AC T05447
XX
ID T05447
XX
DT 22.02.2003 (created); oke.
DT 02.09.2003 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA RFXAP
XX
SY regulatory factor X-associated protein.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G005120 Rfxap.
XX
SZ 231 AA; 24.8 kDa (calc.).
XX
SQ MEAQAVPEGSGPSTASPRTAPPVTVLVMRQDEAEADGALRPGLAGSEAAADAEDEAGDDD
SQ ADLLDTSDPAGGGESAASPEELEDEDAEGGGAARRRGSKTCTYEGCRETTSQVAKQRKPW
SQ MCKKHRNKMYKDKYKKKKSDQALGSGGPSAASTGNVKLEESTDNILSIVKQRTGSFGDRP
SQ ARPTLLEQVLNQKRLSLLRSPEVVQFLQKQQQLLNQQVLEQRQQHFPGAPV
XX
SC translated from EMBL #AF335512
XX
FT 47 91 
acidic (aspartate-/glutamate-rich) region (19/45) [1].
FT 99 182 
MCH class II isotype-specific function [1].
FT 115 139 
basic (lysine-/arginine-rich) region (13/25) [1].
FT 205 225 
glutamine-rich region (10/21) [1].
XX
SF subunit of the RFX complex, for human complex see T05444, mouse RFXAP is functionally equivalent to human RFXAP [1];
SF C-terminal glutamine-rich region is essential for the RFX complex formation and for activation of all three MHC II isotypes [1];
SF isotype-specific region is required for expression of DQA and DPA, but not DRA [1];
XX
FF important regulator of MHC class II gene expression;
XX
MX M00975 V$RFX_Q6.
XX
DR TRANSPATH: MO000034951.
DR UniProtKB: Q8VCG9;
XX
RN [1]; RE0022533.
RX PUBMED: 11486010.
RA Peretti M., Villard J., Barras E., Zufferey M., Reith W.
RT Expression of the three human major histocompatibility complex class II isotypes exhibits a differential dependence on the transcription factor RFXAP.
RL Mol. Cell. Biol. 21:5699-5709 (2001).
XX
//