a; human, Homo sapiens. IN T00305 GATA-1; mouse, Mus musculus. IN T17995 GATA-2; Mammalia. IN T05076 GR; human, Homo sapiens. IN T04106 HDAC1; human, Homo sapiens. IN T01043 HSF2; human, Homo sapiens. IN T00992 Hsp90; human, Homo sapiens. IN T06375 ING1b; human, Homo sapiens. IN T10510 JunB; Mammalia. IN T09447 JunD; Mammalia. IN T05110 Ku70; human, Homo sapiens. IN T05111 Ku80; human, Homo sapiens. IN T04453 LXR-beta; human, Homo sapiens. IN T02187 MAT1; human, Homo sapiens. IN T18783 MRF1; human, Homo sapiens. IN T10759 MTA-1; human, Homo sapiens. IN T00593 NF-kappaB1-p50; human, Homo sapiens. IN T01804 NF-YA; human, Homo sapiens. IN T00154 NF-YB; human, Homo sapiens. IN T10617 NF-YC; human, Homo sapiens. IN T23091 p300; Mammalia. IN T34674 prohibitin-2; human, Homo sapiens. IN T00594 RelA-p65-isoform1; human, Homo sapiens. IN T08711 RelA-p65; human, Homo sapiens. IN T04597 SKIP; human, Homo sapiens. IN T24830 Smad2; Mammalia. IN T09538 Smad3; Mammalia. IN T10378 Smad3; human, Homo sapiens. IN T13998 Smad4; Mammalia. IN T04642 SnoN; human, Homo sapiens. IN T08326 Sp1; Mammalia. IN T04632 SRC-1; human, Homo sapiens. IN T21552 SRC-1; Mammalia. IN T22417 SRC-1E; human, Homo sapiens. IN T04640 SRC3; human, Homo sapiens. IN T01574 STAT3; mouse, Mus musculus. IN T22561 STAT3{p}; human, Homo sapiens. IN T02118 TAFII30; human, Homo sapiens. IN T02143 TIF1; mouse, Mus musculus. IN T02482 TIF2; mouse, Mus musculus. IN T02483 TIF2; human, Homo sapiens. IN T19142 TR2; human, Homo sapiens. IN T08700 XBP-1S; human, Homo sapiens. IN T08699 XBP-1U; human, Homo sapiens. IN T05150 ZAC-1b; mouse, Mus musculus. IN T05129 ZER6 p52; human, Homo sapiens. IN T20365 ZNF131; human, Homo sapiens. XX MX M01801 V$ERALPHA_01. MX M07283 V$ERALPHA_Q4. MX M03547 V$ERALPHA_Q6_01. MX M03820 V$ERALPHA_Q6_02. MX M00191 V$ER_Q6. MX M00959 V$ER_Q6_02. MX M02261 V$ESR1_01. MX M04738 V$ESR1_04. MX M04881 V$ESR1_05. XX BS R30301. BS R02150. BS R03564. BS R13349. BS R14257. BS R24845. BS R24995. BS R25111. BS R18719. BS R03565. BS R19794. BS R34977. BS R71317. BS R63929. BS R63936. BS R62268. BS R22139. BS R25013. BS R62297. BS R62976. BS R62978. BS R62979. BS R62980. BS R14229. BS R14230. BS R24713. BS R24989. BS R24726. BS R24764. BS R66181. BS R61708. BS R14231. BS R20451. BS R20452. BS R20453. BS R60809. BS R60818. BS R60819. BS R65856. BS R35117. BS R36830. BS R19775. BS R35028. BS R32284. BS R35021. BS R30024. BS R24844. BS R14232. BS R56393. BS R56394. BS R61460. BS R68791. BS R68792. BS R68793. BS R34965. BS R62265. BS R62266. BS R27889. BS R03958. BS R39441. BS R39444. BS R39445. BS R57087. BS R35119. BS R62743. BS R18539. BS R63534. BS R63538. BS R63539. BS R69368. BS R69373. BS R69374. BS R69375. BS R69376. BS R33451. BS R33453. BS R33454. BS R14217. BS R66984. BS R30109. BS R66986. BS R62508. BS R35940. BS R67006. BS R67007. BS R67008. BS R67009. BS R25022. BS R24877. BS R57585. BS R64788. BS R64789. BS R64790. BS R36148. BS R36153. BS R36155. BS R25127. BS R62998. BS R62999. BS R63000. BS R63001. BS R71377. BS R62992. BS R62994. BS R62995. BS R62996. BS R24669. BS R24670. BS R24671. BS R24673. BS R24674. BS R24675. BS R62347. BS R28709. BS R35118. BS R16684. BS R66182. BS R42482. BS R42484. BS R67952. BS R14211. BS R25049. BS R23769. BS R32689. BS R32690. BS R32691. BS R64630. BS R30911. BS R37749. BS R30368. BS R30572. BS R25135. BS R14194. BS R24725. BS R35215. BS R35216. BS R65841. BS R72617. BS R72618. BS R72619. BS R64082. BS R62640. BS R25188. BS R68291. BS R58554. BS R59544. BS R35040. BS R28285. BS R28286. BS R24912. BS R33051. BS R25176. BS R63782. BS R35090. BS R35091. BS R35092. BS R30089. BS R35144. BS R35227. BS R03563. BS R35094. BS R22514. BS R14214. BS R56355. BS R30481. BS R01267. BS R63073. BS R01906. BS R28284. BS R35121. XX DR TRANSPATH: MO000019431. DR TRANSCOMPEL: C00363. DR TRANSCOMPEL: C00398. DR TRANSCOMPEL: C00399. DR TRANSCOMPEL: C00400. DR TRANSCOMPEL: C00401. DR TRANSCOMPEL: C00402. DR TRANSCOMPEL: C00403. DR TRANSCOMPEL: C00404. DR TRANSCOMPEL: C00598. DR PATHODB: MT010568. DR PATHODB: MT010573. DR PATHODB: MT010574. DR PATHODB: MT010577. DR PATHODB: MT010578. DR PATHODB: MT010579. DR PATHODB: MT010580. DR PATHODB: MT010591. DR PATHODB: MT010592. DR PATHODB: MT010603. DR PATHODB: MT010604. DR PATHODB: MT010605. DR UniProtKB: P03372; XX RN [1]; RE0000133. RX PUBMED: 3167974. RA Kumar V., Chambon P. RT The Estrogen Receptor Binds Tightly to Its Responsive Element as a Ligand-Induced Homodimer RL Cell 55:145-156 (1988). RN [2]; RE0000250. RX PUBMED: 2805068. RA Tora L., White J., Brou C., Tasset D., Webster N., Scheer E., Chambon P. RT The human estrogen receptor has two independent nonacidic transcriptional activation functions RL Cell 59:477-487 (1989). RN [3]; RE0000304. RX PUBMED: 1327748. RA Ylikomi T., Bocquel M. T., Berry M., Gronemeyer H., Chambon P. RT Cooperation of proto-signals for nuclear accumulation of estrogen and progesterone receptors RL EMBO J. 11:3681-3694 (1992). RN [4]; RE0000391. RX PUBMED: 3208750. RA Tora L., Gaub M.-P., Mader S., Dierich A., Bellard M., Chambon P. RT Cell-specific activity of a GGTCA half-palindromic oestrogen-responsive element in the chicken ovalbumin gene promoter RL EMBO J. 7:3771-3778 (1988). RN [5]; RE0000415. RX PUBMED: 3755102. RA Krust A., Green S., Argos P., Kumar V., Walter P., Bornert J.-M., Chambon P. RT The chicken oestrogen receptor sequence: homology with v-erbA and the human oestrogen and glucocorticoid receptors RL EMBO J. 5:891-897 (1986). RN [6]; RE0000441. RX PUBMED: 2583118. RA Martinez E., Wahli W. RT Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity RL EMBO J. 8:3781-3791 (1989). RN [7]; RE0000518. RX PUBMED: 2050123. RA Savouret J. F., Bailly A., Mirashi M., Rauch C., Redeuilh G., Chauchereau A., Milgrom E. RT Characterization of the hormone responsive element involved in the regulation of the progesterone receptor gene RL EMBO J. 10:1875-1883 (1991). RN [8]; RE0000817. RX PUBMED: 3372525. RA Smith J. D., Melian A., Leff T., Breslow J. L. RT Expression of the Human Apolipoprotein E Gene is Regulated by Multiple Positive and Negative Elements RL J. Biol. Chem. 263:8300-8308 (1988). RN [9]; RE0001752. RX PUBMED: 2172797. RA Forman B. M., Samuels H. H. RT Interactions among a subfamily of nuclear hormone receptors: the regulatory zipper model RL Mol. Endocrinol. 4:1293-1301 (1990). RN [10]; RE0001827. RX PUBMED: 3754034. RA Green S., Walter P., Kumar V., Krust A., Bornert J.-M., Argos P., Chambon P. RT Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A RL Nature 320:134-139 (1986). RN [11]; RE0001894. RX PUBMED: 2247153. RA Schwabe J. W. R., Neuhaus D., Rhodes D. RT Solution structure of the DNA-binding domain of the oestrogen receptor RL Nature 348:458-461 (1990). RN [12]; RE0001904. RX PUBMED: 2922054. RA Mader S., Kumar V., de Verneuil H., Chambon P. RT Three amino acids of the oestrogen receptor are essential to its ability to distinguish an oestrogen from a glucocorticoid-responsive element RL Nature 338:271-275 (1989). RN [13]; RE0002075. RX PUBMED: 1975094. RA de Verneuil H., Metzger D. RT The lack of transcriptional activation of the v-erbA oncogene is in part due to a mutation in the DNA binding domain of the protein RL Nucleic Acids Res. 18:4489-4497 (1990). RN [14]; RE0002358. RX PUBMED: 3865204. RA Walter P., Greene S., Greene G. L., Krust A., Bornert J.-M., Jeltsch J. M., Staub A., Jensen E., Serace G., Waterfield M., Chambon P. RT Cloning of the human estrogen receptor cDNA RL Proc. Natl. Acad. Sci. USA 82:7889-7893 (1985). RN [15]; RE0002633. RX PUBMED: 3753802. RA Greene G. L., Gilna P., Waterfield M., Baker A., Hort Y., Shine J. RT Sequence and expression of human estrogen receptor complementary DNA RL Science 231:1150-1154 (1986). RN [16]; RE0002741. RX PUBMED: 2357968. RA Ponglikitmongkol M., White J. H., Chambon P. RT Synergistic activation of transcription by the human estrogen receptor bound to tandem responsive elements RL EMBO J. 9:2221-2231 (1990). RN [17]; RE0003771. RX PUBMED: 8385312. RA Mader S., Chambon P., White J. H. RT Defining a minimal estrogen receptor DNA binding domain RL Nucleic Acids Res. 21:1125-1132 (1993). RN [18]; RE0003772. RX PUBMED: 3690665. RA Kumar V., Green S., Stack G., Berry M., Jin J.-R., Chambon P. RT Functional domains of the human estrogen receptor RL Cell 51:941-951 (1987). RN [19]; RE0003773. RX PUBMED: 3780678. RA Kumar V., Green S., Staub A., Chambon P. RT Localization of the oestradiol-binding and putative DNA-binding domains of the human oestrogen receptor RL EMBO J. 5:2231-2236 (1986). RN [20]; RE0003775. RX PUBMED: 3145193. RA Ponglikitmongkol M., Green S., Chambon P. RT Genomic organization of the human oestrogen receptor gene RL EMBO J. 7:3385-3388 (1988). RN [21]; RE0003776. RX PUBMED: 2243115. RA Chambraud B., Berry M., Redeuilh G., Chambon P., Baulieu E.-E. RT Several regions of the human estrogen receptor are involved in the formation of receptor heat-shock protein 90 complexes RL J. Biol. Chem. 265:20686-20691 (1990). RN [22]; RE0003777. RX PUBMED: 8221895. RA Schwabe J. W. R., Chapman L., Finch J. T., Rhodes D. RT The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements RL Cell 75:567-578 (1993). RN [23]; RE0003779. RX PUBMED: 1408752. RA Gilbert D. M., Losson R., Chambon P. RT Ligand dependence of estrogen receptor induces changes in chromatin structure RL Nucleic Acids Res. 20:4525-4531 (1992). RN [24]; RE0003780. RX PUBMED: 3882696. RA Lubahn D. B., McCarty jr K. S., McCarty sr K. S. RT Electrophoretic characterization of purified bovine, porcine, murine, rat, and human uterine estrogen receptors RL J. Biol. Chem. 260:2515-2526 (1985). RN [25]; RE0003801. RX PUBMED: 7721882. RA Metzger D., Ali A., Bornet S.-M., Chambon P. RT Characterization of the amino-terminal transcriptional activation function of the human estrogen receptor in animal and yeast cells RL J. Biol. Chem. 270:9535-9542 (1995). RN [26]; RE0004844. RX PUBMED: 2119495. RA Weisz A., Rosales R. RT Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor RL Nucleic Acids Res. 18:5097-5106 (1990). RN [27]; RE0010521. RX PUBMED: 7760810. RA Blobel G. A., Sieff C. A., Orkin S. H. RT Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor RL Mol. Cell. Biol. 15:3147-3153 (1995). RN [28]; RE0013427. RX PUBMED: 8657144. RA Blobel G. A., Orkin S. H. RT Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1. RL Mol. Cell. Biol. 16:1687-1694 (1996). RN [29]; RE0016367. RX PUBMED: 10874567. RA Beato M., Klug J. RT Steroid hormone receptors: an update RL Hum. Reprod. Update 6:225-236 (2000). RN [30]; RE0016449. RX PUBMED: 10428842. RA Hong H., Yang L., Stallcup M. R. RT Hormone-independent transcriptional activation and coactivator binding by novel orphan nuclear receptor ERR3 RL J. Biol. Chem. 274:22618-22626 (1999). RN [31]; RE0018645. RX PUBMED: 10217432. RA El Khissiin A., Leclercq G. RT Implication of proteasome in estrogen receptor degradation RL FEBS Lett. 448:160-166 (1999). RN [32]; RE0020843. RX PUBMED: 11032808. RA Migliaccio A., Castoria G., Di Domenico M., de Falco A., Bilancio A., Lombardi M., Barone M. V., Ametrano D., Zannini M. S., Abbondanza C., Auricchio F. RT Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation RL EMBO J. 19:5406-5417 (2000). RN [33]; RE0022284. RX PUBMED: 9528985. RA Duan R., Porter W., Safe S. RT Estrogen-induced c-fos protooncogene expression in MCF-7 human breast cancer cells: role of estrogen receptor Sp1 complex formation. RL Endocrinology 139:1981-1990 (1998). RN [34]; RE0023324. RX PUBMED: 9626663. RA Sun G., Porter W., Safe S. RT Estrogen-induced retinoic acid receptor alpha 1 gene expression: role of estrogen receptor-Sp1 complex. RL Mol. Endocrinol. 12:882-890 (1998). RN [35]; RE0023327. RX PUBMED: 8621448. RA Yang N., Shigeta H., Shi H., Teng C. T. RT Estrogen-related receptor, hERR1, modulates estrogen receptor-mediated response of human lactoferrin gene promoter. RL J. Biol. Chem. 271:5795-5804 (1996). RN [36]; RE0023363. RX PUBMED: 9242648. RA Cowley S. M., Hoare S., Mosselman S., Parker M. G. RT Estrogen receptors alpha and beta form heterodimers on DNA. RL J. Biol. Chem. 272:19858-19862 (1997). RN [37]; RE0023554. RX PUBMED: 9973262. RA Wyszomierski S. L., Yeh J., Rosen J. M. RT Glucocorticoid receptor/signal transducer and activator of transcription 5 (STAT5) interactions enhance STAT5 activation by prolonging STAT5 DNA binding and tyrosine phosphorylation. RL Mol. Endocrinol. 13:330-343 (1999). RN [38]; RE0026788. RX PUBMED: 11029009. RA Simoncini T., Hafezi-Moghadam A., Brazil D. P., Ley K., Chin W. W., Liao J. K. RT Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase RL Nature 407:538-41 (2000). RN [39]; RE0029298. RX PUBMED: 11579095. RA Driggers P. H., Segars J. H., Rubino D. M. RT The proto-oncoprotein Brx activates estrogen receptor beta by a p38 mitogen-activated protein kinase pathway. RL J. Biol. Chem. 276:46792-7 (2001). RN [40]; RE0031549. RX PUBMED: 11477071. RA Teyssier C., Belguise K., Galtier F., Chalbos D. RT Characterization of the physical interaction between estrogen receptor alpha and JUN proteins. RL J. Biol. Chem. 276:36361-9 (2001). RN [41]; RE0035802. RX PUBMED: 12374744. RA Wang R. A., Mazumdar A., Vadlamudi R. K., Kumar R. RT P21-activated kinase-1 phosphorylates and transactivates estrogen receptor-alpha and promotes hyperplasia in mammary epithelium. RL EMBO J. 21:5437-5447 (2002). RN [42]; RE0036174. RX PUBMED: 15899841. RA Callige M., Kieffer I., Richard-Foy H. RT CSN5/Jab1 is involved in ligand-dependent degradation of estrogen receptor {alpha} by the proteasome. RL Mol. Cell. Biol. 25:4349-4358 (2005). RN [43]; RE0041862. RX PUBMED: 11555647. RA Matsuda T., Yamamoto T., Muraguchi A., Saatcioglu F. RT Cross-talk between transforming growth factor-beta and estrogen receptor signaling through Smad3 RL J. Biol. Chem. 276:42908-14 (2001). RN [44]; RE0046883. RX PUBMED: 15169784. RA Mishra S. K., Talukder A. H., Gururaj A. E., Yang Z., Singh R. R., Mahoney M. G., Franci C., Vadlamudi R. K., Kumar R. RT Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway RL J. Biol. Chem. 279:32709-15 (2004). RN [45]; RE0047167. RX PUBMED: 15137909. RA Huang S. M., Cheng Y. S. RT Analysis of two CBP (cAMP-response-element-binding protein-binding protein) interacting sites in GRIP1 (glucocorticoid-receptor-interacting protein), and their importance for the function of GRIP1 RL Biochem. J. 382:111-9 (2004). RN [46]; RE0047243. RX PUBMED: 15047147. RA Bu H., Kashireddy P., Chang J., Zhu Y. T., Zhang Z., Zheng W., Rao S. M., Zhu Y. J. RT ERBP, a novel estrogen receptor binding protein enhancing the activity of estrogen receptor RL Biochem. Biophys. Res. Commun. 317:54-9 (2004). RN [47]; RE0047405. RX PUBMED: 12954762. RA Ding L., Yan J., Zhu J., Zhong H., Lu Q., Wang Z., Huang C., Ye Q. RT Ligand-independent activation of estrogen receptor alpha by XBP-1. RL Nucleic Acids Res. 31:5266-5274 (2003). RN [48]; RE0047410. RX PUBMED: 11459781. RA Farsetti A., Narducci M., Moretti F., Nanni S., Mantovani R., Sacchi A., Pontecorvi A. RT Inhibition of ERalpha-mediated trans-activation of human coagulation factor XII gene by heteromeric transcription factor NF-Y. RL Endocrinology 142:3380-3388 (2001). RN [49]; RE0047416. RX PUBMED: 12034840. RA Benecke A., Gaudon C., Garnier J. M., vom Baur E., Chambon P., Losson R. RT ADA3-containing complexes associate with estrogen receptor alpha. RL Nucleic Acids Res. 30:2508-2514 (2002). RN [50]; RE0047429. RX PUBMED: 15569929. RA Lu Q., Pallas D. C., Surks H. K., Baur W. E., Mendelsohn M. E., Karas R. H. RT Striatin assembles a membrane signaling complex necessary for rapid, nongenomic activation of endothelial NO synthase by estrogen receptor alpha. RL Proc. Natl. Acad. Sci. USA 101:17126-17131 (2004). RN [51]; RE0047450. RX PUBMED: 11773443. RA Song R. X., McPherson R. A., Adam L., Bao Y., Shupnik M., Kumar R., Santen R. J. RT Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation. RL Mol. Endocrinol. 16:116-127 (2002). RN [52]; RE0047527. RX PUBMED: 10866662. RA Mahajan M. A., Samuels H. H. RT A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein. RL Mol. Cell. Biol. 20:5048-5063 (2000). RN [53]; RE0047547. RX PUBMED: 11146623. RA Mazumdar A., Wang R. A., Mishra S. K., Adam L., Bagheri-Yarmand R., Mandal M., Vadlamudi R. K., Kumar R. RT Transcriptional repression of oestrogen receptor by metastasis-associated protein 1 corepressor. RL Nat. Cell Biol. 3:30-37 (2001). RN [54]; RE0047561. RX PUBMED: 15655247. RA Bourguignon L. Y., Gilad E., Rothman K., Peyrollier K. RT Hyaluronan-CD44 interaction with IQGAP1 promotes Cdc42 and ERK signaling, leading to actin binding, Elk-1/estrogen receptor transcriptional activation, and ovarian cancer progression. RL J. Biol. Chem. 280:11961-11972 (2005). RN [55]; RE0047577. RX PUBMED: 16144913. RA Bonofiglio D., Gabriele S., Aquila S., Catalano S., Gentile M., Middea E., Giordano F., Ando S. RT Estrogen receptor alpha binds to peroxisome proliferator-activated receptor response element and negatively interferes with peroxisome proliferator-activated receptor gamma signaling in breast cancer cells. RL Clin. Cancer Res. 11:6139-6147 (2005). RN [56]; RE0047605. RX PUBMED: 15579769. RA Vadlamudi R. K., Balasenthil S., Broaddus R. R., Gustafsson J. A., Kumar R. RT Deregulation of estrogen receptor coactivator proline-, glutamic acid-, and leucine-rich protein-1/modulator of nongenomic activity of estrogen receptor in human endometrial tumors. RL J. Clin. Endocrinol. Metab. 89:6130-6138 (2004). RN [57]; RE0047675. RX PUBMED: 15886699. RA Wada-Hiraike O., Yano T., Nei T., Matsumoto Y., Nagasaka K., Takizawa S., Oishi H., Arimoto T., Nakagawa S., Yasugi T., Kato S., Taketani Y. RT The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha. RL Br. J. Cancer 92:2286-2291 (2005). RN [58]; RE0049207. RX PUBMED: 14980219. RA Perissi V., Aggarwal A., Glass C. K., Rose D. W., Rosenfeld M. G. RT A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. RL Cell 116:511-526 (2004). RN [59]; RE0049387. RX PUBMED: 15961505. RA Sentis S., Le Romancer M., Bianchin C., Rostan M. C., Corbo L. RT Sumoylation of the estrogen receptor alpha hinge region regulates its transcriptional activity. RL Mol. Endocrinol. 19:2671-2684 (2005). RN [60]; RE0050085. RX PUBMED: 16452229. RA Rayala S. K., Talukder A. H., Balasenthil S., Tharakan R., Barnes C. J., Wang R. A., Aldaz M., Khan S., Kumar R. RT P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. RL Cancer Res. 66:1694-1701 (2006). RN [61]; RE0050820. RX PUBMED: 12400015. RA Kawai H., Li H., Chun P., Avraham S., Avraham H. K. RT Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. RL Oncogene 21:7730-7739 (2002). RN [62]; RE0050911. RX PUBMED: 15674350. RA Ma Y. X., Tomita Y., Fan S., Wu K., Tong Y., Zhao Z., Song L. N., Goldberg I. D., Rosen E. M. RT Structural determinants of the BRCA1 : estrogen receptor interaction. RL Oncogene 24:1831-1846 (2005). RN [63]; RE0050936. RX PUBMED: 16417649. RA Crowe D. L., Lee M. K. RT New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines. RL Breast Cancer Res. 8:R1 (2006). RN [64]; RE0051649. RX PUBMED: 12093745. RA Metivier R., Gay F. A., Hubner M. R., Flouriot G., Salbert G., Gannon F., Kah O., Pakdel F. RT Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK. RL EMBO J. 21:3443-3453 (2002). RN [65]; RE0052502. RX PUBMED: 9713824. RA Biswas D. K., Averboukh L., Sheng S., Martin K., Ewaniuk D. S., Jawde T. F., Wang F., Pardee A. B. RT Classification of breast cancer cells on the basis of a functional assay for estrogen receptor. RL Mol. Med. 4:454-467 (1998). RN [66]; RE0053001. RX PUBMED: 11481323. RA Vadlamudi R. K., Wang R. A., Mazumdar A., Kim Y., Shin J., Sahin A., Kumar R. RT Molecular cloning and characterization of PELP1, a novel human coregulator of estrogen receptor alpha. RL J. Biol. Chem. 276:38272-38279 (2001). RN [67]; RE0053408. RX PUBMED: 17166846. RA Cascio S., Bartella V., Garofalo C., Russo A., Giordano A., Surmacz E. RT Insulin-like growth factor 1 differentially regulates estrogen receptor-dependent transcription at estrogen response element and AP-1 sites in breast cancer cells. RL J. Biol. Chem. 282:3498-3506 (2007). RN [68]; RE0053443. RX PUBMED: 16608856. RA Stossi F., Likhite V. S., Katzenellenbogen J. A., Katzenellenbogen B. S. RT Estrogen-occupied estrogen receptor represses cyclin G2 gene expression and recruits a repressor complex at the cyclin G2 promoter. RL J. Biol. Chem. 281:16272-16278 (2006). RN [69]; RE0053456. RX PUBMED: 15557281. RA Varshochi R., Halim F., Sunters A., Alao J. P., Madureira P. A., Hart S. M., Ali S., Vigushin D. M., Coombes R. C., Lam E. W. RT ICI182,780 induces p21Waf1 gene transcription through releasing histone deacetylase 1 and estrogen receptor alpha from Sp1 sites to induce cell cycle arrest in MCF-7 breast cancer cell line. RL J. Biol. Chem. 280:3185-3196 (2005). RN [70]; RE0053494. RX PUBMED: 12138194. RA Lee H., Bai W. RT Regulation of estrogen receptor nuclear export by ligand-induced and p38-mediated receptor phosphorylation. RL Mol. Cell. Biol. 22:5835-5845 (2002). RN [71]; RE0053507. RX PUBMED: 17068199. RA Al-Dhaheri M. H., Rowan B. G. RT Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation. RL Mol. Endocrinol. 21:439-456 (2007). RN [72]; RE0053517. RX PUBMED: 16945990. RA Likhite V. S., Stossi F., Kim K., Katzenellenbogen B. S., Katzenellenbogen J. A. RT Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity. RL Mol. Endocrinol. 20:3120-3132 (2006). RN [73]; RE0053632. RX PUBMED: 15084343. RA Petz L. N., Ziegler Y. S., Schultz J. R., Kim H., Kemper J. K., Nardulli A. M. RT Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sites. RL J. Steroid Biochem. Mol. Biol. 88:113-122 (2004). RN [74]; RE0053707. RX PUBMED: 9528769. RA Joel P. B., Smith J., Sturgill T. W., Fisher T. L., Blenis J., Lannigan D. A. RT pp90rsk1 regulates estrogen receptor-mediated transcription through phosphorylation of Ser-167. RL Mol. Cell. Biol. 18:1978-1984 (1998). RN [75]; RE0053742. RX PUBMED: 15496458. RA Acconcia F., Ascenzi P., Bocedi A., Spisni E., Tomasi V., Trentalance A., Visca P., Marino M. RT Palmitoylation-dependent estrogen receptor alpha membrane localization: regulation by 17beta-estradiol. RL Mol. Biol. Cell 16:231-237 (2005). RN [76]; RE0053886. RX PUBMED: 14684847. RA Petz L. N., Ziegler Y. S., Schultz J. R., Nardulli A. M. RT Fos and Jun inhibit estrogen-induced transcription of the human progesterone receptor gene through an activator protein-1 site. RL Mol. Endocrinol. 18:521-532 (2004). RN [77]; RE0053992. RX PUBMED: 16037132. RA Fan M., Park A., Nephew K. P. RT CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. RL Mol. Endocrinol. 19:2901-2914 (2005). RN [78]; RE0054081. RX PUBMED: 16679312. RA Huang Y., Keen J. C., Pledgie A., Marton L. J., Zhu T., Sukumar S., Park B. H., Blair B., Brenner K., Casero RA J. r., Davidson N. E. RT Polyamine analogues down-regulate estrogen receptor alpha expression in human breast cancer cells. RL J. Biol. Chem. 281:19055-19063 (2006). RN [79]; RE0054090. RX PUBMED: 10611355. RA An J., Ribeiro R. C., Webb P., Gustafsson J. A., Kushner P. J., Baxter J. D., Leitman D. C. RT Estradiol repression of tumor necrosis factor-alpha transcription requires estrogen receptor activation function-2 and is enhanced by coactivators. RL Proc. Natl. Acad. Sci. USA 96:15161-15166 (1999). RN [80]; RE0054228. RX PUBMED: 11073968. RA Lamb J., Ladha M. H., McMahon C., Sutherland R. L., Ewen M. E. RT Regulation of the functional interaction between cyclin D1 and the estrogen receptor. RL Mol. Cell. Biol. 20:8667-8675 (2000). RN [81]; RE0054989. RX PUBMED: 15604093. RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M. RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. RL Mol. Cell. Proteomics 4:205-213 (2005). RN [82]; RE0055712. RX PUBMED: 17283173. RA Fan P., Wang J., Santen R. J., Yue W. RT Long-term treatment with tamoxifen facilitates translocation of estrogen receptor alpha out of the nucleus and enhances its interaction with EGFR in MCF-7 breast cancer cells. RL Cancer Res. 67:1352-1360 (2007). RN [83]; RE0059382. RX PUBMED: 14506733. RA Kawai H., Li H., Avraham S., Jiang S., Avraham H. K. RT Overexpression of histone deacetylase HDAC1 modulates breast cancer progression by negative regulation of estrogen receptor alpha. RL Int. J. Cancer 107:353-358 (2003). RN [84]; RE0059561. RX PUBMED: 15073177. RA Jiang C., Ito M., Piening V., Bruck K., Roeder R. G., Xiao H. RT TIP30 interacts with an estrogen receptor alpha-interacting coactivator CIA and regulates c-myc transcription. RL J. Biol. Chem. 279:27781-27789 (2004). RN [85]; RE0062553. RX PUBMED: 16169518. RA Lee Y. R., Park J., Yu H. N., Kim J. S., Youn H. J., Jung S. H. RT Up-regulation of PI3K/Akt signaling by 17beta-estradiol through activation of estrogen receptor-alpha, but not estrogen receptor-beta, and stimulates cell growth in breast cancer cells. RL Biochem. Biophys. Res. Commun. 336:1221-1226 (2005). RN [86]; RE0062640. RX PUBMED: 16076840. RA Medunjanin S., Hermani A., De Servi B., Grisouard J., Rincke G., Mayer D. RT Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor alpha and is involved in the regulation of receptor activity. RL J. Biol. Chem. 280:33006-33014 (2005). RN [87]; RE0062855. RX PUBMED: 19117054. RA Karmakar S., Foster E. A., Smith C. L. RT Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor. RL Int. J. Cancer 124:1841-1851 (2009). RN [88]; RE0062988. RX PUBMED: 17998543. RA Zou J. X., Revenko A. S., Li L. B., Gemo A. T., Chen H. W. RT ANCCA, an estrogen-regulated AAA+ ATPase coactivator for ERalpha, is required for coregulator occupancy and chromatin modification. RL Proc. Natl. Acad. Sci. USA 104:18067-18072 (2007). RN [89]; RE0063919. RX PUBMED: 17609434. RA Grisouard J., Medunjanin S., Hermani A., Shukla A., Mayer D. RT Glycogen synthase kinase-3 protects estrogen receptor alpha from proteasomal degradation and is required for full transcriptional activity of the receptor. RL Mol. Endocrinol. 21:2427-2439 (2007). RN [90]; RE0064788. RX PUBMED: 18829541. RA John S., Nayvelt I., Hsu H. C., Yang P., Liu W., Das G. M., Thomas T., Thomas T. J. RT Regulation of estrogenic effects by beclin 1 in breast cancer cells. RL Cancer Res. 68:7855-7863 (2008). RN [91]; RE0065802. RX PUBMED: 18653622. RA Nagayama K., Sasaki S., Matsushita A., Ohba K., Iwaki H., Matsunaga H., Suzuki S., Misawa H., Ishizuka K., Oki Y., Noh J. Y., Nakamura H. RT Inhibition of GATA2-dependent transactivation of the TSHbeta gene by ligand-bound estrogen receptor alpha. RL J. Endocrinol. 199:113-125 (2008). RN [92]; RE0065817. RX PUBMED: 17932106. RA Nettles K. W., Gil G., Nowak J., Metivier R., Sharma V. B., Greene G. L. RT CBP Is a dosage-dependent regulator of nuclear factor-kappaB suppression by the estrogen receptor. RL Mol. Endocrinol. 22:263-272 (2008). RN [93]; RE0068553. RX PUBMED: 15199063. RA Damdimopoulos A. E., Miranda-Vizuete A., Treuter E., Gustafsson J. A., Spyrou G. RT An alternative splicing variant of the selenoprotein thioredoxin reductase is a modulator of estrogen signaling. RL J. Biol. Chem. 279:38721-38729 (2004). RN [94]; RE0069750. RX PUBMED: 11429412. RA Wang L. H., Yang X. Y., Mihalic K., Xiao W., Li D., Farrar W. L. RT Activation of estrogen receptor blocks interleukin-6-inducible cell growth of human multiple myeloma involving molecular cross-talk between estrogen receptor and STAT3 mediated by co-regulator PIAS3. RL J. Biol. Chem. 276:31839-31844 (2001). RN [95]; RE0069780. RX PUBMED: 21378170. RA Li Y., Sun L., Zhang Y., Wang D., Wang F., Liang J., Gui B., Shang Y. RT The histone modifications governing TFF1 transcription mediated by estrogen receptor. RL J. Biol. Chem. 286:13925-13936 (2011). RN [96]; RE0070040. RX PUBMED: 20219974. RA Medunjanin S., Weinert S., Schmeisser A., Mayer D., Braun-Dullaeus R. C. RT Interaction of the double-strand break repair kinase DNA-PK and estrogen receptor-alpha. RL Mol. Biol. Cell 21:1620-1628 (2010). RN [97]; RE0016540. RX PUBMED: 8769313. RA Mosselman S., Polman J., Dijkema R. RT ER beta: identification and characterization of a novel human estrogen receptor RL FEBS Lett. 392:49-53 (1996). XX //