AC T06136
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ID T06136
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DT 10.09.2004 (created); oke.
DT 11.11.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA p63-isoform6
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SY DeltaN-gamma; DN p63 gamma; DN p63gamma; P51 isoform delNgamma; P51delNgamma.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009616 TP63; HGNC: TP63.
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CL C0057; P53; 6.3.1.0.2.6.
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SZ 393 AA; 44.7 kDa (calc.).
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SQ MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSS
SQ TFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIK
SQ VMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
SQ YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQV
SQ LGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRR
SQ SPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKHLLSA
SQ CFRNELVEPRRETPKQSDVFFRHSKPPNRSVYP
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SC Swiss-Prot#Q9H3D4-6
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FT 58 351 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 69 265 
PF00870; P53 DNA-binding domain.
FT 297 338 
PF07710; P53 tetramerisation motif.
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SF several alternative products are known, p63alpha T06132, p63beta T06133, p63gamma T06135, p63delta T06005, DeltaN p63alpha T06004, DeltaN p63beta T06134, p63-isoform6 T06136 [1] [2];
SF has DNA binding and oligomerization domains [1];
SF this splice variant lack N-terminal transactivation domain and exons 11, 12, 13, 14 in comparison with p63alpha T06132 [1];
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FF low but measurable activity in gene transcription activation assay [1];
FF is able to induce slight level of apoptosis [1];
FF acts as a dominant-negative suppressor of p53 activity, but not of p63gamma activity [1];
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IN T04074 brca1; human, Homo sapiens.
IN T15204 brca1; Mammalia.
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MX M00761 V$P53DECAMER_Q2.
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BS R64794.
BS R64796.
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DR TRANSPATH: MO000043734.
DR EMBL: AF124540;
DR UniProtKB: Q9H3D4-6;
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RN [1]; RE0024711.
RX PUBMED: 9774969.
RA Yang A., Kaghad M., Wang Y., Gillett E., Fleming M. D., Dotsch V., Andrews N. C., Caput D., McKeon F.
RT p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
RL Mol. Cell 2:305-316 (1998).
RN [2]; RE0024715.
RX PUBMED: 11477076.
RA Klein C., Georges G., Kunkele K. P., Huber R., Engh R. A., Hansen S.
RT High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.
RL J. Biol. Chem. 276:37390-37401 (2001).
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