AC T00150
AS T01203, T10328.
XX
ID T00150
XX
DT 15.10.1992 (created); ewi.
DT 14.08.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
XX
FA NF-Y
XX
SY alpha-CP1; CBF; CP1; NF-Y; NF-Y complex; NF-YA(h):NF-YB(h):NF-YC(h); trimer NF-Y.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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SF consists of three subunits encoded by different genes: CP1A T00154, CP1B T01804 and CP1C T02478;
SF previously was thought to be composed of seven polypeptides of three groups observed: alpha (35 kDa), beta (28, 27 kDa), gamma (33, 34, 37, 38 kDa);
SF stable alpha:beta association, weak association of gamma [4];
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CP HP100 [17].
XX
FF essential coactivator of the cholesterol response of human FAS promoter I;
FF ubiquitous transcription factor [20];
FF activator;
FF important regulator of MHC class II gene transcription;
FF binds to X-Y-boxes cooperatively with the RFX complex T05444, stabilizes binding of the RFX, activates transcription synergistically with the RFX complex [15];
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IN T00086 NOC1; human, Homo sapiens.
IN T05444 rfx5:RFXAP:RFXANK; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
XX
MX M00687 V$ALPHACP1_01.
MX M00287 V$NFY_01.
MX M00209 V$NFY_C.
MX M07302 V$NFY_Q3.
MX M00185 V$NFY_Q6.
MX M00775 V$NFY_Q6_01.
XX
BS R23183.
BS R23483.
BS R37426.
BS R37427.
BS R20553.
BS R69245.
BS R35116.
BS R38073.
BS R35981.
BS R35983.
BS R40867.
BS R40868.
BS R40869.
BS R24187.
BS R21155.
BS R58364.
BS R70781.
BS R20773.
BS R26783.
BS R20798.
BS R20904.
BS R21047.
BS R04358.
BS R33457.
BS R16055.
BS R19303.
BS R20764.
BS R25570.
BS R21558.
BS R59033.
BS R32745.
BS R00564.
BS R01858.
BS R02048.
BS R02888.
BS R04200.
BS R58086.
BS R22907.
BS R03119.
BS R16628.
BS R39682.
BS R22694.
BS R31443.
BS R00766.
BS R00768.
BS R36129.
BS R37312.
BS R01088.
BS R13374.
BS R04736.
BS R20809.
BS R16941.
BS R16682.
BS R38517.
BS R59003.
BS R37326.
BS R03038.
BS R66790.
BS R21179.
BS R21177.
BS R20886.
BS R29571.
BS R36031.
BS R67558.
BS R58569.
BS R42197.
BS R22460.
BS R16237.
BS R16238.
BS R19533.
BS R22518.
BS R38944.
BS R16955.
BS R22610.
BS R22611.
BS R33205.
BS R01443.
BS R20768.
BS R34164.
BS R00511.
BS R27263.
BS R27264.
BS R27265.
BS R13353.
BS R37388.
BS R22901.
BS R17073.
BS R03043.
BS R22612.
BS R61165.
BS R61167.
BS R05057.
BS R18473.
BS R18859.
BS R22137.
XX
DR TRANSPATH: MO000024737.
DR TRANSCOMPEL: C00180.
DR TRANSCOMPEL: C00497.
DR TRANSCOMPEL: C00542.
XX
RN [1]; RE0000036.
RX PUBMED: 3349524.
RA Chodosh L. A., Baldwin jr A. S., Carthew R. W., Sharp P. A.
RT Human CCAAT-Binding Proteins Have Heterologous Subunits
RL Cell 53:11-24 (1988).
RN [2]; RE0000037.
RX PUBMED: 3280141.
RA Chodosh L. A., Olesen J., Hahn S., Baldwin jr A. S., Guarente L., Sharp P. A.
RT A Yeast and a Human CCAAT-Binding Protein Have Heterologous Subunits That Are Functionally Interchangeable
RL Cell 53:25-35 (1988).
RN [3]; RE0000346.
RX PUBMED: 3181130.
RA Superti-Furga G., Barberis A., Schaffner G., Busslinger M.
RT The -117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma-globin gene
RL EMBO J. 7:3099-3107 (1988).
RN [4]; RE0000946.
RX PUBMED: 2376599.
RA Kim C. G., Sheffery M.
RT Physical characterization of the purified CCAAT transcription factor, alpha-CP1
RL J. Biol. Chem. 265:13362-13369 (1990).
RN [5]; RE0001257.
RX PUBMED: 2905426.
RA Barnhart K. M., Kim C. G., Banerji S. S., Sheffery M.
RT Identification and Characterization of Multiple Erythroid Cell Proteins That Interact with the Promoter of the Murine alpha-Globin Gene
RL Mol. Cell. Biol. 8:3215-3226 (1988).
RN [6]; RE0001258.
RX PUBMED: 3185549.
RA Kim C. G., Barnhart K. M., Sheffery M.
RT Purification of Multiple Erythroid Cell Proteins That Bind the Promoter of the alpha-Globin Gene
RL Mol. Cell. Biol. 8:4270-4281 (1988).
RN [7]; RE0001435.
RX PUBMED: 2294402.
RA Taylor I. C. A., Kingston R. E.
RT Factor Substitution in a Human HSP70 Gene Promoter: TATA-Dependent and TATA-Independent Interactions
RL Mol. Cell. Biol. 10:165-175 (1990).
RN [8]; RE0001611.
RX PUBMED: 1672442.
RA Spanopoulou E., Giguere V., Grosveld F.
RT The functional domains of the murine Thy-1 gene promoter
RL Mol. Cell. Biol. 11:2216-2228 (1991).
RN [9]; RE0002047.
RX PUBMED: 2476717.
RA Mantovani R., Superti-Furga G., Gilman J., Ottolenghi S.
RT The deletion of the distal CCAAT box region of the Agamma-globin gene in black HPFH abolishes the binding of the erythroid specific protein NFE3 and of the CCAAT displacement protein
RL Nucleic Acids Res. 17:6681-6691 (1989).
RN [10]; RE0002066.
RX PUBMED: 2557588.
RA Ben-Hattar J., Beard P., Jiricny J.
RT Cytosine methylation in CTF and Sp1 recognition sites of an HSV tk promoter: effects on transcription in vivo and on factor binding in vitro
RL Nucleic Acids Res. 17:10179-10190 (1989).
RN [11]; RE0002078.
RX PUBMED: 1698280.
RA Fucharoen S., Shimizu K., Fukumaki Y.
RT A novel C-T transition within the distal CCAAT motif of the Ggamma-globin gene in the Japanese HPFH: implication of factor binding in elevated fetal globin expression
RL Nucleic Acids Res. 18:5245 (1990).
RN [12]; RE0006902.
RX PUBMED: 9287329.
RA Orita T., Shimozaki K., Murakami H., Nagata S.
RT Binding of NF-Y transcription factor to one of the cis-elements in the myeloperoxidase gene promoter that responds to granulocyte colony-stimulating factor
RL J. Biol. Chem. 272:23216-23223 (1997).
RN [13]; RE0008202.
RX PUBMED: 8444876.
RA Framson P., Bornstein P.
RT A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene
RL J. Biol. Chem. 268:4989-4996 (1993).
RN [14]; RE0016548.
RX PUBMED: 8076600.
RA Wright K. L., Vilen B. J., Itoh-Lindstorm Y., Moore T. L., Li G., Criscitiello M., Cogswell P., Clarke J. B., Ting J. P.-Y.
RT CCAAT box binding protein NF-Y facilitates in vivo recruitment of upstream DNA binding transcription factors.
RL EMBO J. 13:4042-4053 (1994).
RN [15]; RE0022579.
RX PUBMED: 10986117.
RA Caretti G., Cocchiarella F., Sidoli C., Villard J., Peretti M., Reith W., Mantovani R.
RT Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter.
RL J. Mol. Biol. 302:539-552 (2000).
RN [16]; RE0022626.
RX PUBMED: 9712144.
RA Collins M., Smith A. A., Parker M. I.
RT Characterization of two distinct families of transcription factors that bind to the CCAAT box region of the human COL1A2 gene.
RL J. Cell. Biochem. 70:455-467 (1998).
RN [17]; RE0034889.
RX PUBMED: 11479230.
RA Nenoi M., Ichimura S., Mita K., Yukawa O., Cartwright I. L.
RT Regulation of the catalase gene promoter by Sp1, CCAAT-recognizing factors, and a WT1/Egr-related factor in hydrogen peroxide-resistant HP100 cells.
RL Cancer Res. 61:5885-94 (2001).
RN [18]; RE0048388.
RX PUBMED: 16757134.
RA Benlhabib H., Herrera J. E.
RT Expression of the Op18 gene is maintained by the CCAAT-binding transcription factor NF-Y.
RL Gene 377:177-185 (2006).
RN [19]; RE0067360.
RX PUBMED: 15647279.
RA Huang W., Zhao S., Ammanamanchi S., Brattain M., Venkatasubbarao K., Freeman J. W.
RT Trichostatin A induces transforming growth factor beta type II receptor promoter activity and acetylation of Sp1 by recruitment of PCAF/p300 to a Sp1.NF-Y complex.
RL J. Biol. Chem. 280:10047-10054 (2005).
RN [20]; RE0047759.
RX PUBMED: 10759542.
RA Xiong S., Chirala S. S., Wakil S. J.
RT Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites.
RL Proc. Natl. Acad. Sci. USA 97:3948-3953 (2000).
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