TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T05444 XX ID T05444 XX DT 22.02.2003 (created); oke. DT 25.07.2011 (updated); jag. CO Copyright (C), QIAGEN. XX FA rfx5:RFXAP:RFXANK XX SY Regulatory Factor X; RFX complex; RFX5(h):RFXAP(h):RFXANK(h); RFXcomplex. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX SF complex consisting of three subunits, rfx5 T01672 that is DNA binding subunit, RFXAP T05443, RFXANK T05441 [2] [7] [9] [10] [11]; SF all three subunit are essential for DNA binding [7] [9]; SF ankyrin repeats of RFXANK could mediate interactions with other subunits [7]; SF mouse rfx5 T05440 could substitute for human protein in the RFX complex [6]; SF mouse RFXAP T05447 could substitute for human protein in the RFX complex [8]; SF within the RFX complex, rfx5 interacts directly with RFXAP [9]; XX CP B-cells. XX FF activator; FF essential for the regulation of MHC class II gene transcription; FF binds to X-boxes; FF functions and binds to DNA cooperatively with X2BP and NF-Y recognizing X2- and Y-boxes [1] [3] [4] [5]; FF different subunits are mutated in MHC class II deficiency (bare lymphocyte syndrome), rfx5 (complementation group C), RFXAP (group D) or RFXANK (group B) [2] [7]; FF binds to X-Y-boxes cooperatively with NF-Y and synergistically activates transcription of the mouse H2-Ealpha promoter [11]; XX IN T00150 NF-Y; human, Homo sapiens. XX MX M00626 V$EFC_Q6. MX M00975 V$RFX_Q6. XX BS R73958. BS R02384. BS R03695. BS R01087. BS R13373. BS R13352. XX DR TRANSPATH: MO000034780. DR TRANSCOMPEL: C00004. DR TRANSCOMPEL: C00106. DR TRANSCOMPEL: C00190. DR TRANSCOMPEL: C00378. DR TRANSCOMPEL: C00382. DR TRANSCOMPEL: C00383. XX RN [1]; RE0003796. RX PUBMED: 8290561. RA Reith W., Siegrist C. A., Durand B., Barras E., Mach B. RT Function of major histocompatibility complex class II promoters requires cooperative binding between factors RFX and NF-Y RL Proc. Natl. Acad. Sci. USA 91:554-558 (1994). RN [2]; RE0013477. RX PUBMED: 9118943. RA Durand B., Sperisen P., Emery P., Barras E., Zufferey M., Mach B., Reith W. RT RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency. RL EMBO J. 16:1045-1055 (1997). RN [3]; RE0016589. RX PUBMED: 9378978. RA Louis-Plence P., Moreno C. S., Boss J. M. RT Formation of a Regulatory Factor X/X2 box-binding protein/Nuclear Factor-Y multiprotein complex on the conserved regulatory regions of HLA Class II genes. RL J. Immunol. 159:3899-3909 (1997). RN [4]; RE0016590. RX PUBMED: 7594590. RA Moreno C. S., Emery P., West J. E., Durand B., Reith W., Mach B., Boss J. M. RT Purified X2 binding protein (X2BP) cooperatively binds the class II MHC X box region in the presence of purified RFX, the X box factor deficient in the Bare lymphocyte syndrome. RL J. Immunol. 155:4313-4321 (1995). RN [5]; RE0016633. RX PUBMED: 8051086. RA Reith W., Korb M., Emery P., Durand B., Siegrist C.-A., Mach B. RT Cooperative binding between factors RFX and X2bp to the X and X2 boxes of MHC Class II promoters. RL J. Biol. Chem. 269:20020-20025 (1994). RN [6]; RE0022529. RX PUBMED: 10779326. RA Villard J., Peretti M., Masternak K., Barras E., Caretti G., Mantovani R., Reith W. RT A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y. RL Mol. Cell. Biol. 20:3364-3376 (2000). RN [7]; RE0022532. RX PUBMED: 9806546. RA Masternak K., Barras E., Zufferey M., Conrad B., Corthals G., Aebersold R., Sanchez J. C., Hochstrasser D. F., Mach B., Reith W. RT A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients. RL Nat. Genet. 20:273-277 (1998). RN [8]; RE0022533. RX PUBMED: 11486010. RA Peretti M., Villard J., Barras E., Zufferey M., Reith W. RT Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAP. RL Mol. Cell. Biol. 21:5699-5709 (2001). RN [9]; RE0022539. RX PUBMED: 10938133. RA DeSandro A. M., Nagarajan U. M., Boss J. M. RT Associations and interactions between bare lymphocyte syndrome factors. RL Mol. Cell. Biol. 20:6587-6599 (2000). RN [10]; RE0022542. RX PUBMED: 10072068. RA Nagarajan U. M., Louis-Plence P., DeSandro A., Nilsen R., Bushey A., Boss J. M. RT RFX-B is the gene responsible for the most common cause of the bare lymphocyte syndrome, an MHC class II immunodeficiency. RL Immunity 10:153-162 (1999). RN [11]; RE0022579. RX PUBMED: 10986117. RA Caretti G., Cocchiarella F., Sidoli C., Villard J., Peretti M., Reith W., Mantovani R. RT Dissection of functional NF-Y-RFX cooperative interactions on the MHC class II Ea promoter. RL J. Mol. Biol. 302:539-552 (2000). XX //