AC T01488
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ID T01488
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DT 08.05.1995 (created); ewi.
DT 28.01.2015 (updated); ros.
CO Copyright (C), QIAGEN.
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FA Cdk2
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SY CDK2; cyclin-dependent kinase 2; p33(cdk2).
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009981 CDK2; HGNC: CDK2.
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EX secondary follicles of peripher lymphoid organs,,,adult; detectable.
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FF Treatment with SU9516 decreases the protein level in HT29, SW480 or RKO cells [15];
FF cell-cycle regulating protein kinase;
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IN T04074 brca1; human, Homo sapiens.
IN T00105 C/EBPalpha; human, Homo sapiens.
IN T23077 CHOP-10; Mammalia.
IN T01487 cyclinA; human, Homo sapiens.
IN T33762 DRIP205; human, Homo sapiens.
IN T00261 ER-alpha; human, Homo sapiens.
IN T02936 FOXO1A; human, Homo sapiens.
IN T10353 FOXO1A; human, Homo sapiens.
IN T01610 HIF-1alpha; human, Homo sapiens.
IN T01804 NF-YA; human, Homo sapiens.
IN T00154 NF-YB; human, Homo sapiens.
IN T02478 NF-YC-isoform3; human, Homo sapiens.
IN T01486 p107; human, Homo sapiens.
IN T01608 p130; human, Homo sapiens.
IN T34034 p21Cip1; human, Homo sapiens.
IN T27178 Tsc-22; human, Homo sapiens.
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BS R01801.
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DR TRANSPATH: MO000021736.
DR UniProtKB: P24941;
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RN [1]; RE0002985.
RX PUBMED: 1328853.
RA Wade M., Kowalik T. F., Mudryj M., Huang E.-S., Azizkhan J. C.
RT E2F mediates dihydrofolate reductase promoter activation and multiprotein complex formation in human cytomegalovirus infection
RL Mol. Cell. Biol. 12:4364-4374 (1992).
RN [2]; RE0023108.
RX PUBMED: 12857729.
RA Yun J., Chae H. D., Choi T. S., Kim E. H., Bang Y. J., Chung J. K., Choi K. S., Mantovani R., Shin D. Y.
RT Cdk2-dependent phosphorylation of the NF-Y transcription factor and its involvement in the p53-p21 signaling pathway.
RL J. Biol. Chem. 278:36966-36972 (2003).
RN [3]; RE0029143.
RX PUBMED: 11884622.
RA Mazumder S., Gong B., Chen Q., Drazba J. A., Buchsbaum J. C., Almasan A.
RT Proteolytic cleavage of cyclin E leads to inactivation of associated kinase activity and amplification of apoptosis in hematopoietic cells.
RL Mol. Cell. Biol. 22:2398-409 (2002).
RN [4]; RE0029146.
RX PUBMED: 11884439.
RA Appleman L. J., van Puijenbroek A. A., Shu K. M., Nadler L. M., Boussiotis V. A.
RT CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells.
RL J. Immunol. 168:2729-36 (2002).
RN [5]; RE0031943.
RX PUBMED: 15241418.
RA Matsuura I., Denissova N. G., Wang G., He D., Long J., Liu F.
RT Cyclin-dependent kinases regulate the antiproliferative function of Smads.
RL Nature 430:226-31 (2004).
RN [6]; RE0037868.
RX PUBMED: 10574984.
RA Rich J. N., Zhang M., Datto M. B., Bigner D. D., Wang X. F.
RT Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines
RL J. Biol. Chem. 274:35053-8 (1999).
RN [7]; RE0042688.
RX PUBMED: 11684017.
RA Wang H., Iakova P., Wilde M., Welm A., Goode T., Roesler W. J., Timchenko N. A.
RT C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
RL Mol. Cell 8:817-28 (2001).
RN [8]; RE0047651.
RX PUBMED: 16174846.
RA Frouin I., Toueille M., Ferrari E., Shevelev I., Hubscher U.
RT Phosphorylation of human DNA polymerase lambda by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen.
RL Nucleic Acids Res. 33:5354-5361 (2005).
RN [9]; RE0048082.
RX PUBMED: 9244350.
RA Wang H., Shao N., Ding Q. M., Cui J., Reddy E. S., Rao V. N.
RT BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases.
RL Oncogene 15:143-157 (1997).
RN [10]; RE0048218.
RX PUBMED: 16226712.
RA Niture S. K., Doneanu C. E., Velu C. S., Bailey N. I., Srivenugopal K. S.
RT Proteomic analysis of human O6-methylguanine-DNA methyltransferase by affinity chromatography and tandem mass spectrometry.
RL Biochem. Biophys. Res. Commun. 337:1176-1184 (2005).
RN [11]; RE0048383.
RX PUBMED: 16139224.
RA Sjostrom S. K., Finn G., Hahn W. C., Rowitch D. H., Kenney A. M.
RT The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors.
RL Dev. Cell 9:327-338 (2005).
RN [12]; RE0048951.
RX PUBMED: 16343435.
RA Oh Y. T., Chun K. H., Oh J. I., Park J. A., Kim Y. U., Lee S. K.
RT PKCdelta modulates p21WAF1/CIP1 ability to bind to Cdk2 during TNFalpha-induced apoptosis.
RL Biochem. Biophys. Res. Commun. 339:1138-1147 (2006).
RN [13]; RE0050272.
RX PUBMED: 16460673.
RA Khwaja F., Tabassum A., Allen J., Djakiew D.
RT The p75(NTR) tumor suppressor induces cell cycle arrest facilitating caspase mediated apoptosis in prostate tumor cells.
RL Biochem. Biophys. Res. Commun. 341:1184-1192 (2006).
RN [14]; RE0053030.
RX PUBMED: 16014626.
RA Han J., Tsukada Y., Hara E., Kitamura N., Tanaka T.
RT Hepatocyte growth factor induces redistribution of p21(CIP1) and p27(KIP1) through ERK-dependent p16(INK4a) up-regulation, leading to cell cycle arrest at G1 in HepG2 hepatoma cells.
RL J. Biol. Chem. 280:31548-31556 (2005).
RN [15]; RE0054610.
RX PUBMED: 12234612.
RA Yu B., Lane M. E., Wadler S.
RT SU9516, a cyclin-dependent kinase 2 inhibitor, promotes accumulation of high molecular weight E2F complexes in human colon carcinoma cells.
RL Biochem. Pharmacol. 64:1091-1100 (2002).
RN [16]; RE0056060.
RX PUBMED: 17038621.
RA Huang H., Regan K. M., Lou Z., Chen J., Tindall D. J.
RT CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage.
RL Science 314:294-297 (2006).
RN [17]; RE0059184.
RX PUBMED: 12588705.
RA Amrani Y., Tliba O., Choubey D., Huang C. D., Krymskaya V. P., Eszterhas A., Lazaar A. L., Panettieri RA J. r.
RT IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway.
RL Am. J. Physiol. Lung Cell. Mol. Physiol. 284:L1063-71 (2003).
RN [18]; RE0062791.
RX PUBMED: 17698606.
RA Tsang W. Y., Wang L., Chen Z., Sanchez I., Dynlacht B. D.
RT SCAPER, a novel cyclin A-interacting protein that regulates cell cycle progression.
RL J. Cell Biol. 178:621-633 (2007).
RN [19]; RE0066515.
RX PUBMED: 8668211.
RA Tiefenbrun N., Melamed D., Levy N., Resnitzky D., Hoffman I., Reed S. I., Kimchi A.
RT Alpha interferon suppresses the cyclin D3 and cdc25A genes, leading to a reversible G0-like arrest.
RL Mol. Cell. Biol. 16:3934-3944 (1996).
RN [20]; RE0066800.
RX PUBMED: 20220142.
RA Por E., Byun H. J., Lee E. J., Lim J. H., Jung S. Y., Park I., Kim Y. M., Jeoung D. I., Lee H.
RT The cancer/testis antigen CAGE with oncogenic potential stimulates cell proliferation by up-regulating cyclins D1 and E in an AP-1- and E2F-dependent manner.
RL J. Biol. Chem. 285:14475-14485 (2010).
RN [21]; RE0067071.
RX PUBMED: 19321452.
RA Imamura Y., Fujigaki Y., Oomori Y., Usui S., Wang P. L.
RT Cooperation of salivary protein histatin 3 with heat shock cognate protein 70 relative to the G1/S transition in human gingival fibroblasts.
RL J. Biol. Chem. 284:14316-14325 (2009).
RN [22]; RE0070681.
RX PUBMED: 19858290.
RA Li C., Andrake M., Dunbrack R., Enders G. H.
RT A bifunctional regulatory element in human somatic Wee1 mediates cyclin A/Cdk2 binding and Crm1-dependent nuclear export.
RL Mol. Cell. Biol. 30:116-130 (2010).
RN [23]; RE0021126.
RX PUBMED: 11781350.
RA Donato J. L., Ko J., Kutok J. L., Cheng T., Shirakawa T., Mao X. Q., Beach D., Scadden D. T., Sayegh M. H., Adra C. N.
RT Human HTm4 is a hematopoietic cell cycle regulator
RL J. Clin. Invest. 109:51-58 (2002).
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