DT 21.02.2003 (created); oke.
DT 12.04.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
SY RFX associated protein.
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
GE G005108 RFXAP; HGNC: RFXAP.
CL C0064; unchar-DBD; 0.0.4.0.1.
SF subunit of RFX complex T05444;
SF previously was known as 36 kDa subunit   ;
SF within RFX complex interacts directly with RFX5 T01672 ;
SF does not belong to the RFX family, has no DNA binding domain ;
SF acidic and glutamine-rich regions are similar to transcriptional activation domains, basic region contains motif similar to nuclear localization signals ;
SF mouse RFXAP T05447 is functionally equivalent to human RFXAP ;
SF glutamine-rich region is required for its association with RFX5 and RFXANK ;
SF C-terminal part is sufficient for The RFX complex formation, for X-box binding, and for cooperativity between the RFX complex and NF-Y complex ;
FF important regulator of MHC class II gene expression, gene is mutated in MHC class II deficiency (complementation group D) ;
IN T21600 nucleolin; human, Homo sapiens.
MX M00975 V$RFX_Q6.
MX M07305 V$RFX_Q6_01.
DR TRANSPATH: MO000034778.
DR UniProtKB: O00287;
RN ; RE0003797.
RX PUBMED: 7744245.
RA Steimle V., Durand B., Barras E., Zufferey M., Hadam M. R., Mach B., Reith W.
RT A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymophocyte syndrome)
RL Genes Dev. 9:1021-1032 (1995).
RN ; RE0013477.
RX PUBMED: 9118943.
RA Durand B., Sperisen P., Emery P., Barras E., Zufferey M., Mach B., Reith W.
RT RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.
RL EMBO J. 16:1045-1055 (1997).
RN ; RE0022533.
RX PUBMED: 11486010.
RA Peretti M., Villard J., Barras E., Zufferey M., Reith W.
RT Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAP.
RL Mol. Cell. Biol. 21:5699-5709 (2001).
RN ; RE0022539.
RX PUBMED: 10938133.
RA DeSandro A. M., Nagarajan U. M., Boss J. M.
RT Associations and interactions between bare lymphocyte syndrome factors.
RL Mol. Cell. Biol. 20:6587-6599 (2000).
RN ; RE0022578.
RX PUBMED: 11003667.
RA Hake S. B., Masternak K., Kammerbauer C., Janzen C., Reith W., Steimle V.
RT CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.
RL Mol. Cell. Biol. 20:7716-7725 (2000).