TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T15204 XX ID T15204 XX DT 12.03.2005 (created); nvo. DT 26.06.2014 (updated); pos. CO Copyright (C), QIAGEN. XX FA brca1 XX SY breast cancer 1; breast cancer type 1. XX OS Mammalia OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia XX FF P53 reduces the DNA binding affinity of the protein [41]; XX IN T08487 AR-isoform1; human, Homo sapiens. IN T10818 arnt; Mammalia. IN T09069 ATF-1-isoform1; human, Homo sapiens. IN T00968 ATF-1; human, Homo sapiens. IN T10236 ATF-2; Mammalia. IN T09252 Bach1; human, Homo sapiens. IN T05551 BRIP1; human, Homo sapiens. IN T00112 c-Ets-1A; human, Homo sapiens. IN T09446 c-Jun; Mammalia. IN T18378 CBP; human, Homo sapiens. IN T04197 CLIM2; human, Homo sapiens. IN T10811 CSDA; human, Homo sapiens. IN T34271 DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide; human, Homo sapiens. IN T34296 DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide; human, Homo sapiens. IN T00250 Elk-1; human, Homo sapiens. IN T14062 Elk-1; Mammalia. IN T00261 ER-alpha; human, Homo sapiens. IN T09637 ER-alpha; Mammalia. IN T26112 EZH2-isoform2; human, Homo sapiens. IN T10472 Fli-1; Mammalia. IN T10516 HIF-1alpha; Mammalia. IN T01977 JunB; human, Homo sapiens. IN T10510 JunB; Mammalia. IN T01978 JunD; human, Homo sapiens. IN T09447 JunD; Mammalia. IN T15389 NF-IX; Mammalia. IN T21600 nucleolin; human, Homo sapiens. IN T23091 p300; Mammalia. IN T09500 p53; Mammalia. IN T06136 p63-isoform6; human, Homo sapiens. IN T08628 POU2F1; Mammalia. IN T24182 PR; Mammalia. IN T10397 RelA-p65; Mammalia. IN T19717 RHA; human, Homo sapiens. IN T28752 RPB1; human, Homo sapiens. IN T24830 Smad2; Mammalia. IN T09538 Smad3; Mammalia. IN T13998 Smad4; Mammalia. IN T23076 STAT1; Mammalia. IN T16819 STAT5A; Mammalia. IN T31844 topoisomerase-II-alpha; human, Homo sapiens. IN T10348 YB-1; human, Homo sapiens. IN T27489 ZBRK1; Mammalia. IN T19561 ZNF787; human, Homo sapiens. XX MX M01082 V$BRCA_01. XX BS R25411. XX DR TRANSPATH: MO000048573. XX RN [1]; RE0017512. RX PUBMED: 10792030. RA Ouchi T., Lee S. W., Ouchi M., Aaronson S. A., Horvath C. M. RT Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes. RL Proc. Natl. Acad. Sci. USA 97:5208-5213 (2000). RN [2]; RE0021190. RX PUBMED: 11114888. RA Tibbetts R. S., Cortez D, Brumbaugh K. M., Scully R., Livingston D., Elledge S. J., Abraham, R. T. RT Functional interactions between BRCA1 and the checkpoint kinase ATR during genotoxic stress RL Genes Dev. 14:2989-3002 (2000). RN [3]; RE0027653. RX PUBMED: 10783165. RA Wang Y., Cortez D., Yazdi P., Neff N., Elledge S. J., Qin J. RT BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures. RL Genes Dev. 14:927-39 (2000). RN [4]; RE0048096. RX PUBMED: 15107825. RA Cabart P., Chew H. K., Murphy S. RT BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II. RL Oncogene 23:5316-5329 (2004). RN [5]; RE0049971. RX PUBMED: 10655477. RA Pao G. M., Janknecht R., Ruffner H., Hunter T., Verma I. M. RT CBP/p300 interact with and function as transcriptional coactivators of BRCA1. RL Proc. Natl. Acad. Sci. USA 97:1020-1025 (2000). RN [6]; RE0050119. RX PUBMED: 17420471. RA Horwitz A. A., Affar el B., Heine G. F., Shi Y., Parvin J. D. RT A mechanism for transcriptional repression dependent on the BRCA1 E3 ubiquitin ligase. RL Proc. Natl. Acad. Sci. USA 104:6614-6619 (2007). RN [7]; RE0050302. RX PUBMED: 15159397. RA Fabbro M., Savage K., Hobson K., Deans A. J., Powell S. N., McArthur G. A., Khanna K. K. RT BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage. RL J. Biol. Chem. 279:31251-31258 (2004). RN [8]; RE0050303. RX PUBMED: 15886201. RA Starita L. M., Horwitz A. A., Keogh M. C., Ishioka C., Parvin J. D., Chiba N. RT BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II. RL J. Biol. Chem. 280:24498-24505 (2005). RN [9]; RE0050323. RX PUBMED: 17283126. RA Wu W., Nishikawa H., Hayami R., Sato K., Honda A., Aratani S., Nakajima T., Fukuda M., Ohta T. RT BRCA1 ubiquitinates RPB8 in response to DNA damage. RL Cancer Res. 67:951-958 (2007). RN [10]; RE0050327. RX PUBMED: 16818604. RA Yu X., Fu S., Lai M., Baer R., Chen J. RT BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. RL Genes Dev. 20:1721-1726 (2006). RN [11]; RE0050340. RX PUBMED: 10945975. RA Houvras Y., Benezra M., Zhang H., Manfredi J. J., Weber B. L., Licht J. D. RT BRCA1 physically and functionally interacts with ATF1. RL J. Biol. Chem. 275:36230-36237 (2000). RN [12]; RE0050357. RX PUBMED: 17603999. RA Hsu L. C. RT Identification and functional characterization of a PP1-binding site in BRCA1. RL Biochem. Biophys. Res. Commun. 360:507-512 (2007). RN [13]; RE0050371. RX PUBMED: 15367667. RA Starita L. M., Machida Y., Sankaran S., Elias J. E., Griffin K., Schlegel B. P., Gygi S. P., Parvin J. D. RT BRCA1-dependent ubiquitination of gamma-tubulin regulates centrosome number. RL Mol. Cell. Biol. 24:8457-8466 (2004). RN [14]; RE0050458. RX PUBMED: 15665273. RA Hayami R., Sato K., Wu W., Nishikawa T., Hiroi J., Ohtani-Kaneko R., Fukuda M., Ohta T. RT Down-regulation of BRCA1-BARD1 ubiquitin ligase by CDK2. RL Cancer Res. 65:6-10 (2005). RN [15]; RE0050487. RX PUBMED: 16452482. RA Aglipay J. A., Martin S. A., Tawara H., Lee S. W., Ouchi T. RT ATM activation by ionizing radiation requires BRCA1-associated BAAT1. RL J. Biol. Chem. 281:9710-9718 (2006). RN [16]; RE0050536. RX PUBMED: 12354784. RA Folias A., Matkovic M., Bruun D., Reid S., Hejna J., Grompe M., D'Andrea A., Moses R. RT BRCA1 interacts directly with the Fanconi anemia protein FANCA. RL Hum. Mol. Genet. 11:2591-2597 (2002). RN [17]; RE0050559. RX PUBMED: 16322207. RA Martin S. A., Ouchi T. RT BRCA1 phosphorylation regulates caspase-3 activation in UV-induced apoptosis. RL Cancer Res. 65:10657-10662 (2005). RN [18]; RE0050588. RX PUBMED: 14636569. RA Dong Y., Hakimi M. A., Chen X., Kumaraswamy E., Cooch N. S., Godwin A. K., Shiekhattar R. RT Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. RL Mol. Cell 12:1087-1099 (2003). RN [19]; RE0050633. RX PUBMED: 17525340. RA Wang B., Matsuoka S., Ballif B. A., Zhang D., Smogorzewska A., Gygi S. P., Elledge S. J. RT Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. RL Science 316:1194-1198 (2007). RN [20]; RE0050662. RX PUBMED: 17525341. RA Sobhian B., Shao G., Lilli D. R., Culhane A. C., Moreau L. A., Xia B., Livingston D. M., Greenberg R. A. RT RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites. RL Science 316:1198-1202 (2007). RN [21]; RE0050678. RX PUBMED: 14660588. RA Tan W., Zheng L., Lee W. H., Boyer T. G. RT Functional dissection of transcription factor ZBRK1 reveals zinc fingers with dual roles in DNA-binding and BRCA1-dependent transcriptional repression. RL J. Biol. Chem. 279:6576-6587 (2004). RN [22]; RE0050687. RX PUBMED: 15485915. RA Yu X., Chen J. RT DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. RL Mol. Cell. Biol. 24:9478-9486 (2004). RN [23]; RE0050737. RX PUBMED: 17700520. RA Maekawa T., Sano Y., Shinagawa T., Rahman Z., Sakuma T., Nomura S., Licht J. D., Ishii S. RT ATF-2 controls transcription of Maspin and GADD45alpha genes independently from p53 to suppress mammary tumors. RL Oncogene 27:1045-1054 (2007). RN [24]; RE0050746. RX PUBMED: 17643122. RA Kim H., Huang J., Chen J. RT CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. RL Nat. Struct. Mol. Biol. 14:710-715 (2007). RN [25]; RE0050802. RX PUBMED: 12700228. RA Benezra M., Chevallier N., Morrison D. J., MacLachlan T. K., El-Deiry W. S., Licht J. D. RT BRCA1 augments transcription by the NF-kappaB transcription factor by binding to the Rel domain of the p65/RelA subunit. RL J. Biol. Chem. 278:26333-26341 (2003). RN [26]; RE0050820. RX PUBMED: 12400015. RA Kawai H., Li H., Chun P., Avraham S., Avraham H. K. RT Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. RL Oncogene 21:7730-7739 (2002). RN [27]; RE0050884. RX PUBMED: 16567799. RA Kang H. J., Kim H. J., Kim S. K., Barouki R., Cho C. H., Khanna K. K., Rosen E. M., Bae I. RT BRCA1 modulates xenobiotic stress-inducible gene expression by interacting with ARNT in human breast cancer cells. RL J. Biol. Chem. 281:14654-14662 (2006). RN [28]; RE0050890. RX PUBMED: 17643121. RA Liu Z., Wu J., Yu X. RT CCDC98 targets BRCA1 to DNA damage sites. RL Nat. Struct. Mol. Biol. 14:716-720 (2007). RN [29]; RE0050911. RX PUBMED: 15674350. RA Ma Y. X., Tomita Y., Fan S., Wu K., Tong Y., Zhao Z., Song L. N., Goldberg I. D., Rosen E. M. RT Structural determinants of the BRCA1 : estrogen receptor interaction. RL Oncogene 24:1831-1846 (2005). RN [30]; RE0050936. RX PUBMED: 16417649. RA Crowe D. L., Lee M. K. RT New role for nuclear hormone receptors and coactivators in regulation of BRCA1-mediated DNA repair in breast cancer cell lines. RL Breast Cancer Res. 8:R1 (2006). RN [31]; RE0050990. RX PUBMED: 16677609. RA Chen Y., Borowicz S., Fackenthal J., Collart F. R., Myatt E., Moy S., Babnigg G., Wilton R., Boernke W. E., Schiffer M., Stevens F. J., Olopade O. I. RT Primary structure-based function characterization of BRCT domain replicates in BRCA1. RL Biochem. Biophys. Res. Commun. 345:188-196 (2006). RN [32]; RE0050996. RX PUBMED: 16061635. RA Wang C., Fan S., Li Z., Fu M., Rao M., Ma Y., Lisanti M. P., Albanese C., Katzenellenbogen B. S., Kushner P. J., Weber B., Rosen E. M., Pestell R. G. RT Cyclin D1 antagonizes BRCA1 repression of estrogen receptor alpha activity. RL Cancer Res. 65:6557-6567 (2005). RN [33]; RE0051005. RX PUBMED: 16109739. RA Ma Y., Katiyar P., Jones L. P., Fan S., Zhang Y., Furth P. A., Rosen E. M. RT The breast cancer susceptibility gene BRCA1 regulates progesterone receptor signaling in mammary epithelial cells. RL Mol. Endocrinol. 20:14-34 (2006). RN [34]; RE0051084. RX PUBMED: 17161371. RA Liu J., Pan Y., Ma B., Nussinov R. RT "Similarity trap" in protein-protein interactions could be carcinogenic: simulations of p53 core domain complexed with 53BP1 and BRCA1 BRCT domains. RL Structure 14:1811-1821 (2006). RN [35]; RE0051121. RX PUBMED: 15965487. RA Lou Z., Minter-Dykhouse K., Chen J. RT BRCA1 participates in DNA decatenation. RL Nat. Struct. Mol. Biol. 12:589-593 (2005). RN [36]; RE0051123. RX PUBMED: 15735739. RA Dubrovska A., Kanamoto T., Lomnytska M., Heldin C. H., Volodko N., Souchelnytskyi S. RT TGFbeta1/Smad3 counteracts BRCA1-dependent repair of DNA damage. RL Oncogene 24:2289-2297 (2005). RN [37]; RE0051155. RX PUBMED: 14576433. RA Yu X., Chini C. C., He M., Mer G., Chen J. RT The BRCT domain is a phospho-protein binding domain. RL Science 302:639-642 (2003). RN [38]; RE0051321. RX PUBMED: 12427729. RA Okada S., Ouchi T. RT Cell cycle differences in DNA damage-induced BRCA1 phosphorylation affect its subcellular localization. RL J. Biol. Chem. 278:2015-2020 (2003). RN [39]; RE0052908. RX PUBMED: 12459499. RA Vidarsson H., Mikaelsdottir E. K., Rafnar T., Bertwistle D., Ashworth A., Eyfjord J. E., Valgeirsdottir S. RT BRCA1 and BRCA2 bind Stat5a and suppress its transcriptional activity. RL FEBS Lett. 532:247-252 (2002). RN [40]; RE0053553. RX PUBMED: 11085509. RA Park J. J., Irvine R. A., Buchanan G., Koh S. S., Park J. M., Tilley W. D., Stallcup M. R., Press M. F., Coetzee G. A. RT Breast cancer susceptibility gene 1 (BRCAI) is a coactivator of the androgen receptor. RL Cancer Res. 60:5946-5949 (2000). RN [41]; RE0054355. RX PUBMED: 18545657. RA Naseem R., Webb M. RT Analysis of the DNA binding activity of BRCA1 and its modulation by the tumour suppressor p53. RL PLoS ONE 3:e2336 (2008). RN [42]; RE0065912. RX PUBMED: 20016594. RA Morris J. R., Boutell C., Keppler M., Densham R., Weekes D., Alamshah A., Butler L., Galanty Y., Pangon L., Kiuchi T., Ng T., Solomon E. RT The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress. RL Nature 462:886-890 (2009). RN [43]; RE0065929. RX PUBMED: 20016603. RA Galanty Y., Belotserkovskaya R., Coates J., Polo S., Miller K. M., Jackson S. P. RT Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks. RL Nature 462:935-939 (2009). RN [44]; RE0067181. RX PUBMED: 11313879. RA Chai Y., Chipitsyna G., Cui J., Liao B., Liu S., Aysola K., Yezdani M., Reddy E. S., Rao V. N. RT c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells. RL Oncogene 20:1357-1367 (2001). XX //