AC T06005
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ID T06005
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DT 08.06.2004 (created); cch.
DT 01.08.2014 (updated); sla.
CO Copyright (C), QIAGEN.
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FA p63-isoform11
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SY p51 isoform delta; p63 delta; p63delta.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009616 TP63; HGNC: TP63.
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CL C0057; P53; 6.3.1.0.2.11.
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SZ 676 AA; 25.8 kDa (calc.), >349 AA [2]
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SQ MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWD
SQ FLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSM
SQ DQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
SQ FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEV
SQ VKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFT
SQ TVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR
SQ KQQVSDSTKNGDAFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKESLELM
SQ QYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQLINP
SQ QQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPPPPYP
SQ TDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKGILDH
SQ RQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWNDFNFD
SQ MDARRNKQQRIKEEGE
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SC Swiss-Prot#Q9H3D4-11
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FT 11 207 
PF00870; P53 DNA-binding domain.
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SF several alternative products are known, p63alpha T06132, p63beta T06133, p63gamma T06135, p63-isoform11 T06005, DeltaN p63alpha T06004, DeltaN p63beta T06134, DeltaNp63gamma T06136 [1] [2];
SF sequence provided is the sequence of the DBD only, it is located in the protein between AA 114 to 349 [2];
SF Zn2+ coordination is required for p63 core DBD DNA binding [2];
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MX M00761 V$P53DECAMER_Q2.
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DR TRANSPATH: MO000043794.
DR EMBL: AJ315499;
DR UniProtKB: Q9H3D4-11;
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RN [1]; RE0024711.
RX PUBMED: 9774969.
RA Yang A., Kaghad M., Wang Y., Gillett E., Fleming M. D., Dotsch V., Andrews N. C., Caput D., McKeon F.
RT p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
RL Mol. Cell 2:305-316 (1998).
RN [2]; RE0024715.
RX PUBMED: 11477076.
RA Klein C., Georges G., Kunkele K. P., Huber R., Engh R. A., Hansen S.
RT High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.
RL J. Biol. Chem. 276:37390-37401 (2001).
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