AC T22876
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ID T22876
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DT 09.06.2004 (created); cch.
DT 19.02.2015 (updated); spk.
CO Copyright (C), QIAGEN.
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FA YAP
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SY YAP; yAP1; YAP2; YAP65; yes-associated protein 1; Yes-associated protein 1, 65kDa; yes-associated protein 2; YKI.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009620 YAP1; HGNC: yAP1.
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IN T18770 ARID1B; human, Homo sapiens.
IN T06368 ASPP2; human, Homo sapiens.
IN T18766 BAF250; human, Homo sapiens.
IN T05453 BAF60A; human, Homo sapiens.
IN T02872 beta-catenin; human, Homo sapiens.
IN T14513 beta-catenin; Mammalia.
IN T22509 dpf2; human, Homo sapiens.
IN T00241 Egr-1; human, Homo sapiens.
IN T06004 p63-isoform2; human, Homo sapiens.
IN T06168 p63alpha; mouse, Mus musculus.
IN T06138 p73; human, Homo sapiens.
IN T06006 p73alpha; monkey, Cercopithecus aethiops.
IN T06009 p73beta; mouse, Mus musculus.
IN T03885 Smad1; human, Homo sapiens.
IN T10783 Smad1; Mammalia.
IN T04222 Smad5; human, Homo sapiens.
IN T04234 Smad7; mouse, Mus musculus.
IN T00806 TEF-1; human, Homo sapiens.
IN T01124 TEF-1; mouse, Mus musculus.
IN T02362 TEF-1; rat, Rattus norvegicus.
IN T04952 TEF-5; human, Homo sapiens.
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BS R62981.
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DR TRANSPATH: MO000042300.
DR UniProtKB: P46937;
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RN [1]; RE0024344.
RX PUBMED: 11278685.
RA Strano S., Munarriz E., Rossi M., Castagnoli L., Shaul Y., Sacchi A., Oren M., Sudol M., Cesareni G., Blandino G.
RT Physical interaction with Yes-associated protein enhances p73 transcriptional activity.
RL J. Biol. Chem. 276:15164-15173 (2001).
RN [2]; RE0025738.
RX PUBMED: 12118366.
RA Ferrigno O., Lallemand F., Verrecchia F., L'Hoste S., Camonis J., Atfi A., Mauviel A.
RT Yes-associated protein (YAP65) interacts with Smad7 and potentiates its inhibitory activity against TGF-beta/Smad signaling.
RL Oncogene 21:4879-84 (2002).
RN [3]; RE0029914.
RX PUBMED: 12535517.
RA Basu S., Totty N. F., Irwin M. S., Sudol M., Downward J.
RT Akt phosphorylates the Yes-associated protein, YAP, to induce interaction with 14-3-3 and attenuation of p73-mediated apoptosis.
RL Mol. Cell 11:11-23 (2003).
RN [4]; RE0071678.
RX PUBMED: 21224387.
RA Chan S. W., Lim C. J., Chong Y. F., Pobbati A. V., Huang C., Hong W.
RT Hippo pathway-independent restriction of TAZ and YAP by angiomotin.
RL J. Biol. Chem. 286:7018-7026 (2011).
RN [5]; RE0071686.
RX PUBMED: 21383157.
RA Ho K. C., Zhou Z., She Y. M., Chun A., Cyr T. D., Yang X.
RT Itch E3 ubiquitin ligase regulates large tumor suppressor 1 stability [corrected].
RL Proc. Natl. Acad. Sci. USA 108:4870-4875 (2011).
RN [6]; RE0071692.
RX PUBMED: 21730131.
RA Kim N. G., Koh E., Chen X., Gumbiner B. M.
RT E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components.
RL Proc. Natl. Acad. Sci. USA 108:11930-11935 (2011).
RN [7]; RE0071699.
RX PUBMED: 21189257.
RA Liu C. Y., Lv X., Li T., Xu Y., Zhou X., Zhao S., Xiong Y., Lei Q. Y., Guan K. L.
RT PP1 cooperates with ASPP2 to dephosphorylate and activate TAZ.
RL J. Biol. Chem. 286:5558-5566 (2011).
RN [8]; RE0071731.
RX PUBMED: 18579750.
RA Zhao B., Ye X., Yu J., Li L., Li W., Li S., Yu J., Lin J. D., Wang C. Y., Chinnaiyan A. M., Lai Z. C., Guan K. L.
RT TEAD mediates YAP-dependent gene induction and growth control.
RL Genes Dev. 22:1962-1971 (2008).
RN [9]; RE0071814.
RX PUBMED: 18158288.
RA Hao Y., Chun A., Cheung K., Rashidi B., Yang X.
RT Tumor suppressor LATS1 is a negative regulator of oncogene YAP.
RL J. Biol. Chem. 283:5496-5509 (2008).
RN [10]; RE0071834.
RX PUBMED: 19739119.
RA Chow A., Hao Y., Yang X.
RT Molecular characterization of human homologs of yeast MOB1.
RL Int. J. Cancer 126:2079-2089 (2010).
RN [11]; RE0071837.
RX PUBMED: 21489991.
RA Donninger H., Allen N., Henson A., Pogue J., Williams A., Gordon L., Kassler S., Dunwell T., Latif F., Clark G. J.
RT Salvador protein is a tumor suppressor effector of RASSF1A with hippo pathway-independent functions.
RL J. Biol. Chem. 286:18483-18491 (2011).
RN [12]; RE0071891.
RX PUBMED: 21832154.
RA Paramasivam M., Sarkeshik A., Yates JR 3. r. d., Fernandes M. J., McCollum D.
RT Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor.
RL Mol. Biol. Cell 22:3725-3733 (2011).
RN [13]; RE0071894.
RX PUBMED: 21233212.
RA Xiao L., Chen Y., Ji M., Dong J.
RT KIBRA regulates Hippo signaling activity via interactions with large tumor suppressor kinases.
RL J. Biol. Chem. 286:7788-7796 (2011).
RN [14]; RE0071904.
RX PUBMED: 21666719.
RA Angus L., Moleirinho S., Herron L., Sinha A., Zhang X., Niestrata M., Dholakia K., Prystowsky M. B., Harvey K. F., Reynolds P. A., Gunn-Moore F. J.
RT Willin/FRMD6 expression activates the Hippo signaling pathway kinases in mammals and antagonizes oncogenic YAP.
RL Oncogene 31:238-250 (2011).
RN [15]; RE0071920.
RX PUBMED: 21187284.
RA Wang W., Huang J., Chen J.
RT Angiomotin-like proteins associate with and negatively regulate YAP1.
RL J. Biol. Chem. 286:4364-4370 (2011).
RN [16]; RE0071968.
RX PUBMED: 21205866.
RA Zhao B., Li L., Lu Q., Wang L. H., Liu C. Y., Lei Q., Guan K. L.
RT Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein.
RL Genes Dev. 25:51-63 (2011).
RN [17]; RE0071974.
RX PUBMED: 21909427.
RA Wang P., Bai Y., Song B., Wang Y., Liu D., Lai Y., Bi X., Yuan Z.
RT PP1A-mediated dephosphorylation positively regulates YAP2 activity.
RL PLoS ONE 6:e24288 (2011).
RN [18]; RE0072967.
RX PUBMED: 21376238.
RA Schlegelmilch K., Mohseni M., Kirak O., Pruszak J., Rodriguez J. R., Zhou D., Kreger B. T., Vasioukhin V., Avruch J., Brummelkamp T. R., Camargo F. D.
RT Yap1 acts downstream of alpha-catenin to control epidermal proliferation.
RL Cell 144:782-795 (2011).
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