AC T02478
XX
ID T02478
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DT 12.06.1998 (created); ewi.
DT 14.09.2006 (updated); sri.
CO Copyright (C), QIAGEN.
XX
FA NF-YC-isoform3
XX
SY CAAT-box DNA-binding protein subunit C; DS2.8; HSM-1; Nuclear transcription factor Y subunit C; Nuclear transcription factor Y subunit gamma; Transactivator HSM-1/2.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004106 NFYC; HGNC: NFYC.
XX
HO HAP4 (yeast).
XX
CL C0075; heteromer-CCAAT; 4.2.1.0.3.3.
XX
SZ 458 AA; 50.3 kDa (cDNA) (calc.).
XX
SQ MSTEGGFGGTSSSDAQQSLQSFWPRVMEEIRNLTVKDFRVQELPLARIKKIMKLDEDVKM
SQ ISAEAPVLFAKAAQIFITELTLRAWIHTEDNKRRTLQRNDIAMAITKFDQFDFLIDIVPR
SQ DELKPPKRQEEVRQSVTPAEPVQYYFTLAQQPTAVQVQGQQQGQQTTSSTTTIQPGQIII
SQ AQPQQGQTTPVTMQVGEGQQVQIVQAQPQGQAQQAQSGTGQTMQVMQQIITNTGEIQQIP
SQ VQLNAGQLQYIRLAQPVSGTQVVQGQIQTLATNAQQGQRNASQGKPRRCLKETLQITQTE
SQ VQQGQQQFSQFTDGQRNSVQQARVSELTGEAEPREVKATGNSTPCTSSLPTTHPPSHRAG
SQ ASCVCCSQPQQSSTSPPPSDALQWVVVEVSGTPNQLETHRELHAPLPGMTSLSPLHPSQQ
SQ LYQIQQVTMPAGQDLAQPMFIQSANQPSDGQAPQVTGD
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SC Swiss-Prot#Q13952-1
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FT 41 105 
PF00808; Histone-like transcription factor (CBF/.
FT 45 108 
PS50028; HIST_TAF.
FT 52 398 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 108 115 
interaction with p73alpha [4].
XX
SF subunit of a trimeric DNA binding complex NF-YA:NF-YB:NF-YC, see T00150;
SF C-terminal HAP5 domain is necessary for binding with p73alpha [4];
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CP ubiquitous.
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FF as a subunit of the NF-Y complex, interacts directly with CIITA T05450 [2];
FF interacts directly with two subunits of the RFX complex, RFX5 T01672 and RFXANK T05441 [3];
FF interacts directly with p63alpha and p73alpha, but not with p53 and other isoforms of p73 [4];
XX
IN T05450 C2TA; human, Homo sapiens.
IN T01488 Cdk2; human, Homo sapiens.
IN T01804 NF-YA; human, Homo sapiens.
IN T00616 NF-YB; mouse, Mus musculus.
IN T06148 p/CAF; human, Homo sapiens.
IN T06132 p63-isoform1; human, Homo sapiens.
IN T04931 p73alpha; human, Homo sapiens.
IN T01672 rfx5; human, Homo sapiens.
IN T05441 RFXANK; human, Homo sapiens.
XX
MX M07302 V$NFY_Q3.
MX M00185 V$NFY_Q6.
MX M00775 V$NFY_Q6_01.
XX
BS R16941.
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DR TRANSPATH: MO000026459.
DR EMBL: D85425;
DR UniProtKB: Q13952-1;
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RN [1]; RE0006902.
RX PUBMED: 9287329.
RA Orita T., Shimozaki K., Murakami H., Nagata S.
RT Binding of NF-Y transcription factor to one of the cis-elements in the myeloperoxidase gene promoter that responds to granulocyte colony-stimulating factor
RL J. Biol. Chem. 272:23216-23223 (1997).
RN [2]; RE0022578.
RX PUBMED: 11003667.
RA Hake S. B., Masternak K., Kammerbauer C., Janzen C., Reith W., Steimle V.
RT CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.
RL Mol. Cell. Biol. 20:7716-7725 (2000).
RN [3]; RE0022593.
RX PUBMED: 12101253.
RA Jabrane-Ferrat N., Nekrep N., Tosi G., Esserman L. J., Peterlin B. M.
RT Major histocompatibility complex class II transcriptional platform: assembly of nuclear factor Y and regulatory factor X (RFX) on DNA requires RFX5 dimers.
RL Mol. Cell. Biol. 22:5616-5625 (2002).
RN [4]; RE0024850.
RX PUBMED: 12167641.
RA Hackzell A., Uramoto H., Izumi H., Kohno K., Funa K.
RT p73 independent of c-Myc represses transcription of platelet-derived growth factor beta-receptor through interaction with NF-Y.
RL J. Biol. Chem. 277:39769-39776 (2002).
RN [5]; RE0035109.
RX PUBMED: 9249075.
RA Bellorini M., Zemzoumi K., Farina A., Berthelsen J., Piaggio G., Mantovani R.
RT Cloning and expression of human NF-YC.
RL Gene 193:119-125 (1997).
XX
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