AC T23076
XX
ID T23076
XX
DT 10.03.2005 (created); nvo.
DT 17.05.2016 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA STAT1
XX
SY Signal Transducer and Activator of Transcription 1.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T09552 AML3; Mammalia.
IN T15204 brca1; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T15118 CBP; Mammalia.
IN T21852 HDAC1; Mammalia.
IN T34788 IRF-9; Mammalia.
IN T06054 islet1-isoform1; mouse, Mus musculus.
IN T23091 p300; Mammalia.
IN T09500 p53; Mammalia.
IN T09964 RXR-alpha; Mammalia.
IN T08326 Sp1; Mammalia.
IN T16670 STAT2; Mammalia.
IN T14458 STAT3; Mammalia.
IN T16672 STAT4; Mammalia.
IN T09516 STAT6; Mammalia.
IN T31896 VDR; Mammalia.
XX
MX M00224 V$STAT1_01.
MX M00492 V$STAT1_02.
MX M00496 V$STAT1_03.
MX M01260 V$STAT1_05.
MX M07064 V$STAT1_Q4.
MX M01823 V$STAT1_Q6.
MX M00223 V$STAT_01.
MX M00777 V$STAT_Q6.
XX
DR TRANSPATH: MO000046373.
DR TRANSCOMPEL: C00589.
XX
RN [1]; RE0005996.
RX PUBMED: 9135145.
RA Wong A. H.-T., Tam N. W. N., Yang Y.-L., Cuddihy A. R., Li S., Kirchhoff S., Hauser H., Decker T., Koromilas A. E.
RT Physical association between STAT1 and the interferon-inducible protein kinase PKR and implications for interferon and double-stranded RNA signaling pathways
RL EMBO J. 16:1291-1304 (1997).
RN [2]; RE0006102.
RX PUBMED: 9069288.
RA Su W. C. S., Kitagawa M., Xue N., Xin B., Garofalo S., Cho J., Deng C., Horton W. A., Fu X. J.
RT Activation of Stat1 by mutant fibroblast growth-factor receptor in thanatophoric dyslasia type II dwarfism
RL Nature 386:288-291 (1997).
RN [3]; RE0006411.
RX PUBMED: 8986769.
RA Zhang J. J., Vinkemeier U., Gu W., Chakravarti D., Horvath C. M., Darnell J. E.
RT Two contact regions between Stat1 and CBP/p300 in interferon (y) signaling
RL Proc. Natl. Acad. Sci. USA 93:15092-15096 (1996).
RN [4]; RE0016631.
RX PUBMED: 9491997.
RA Muhlethaler-Mottet A., Berardino W. D., Otten L. A., Mach B.
RT Activation of the MHC Class II Transactivator CIITA by interferon-gamma requires cooperative interaction between Stat1 and USF-1.
RL Immunity 8:157-166 (1998).
RN [5]; RE0017512.
RX PUBMED: 10792030.
RA Ouchi T., Lee S. W., Ouchi M., Aaronson S. A., Horvath C. M.
RT Collaboration of signal transducer and activator of transcription 1 (STAT1) and BRCA1 in differential regulation of IFN-gamma target genes.
RL Proc. Natl. Acad. Sci. USA 97:5208-5213 (2000).
RN [6]; RE0025864.
RX PUBMED: 12668667.
RA Soto P., Price-Schiavi S. A., Carraway K. L.
RT SMAD2 and SMAD7 involvement in the post-translational regulation of Muc4 via the transforming growth factor-beta and interferon-gamma pathways in rat mammary epithelial cells.
RL J. Biol. Chem. 278:20338-44 (2003).
RN [7]; RE0027987.
RX PUBMED: 11278437.
RA Madamanchi N. R., Li S., Patterson C., Runge M. S.
RT Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway.
RL J. Biol. Chem. 276:18915-24 (2001).
RN [8]; RE0028237.
RX PUBMED: 11309383.
RA Lukashova V., Asselin C., Krolewski J. J., Rola-Pleszczynski M., Stankova J.
RT G-protein-independent activation of Tyk2 by the platelet-activating factor receptor.
RL J. Biol. Chem. 276:24113-21 (2001).
RN [9]; RE0029513.
RX PUBMED: 11923478.
RA Ray S., Sherman C. T., Lu M., Brasier A. R.
RT Angiotensinogen gene expression is dependent on signal transducer and activator of transcription 3-mediated p300/cAMP response element binding protein-binding protein coactivator recruitment and histone acetyltransferase activity.
RL Mol. Endocrinol. 16:824-36 (2002).
RN [10]; RE0030029.
RX PUBMED: 12459177.
RA Liu D., Scafidi J., Prada A. E., Zahedi K., Davis A. E. 3rd.
RT Nuclear phosphatases and the proteasome in suppression of STAT1 activity in hepatocytes.
RL Biochem. Biophys. Res. Commun. 299:574-80 (2002).
RN [11]; RE0030933.
RX PUBMED: 10919667.
RA Kominsky S. L., Hobeika A. C., Lake F. A., Torres B. A., Johnson H. M.
RT Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells.
RL Cancer Res. 60:3904-8 (2000).
RN [12]; RE0032092.
RX PUBMED: 12719586.
RA Zhang Y., Jamaluddin M., Wang S., Tian B., Garofalo R. P., Casola A., Brasier A. R.
RT Ribavirin treatment up-regulates antiviral gene expression via the interferon-stimulated response element in respiratory syncytial virus-infected epithelial cells.
RL J. Virol. 77:5933-47 (2003).
RN [13]; RE0032490.
RX PUBMED: 15150095.
RA El-Hashemite N., Zhang H., Walker V., Hoffmeister K. M., Kwiatkowski D. J.
RT Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment.
RL Cancer Res. 64:3436-43 (2004).
RN [14]; RE0032507.
RX PUBMED: 9154828.
RA Chaturvedi P., Sharma S., Reddy E. P.
RT Abrogation of interleukin-3 dependence of myeloid cells by the v-src oncogene requires SH2 and SH3 domains which specify activation of STATs.
RL Mol. Cell. Biol. 17:3295-304 (1997).
RN [15]; RE0032571.
RX PUBMED: 9880553.
RA Stephanou A., Isenberg D. A., Nakajima K., Latchman D. S.
RT Signal transducer and activator of transcription-1 and heat shock factor-1 interact and activate the transcription of the Hsp-70 and Hsp-90beta gene promoters.
RL J. Biol. Chem. 274:1723-8 (1999).
RN [16]; RE0033943.
RX PUBMED: 12817007.
RA Deb D. K., Sassano A., Lekmine F., Majchrzak B., Verma A., Kambhampati S., Uddin S., Rahman A., Fish E. N., Platanias L. C.
RT Activation of protein kinase C delta by IFN-gamma.
RL J. Immunol. 171:267-73 (2003).
RN [17]; RE0035370.
RX PUBMED: 11399774.
RA Yang J. B., Duan Z. J., Yao W., Lee O., Yang L., Yang X. Y., Sun X., Chang C. C., Chang T. Y., Li B. L.
RT Synergistic transcriptional activation of human Acyl-coenzyme A: cholesterol acyltransterase-1 gene by interferon-gamma and all-trans-retinoic acid THP-1 cells.
RL J. Biol. Chem. 276:20989-20998 (2001).
RN [18]; RE0037500.
RX PUBMED: 12509459.
RA Lau J. F., Nusinzon I., Burakov D., Freedman L. P., Horvath C. M.
RT Role of metazoan mediator proteins in interferon-responsive transcription
RL Mol. Cell. Biol. 23:620-8 (2003).
RN [19]; RE0037671.
RX PUBMED: 10930443.
RA Kelley T. J., Elmer H. L.
RT In vivo alterations of IFN regulatory factor-1 and PIAS1 protein levels in cystic fibrosis epithelium
RL J. Clin. Invest. 106:403-10 (2000).
RN [20]; RE0038525.
RX PUBMED: 11536325.
RA Dell'Albani P., Santangelo R., Torrisi L., Nicoletti V. G., de Vellis J., Giuffrida Stella A. M.
RT JAK/STAT signaling pathway mediates cytokine-induced iNOS expression in primary astroglial cell cultures
RL J. Neurosci. Res. 65:417-24 (2001).
RN [21]; RE0038944.
RX PUBMED: 11438703.
RA Ganster R. W., Taylor B. S., Shao L., Geller D. A.
RT Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B
RL Proc. Natl. Acad. Sci. USA 98:8638-43 (2001).
RN [22]; RE0039388.
RX PUBMED: 12925694.
RA Wang J., Pham-Mitchell N., Schindler C., Campbell I. L.
RT Dysregulated Sonic hedgehog signaling and medulloblastoma consequent to IFN-alpha-stimulated STAT2-independent production of IFN-gamma in the brain
RL J. Clin. Invest. 112:535-43 (2003).
RN [23]; RE0039839.
RX PUBMED: 12218120.
RA Barton L. F., Cruz M., Rangwala R., Deepe G. S. Jr, Monaco J. J.
RT Regulation of immunoproteasome subunit expression in vivo following pathogenic fungal infection
RL J. Immunol. 169:3046-52 (2002).
RN [24]; RE0039948.
RX PUBMED: 9084411.
RA Kahn M. A., Huang C. J., Caruso A., Barresi V., Nazarian R., Condorelli D. F., de Vellis J.
RT Ciliary neurotrophic factor activates JAK/Stat signal transduction cascade and induces transcriptional expression of glial fibrillary acidic protein in glial cells
RL J. Neurochem 68:1413-23 (1997).
RN [25]; RE0039949.
RX PUBMED: 15240658.
RA O'Donnell P. W., Haque A., Klemsz M. J., Kaplan M. H., Blum J. S.
RT Cutting edge: induction of the antigen-processing enzyme IFN-gamma-inducible lysosomal thiol reductase in melanoma cells Is STAT1-dependent but CIITA-independent
RL J. Immunol. 173:731-5 (2004).
RN [26]; RE0040126.
RX PUBMED: 11248027.
RA DaFonseca C. J., Shu F., Zhang J. J.
RT Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma
RL Proc. Natl. Acad. Sci. USA 98:3034-9 (2001).
RN [27]; RE0040127.
RX PUBMED: 12923053.
RA Kim S., Koga T., Isobe M., Kern B. E., Yokochi T., Chin Y. E., Karsenty G., Taniguchi T., Takayanagi H.
RT Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation
RL Genes Dev. 17:1979-91 (2003).
RN [28]; RE0040128.
RX PUBMED: 10645005.
RA Bauvois B., Djavaheri-Mergny M., Rouillard D., Dumont J., Wietzerbin J.
RT Regulation of CD26/DPPIV gene expression by interferons and retinoic acid in tumor B cells
RL Oncogene 19:265-72 (2000).
RN [29]; RE0040129.
RX PUBMED: 10585866.
RA Takahashi H., Asano K., Nakamura S., Ishida-Yamamoto A., Iizuka H.
RT Interferon-gamma-dependent stimulation of human involucrin gene expression: STAT1 (signal transduction and activators of transcription 1) protein activates involucrin promoter activity
RL Biochem. J. 344:797-802 (1999).
RN [30]; RE0040131.
RX PUBMED: 11180401.
RA Huang J. S., Guh J. Y., Chen H. C., Hung W. C., Lai Y. H., Chuang L. Y.
RT Role of receptor for advanced glycation end-product (RAGE) and the JAK/STAT-signaling pathway in AGE-induced collagen production in NRK-49F cells
RL J. Cell. Biochem. 81:102-13 (2001).
RN [31]; RE0040362.
RX PUBMED: 11080165.
RA McBride K. M., McDonald C., Reich N. C.
RT Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor
RL EMBO J. 19:6196-206 (2000).
RN [32]; RE0040630.
RX PUBMED: 10848598.
RA Pang Q., Fagerlie S., Christianson T. A., Keeble W., Faulkner G., Diaz J., Rathbun R. K., Bagby G. C.
RT The fanconi anemia protein FANCC binds to and facilitates the activation of STAT1 by gamma interferon and hematopoietic growth factors
RL Mol. Cell. Biol. 20:4724-35 (2000).
RN [33]; RE0041242.
RX PUBMED: 10881177.
RA Farrar J. D., Smith J. D., Murphy T. L., Leung S., Stark G. R., Murphy K. M.
RT Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2
RL Nat. Immunol. 1:65-9 (2000).
RN [34]; RE0041246.
RX PUBMED: 11248056.
RA Liu B., Gross M., ten Hoeve J., Shuai K.
RT A transcriptional corepressor of Stat1 with an essential LXXLL signature motif
RL Proc. Natl. Acad. Sci. USA 98:3203-7 (2001).
RN [35]; RE0041567.
RX PUBMED: 14500361.
RA Choi E. A., Lei H., Maron D. J., Wilson J. M., Barsoum J., Fraker D. L., El-Deiry W. S., Spitz F. R.
RT Stat1-dependent induction of tumor necrosis factor-related apoptosis-inducing ligand and the cell-surface death signaling pathway by interferon beta in human cancer cells
RL Cancer Res. 63:5299-307 (2003).
RN [36]; RE0041996.
RX PUBMED: 12948850.
RA Osna N. A., Clemens D. L., Donohue T. M. Jr.
RT Interferon gamma enhances proteasome activity in recombinant Hep G2 cells that express cytochrome P4502E1: modulation by ethanol
RL Biochem. Pharmacol. 66:697-710 (2003).
RN [37]; RE0041997.
RX PUBMED: 12642464.
RA Pan J., Xiang Q., Ball S., Scatina J., Kao J., Hong J. Y.
RT Lipopolysaccharide-mediated modulation of cytochromes P450 in Stat1 null mice
RL Drug Metab. Dispos. 31:392-7 (2003).
RN [38]; RE0042281.
RX PUBMED: 10805787.
RA Liao J., Fu Y., Shuai K.
RT Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction
RL Proc. Natl. Acad. Sci. USA 97:5267-72 (2000).
RN [39]; RE0042819.
RX PUBMED: 15107417.
RA Marson A., Lawn R. M., Mikita T.
RT Oxidized low density lipoprotein blocks lipopolysaccharide-induced interferon beta synthesis in human macrophages by interfering with IRF3 activation
RL J. Biol. Chem. 279:28781-8 (2004).
RN [40]; RE0043959.
RX PUBMED: 15073186.
RA Xiao L., Naganawa T., Obugunde E., Gronowicz G., Ornitz D. M., Coffin J. D., Hurley M. M.
RT Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts
RL J. Biol. Chem. 279:27743-52 (2004).
RN [41]; RE0044151.
RX PUBMED: 12738234.
RA Xuan Y. T., Guo Y., Zhu Y., Han H., Langenbach R., Dawn B., Bolli R.
RT Mechanism of cyclooxygenase-2 upregulation in late preconditioning
RL J. Mol. Cell. Cardiol. 35:525-37 (2003).
RN [42]; RE0044204.
RX PUBMED: 12048190.
RA Fagerlund R., Melen K., Kinnunen L., Julkunen I.
RT Arginine/lysine-rich nuclear localization signals mediate interactions between dimeric STATs and importin alpha 5
RL J. Biol. Chem. 277:30072-8 (2002).
RN [43]; RE0044331.
RX PUBMED: 11278462.
RA Xie B., Zhao J., Kitagawa M., Durbin J., Madri J. A., Guan J. L., Fu X. Y.
RT Focal adhesion kinase activates Stat1 in integrin-mediated cell migration and adhesion
RL J. Biol. Chem. 276:19512-23 (2001).
RN [44]; RE0046834.
RX PUBMED: 11781233.
RA Wagner A. H., Gebauer M., Pollok-Kopp B., Hecker M.
RT Cytokine-inducible CD40 expression in human endothelial cells is mediated by interferon regulatory factor-1
RL Blood 99:520-5 (2002).
RN [45]; RE0047346.
RX PUBMED: 12855578.
RA Ungureanu D., Vanhatupa S., Kotaja N., Yang J., Aittomaki S., Janne O. A., Palvimo J. J., Silvennoinen O.
RT PIAS proteins promote SUMO-1 conjugation to STAT1.
RL Blood 102:3311-3313 (2003).
RN [46]; RE0047403.
RX PUBMED: 15659653.
RA Hao A., Novotny-Diermayr V., Bian W., Lin B., Lim C. P., Jing N., Cao X.
RT The LIM/homeodomain protein Islet1 recruits Janus tyrosine kinases and signal transducer and activator of transcription 3 and stimulates their activities.
RL Mol. Biol. Cell 16:1569-1583 (2005).
RN [47]; RE0048541.
RX PUBMED: 10551884.
RA Sayeski P. P., Ali M. S., Safavi A., Lyles M., Kim S. O., Frank S. J., Bernstein K. E.
RT A catalytically active Jak2 is required for the angiotensin II-dependent activation of Fyn.
RL J. Biol. Chem. 274:33131-33142 (1999).
RN [48]; RE0049155.
RX PUBMED: 16940534.
RA Lin W., Kim S. S., Yeung E., Kamegaya Y., Blackard J. T., Kim K. A., Holtzman M. J., Chung R. T.
RT Hepatitis C virus core protein blocks interferon signaling by interaction with the STAT1 SH2 domain.
RL J. Virol. 80:9226-9235 (2006).
RN [49]; RE0049505.
RX PUBMED: 14602726.
RA Townsend P. A., Scarabelli T. M., Davidson S. M., Knight R. A., Latchman D. S., Stephanou A.
RT STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis.
RL J. Biol. Chem. 279:5811-5820 (2004).
RN [50]; RE0051449.
RX PUBMED: 17157040.
RA An H., Zhao W., Hou J., Zhang Y., Xie Y., Zheng Y., Xu H., Qian C., Zhou J., Yu Y., Liu S., Feng G., Cao X.
RT SHP-2 phosphatase negatively regulates the TRIF adaptor protein-dependent type I interferon and proinflammatory cytokine production.
RL Immunity 25:919-928 (2006).
RN [51]; RE0063808.
RX PUBMED: 11742534.
RA Haan C., Heinrich P. C., Behrmann I.
RT Structural requirements of the interleukin-6 signal transducer gp130 for its interaction with Janus kinase 1: the receptor is crucial for kinase activation.
RL Biochem. J. 361:105-111 (2002).
RN [52]; RE0065138.
RX PUBMED: 16710296.
RA Malakhova O. A., Kim K. I., Luo J. K., Zou W., Kumar K. G., Fuchs S. Y., Shuai K., Zhang D. E.
RT UBP43 is a novel regulator of interferon signaling independent of its ISG15 isopeptidase activity.
RL EMBO J. 25:2358-2367 (2006).
RN [53]; RE0065562.
RX PUBMED: 11972023.
RA Nair J. S., DaFonseca C. J., Tjernberg A., Sun W., Darnell JE J. r., Chait B. T., Zhang J. J.
RT Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma.
RL Proc. Natl. Acad. Sci. USA 99:5971-5976 (2002).
RN [54]; RE0065591.
RX PUBMED: 18574148.
RA Sadzak I., Schiff M., Gattermeier I., Glinitzer R., Sauer I., Saalmuller A., Yang E., Schaljo B., Kovarik P.
RT Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain.
RL Proc. Natl. Acad. Sci. USA 105:8944-8949 (2008).
RN [55]; RE0066287.
RX PUBMED: 11839738.
RA Uddin S., Sassano A., Deb D. K., Verma A., Majchrzak B., Rahman A., Malik A. B., Fish E. N., Platanias L. C.
RT Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.
RL J. Biol. Chem. 277:14408-14416 (2002).
XX
//