TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T05443 XX ID T05443 XX DT 21.02.2003 (created); oke. DT 12.04.2013 (updated); mkl. CO Copyright (C), QIAGEN. XX FA RFXAP XX SY RFX associated protein. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G005108 RFXAP; HGNC: RFXAP. XX CL C0064; unchar-DBD; XX SF subunit of RFX complex T05444; SF previously was known as 36 kDa subunit [2] [4] [1]; SF within RFX complex interacts directly with RFX5 T01672 [2]; SF does not belong to the RFX family, has no DNA binding domain [2]; SF acidic and glutamine-rich regions are similar to transcriptional activation domains, basic region contains motif similar to nuclear localization signals [2]; SF mouse RFXAP T05447 is functionally equivalent to human RFXAP [3]; SF glutamine-rich region is required for its association with RFX5 and RFXANK [4]; SF C-terminal part is sufficient for The RFX complex formation, for X-box binding, and for cooperativity between the RFX complex and NF-Y complex [5]; XX FF important regulator of MHC class II gene expression, gene is mutated in MHC class II deficiency (complementation group D) [2]; XX IN T21600 nucleolin; human, Homo sapiens. XX MX M00975 V$RFX_Q6. MX M07305 V$RFX_Q6_01. XX DR TRANSPATH: MO000034778. DR UniProtKB: O00287; XX RN [1]; RE0003797. RX PUBMED: 7744245. RA Steimle V., Durand B., Barras E., Zufferey M., Hadam M. R., Mach B., Reith W. RT A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymophocyte syndrome) RL Genes Dev. 9:1021-1032 (1995). RN [2]; RE0013477. RX PUBMED: 9118943. RA Durand B., Sperisen P., Emery P., Barras E., Zufferey M., Mach B., Reith W. RT RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency. RL EMBO J. 16:1045-1055 (1997). RN [3]; RE0022533. RX PUBMED: 11486010. RA Peretti M., Villard J., Barras E., Zufferey M., Reith W. RT Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAP. RL Mol. Cell. Biol. 21:5699-5709 (2001). RN [4]; RE0022539. RX PUBMED: 10938133. RA DeSandro A. M., Nagarajan U. M., Boss J. M. RT Associations and interactions between bare lymphocyte syndrome factors. RL Mol. Cell. Biol. 20:6587-6599 (2000). RN [5]; RE0022578. RX PUBMED: 11003667. RA Hake S. B., Masternak K., Kammerbauer C., Janzen C., Reith W., Steimle V. RT CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation. RL Mol. Cell. Biol. 20:7716-7725 (2000). XX //