AC T06132
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ID T06132
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DT 09.09.2004 (created); oke.
DT 01.08.2014 (updated); sla.
CO Copyright (C), QIAGEN.
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FA p63-isoform1
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SY EEC3; KET; LMS; p51; P51B; p63; p73H; p73L; SHFM4; TA p63 alpha; TA p63alpha; TAp63alpha; TP63; TP73L; tumor protein p73-like.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009616 TP63; HGNC: TP63.
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CL C0057; P53; 6.3.1.0.2.1.
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SZ 680 AA; 76.8 kDa (calc.).
XX
SQ MNFETSRCATLQYCPDPYIQRFVETPAHFSWKESYYRSTMSQSTQTNEFLSPEVFQHIWD
SQ FLEQPICSVQPIDLNFVDEPSEDGATNKIEISMDCIRMQDSDLSDPMWPQYTNLGLLNSM
SQ DQQIQNGSSSTSPYNTDHAQNSVTAPSPYAQPSSTFDALSPSPAIPSNTDYPGPHSFDVS
SQ FQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEV
SQ VKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFT
SQ TVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSIR
SQ KQQVSDSTKNGDGTKRPFRQNTHGIQMTSIKKRRSPDDELLYLPVRGRETYEMLLKIKES
SQ LELMQYLPQHTIETYRQQQQQQHQHLLQKQTSIQSPSSYGNSSPPLNKMNSMNKLPSVSQ
SQ LINPQQRNALTPTTIPDGMGANIPMMGTHMPMAGDMNGLSPTQALPPPLSMPSTSHCTPP
SQ PPYPTDCSIVSFLARLGCSSCLDYFTTQGLTTIYQIEHYSMDDLASLKIPEQFRHAIWKG
SQ ILDHRQLHEFSSPSHLLRTPSSASTVSVGSSETRGERVIDAVRFTLRQTISFPPRDEWND
SQ FNFDMDARRNKQQRIKEEGE
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SC Swiss-Prot#Q9H3D4-1
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FT 152 445 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 153 388 
DNA binding domain, DBD [3].
FT 163 359 
PF00870; P53 DNA-binding domain.
FT 391 432 
PF07710; P53 tetramerisation motif.
FT 540 654 
SAM homology domain [1].
FT 541 607 
PF07647; SAM domain (Sterile alpha motif).
FT 541 607 
SM00454; SAM.
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SF several alternative products are known, p63-isoform1 T06132, p63beta T06133, p63gamma T06135, p63delta T06005, DeltaN p63-isoform1 T06004, DeltaN p63beta T06134, DeltaNp63gamma T06136 [2] [3];
SF has transactivation, DNA binding and oligomerization domains [2];
SF SAM homology domain is a globular alpha-helical domain probably involved in protein-protein interactions [1];
SF C-terminal SAM homology domain is highly conserved between human p73 T04931 alpha and human p63-isoform1 [1];
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FF is not able to activate transcription [2];
FF is not able to cause apoptosis [2];
FF similar to p73alpha, directly interacts with NF-Y [4];
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IN T02872 beta-catenin; human, Homo sapiens.
IN T02944 Daxx; human, Homo sapiens.
IN T25709 hnRPAB-isoform3; human, Homo sapiens.
IN T00616 NF-YB; mouse, Mus musculus.
IN T02478 NF-YC-isoform3; human, Homo sapiens.
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MX M00761 V$P53DECAMER_Q2.
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DR TRANSPATH: MO000042286.
DR EMBL: AF075431;
DR EMBL: AF124539; AF124539.
DR UniProtKB: Q9H3D4-1;
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RN [1]; RE0017273.
RX PUBMED: 10449409.
RA Chi S. W., Ayed A., Arrowsmith C. H.
RT Solution structure of a conserved C-terminal domain of p73 with structural homology to the SAM domain
RL EMBO J. 18:4438-4445 (1999).
RN [2]; RE0024711.
RX PUBMED: 9774969.
RA Yang A., Kaghad M., Wang Y., Gillett E., Fleming M. D., Dotsch V., Andrews N. C., Caput D., McKeon F.
RT p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities.
RL Mol. Cell 2:305-316 (1998).
RN [3]; RE0024715.
RX PUBMED: 11477076.
RA Klein C., Georges G., Kunkele K. P., Huber R., Engh R. A., Hansen S.
RT High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53.
RL J. Biol. Chem. 276:37390-37401 (2001).
RN [4]; RE0024850.
RX PUBMED: 12167641.
RA Hackzell A., Uramoto H., Izumi H., Kohno K., Funa K.
RT p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y.
RL J. Biol. Chem. 277:39769-39776 (2002).
RN [5]; RE0049696.
RX PUBMED: 15539951.
RA Huang Y. P., Wu G., Guo Z., Osada M., Fomenkov T., Park H. L., Trink B., Sidransky D., Fomenkov A., Ratovitski E. A.
RT Altered sumoylation of p63alpha contributes to the split-hand/foot malformation phenotype.
RL Cell Cycle 3:1587-1596 (2004).
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