AC T06133
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ID T06133
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DT 09.09.2004 (created); oke.
DT 01.08.2014 (updated); sla.
CO Copyright (C), QIAGEN.
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FA p63-isoform3
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SY TA p63 beta; TA p63beta.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009616 TP63; HGNC: TP63.
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CL C0057; P53; 6.3.1.0.2.3.
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SZ 555 AA; 62.4 kDa (calc.).
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SQ MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWD
SQ FLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSM
SQ DQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
SQ FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEV
SQ VKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFT
SQ TVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR
SQ KQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKES
SQ LELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQ
SQ LINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPP
SQ PPYPTDCSIVRIWQV
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SC Swiss-Prot#Q9H3D4-3
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FT 152 445 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 153 388 
DNA binding domain, DBD [2].
FT 163 359 
PF00870; P53 DNA-binding domain.
FT 391 432 
PF07710; P53 tetramerisation motif.
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SF several alternative products are known, p63alpha T06132, p63-isoform3 T06133, p63gamma T06135, p63delta T06005, DeltaN p63alpha T06004, DeltaN p63-isoform3 T06134, DeltaNp63gamma T06136 [1] [2];
SF has transactivation, DNA binding and oligomerization domains [1];
SF in this splice variant exon 13 is absent in comparison with p63alpha T06132 [1];
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MX M00761 V$P53DECAMER_Q2.
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DR TRANSPATH: MO000043729.
DR EMBL: AF124539;
DR UniProtKB: Q9H3D4-3;
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RN [1]; RE0024711.
RX PUBMED: 9774969.
RA Yang A., Kaghad M., Wang Y., Gillett E., Fleming M. D., Dotsch V., Andrews N. C., Caput D., McKeon F.
RT p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
RL Mol. Cell 2:305-316 (1998).
RN [2]; RE0024715.
RX PUBMED: 11477076.
RA Klein C., Georges G., Kunkele K. P., Huber R., Engh R. A., Hansen S.
RT High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.
RL J. Biol. Chem. 276:37390-37401 (2001).
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