AC T01672
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ID T01672
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DT 15.02.1996 (created); ewi.
DT 17.02.2014 (updated); msr.
CO Copyright (C), QIAGEN.
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FA rfx5
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SY regulatory factor X, 5 (influences HLA class II expression); RFX5.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G005106 RFX5; HGNC: RFX5.
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CL C0023; fork head; 3.3.3.0.5.
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SF member of winged-helix class of helix-turn-helix superclass of factors [5];
SF rfx5 is the most divergent member of the RFX factor family;
SF it does not reveal any homology to the dimerization domain of other RFX proteins [1];
SF binds to DNA in a stable complex with two other subunits, RFXAP T05443 (previously known as a 41-kDa subunit) and RFXANK T05441 (previously known as a 33-kDa subunit) [4] [7] [9] [1];
SF within RFX complex T05444, interacts directly with RFXAP [4] [8];
SF within RFX complex T05444, interacts directly and with RFXANK [8];
SF although rfx5 does not contain a classical dimerization motif, it forms dimers [12];
SF dimer formation is shown to be dependent on a leucine-rich stretch [12];
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FF DNA binding subunit of trimeric RFX complex T05444 [4] [7] [8];
FF important regulator of MHC class II gene expression;
FF mutated in patients with group C MHC class II deficiency (bare lymphocyte syndrome) [1];
FF within the RFX complex, rfx5 is involved in direct interactions with co-activator CIITA T05450 [8] [10] [11];
FF interacts directly with all three subunits of the NF-Y [12];
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IN T05450 C2TA; human, Homo sapiens.
IN T01804 NF-YA; human, Homo sapiens.
IN T00154 NF-YB; human, Homo sapiens.
IN T02478 NF-YC-isoform3; human, Homo sapiens.
IN T05351 PPARgamma; human, Homo sapiens.
IN T10780 RBMS1; human, Homo sapiens.
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MX M04707 V$RFX5_03.
MX M04841 V$RFX5_05.
MX M07123 V$RFX5_06.
MX M00975 V$RFX_Q6.
MX M07305 V$RFX_Q6_01.
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BS R60315.
BS R18813.
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DR TRANSPATH: MO000025857.
DR UniProtKB: P48382;
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RN [1]; RE0003797.
RX PUBMED: 7744245.
RA Steimle V., Durand B., Barras E., Zufferey M., Hadam M. R., Mach B., Reith W.
RT A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymophocyte syndrome)
RL Genes Dev. 9:1021-1032 (1995).
RN [2]; RE0006619.
RX PUBMED: 9190936.
RA Moreno C. S., Rogers E. M., Brown J. A., Boss J. M.
RT Regulatory factor X, a bare lymphocyte syndrome transcription factor, is a multimeric phosphoprotein complex
RL J. Immunol. 158:5841-5848 (1997).
RN [3]; RE0006621.
RX PUBMED: 7693708.
RA Boisclair Y. R., Brown A. L., Casola S., Rechler M. M.
RT Three clustered Sp1 sites are required for efficient transcription of the TATA-less promoter of the gene for insulin-like growth factor-binding protein-2 from the rat
RL J. Biol. Chem. 268:24892- 24901 (1993).
RN [4]; RE0013477.
RX PUBMED: 9118943.
RA Durand B., Sperisen P., Emery P., Barras E., Zufferey M., Mach B., Reith W.
RT RFXAP, a novel subunit of the RFX DNA binding complex is mutated in MHC class II deficiency.
RL EMBO J. 16:1045-1055 (1997).
RN [5]; RE0022520.
RX PUBMED: 10706293.
RA Gajiwala K. S., Chen H., Cornille F., Roques B. P., Reith W., Mach B., Burley S. K.
RT Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding.
RL Nature 403:916-921 (2000).
RN [6]; RE0022529.
RX PUBMED: 10779326.
RA Villard J., Peretti M., Masternak K., Barras E., Caretti G., Mantovani R., Reith W.
RT A functionally essential domain of RFX5 mediates activation of major histocompatibility complex class II promoters by promoting cooperative binding between RFX and NF-Y.
RL Mol. Cell. Biol. 20:3364-3376 (2000).
RN [7]; RE0022532.
RX PUBMED: 9806546.
RA Masternak K., Barras E., Zufferey M., Conrad B., Corthals G., Aebersold R., Sanchez J. C., Hochstrasser D. F., Mach B., Reith W.
RT A gene encoding a novel RFX-associated transactivator is mutated in the majority of MHC class II deficiency patients.
RL Nat. Genet. 20:273-277 (1998).
RN [8]; RE0022539.
RX PUBMED: 10938133.
RA DeSandro A. M., Nagarajan U. M., Boss J. M.
RT Associations and interactions between bare lymphocyte syndrome factors.
RL Mol. Cell. Biol. 20:6587-6599 (2000).
RN [9]; RE0022541.
RX PUBMED: 10075994.
RA Westerheide S. D., Boss J. M.
RT Orientation and positional mapping of the subunits of the multicomponent transcription factors RFX and X2BP to the major histocompatibility complex class II transcriptional enhancer.
RL Nucleic Acids Res. 27:1635-1641 (1999).
RN [10]; RE0022569.
RX PUBMED: 9177217.
RA Scholl T., Mahanta S. K., Strominger J. L.
RT Specific complex formation between the type II bare lymphocyte syndrome-associated transactivators CIITA and RFX5.
RL Proc. Natl. Acad. Sci. USA 94:6330-6334 (1997).
RN [11]; RE0022578.
RX PUBMED: 11003667.
RA Hake S. B., Masternak K., Kammerbauer C., Janzen C., Reith W., Steimle V.
RT CIITA leucine-rich repeats control nuclear localization, in vivo recruitment to the major histocompatibility complex (MHC) class II enhanceosome, and MHC class II gene transactivation.
RL Mol. Cell. Biol. 20:7716-7725 (2000).
RN [12]; RE0022593.
RX PUBMED: 12101253.
RA Jabrane-Ferrat N., Nekrep N., Tosi G., Esserman L. J., Peterlin B. M.
RT Major histocompatibility complex class II transcriptional platform: assembly of nuclear factor Y and regulatory factor X (RFX) on DNA requires RFX5 dimers.
RL Mol. Cell. Biol. 22:5616-5625 (2002).
RN [13]; RE0047255.
RX PUBMED: 14678199.
RA Rousseau P., Masternak K., Krawczyk M., Reith W., Dausset J., Carosella E. D., Moreau P.
RT In vivo, RFX5 binds differently to the human leucocyte antigen-E, -F, and -G gene promoters and participates in HLA class I protein expression in a cell type-dependent manner
RL Immunology 111:53-65 (2004).
RN [14]; RE0050639.
RX PUBMED: 17611194.
RA Yong X., Farmer S. R., Smith B. D.
RT PPARgamma interacts with CIITA/RFX5 complex to repress collagen type I gene expression.
RL J. Biol. Chem. 282:26046-26056 (2007).
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