AC T09500
XX
ID T09500
XX
DT 10.03.2005 (created); nvo.
DT 08.08.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA p53
XX
SY Cellular tumor antigen p53; P53; Tp53; Tumor suppressor p53.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T08146 AP-2alpha; human, Homo sapiens.
IN T09207 AP-2gamma-isoform1; human, Homo sapiens.
IN T19482 Apak-isoform1; human, Homo sapiens.
IN T06368 ASPP2; human, Homo sapiens.
IN T15204 brca1; Mammalia.
IN T30879 BRD4-isoform1; human, Homo sapiens.
IN T17201 BTEB2; Mammalia.
IN T15118 CBP; Mammalia.
IN T16138 DEC1; Mammalia.
IN T04106 HDAC1; human, Homo sapiens.
IN T10020 HNF-6alpha; Mammalia.
IN T08907 hnRNPK-isoform1; human, Homo sapiens.
IN T14490 hnRNPK; Mammalia.
IN T33892 MTA-1; Mammalia.
IN T25633 NDPKB; human, Homo sapiens.
IN T31332 NDPKB; Mammalia.
IN T01427 p300; human, Homo sapiens.
IN T23091 p300; Mammalia.
IN T08321 p53-isoform1; human, Homo sapiens.
IN T09500 p53; Mammalia.
IN T24830 Smad2; Mammalia.
IN T09538 Smad3; Mammalia.
IN T28121 SMAR1; Mammalia.
IN T23076 STAT1; Mammalia.
IN T25786 STRAP-isoform1; human, Homo sapiens.
IN T09977 TWIST; human, Homo sapiens.
IN T16205 Twist; Mammalia.
IN T20957 ZNF668; human, Homo sapiens.
XX
MX M00761 V$P53DECAMER_Q2.
MX M00034 V$P53_01.
MX M00272 V$P53_02.
MX M01651 V$P53_03.
MX M01652 V$P53_04.
MX M01655 V$P53_05.
MX M07054 V$P53_Q3_01.
XX
BS R66631.
BS R66634.
BS R68158.
BS R68161.
BS R31437.
BS R12753.
BS R73535.
BS R72078.
BS R72080.
BS R72081.
BS R72082.
BS R72083.
BS R72084.
BS R72085.
BS R72086.
BS R29992.
BS R11276.
BS R31493.
BS R31435.
BS R71708.
BS R16694.
BS R28001.
BS R28204.
BS R38621.
BS R38614.
BS R38618.
BS R20164.
BS R31653.
BS R66502.
BS R11723.
BS R37001.
BS R70144.
BS R70153.
BS R70161.
BS R70143.
BS R41345.
BS R11387.
BS R27048.
BS R31400.
BS R31485.
BS R61388.
BS R24827.
BS R39414.
BS R57740.
BS R70139.
BS R31701.
BS R59240.
BS R59241.
BS R31250.
BS R56404.
BS R11385.
BS R69082.
BS R69084.
BS R56085.
BS R31375.
BS R70142.
BS R36855.
BS R33957.
BS R66576.
BS R16302.
BS R38583.
BS R61791.
BS R11722.
BS R27114.
BS R63117.
BS R70419.
BS R70420.
BS R61447.
BS R61448.
BS R61449.
BS R31672.
BS R40152.
BS R57541.
BS R34872.
BS R30953.
BS R31348.
BS R31575.
BS R67131.
BS R67133.
BS R71880.
BS R33428.
BS R33430.
BS R35913.
BS R57717.
BS R38610.
BS R38611.
BS R66547.
BS R66548.
BS R39642.
BS R40819.
BS R26896.
BS R26894.
BS R31925.
BS R70289.
BS R38623.
BS R20521.
BS R31667.
BS R31518.
BS R24829.
BS R11305.
BS R39586.
BS R39588.
BS R31678.
BS R26961.
BS R33393.
XX
DR TRANSPATH: MO000048095.
DR TRANSCOMPEL: C00487.
DR TRANSCOMPEL: C00492.
XX
RN [1]; RE0027548.
RX PUBMED: 10608806.
RA Kim S. T., Lim D. S., Canman C. E., Kastan M. B.
RT Substrate specificities and identification of putative substrates of ATM kinase family members.
RL J. Biol. Chem. 274:37538-43 (1999).
RN [2]; RE0046957.
RX PUBMED: 15548678.
RA Nag A., Bagchi S., Raychaudhuri P.
RT Cul4A physically associates with MDM2 and participates in the proteolysis of p53
RL Cancer Res. 64:8152-5 (2004).
RN [3]; RE0047317.
RX PUBMED: 9278461.
RA Chen L., Marechal V., Moreau J., Levine A. J., Chen J.
RT Proteolytic cleavage of the mdm2 oncoprotein during apoptosis.
RL J. Biol. Chem. 272:22966-22973 (1997).
RN [4]; RE0047336.
RX PUBMED: 16024788.
RA Chen L., Li C., Pan Y., Chen J.
RT Regulation of p53-MDMX interaction by casein kinase 1 alpha.
RL Mol. Cell. Biol. 25:6509-6520 (2005).
RN [5]; RE0047502.
RX PUBMED: 16024799.
RA Pedeux R., Sengupta S., Shen J. C., Demidov O. N., Saito S., Onogi H., Kumamoto K., Wincovitch S., Garfield S. H., McMenamin M., Nagashima M., Grossman S. R., Appella E., Harris C. C.
RT ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation.
RL Mol. Cell. Biol. 25:6639-6648 (2005).
RN [6]; RE0047639.
RX PUBMED: 12068014.
RA Jin Y., Zeng S. X., Dai M. S., Yang X. J., Lu H.
RT MDM2 inhibits PCAF (p300/CREB-binding protein-associated factor)-mediated p53 acetylation.
RL J. Biol. Chem. 277:30838-30843 (2002).
RN [7]; RE0047694.
RX PUBMED: 14769800.
RA Jin Y., Zeng S. X., Lee H., Lu H.
RT MDM2 mediates p300/CREB-binding protein-associated factor ubiquitination and degradation.
RL J. Biol. Chem. 279:20035-20043 (2004).
RN [8]; RE0047817.
RX PUBMED: 15364958.
RA Sengupta S., Robles A. I., Linke S. P., Sinogeeva N. I., Zhang R., Pedeux R., Ward I. M., Celeste A., Nussenzweig A., Chen J., Halazonetis T. D., Harris C. C.
RT Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest.
RL J. Cell Biol. 166:801-813 (2004).
RN [9]; RE0047894.
RX PUBMED: 11179235.
RA Zhou J., Ahn J., Wilson S. H., Prives C.
RT A role for p53 in base excision repair.
RL EMBO J. 20:914-923 (2001).
RN [10]; RE0048006.
RX PUBMED: 14500729.
RA Fusaro G., Dasgupta P., Rastogi S., Joshi B., Chellappan S.
RT Prohibitin induces the transcriptional activity of p53 and is exported from the nucleus upon apoptotic signaling.
RL J. Biol. Chem. 278:47853-47861 (2003).
RN [11]; RE0048014.
RX PUBMED: 12226108.
RA McPherson L. A., Loktev A. V., Weigel R. J.
RT Tumor suppressor activity of AP2alpha mediated through a direct interaction with p53.
RL J. Biol. Chem. 277:45028-45033 (2002).
RN [12]; RE0048018.
RX PUBMED: 15186775.
RA An W., Kim J., Roeder R. G.
RT Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53.
RL Cell 117:735-748 (2004).
RN [13]; RE0048020.
RX PUBMED: 15358233.
RA Oyama M., Wakasugi M., Hama T., Hashidume H., Iwakami Y., Imai R., Hoshino S., Morioka H., Ishigaki Y., Nikaido O., Matsunaga T.
RT Human NTH1 physically interacts with p53 and proliferating cell nuclear antigen.
RL Biochem. Biophys. Res. Commun. 321:183-191 (2004).
RN [14]; RE0048943.
RX PUBMED: 15923642.
RA Gupta A., Sharma G. G., Young C. S., Agarwal M., Smith E. R., Paull T. T., Lucchesi J. C., Khanna K. K., Ludwig T., Pandita T. K.
RT Involvement of human MOF in ATM function.
RL Mol. Cell. Biol. 25:5292-5305 (2005).
RN [15]; RE0049038.
RX PUBMED: 15989956.
RA Chen D., Kon N., Li M., Zhang W., Qin J., Gu W.
RT ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.
RL Cell 121:1071-1083 (2005).
RN [16]; RE0049040.
RX PUBMED: 15983031.
RA Seth R., Yang C., Kaushal V., Shah S. V., Kaushal G. P.
RT p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury.
RL J. Biol. Chem. 280:31230-31239 (2005).
RN [17]; RE0049081.
RX PUBMED: 16916644.
RA Li A. G., Piluso L. G., Cai X., Wei G., Sellers W. R., Liu X.
RT Mechanistic insights into maintenance of high p53 acetylation by PTEN.
RL Mol. Cell 23:575-587 (2006).
RN [18]; RE0049097.
RX PUBMED: 16508011.
RA Paliwal S., Pande S., Kovi R. C., Sharpless N. E., Bardeesy N., Grossman S. R.
RT Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis.
RL Mol. Cell. Biol. 26:2360-2372 (2006).
RN [19]; RE0049169.
RX PUBMED: 16690937.
RA Deng L., Nagano-Fujii M., Tanaka M., Nomura-Takigawa Y., Ikeda M., Kato N., Sada K., Hotta H.
RT NS3 protein of Hepatitis C virus associates with the tumour suppressor p53 and inhibits its function in an NS3 sequence-dependent manner.
RL J. Gen. Virol. 87:1703-1713 (2006).
RN [20]; RE0049242.
RX PUBMED: 16923962.
RA Fu M., Liu M., Sauve A. A., Jiao X., Zhang X., Wu X., Powell M. J., Yang T., Gu W., Avantaggiati M. L., Pattabiraman N., Pestell T. G., Wang F., Quong A. A., Wang C., Pestell R. G.
RT Hormonal control of androgen receptor function through SIRT1.
RL Mol. Cell. Biol. 26:8122-8135 (2006).
RN [21]; RE0049248.
RX PUBMED: 17202138.
RA Wrighton K. H., Liang M., Bryan B., Luo K., Liu M., Feng X. H., Lin X.
RT Transforming growth factor-beta-independent regulation of myogenesis by SnoN sumoylation.
RL J. Biol. Chem. 282:6517-6524 (2007).
RN [22]; RE0049258.
RX PUBMED: 11152513.
RA Majumder M., Ghosh A. K., Steele R., Ray R., Ray R. B.
RT Hepatitis C virus NS5A physically associates with p53 and regulates p21/waf1 gene expression in a p53-dependent manner.
RL J. Virol. 75:1401-1407 (2001).
RN [23]; RE0049260.
RX PUBMED: 12101418.
RA Lan K. H., Sheu M. L., Hwang S. J., Yen S. H., Chen S. Y., Wu J. C., Wang Y. J., Kato N., Omata M., Chang F. Y., Lee S. D.
RT HCV NS5A interacts with p53 and inhibits p53-mediated apoptosis.
RL Oncogene 21:4801-4811 (2002).
RN [24]; RE0049299.
RX PUBMED: 12379483.
RA Qadri I., Iwahashi M., Simon F.
RT Hepatitis C virus NS5A protein binds TBP and p53, inhibiting their DNA binding and p53 interactions with TBP and ERCC3.
RL Biochim. Biophys. Acta 1592:193-204 (2002).
RN [25]; RE0049323.
RX PUBMED: 16702947.
RA Dias S. S., Milne D. M., Meek D. W.
RT c-Abl phosphorylates Hdm2 at tyrosine 276 in response to DNA damage and regulates interaction with ARF.
RL Oncogene 25:6666 (2006).
RN [26]; RE0049329.
RX PUBMED: 17000778.
RA Jiang P., Du W., Heese K., Wu M.
RT The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis.
RL Mol. Cell. Biol. 26:9071-9082 (2006).
RN [27]; RE0049412.
RX PUBMED: 15242646.
RA Xirodimas D. P., Saville M. K., Bourdon J. C., Hay R. T., Lane D. P.
RT Mdm2-mediated NEDD8 conjugation of p53 inhibits its transcriptional activity.
RL Cell 118:83-97 (2004).
RN [28]; RE0049485.
RX PUBMED: 16122737.
RA Weger S., Hammer E., Heilbronn R.
RT Topors acts as a SUMO-1 E3 ligase for p53 in vitro and in vivo.
RL FEBS Lett. 579:5007-5012 (2005).
RN [29]; RE0049492.
RX PUBMED: 15247280.
RA Rajendra R., Malegaonkar D., Pungaliya P., Marshall H., Rasheed Z., Brownell J., Liu L. F., Lutzker S., Saleem A., Rubin E. H.
RT Topors functions as an E3 ubiquitin ligase with specific E2 enzymes and ubiquitinates p53.
RL J. Biol. Chem. 279:36440-36444 (2004).
RN [30]; RE0049505.
RX PUBMED: 14602726.
RA Townsend P. A., Scarabelli T. M., Davidson S. M., Knight R. A., Latchman D. S., Stephanou A.
RT STAT-1 interacts with p53 to enhance DNA damage-induced apoptosis.
RL J. Biol. Chem. 279:5811-5820 (2004).
RN [31]; RE0049576.
RX PUBMED: 16511572.
RA Jin Y., Dai M. S., Lu S. Z., Xu Y., Luo Z., Zhao Y., Lu H.
RT 14-3-3gamma binds to MDMX that is phosphorylated by UV-activated Chk1, resulting in p53 activation.
RL EMBO J. 25:1207-1218 (2006).
RN [32]; RE0049598.
RX PUBMED: 16862174.
RA Inoue Y., Itoh Y., Abe K., Okamoto T., Daitoku H., Fukamizu A., Onozaki K., Hayashi H.
RT Smad3 is acetylated by p300/CBP to regulate its transactivation activity.
RL Oncogene 26:500-508 (2007).
RN [33]; RE0049655.
RX PUBMED: 17012228.
RA Li T., Santockyte R., Shen R. F., Tekle E., Wang G., Yang D. C., Chock P. B.
RT Expression of SUMO-2/3 induced senescence through p53- and pRB-mediated pathways.
RL J. Biol. Chem. 281:36221-36227 (2006).
RN [34]; RE0049678.
RX PUBMED: 15572666.
RA Munarriz E., Barcaroli D., Stephanou A., Townsend P. A., Maisse C., Terrinoni A., Neale M. H., Martin S. J., Latchman D. S., Knight R. A., Melino G., De Laurenzi V.
RT PIAS-1 is a checkpoint regulator which affects exit from G1 and G2 by sumoylation of p73.
RL Mol. Cell. Biol. 24:10593-10610 (2004).
RN [35]; RE0049747.
RX PUBMED: 15843377.
RA Mayo L. D., Seo Y. R., Jackson M. W., Smith M. L., Rivera Guzman J., Korgaonkar C. K., Donner D. B.
RT Phosphorylation of human p53 at serine 46 determines promoter selection and whether apoptosis is attenuated or amplified.
RL J. Biol. Chem. 280:25953-25959 (2005).
RN [36]; RE0049870.
RX PUBMED: 12730672.
RA Alisi A., Giambartolomei S., Cupelli F., Merlo P., Fontemaggi G., Spaziani A., Balsano C.
RT Physical and functional interaction between HCV core protein and the different p73 isoforms.
RL Oncogene 22:2573-2580 (2003).
RN [37]; RE0049889.
RX PUBMED: 9827557.
RA Ishido S., Hotta H.
RT Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor.
RL FEBS Lett. 438:258-262 (1998).
RN [38]; RE0049918.
RX PUBMED: 16293623.
RA Dodson G. E., Tibbetts R. S.
RT DNA replication stress-induced phosphorylation of cyclic AMP response element-binding protein mediated by ATM.
RL J. Biol. Chem. 281:1692-1697 (2006).
RN [39]; RE0049956.
RX PUBMED: 16849690.
RA Wang J., Pabla N., Wang C. Y., Wang W., Schoenlein P. V., Dong Z.
RT Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53.
RL Am. J. Physiol. Renal Physiol. 291:F1300-7 (2006).
RN [40]; RE0049999.
RX PUBMED: 10518217.
RA Shikama N., Lee C. W., France S., Delavaine L., Lyon J., Krstic-Demonacos M., La Thangue N. B.
RT A novel cofactor for p300 that regulates the p53 response.
RL Mol. Cell 4:365-376 (1999).
RN [41]; RE0050074.
RX PUBMED: 15723830.
RA Hanamoto T., Ozaki T., Furuya K., Hosoda M., Hayashi S., Nakanishi M., Yamamoto H., Kikuchi H., Todo S., Nakagawara A.
RT Identification of protein kinase A catalytic subunit beta as a novel binding partner of p73 and regulation of p73 function.
RL J. Biol. Chem. 280:16665-16675 (2005).
RN [42]; RE0050138.
RX PUBMED: 17293853.
RA Linares L. K., Kiernan R., Triboulet R., Chable-Bessia C., Latreille D., Cuvier O., Lacroix M., Le Cam L., Coux O., Benkirane M.
RT Intrinsic ubiquitination activity of PCAF controls the stability of the oncoprotein Hdm2.
RL Nat. Cell Biol. 9:331-338 (2007).
RN [43]; RE0050466.
RX PUBMED: 15184379.
RA Sato K., Hayami R., Wu W., Nishikawa T., Nishikawa H., Okuda Y., Ogata H., Fukuda M., Ohta T.
RT Nucleophosmin/B23 is a candidate substrate for the BRCA1-BARD1 ubiquitin ligase.
RL J. Biol. Chem. 279:30919-30922 (2004).
RN [44]; RE0050471.
RX PUBMED: 17210684.
RA Li Q., Wang X., Wu X., Rui Y., Liu W., Wang J., Wang X., Liou Y. C., Ye Z., Lin S. C.
RT Daxx cooperates with the Axin/HIPK2/p53 complex to induce cell death.
RL Cancer Res. 67:66-74 (2007).
RN [45]; RE0050544.
RX PUBMED: 17234915.
RA Cordenonsi M., Montagner M., Adorno M., Zacchigna L., Martello G., Mamidi A., Soligo S., Dupont S., Piccolo S.
RT Integration of TGF-beta and Ras/MAPK signaling through p53 phosphorylation.
RL Science 315:840-843 (2007).
RN [46]; RE0050588.
RX PUBMED: 14636569.
RA Dong Y., Hakimi M. A., Chen X., Kumaraswamy E., Cooch N. S., Godwin A. K., Shiekhattar R.
RT Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair.
RL Mol. Cell 12:1087-1099 (2003).
RN [47]; RE0050640.
RX PUBMED: 12690203.
RA Grossman S. R., Deato M. E., Brignone C., Chan H. M., Kung A. L., Tagami H., Nakatani Y., Livingston D. M.
RT Polyubiquitination of p53 by a ubiquitin ligase activity of p300.
RL Science 300:342-344 (2003).
RN [48]; RE0050990.
RX PUBMED: 16677609.
RA Chen Y., Borowicz S., Fackenthal J., Collart F. R., Myatt E., Moy S., Babnigg G., Wilton R., Boernke W. E., Schiffer M., Stevens F. J., Olopade O. I.
RT Primary structure-based function characterization of BRCT domain replicates in BRCA1.
RL Biochem. Biophys. Res. Commun. 345:188-196 (2006).
RN [49]; RE0051084.
RX PUBMED: 17161371.
RA Liu J., Pan Y., Ma B., Nussinov R.
RT "Similarity trap" in protein-protein interactions could be carcinogenic: simulations of p53 core domain complexed with 53BP1 and BRCA1 BRCT domains.
RL Structure 14:1811-1821 (2006).
RN [50]; RE0051930.
RX PUBMED: 17644309.
RA Yamaguchi T., Miki Y., Yoshida K.
RT Protein kinase C delta activates IkappaB-kinase alpha to induce the p53 tumor suppressor in response to oxidative stress.
RL Cell. Signal. 19:2088-2097 (2007).
RN [51]; RE0052787.
RX PUBMED: 18160537.
RA Di Lello P., Miller Jenkins L. M., Mas C., Langlois C., Malitskaya E., Fradet-Turcotte A., Archambault J., Legault P., Omichinski J. G.
RT p53 and TFIIEalpha share a common binding site on the Tfb1/p62 subunit of TFIIH.
RL Proc. Natl. Acad. Sci. USA 105:106-111 (2008).
RN [52]; RE0052968.
RX PUBMED: 16173922.
RA Wang J., He X., Luo Y., Yarbrough W. G.
RT A novel ARF-binding protein (LZAP) alters ARF regulation of HDM2.
RL Biochem. J. 393:489-501 (2006).
RN [53]; RE0053054.
RX PUBMED: 12640129.
RA Lyakhovich A., Shekhar M. P.
RT Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response.
RL Mol. Cell. Biol. 23:2463-2475 (2003).
RN [54]; RE0053077.
RX PUBMED: 17371868.
RA Nie L., Sasaki M., Maki C. G.
RT Regulation of p53 nuclear export through sequential changes in conformation and ubiquitination.
RL J. Biol. Chem. 282:14616-14625 (2007).
RN [55]; RE0053243.
RX PUBMED: 12920132.
RA Yao Y. L., Yang W. M.
RT The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity.
RL J. Biol. Chem. 278:42560-42568 (2003).
RN [56]; RE0053384.
RX PUBMED: 17000756.
RA Laine A., Topisirovic I., Zhai D., Reed J. C., Borden K. L., Ronai Z.
RT Regulation of p53 localization and activity by Ubc13.
RL Mol. Cell. Biol. 26:8901-8913 (2006).
RN [57]; RE0053499.
RX PUBMED: 18524770.
RA Pietsch E. C., Perchiniak E., Canutescu A. A., Wang G., Dunbrack R. L., Murphy M. E.
RT Oligomerization of bak by p53 utilizes conserved residues of the p53 DNA binding domain.
RL J. Biol. Chem. 283:21294-21304 (2008).
RN [58]; RE0054653.
RX PUBMED: 10490106.
RA Chen H., Lin R. J., Xie W., Wilpitz D., Evans R. M.
RT Regulation of hormone-induced histone hyperacetylation and gene activation via acetylation of an acetylase.
RL Cell 98:675-686 (1999).
RN [59]; RE0054655.
RX PUBMED: 11459832.
RA Lin W. C., Lin F. T., Nevins J. R.
RT Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation.
RL Genes Dev. 15:1833-1844 (2001).
RN [60]; RE0055920.
RX PUBMED: 18208837.
RA Zaky A., Busso C., Izumi T., Chattopadhyay R., Bassiouny A., Mitra S., Bhakat K. K.
RT Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage.
RL Nucleic Acids Res. 36:1555-1566 (2008).
RN [61]; RE0055994.
RX PUBMED: 16595680.
RA Zhu N., Gu L., Findley H. W., Chen C., Dong J. T., Yang L., Zhou M.
RT KLF5 Interacts with p53 in regulating survivin expression in acute lymphoblastic leukemia.
RL J. Biol. Chem. 281:14711-14718 (2006).
RN [62]; RE0058765.
RX PUBMED: 11420692.
RA Bentires-Alj M., Dejardin E., Viatour P., van Lint C., Froesch B., Reed J. C., Merville M. P., Bours V.
RT Inhibition of the NF-kappa B transcription factor increases Bax expression in cancer cell lines.
RL Oncogene 20:2805-2813 (2001).
RN [63]; RE0063125.
RX PUBMED: 16839881.
RA Crighton D., Wilkinson S., O'Prey J., Syed N., Smith P., Harrison P. R., Gasco M., Garrone O., Crook T., Ryan K. M.
RT DRAM, a p53-induced modulator of autophagy, is critical for apoptosis.
RL Cell 126:121-134 (2006).
RN [64]; RE0063151.
RX PUBMED: 17304243.
RA Crighton D., O'Prey J., Bell H. S., Ryan K. M.
RT p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death.
RL Cell Death Differ. 14:1071-1079 (2007).
RN [65]; RE0063318.
RX PUBMED: 17916563.
RA Jung H., Seong H. A., Ha H.
RT NM23-H1 tumor suppressor and its interacting partner STRAP activate p53 function.
RL J. Biol. Chem. 282:35293-35307 (2007).
RN [66]; RE0063347.
RX PUBMED: 18815136.
RA Jung H., Seong H. A., Ha H.
RT Direct interaction between NM23-H1 and macrophage migration inhibitory factor (MIF) is critical for alleviation of MIF-mediated suppression of p53 activity.
RL J. Biol. Chem. 283:32669-32679 (2008).
RN [67]; RE0063394.
RX PUBMED: 18502749.
RA Jung H., Seong H. A., Ha H.
RT Critical role of cysteine residue 81 of macrophage migration inhibitory factor (MIF) in MIF-induced inhibition of p53 activity.
RL J. Biol. Chem. 283:20383-20396 (2008).
RN [68]; RE0063827.
RX PUBMED: 19308289.
RA Xu L., Chen Y., Song Q., Xu D., Wang Y., Ma D.
RT PDCD5 interacts with Tip60 and functions as a cooperator in acetyltransferase activity and DNA damage-induced apoptosis.
RL Neoplasia 11:345-354 (2009).
RN [69]; RE0063941.
RX PUBMED: 18215142.
RA Golubovskaya V. M., Finch R., Zheng M., Kurenova E. V., Cance W. G.
RT The 7-amino-acid site in the proline-rich region of the N-terminal domain of p53 is involved in the interaction with FAK and is critical for p53 functioning.
RL Biochem. J. 411:151-160 (2008).
RN [70]; RE0064377.
RX PUBMED: 17999388.
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RT p53 regulates FAK expression in human tumor cells.
RL Mol. Carcinog. 47:373-382 (2008).
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RA Tian C., Xing G., Xie P., Lu K., Nie J., Wang J., Li L., Gao M., Zhang L., He F.
RT KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis.
RL Nat. Cell Biol. 11:580-591 (2009).
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RA Hu M., Gu L., Li M., Jeffrey P. D., Gu W., Shi Y.
RT Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway.
RL PLoS Biol. 4:e27 (2006).
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RT A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7.
RL J. Biol. Chem. 279:38160-38168 (2004).
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RT Chfr is linked to tumour metastasis through the downregulation of HDAC1.
RL Nat. Cell Biol. 11:295-302 (2009).
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RT The p53--Mdm2--HAUSP complex is involved in p53 stabilization by HAUSP.
RL Oncogene 26:7262-7266 (2007).
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RA Lo H. W., Stephenson L., Cao X., Milas M., Pollock R., Ali-Osman F.
RT Identification and functional characterization of the human glutathione S-transferase P1 gene as a novel transcriptional target of the p53 tumor suppressor gene.
RL Mol. Cancer Res. 6:843-850 (2008).
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RA Cui R., Widlund H. R., Feige E., Lin J. Y., Wilensky D. L., Igras V. E., D Orazio J., Fung C. Y., Schanbacher C. F., Granter S. R., Fisher D. E.
RT Central role of p53 in the suntan response and pathologic hyperpigmentation.
RL Cell 128:853-864 (2007).
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RA Ueda K., Arakawa H., Nakamura Y.
RT Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53.
RL Oncogene 22:5586-5591 (2003).
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RT p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line.
RL Exp. Mol. Med. 38:625-633 (2006).
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RT Mdmx enhances p53 ubiquitination by altering the substrate preference of the Mdm2 ubiquitin ligase.
RL FEBS Lett. 583:2710-2714 (2009).
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RT ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.
RL Mol. Cell 18:577-587 (2005).
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RA Maeda Y., Hwang-Verslues W. W., Wei G., Fukazawa T., Durbin M. L., Owen L. B., Liu X., Sladek F. M.
RT Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene.
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RA Nie J., Xie P., Liu L., Xing G., Chang Z., Yin Y., Tian C., He F., Zhang L.
RT Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by stabilizing the E3 ligase MDM2.
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RA Wang Y., Debatin K. M., Hug H.
RT HIPK2 overexpression leads to stabilization of p53 protein and increased p53 transcriptional activity by decreasing Mdm2 protein levels.
RL BMC Mol. Biol. 2:8 (2001).
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RA Le Cam L., Linares L. K., Paul C., Julien E., Lacroix M., Hatchi E., Triboulet R., Bossis G., Shmueli A., Rodriguez M. S., Coux O., Sardet C.
RT E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation.
RL Cell 127:775-788 (2006).
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RA Yamasaki S., Yagishita N., Sasaki T., Nakazawa M., Kato Y., Yamadera T., Bae E., Toriyama S., Ikeda R., Zhang L., Fujitani K., Yoo E., Tsuchimochi K., Ohta T., Araya N., Fujita H., Aratani S., Eguchi K., Komiya S., Maruyama I., Higashi N., Sato M., Senoo H., Ochi T., Yokoyama S., Amano T., Kim J., Gay S., Fukamizu A., Nishioka K., Tanaka K., Nakajima T.
RT Cytoplasmic destruction of p53 by the endoplasmic reticulum-resident ubiquitin ligase 'Synoviolin'.
RL EMBO J. 26:113-122 (2007).
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RA Jansson M., Durant S. T., Cho E. C., Sheahan S., Edelmann M., Kessler B., La Thangue N. B.
RT Arginine methylation regulates the p53 response.
RL Nat. Cell Biol. 10:1431-1439 (2008).
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RA Liu X., Wang D., Zhao Y., Tu B., Zheng Z., Wang L., Wang H., Gu W., Roeder R. G., Zhu W. G.
RT Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1).
RL Proc. Natl. Acad. Sci. USA 108:1925-1930 (2011).
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RA Maiuri M. C., Malik S. A., Morselli E., Kepp O., Criollo A., Mouchel P. L., Carnuccio R., Kroemer G.
RT Stimulation of autophagy by the p53 target gene Sestrin2.
RL Cell Cycle 8:1571-1576 (2009).
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RA Candeias M. M., Malbert-Colas L., Powell D. J., Daskalogianni C., Maslon M. M., Naski N., Bourougaa K., Calvo F., Fahraeus R.
RT P53 mRNA controls p53 activity by managing Mdm2 functions.
RL Nat. Cell Biol. 10:1098-1105 (2008).
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RT DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation.
RL Nature 421:499-506 (2003).
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RT The GAS41-PP2Cbeta complex dephosphorylates p53 at serine 366 and regulates its stability.
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RT p53 target genes sestrin1 and sestrin2 connect genotoxic stress and mTOR signaling.
RL Cell 134:451-460 (2008).
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RT The laforin-malin complex, involved in Lafora disease, promotes the incorporation of K63-linked ubiquitin chains into AMP-activated protein kinase beta subunits.
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RT hCDC4b, a regulator of cyclin E, as a direct transcriptional target of p53.
RL Cancer Sci. 94:431-436 (2003).
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