AC T06368
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ID T06368
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DT 01.12.2004 (created); cch.
DT 08.12.2014 (updated); spk.
CO Copyright (C), QIAGEN.
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FA ASPP2
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SY 53BP2; apoptosis-stimulating protein of p53, 2; Bbp; Bcl2-binding protein; p53-binding protein 2; PPP1R13A; TP53BP2; tumor protein p53 binding protein, 2; tumor protein p53-binding protein, 2; tumor suppressor p53-binding protein 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G013616 TP53BP2; HGNC: TP53BP2.
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FF ASPP2 stimulates transcriptional activity of p63gamma and p73alpha on promoters of Bax, PIG3, and PUMA but not of mdm2 and p21 [3];
FF ASPP2 stimulates DNA binding and transcriptional activity of p53 on proaptotic genes Bax and PIG-3 [1];
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IN T00671 p53; human, Homo sapiens.
IN T09500 p53; Mammalia.
IN T06135 p63-isoform5; human, Homo sapiens.
IN T04931 p73alpha; human, Homo sapiens.
IN T22876 YAP; human, Homo sapiens.
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DR TRANSPATH: MO000044901.
DR UniProtKB: Q13625;
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RN [1]; RE0016209.
RX PUBMED: 10462436.
RA Waxman D. J.
RT P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR
RL Arch. Biochem. Biophys. 369:11-23 (1999).
RN [2]; RE0024790.
RX PUBMED: 11684014.
RA Samuels-Lev Y., O Connor D. J., Bergamaschi D., Trigiante G., Hsieh J. K., Zhong S., Campargue I., Naumovski L., Crook T., Lu X.
RT ASPP proteins specifically stimulate the apoptotic function of p53.
RL Mol. Cell 8:781-794 (2001).
RN [3]; RE0025178.
RX PUBMED: 14729977.
RA Bergamaschi D., Samuels Y., Jin B., Duraisingham S., Crook T., Lu X.
RT ASPP1 and ASPP2: common activators of p53 family members.
RL Mol. Cell. Biol. 24:1341-1350 (2004).
RN [4]; RE0049880.
RX PUBMED: 14985081.
RA Cao Y., Hamada T., Matsui T., Date T., Iwabuchi K.
RT Hepatitis C virus core protein interacts with p53-binding protein, 53BP2/Bbp/ASPP2, and inhibits p53-mediated apoptosis.
RL Biochem. Biophys. Res. Commun. 315:788-795 (2004).
RN [5]; RE0063261.
RX PUBMED: 16169070.
RA Stelzl U., Worm U., Lalowski M., Haenig C., Brembeck F. H., Goehler H., Stroedicke M., Zenkner M., Schoenherr A., Koeppen S., Timm J., Mintzlaff S., Abraham C., Bock N., Kietzmann S., Goedde A., Toksoz E., Droege A., Krobitsch S., Korn B., Birchmeier W., Lehrach H., Wanker E. E.
RT A human protein-protein interaction network: a resource for annotating the proteome.
RL Cell 122:957-968 (2005).
RN [6]; RE0064367.
RX PUBMED: 18448430.
RA Rotem S., Katz C., Benyamini H., Lebendiker M., Veprintsev D., Rudiger S., Danieli T., Friedler A.
RT The structure and interactions of the proline-rich domain of ASPP2.
RL J. Biol. Chem. 283:18990-18999 (2008).
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