TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04074 XX ID T04074 XX DT 07.12.2000 (created); rio. DT 15.09.2014 (updated); jtr. CO Copyright (C), QIAGEN. XX FA brca1 XX SY BRC1; BRCA1; BRCAI; BRCC1; breast cancer 1, early onset; breast cancer type 1 susceptibility protein; BROVCA1; IRIS; PNCA4; PPP1R53; PSCP; RNF53. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002124 BRCA1; HGNC: BRCA1. XX CL C0049; RING. XX SF N-terminal RING finger domain important for protein-protein interactions, a domain in the middle of brca1 associates with the DNA repair protein RAD51 and the C-terminal containing two repeats of the BRCT domains [72]; SF linked to the Meox1 T04046 chromosomal region [1]; XX CP H-MEC, MCF-7, T47D, HBL-100, MDA-MB-453, BT-549, BT-20, MDA-MB-436, SK-BR-3, MDA-MB-231, MDA-MB-361 [58]. XX FF ZBRK1 T08577 binds to brca1 aa 341-748 [75]; FF brca1/BARD1 complex containing TopBP1 and BACH1 participates in replication origin- and initiation-related events critical for the activation of the S-phase checkpoint through a non-canonical, CHK1/CHK2-independent pathway. [34]; FF FOXA1 T02512 protein expression is enhanced by coexpression with brca1 and cotransfection of brca1 with FOXA1 increases the half-life of FOXA1 protein suggesting that brca1 might be stabilizing FOXA1 protein [71]; FF paradoxically involved in both: transcriptional activation and repression [73]; FF brca1 negatively regulates the hTERT promoter G002001; FF brca1 regulates cellular immortalization through hTERT, which is a critical step in carcinogenesis; FF negative regulation of hTERT by brca1 might be involved in the suppression of ovarian cancer development; FF loss of brca1 inhibition may lead to immortalization and to subsequent development of ovarian cancer [74]; FF transcriptional corepressor of ZBRK1T08577 [75]; FF transcriptional activator [72]; XX IN T08146 AP-2alpha; human, Homo sapiens. IN T02468 AP-2gamma; human, Homo sapiens. IN T10835 arnt; human, Homo sapiens. IN T00968 ATF-1; human, Homo sapiens. IN T09252 Bach1; human, Homo sapiens. IN T05451 BRG1; human, Homo sapiens. IN T16987 BRG1; Mammalia. IN T05551 BRIP1; human, Homo sapiens. IN T00133 c-Jun; human, Homo sapiens. IN T09446 c-Jun; Mammalia. IN T00140 c-Myc-isoform1; human, Homo sapiens. IN T18378 CBP; human, Homo sapiens. IN T08875 Cdk2-isoform1; human, Homo sapiens. IN T01488 Cdk2; human, Homo sapiens. IN T01487 cyclinA; human, Homo sapiens. IN T09117 E2F-1; human, Homo sapiens. IN T09570 E2F-1; Mammalia. IN T01546 E2F-4; human, Homo sapiens. IN T10751 E2F-4; Mammalia. IN T02997 E2F-6; human, Homo sapiens. IN T00250 Elk-1; human, Homo sapiens. IN T00261 ER-alpha; human, Homo sapiens. IN T04888 EZH2; human, Homo sapiens. IN T06586 gfi1b; human, Homo sapiens. IN T01610 HIF-1alpha; human, Homo sapiens. IN T11427 hltf; human, Homo sapiens. IN T02512 HNF-3alpha; human, Homo sapiens. IN T01977 JunB; human, Homo sapiens. IN T10510 JunB; Mammalia. IN T09447 JunD; Mammalia. IN T34269 NBS1; human, Homo sapiens. IN T01804 NF-YA; human, Homo sapiens. IN T21984 p300; human, Homo sapiens. IN T23091 p300; Mammalia. IN T00671 p53; human, Homo sapiens. IN T06136 p63-isoform6; human, Homo sapiens. IN T18226 plakoglobin; human, Homo sapiens. IN T00545 POU2F1; human, Homo sapiens. IN T01661 PR A; human, Homo sapiens. IN T00696 PR B; human, Homo sapiens. IN T25008 pRb; Mammalia. IN T14648 PRDII-BF1; human, Homo sapiens. IN T34266 Rad51; human, Homo sapiens. IN T08711 RelA-p65; human, Homo sapiens. IN T19717 RHA; human, Homo sapiens. IN T10378 Smad3; human, Homo sapiens. IN T00759 Sp1; human, Homo sapiens. IN T01492 STAT1alpha; human, Homo sapiens. IN T01573 STAT1beta; human, Homo sapiens. IN T04683 STAT5A; human, Homo sapiens. IN T18015 SUZ12; human, Homo sapiens. IN T00878 USF2; human, Homo sapiens. IN T08577 ZBRK1; human, Homo sapiens. XX MX M04687 V$BRCA1_02. MX M01082 V$BRCA_01. XX BS R18756. BS R18757. BS R18758. BS R18759. BS R18760. BS R18761. BS R18762. BS R18763. BS R18764. BS R18765. BS R18766. BS R18767. BS R18768. BS R18769. BS R18770. BS R18771. BS R18772. BS R18773. BS R18774. BS R18775. BS R18776. BS R18777. BS R18778. BS R18779. BS R18780. BS R18781. BS R18782. BS R18783. BS R18784. BS R18785. BS R18786. BS R18787. BS R18788. BS R18789. BS R18790. BS R18791. BS R18792. BS R18793. BS R18794. BS R18795. BS R18796. BS R18797. BS R18798. BS R18799. BS R18801. BS R63927. BS R63928. BS R18755. BS R69962. BS R73660. BS R73661. BS R73662. BS R73663. BS R73664. BS R73665. BS R73666. BS R18677. BS R18752. BS R18753. BS R18754. XX DR TRANSPATH: MO000021981. DR UniProtKB: P38398; XX RN [1]; RE0015388. RX PUBMED: 7987315. RA Futreal P. A., Cochran C., Rosenthal J., Miki Y., Swenson J., Hobbs M., Bennett L. M., Haugen-Strano A., Marks J., Barrett J. C. RT Isolation of a diverged homeobox gene, MOX1, from the BRCA1 region on 17q21 by solution hybrid capture RL Hum. Mol. Genet. 3:1359-1364 (1994). RN [2]; RE0017512. RX PUBMED: 10792030. RA Ouchi T., Lee S. W., Ouchi M., Aaronson S. A., Horvath C. M. RT Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. RL Proc. Natl. Acad. Sci. USA 97:5208-5213 (2000). RN [3]; RE0017598. RX PUBMED: 9582019. RA Zhang H., Somasundaram K., Peng Y., Tian H., Zhang H., Bi D., Weber B. L., El-Deiry W. S. RT BRCA1 physically associates with p53 and stimulates its transcriptional activity. RL Oncogene 16:1713-1721 (1998). RN [4]; RE0017774. RX PUBMED: 9926942. RA Chai Y. L., Cui J., Shao N., Shyam E., Reddy P., Rao V. N. RT The second BRCT domain of BRCA1 proteins interacts with p53 and stimulates transcription from the p21WAF1/CIP1 promoter. RL Oncogene 18:263-268 (1999). RN [5]; RE0017778. RX PUBMED: 11877378. RA Joo W. S., Jeffrey P. D., Cantor S. B., Finnin M. S., Livingston D. M., Pavletich N. P. RT Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure. RL Genes Dev. 16:583-593 (2002). RN [6]; RE0021190. RX PUBMED: 11114888. RA Tibbetts R. S., Cortez D, Brumbaugh K. M., Scully R., Livingston D., Elledge S. J., Abraham, R. T. RT Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress RL Genes Dev. 14:2989-3002 (2000). RN [7]; RE0027653. RX PUBMED: 10783165. RA Wang Y., Cortez D., Yazdi P., Neff N., Elledge S. J., Qin J. RT BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. RL Genes Dev. 14:927-39 (2000). RN [8]; RE0031752. RX PUBMED: 15205325. RA Gilmore P. M., McCabe N., Quinn J. E., Kennedy R. D., Gorski J. J., Andrews H. N., McWilliams S., Carty M., Mullan P. B., Duprex W. P., Liu E. T., Johnston P. G., Harkin D. P. RT BRCA1 interacts with and is required for paclitaxel-induced activation of mitogen-activated protein kinase kinase kinase 3. RL Cancer Res. 64:4148-54 (2004). RN [9]; RE0038770. RX PUBMED: 15096610. RA Lin S. Y., Li K., Stewart G. S., Elledge S. J. RT Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation RL Proc. Natl. Acad. Sci. USA 101:6484-9 (2004). RN [10]; RE0047675. RX PUBMED: 15886699. RA Wada-Hiraike O., Yano T., Nei T., Matsumoto Y., Nagasaka K., Takizawa S., Oishi H., Arimoto T., Nakagawa S., Yasugi T., Kato S., Taketani Y. RT The DNA mismatch repair gene hMSH2 is a potent coactivator of oestrogen receptor alpha. RL Br. J. Cancer 92:2286-2291 (2005). RN [11]; RE0047945. RX PUBMED: 11777930. RA Fan W., Jin S., Tong T., Zhao H., Fan F., Antinore M. J., Rajasekaran B., Wu M., Zhan Q. RT BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs. RL J. Biol. Chem. 277:8061-8067 (2002). RN [12]; RE0047946. RX PUBMED: 15563594. RA Wang R. H., Yu H., Deng C. X. RT A requirement for breast-cancer-associated gene 1 (BRCA1) in the spindle checkpoint. RL Proc. Natl. Acad. Sci. USA 101:17108-17113 (2004). RN [13]; RE0048028. RX PUBMED: 14550570. RA Yan J., Zhu J., Zhong H., Lu Q., Huang C., Ye Q. RT BRCA1 interacts with FHL2 and enhances FHL2 transactivation function. RL FEBS Lett. 553:183-189 (2003). RN [14]; RE0048037. RX PUBMED: 12080089. RA Hu Y. F., Li R. RT JunB potentiates function of BRCA1 activation domain 1 (AD1) through a coiled-coil-mediated interaction. RL Genes Dev. 16:1509-1517 (2002). RN [15]; RE0048082. RX PUBMED: 9244350. RA Wang H., Shao N., Ding Q. M., Cui J., Reddy E. S., Rao V. N. RT BRCA1 proteins are transported to the nucleus in the absence of serum and splice variants BRCA1a, BRCA1b are tyrosine phosphoproteins that associate with E2F, cyclins and cyclin dependent kinases. RL Oncogene 15:143-157 (1997). RN [16]; RE0048090. RX PUBMED: 12592385. RA Schlegel B. P., Starita L. M., Parvin J. D. RT Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. RL Oncogene 22:983-991 (2003). RN [17]; RE0048096. RX PUBMED: 15107825. RA Cabart P., Chew H. K., Murphy S. RT BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II. RL Oncogene 23:5316-5329 (2004). RN [18]; RE0048205. RX PUBMED: 10220405. RA Yarden R. I., Brody L. C. RT BRCA1 interacts with components of the histone deacetylase complex. RL Proc. Natl. Acad. Sci. USA 96:4983-4988 (1999). RN [19]; RE0049971. RX PUBMED: 10655477. RA Pao G. M., Janknecht R., Ruffner H., Hunter T., Verma I. M. RT CBP/p300 interact with and function as transcriptional coactivators of BRCA1. RL Proc. Natl. Acad. Sci. USA 97:1020-1025 (2000). RN [20]; RE0050302. RX PUBMED: 15159397. RA Fabbro M., Savage K., Hobson K., Deans A. J., Powell S. N., McArthur G. A., Khanna K. K. RT BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. RL J. Biol. Chem. 279:31251-31258 (2004). RN [21]; RE0050323. RX PUBMED: 17283126. RA Wu W., Nishikawa H., Hayami R., Sato K., Honda A., Aratani S., Nakajima T., Fukuda M., Ohta T. RT BRCA1 ubiquitinates RPB8 in response to DNA damage. RL Cancer Res. 67:951-958 (2007). RN [22]; RE0050340. RX PUBMED: 10945975. RA Houvras Y., Benezra M., Zhang H., Manfredi J. J., Weber B. L., Licht J. D. RT BRCA1 physically and functionally interacts with ATF1. RL J. Biol. Chem. 275:36230-36237 (2000). RN [23]; RE0050357. RX PUBMED: 17603999. RA Hsu L. C. RT Identification and functional characterization of a PP1-binding site in BRCA1. RL Biochem. Biophys. Res. Commun. 360:507-512 (2007). RN [24]; RE0050437. RX PUBMED: 16782705. RA Dizin E., Gressier C., Magnard C., Ray H., Decimo D., Ohlmann T., Dalla Venezia N. RT BRCA1 interacts with poly(A)-binding protein: implication of BRCA1 in translation regulation. RL J. Biol. Chem. 281:24236-24246 (2006). RN [25]; RE0050474. RX PUBMED: 16543242. RA Kang H. J., Kim H. J., Rih J. K., Mattson T. L., Kim K. W., Cho C. H., Isaacs J. S., Bae I. RT BRCA1 plays a role in the hypoxic response by regulating HIF-1alpha stability and by modulating vascular endothelial growth factor expression. RL J. Biol. Chem. 281:13047-13056 (2006). RN [26]; RE0050487. RX PUBMED: 16452482. RA Aglipay J. A., Martin S. A., Tawara H., Lee S. W., Ouchi T. RT ATM activation by ionizing radiation requires BRCA1-associated BAAT1. RL J. Biol. Chem. 281:9710-9718 (2006). RN [27]; RE0050536. RX PUBMED: 12354784. RA Folias A., Matkovic M., Bruun D., Reid S., Hejna J., Grompe M., D'Andrea A., Moses R. RT BRCA1 interacts directly with the Fanconi anemia protein FANCA. RL Hum. Mol. Genet. 11:2591-2597 (2002). RN [28]; RE0050559. RX PUBMED: 16322207. RA Martin S. A., Ouchi T. RT BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis. RL Cancer Res. 65:10657-10662 (2005). RN [29]; RE0050576. RX PUBMED: 11278964. RA Gatei M., Zhou B. B., Hobson K., Scott S., Young D., Khanna K. K. RT Ataxia telangiectasia mutated (ATM) kinase and ATM and Rad3 related kinase mediate phosphorylation of Brca1 at distinct and overlapping sites. In vivo assessment using phospho-specific antibodies. RL J. Biol. Chem. 276:17276-17280 (2001). RN [30]; RE0050584. RX PUBMED: 16707425. RA Chen X., Arciero C. A., Wang C., Broccoli D., Godwin A. K. RT BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation. RL Cancer Res. 66:5039-5046 (2006). RN [31]; RE0050603. RX PUBMED: 16628214. RA Polanowska J., Martin J. S., Garcia-Muse T., Petalcorin M. I., Boulton S. J. RT A conserved pathway to activate BRCA1-dependent ubiquitylation at DNA damage sites. RL EMBO J. 25:2178-2188 (2006). RN [32]; RE0050627. RX PUBMED: 16698035. RA Ray H., Moreau K., Dizin E., Callebaut I., Venezia N. D. RT ACCA phosphopeptide recognition by the BRCT repeats of BRCA1. RL J. Mol. Biol. 359:973-982 (2006). RN [33]; RE0050633. RX PUBMED: 17525340. RA Wang B., Matsuoka S., Ballif B. A., Zhang D., Smogorzewska A., Gygi S. P., Elledge S. J. RT Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. RL Science 316:1194-1198 (2007). RN [34]; RE0050647. RX PUBMED: 16391231. RA Greenberg R. A., Sobhian B., Pathania S., Cantor S. B., Nakatani Y., Livingston D. M. RT Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes. RL Genes Dev. 20:34-46 (2006). RN [35]; RE0050665. RX PUBMED: 17621610. RA Yan J., Kim Y. S., Yang X. P., Li L. P., Liao G., Xia F., Jetten A. M. RT The ubiquitin-interacting motif containing protein RAP80 interacts with BRCA1 and functions in DNA damage repair response. RL Cancer Res. 67:6647-6656 (2007). RN [36]; RE0050672. RX PUBMED: 16843262. RA Furuta S., Wang J. M., Wei S., Jeng Y. M., Jiang X., Gu B., Chen P. L., Lee E. Y., Lee W. H. RT Removal of BRCA1/CtIP/ZBRK1 repressor complex on ANG1 promoter leads to accelerated mammary tumor growth contributed by prominent vasculature. RL Cancer Cell 10:13-24 (2006). RN [37]; RE0050687. RX PUBMED: 15485915. RA Yu X., Chen J. RT DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. RL Mol. Cell. Biol. 24:9478-9486 (2004). RN [38]; RE0050725. RX PUBMED: 17007555. RA Gibson S.L., Bindra R.S., Glazer P.M. RT CHK2-dependent phosphorylation of BRCA1 in hypoxia. RL Radiat. Res. 166:646-651 (2006). RN [39]; RE0050737. RX PUBMED: 17700520. RA Maekawa T., Sano Y., Shinagawa T., Rahman Z., Sakuma T., Nomura S., Licht J. D., Ishii S. RT ATF-2 controls transcription of Maspin and GADD45alpha genes independently from p53 to suppress mammary tumors. RL Oncogene 27:1045-1054 (2007). RN [40]; RE0050745. RX PUBMED: 17664283. RA Kumaraswamy E., Shiekhattar R. RT Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S Phase. RL Mol. Cell. Biol. 27:6733-6741 (2007). RN [41]; RE0050746. RX PUBMED: 17643122. RA Kim H., Huang J., Chen J. RT CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. RL Nat. Struct. Mol. Biol. 14:710-715 (2007). RN [42]; RE0050802. RX PUBMED: 12700228. RA Benezra M., Chevallier N., Morrison D. J., MacLachlan T. K., El-Deiry W. S., Licht J. D. RT BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit. RL J. Biol. Chem. 278:26333-26341 (2003). RN [43]; RE0050820. RX PUBMED: 12400015. RA Kawai H., Li H., Chun P., Avraham S., Avraham H. K. RT Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. RL Oncogene 21:7730-7739 (2002). RN [44]; RE0050884. RX PUBMED: 16567799. RA Kang H. J., Kim H. J., Kim S. K., Barouki R., Cho C. H., Khanna K. K., Rosen E. M., Bae I. RT BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells. RL J. Biol. Chem. 281:14654-14662 (2006). RN [45]; RE0050890. RX PUBMED: 17643121. RA Liu Z., Wu J., Yu X. RT CCDC98 targets BRCA1 to DNA damage sites. RL Nat. Struct. Mol. Biol. 14:716-720 (2007). RN [46]; RE0050908. RX PUBMED: 17096023. RA Yang W. W., Wang Z. H., Zhu Y., Yang H. T. RT E2F6 negatively regulates ultraviolet-induced apoptosis via modulation of BRCA1. RL Cell Death Differ. 14:807-817 (2007). RN [47]; RE0050936. RX PUBMED: 16417649. RA Crowe D. L., Lee M. K. RT New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines. RL Breast Cancer Res. 8:R1 (2006). RN [48]; RE0050996. RX PUBMED: 16061635. RA Wang C., Fan S., Li Z., Fu M., Rao M., Ma Y., Lisanti M. P., Albanese C., Katzenellenbogen B. S., Kushner P. J., Weber B., Rosen E. M., Pestell R. G. RT Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. RL Cancer Res. 65:6557-6567 (2005). RN [49]; RE0051005. RX PUBMED: 16109739. RA Ma Y., Katiyar P., Jones L. P., Fan S., Zhang Y., Furth P. A., Rosen E. M. RT The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells. RL Mol. Endocrinol. 20:14-34 (2006). RN [50]; RE0051043. RX PUBMED: 16462773. RA Peng M., Litman R., Jin Z., Fong G., Cantor S. B. RT BACH1 is a DNA repair protein supporting BRCA1 damage response. RL Oncogene 25:2245-2253 (2006). RN [51]; RE0051076. RX PUBMED: 16091739. RA Xiao H., Goodrich D. W. RT The retinoblastoma tumor suppressor protein is required for efficient processing and repair of trapped topoisomerase II-DNA-cleavable complexes. RL Oncogene 24:8105-8113 (2005). RN [52]; RE0051123. RX PUBMED: 15735739. RA Dubrovska A., Kanamoto T., Lomnytska M., Heldin C. H., Volodko N., Souchelnytskyi S. RT TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage. RL Oncogene 24:2289-2297 (2005). RN [53]; RE0051155. RX PUBMED: 14576433. RA Yu X., Chini C. C., He M., Mer G., Chen J. RT The BRCT domain is a phospho-protein binding domain. RL Science 302:639-642 (2003). RN [54]; RE0051321. RX PUBMED: 12427729. RA Okada S., Ouchi T. RT Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. RL J. Biol. Chem. 278:2015-2020 (2003). RN [55]; RE0051332. RX PUBMED: 10542266. RA Altiok S., Batt D., Altiok N., Papautsky A., Downward J., Roberts T. M., Avraham H. RT Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. RL J. Biol. Chem. 274:32274-32278 (1999). RN [56]; RE0051339. RX PUBMED: 11016625. RA Chen J. RT Ataxia telangiectasia-related protein is involved in the phosphorylation of BRCA1 following deoxyribonucleic acid damage. RL Cancer Res. 60:5037-5039 (2000). RN [57]; RE0051647. RX PUBMED: 15166217. RA Choudhury A. D., Xu H., Baer R. RT Ubiquitination and proteasomal degradation of the BRCA1 tumor suppressor is regulated during cell cycle progression. RL J. Biol. Chem. 279:33909-33918 (2004). RN [58]; RE0051834. RX PUBMED: 12640109. RA Baldassarre G., Battista S., Belletti B., Thakur S., Pentimalli F., Trapasso F., Fedele M., Pierantoni G., Croce C. M., Fusco A. RT Negative regulation of BRCA1 gene expression by HMGA1 proteins accounts for the reduced BRCA1 protein levels in sporadic breast carcinoma. RL Mol. Cell. Biol. 23:2225-2238 (2003). RN [59]; RE0052908. RX PUBMED: 12459499. RA Vidarsson H., Mikaelsdottir E. K., Rafnar T., Bertwistle D., Ashworth A., Eyfjord J. E., Valgeirsdottir S. RT BRCA1 and BRCA2 bind Stat5a and suppress its transcriptional activity. RL FEBS Lett. 532:247-252 (2002). RN [60]; RE0062962. RX PUBMED: 16123590. RA Zhong X., Liu L., Zhao A., Pfeifer G. P., Xu X. RT The abnormal spindle-like, microcephaly-associated (ASPM) gene encodes a centrosomal protein. RL Cell Cycle 4:1227-1229 (2005). RN [61]; RE0064049. RX PUBMED: 12360400. RA Magnard C., Bachelier R., Vincent A., Jaquinod M., Kieffer S., Lenoir G. M., Venezia N. D. RT BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains. RL Oncogene 21:6729-6739 (2002). RN [62]; RE0064477. RX PUBMED: 18083712. RA Subbaramaiah K., Hudis C., Chang S. H., Hla T., Dannenberg A. J. RT EP2 and EP4 receptors regulate aromatase expression in human adipocytes and breast cancer cells. Evidence of a BRCA1 and p300 exchange. RL J. Biol. Chem. 283:3433-3444 (2008). RN [63]; RE0065412. RX PUBMED: 19525936. RA Peng G., Yim E. K., Dai H., Jackson A. P., Burgt I., Pan M. R., Hu R., Li K., Lin S. Y. RT BRIT1/MCPH1 links chromatin remodelling to DNA damage response. RL Nat. Cell Biol. 11:865-872 (2009). RN [64]; RE0065912. RX PUBMED: 20016594. RA Morris J. R., Boutell C., Keppler M., Densham R., Weekes D., Alamshah A., Butler L., Galanty Y., Pangon L., Kiuchi T., Ng T., Solomon E. RT The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. RL Nature 462:886-890 (2009). RN [65]; RE0066290. RX PUBMED: 18847501. RA Han X., Guo J., Deng W., Zhang C., Du P., Shi T., Ma D. RT High-throughput cell-based screening reveals a role for ZNF131 as a repressor of ERalpha signaling. RL BMC Genomics 9:476 (2008). RN [66]; RE0067181. RX PUBMED: 11313879. RA Chai Y., Chipitsyna G., Cui J., Liao B., Liu S., Aysola K., Yezdani M., Reddy E. S., Rao V. N. RT c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. RL Oncogene 20:1357-1367 (2001). RN [67]; RE0068584. RX PUBMED: 19584259. RA Zhang F., Fan Q., Ren K., Andreassen P. R. RT PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2. RL Mol. Cancer Res. 7:1110-1118 (2009). RN [68]; RE0069409. RX PUBMED: 18344987. RA Tsai W. B., Chung Y. M., Takahashi Y., Xu Z., Hu M. C. RT Functional interaction between FOXO3a and ATM regulates DNA damage response. RL Nat. Cell Biol. 10:460-467 (2008). RN [69]; RE0021193. RX PUBMED: 9008167. RA Scully R., Chen J., Plug A., Xiao Y., Weaver D., Feunteun J., Ashley T., Livingston D. M. RT Association of BRCA1 with Rad51 in mitotic and meiotic cells RL Cell 88:265-275 (1997). RN [70]; RE0021202. RX PUBMED: 11836499. RA Yarden R. I., Pardo-Reoyo S., Sgagias M., Cowan K. H., Brody L. C. RT BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage RL Nat. Genet. 30:285-289 (2002). RN [71]; RE0035617. RX PUBMED: 16331276. RA Williamson E. A., Wolf I., Okelly J., Bose S., Tanosaki S., Koeffler H. P. RT BRCA1 and FOXA1 proteins coregulate the expression of the cell cycle-dependent kinase inhibitor p27(Kip1). RL Oncogene 25:1391-1319 (2006). RN [72]; RE0017377. RX PUBMED: 10448078. RA Law D. J., Du M., Law G. L., Merchant J. L. RT ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression RL Biochem. Biophys. Res. Commun. 262:113-120 (1999). RN [73]; RE0035633. RX PUBMED: 14502648. RA Cable P. L., Wilson C. A., Calzone F. J., Rauscher FJ 3. r. d., Scully R., Livingston D. M., Li L., Blackwell C. B., Futreal P. A., Afshari C. A. RT Novel consensus DNA-binding sequence for BRCA1 protein complexes. RL Mol. Carcinog. 38:85-96 (2003). RN [74]; RE0030270. RX PUBMED: 12646176. RA Zhou C., Liu J. RT Inhibition of human telomerase reverse transcriptase gene expression by BRCA1 in human ovarian cancer cells. RL Biochem. Biophys. Res. Commun. 303:130-6 (2003). RN [75]; RE0035939. RX PUBMED: 11090615. RA Zheng L., Pan H., Li S., Flesken-Nikitin A., Chen P. L., Boyer T. G., Lee W. H. RT Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. RL Mol. Cell 6:757-768 (2000). XX //