AC T05444
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ID T05444
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DT 22.02.2003 (created); oke.
DT 25.07.2011 (updated); jag.
CO Copyright (C), QIAGEN.
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FA rfx5:RFXAP:RFXANK
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SY Regulatory Factor X; RFX complex; RFX5(h):RFXAP(h):RFXANK(h); RFXcomplex.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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SF complex consisting of three subunits, rfx5 T01672 that is DNA binding subunit, RFXAP T05443, RFXANK T05441 [2] [7] [9] [10] [11];
SF all three subunit are essential for DNA binding [7] [9];
SF ankyrin repeats of RFXANK could mediate interactions with other subunits [7];
SF mouse rfx5 T05440 could substitute for human protein in the RFX complex [6];
SF mouse RFXAP T05447 could substitute for human protein in the RFX complex [8];
SF within the RFX complex, rfx5 interacts directly with RFXAP [9];
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CP B-cells.
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FF activator;
FF essential for the regulation of MHC class II gene transcription;
FF binds to X-boxes;
FF functions and binds to DNA cooperatively with X2BP and NF-Y recognizing X2- and Y-boxes [1] [3] [4] [5];
FF different subunits are mutated in MHC class II deficiency (bare lymphocyte syndrome), rfx5 (complementation group C), RFXAP (group D) or RFXANK (group B) [2] [7];
FF binds to X-Y-boxes cooperatively with NF-Y and synergistically activates transcription of the mouse H2-Ealpha promoter [11];
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IN T00150 NF-Y; human, Homo sapiens.
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MX M00626 V$EFC_Q6.
MX M00975 V$RFX_Q6.
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BS R73958.
BS R02384.
BS R03695.
BS R01087.
BS R13373.
BS R13352.
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DR TRANSPATH: MO000034780.
DR TRANSCOMPEL: C00004.
DR TRANSCOMPEL: C00106.
DR TRANSCOMPEL: C00190.
DR TRANSCOMPEL: C00378.
DR TRANSCOMPEL: C00382.
DR TRANSCOMPEL: C00383.
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RN [1]; RE0003796.
RX PUBMED: 8290561.
RA Reith W., Siegrist C. A., Durand B., Barras E., Mach B.
RT Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y
RL Proc. Natl. Acad. Sci. USA 91:554-558 (1994).
RN [2]; RE0013477.
RX PUBMED: 9118943.
RA Durand B., Sperisen P., Emery P., Barras E., Zufferey M., Mach B., Reith W.
RT RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.
RL EMBO J. 16:1045-1055 (1997).
RN [3]; RE0016589.
RX PUBMED: 9378978.
RA Louis-Plence P., Moreno C. S., Boss J. M.
RT Formation of a Regulatory Factor X/X2 box-binding protein/Nuclear Factor-Y multiprotein complex on the conserved regulatory regions of HLA Class II genes.
RL J. Immunol. 159:3899-3909 (1997).
RN [4]; RE0016590.
RX PUBMED: 7594590.
RA Moreno C. S., Emery P., West J. E., Durand B., Reith W., Mach B., Boss J. M.
RT Purified X2 binding protein (X2BP) cooperatively binds the class II MHC X box region in the presence of purified RFX, the X box factor deficient in the Bare lymphocyte syndrome.
RL J. Immunol. 155:4313-4321 (1995).
RN [5]; RE0016633.
RX PUBMED: 8051086.
RA Reith W., Korb M., Emery P., Durand B., Siegrist C.-A., Mach B.
RT Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC Class II promoters.
RL J. Biol. Chem. 269:20020-20025 (1994).
RN [6]; RE0022529.
RX PUBMED: 10779326.
RA Villard J., Peretti M., Masternak K., Barras E., Caretti G., Mantovani R., Reith W.
RT A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.
RL Mol. Cell. Biol. 20:3364-3376 (2000).
RN [7]; RE0022532.
RX PUBMED: 9806546.
RA Masternak K., Barras E., Zufferey M., Conrad B., Corthals G., Aebersold R., Sanchez J. C., Hochstrasser D. F., Mach B., Reith W.
RT A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.
RL Nat. Genet. 20:273-277 (1998).
RN [8]; RE0022533.
RX PUBMED: 11486010.
RA Peretti M., Villard J., Barras E., Zufferey M., Reith W.
RT Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAP.
RL Mol. Cell. Biol. 21:5699-5709 (2001).
RN [9]; RE0022539.
RX PUBMED: 10938133.
RA DeSandro A. M., Nagarajan U. M., Boss J. M.
RT Associations and interactions between bare lymphocyte syndrome factors.
RL Mol. Cell. Biol. 20:6587-6599 (2000).
RN [10]; RE0022542.
RX PUBMED: 10072068.
RA Nagarajan U. M., Louis-Plence P., DeSandro A., Nilsen R., Bushey A., Boss J. M.
RT RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency.
RL Immunity 10:153-162 (1999).
RN [11]; RE0022579.
RX PUBMED: 10986117.
RA Caretti G., Cocchiarella F., Sidoli C., Villard J., Peretti M., Reith W., Mantovani R.
RT Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter.
RL J. Mol. Biol. 302:539-552 (2000).
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