AC T06134
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ID T06134
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DT 09.09.2004 (created); oke.
DT 11.11.2014 (updated); pro.
CO Copyright (C), QIAGEN.
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FA p63-isoform4
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SY DN p63 beta; DN p63beta.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009616 TP63; HGNC: TP63.
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CL C0057; P53; 6.3.1.0.2.4.
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SZ 461 AA; 51.4 kDa (calc.).
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SQ MLYLENNAQTQFSEPQYTNLGLLNSMDQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSS
SQ TFDALSPSPAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIK
SQ VMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQ
SQ YVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQV
SQ LGRRCFEARICACPGRDRKADEDSIRKQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRR
SQ SPDDELLYLPVRGRETYEMLLKIKESLELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQ
SQ SPSSYGNSSPPLNKMNSMNKLPSVSQLINPQQRNALTPTTIPDGMGANIPMMGTHMPMAG
SQ DMNGLSPTQALPPPLSMPSTSHCTPPPPYPTDCSIVRIWQV
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SC Swiss-Prot#Q9H3D4-4
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FT 58 351 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 69 265 
PF00870; P53 DNA-binding domain.
FT 297 338 
PF07710; P53 tetramerisation motif.
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SF several alternative products are known, p63alpha T06132, p63beta T06133, p63gamma T06135, p63delta T06005, DeltaN p63alpha T06004, p63-isoform4 T06134, DeltaNp63gamma T06136 [1] [2];
SF has DNA binding and oligomerization domains [1];
SF this splice variant lack N-terminal transactivation domain and exon 13 in comparison with p63alpha T06132 [1];
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MX M00761 V$P53DECAMER_Q2.
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BS R64794.
BS R64796.
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DR TRANSPATH: MO000043730.
DR EMBL: AF124539;
DR UniProtKB: Q9H3D4-4;
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RN [1]; RE0024711.
RX PUBMED: 9774969.
RA Yang A., Kaghad M., Wang Y., Gillett E., Fleming M. D., Dotsch V., Andrews N. C., Caput D., McKeon F.
RT p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
RL Mol. Cell 2:305-316 (1998).
RN [2]; RE0024715.
RX PUBMED: 11477076.
RA Klein C., Georges G., Kunkele K. P., Huber R., Engh R. A., Hansen S.
RT High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.
RL J. Biol. Chem. 276:37390-37401 (2001).
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