DT 21.02.2003 (created); oke.
DT 06.12.2013 (updated); asv.
CO Copyright (C), QIAGEN.
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
GE G005112 Rfx5.
CL C0023; fork head; 188.8.131.52.5.
SF member of winged-helix class of helix-turn-helix superclass of factors ;
SF DNA binding subunit of the RFX complex, for human RFX complex see T05444;
SF N-terminal region is required for its association with RFXAP T05443 and RFXANK T05441 and for binding of RFX complex to X-boxes ;
SF C-terminal domain of rfx5 mediates cooperation of RFX complex with NF-Y and transcription activation ;
SF mouse gene could fully substitute for human rfx5 to regulate MHC-II gene expression ;
FF important regulator of MHC class II gene expression;
MX M00975 V$RFX_Q6.
MX M07305 V$RFX_Q6_01.
DR TRANSPATH: MO000034949.
DR UniProtKB: Q9JL61;
RN ; RE0022529.
RX PUBMED: 10779326.
RA Villard J., Peretti M., Masternak K., Barras E., Caretti G., Mantovani R., Reith W.
RT A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.
RL Mol. Cell. Biol. 20:3364-3376 (2000).