AC T05440
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ID T05440
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DT 21.02.2003 (created); oke.
DT 06.12.2013 (updated); asv.
CO Copyright (C), QIAGEN.
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FA rfx5
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G005112 Rfx5.
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CL C0023; fork head; 3.3.3.0.5.
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SF member of winged-helix class of helix-turn-helix superclass of factors [1];
SF DNA binding subunit of the RFX complex, for human RFX complex see T05444;
SF N-terminal region is required for its association with RFXAP T05443 and RFXANK T05441 and for binding of RFX complex to X-boxes [1];
SF C-terminal domain of rfx5 mediates cooperation of RFX complex with NF-Y and transcription activation [1];
SF mouse gene could fully substitute for human rfx5 to regulate MHC-II gene expression [1];
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FF important regulator of MHC class II gene expression;
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MX M00975 V$RFX_Q6.
MX M07305 V$RFX_Q6_01.
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DR TRANSPATH: MO000034949.
DR UniProtKB: Q9JL61;
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RN [1]; RE0022529.
RX PUBMED: 10779326.
RA Villard J., Peretti M., Masternak K., Barras E., Caretti G., Mantovani R., Reith W.
RT A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.
RL Mol. Cell. Biol. 20:3364-3376 (2000).
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