AC T06006
XX
ID T06006
XX
DT 09.06.2004 (created); cch.
DT 20.02.2006 (updated); rad.
CO Copyright (C), QIAGEN.
XX
FA p73alpha
XX
SY TAp73alpha.
XX
OS monkey, Cercopithecus aethiops
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates; haplorhini; catarrhini; cercopithecidae; cercopithecinae
XX
CL C0057; P53.
XX
SZ 637 AA; 69.6 kDa (calc.).
XX
SQ MAQSTTTSPDGGTTFEHLWSSLEPDSTYFDLPQSSRGNNEVVGGTDSSMDVFHLEGMTTS
SQ VMAQFNLLSSTMDQMSSRAASASPYTPEHAASVPTHSPYAQPSSTFDTMSPAPVIPSNTD
SQ YPGPHHFEVTFQQSSTAKSATWTYSPLLKKLYCQIAKTCPIQIKVSAPPPPGTAIRAMPV
SQ YKKAEHVTDIVKRCPNHELGRDFNEGQSAPASHLIRVEGNNLSQYVDDPVTGRQSVVVPY
SQ EPPQVGTEFTTILYNFMCNSSCVGGMNRRPILIIITLETRDGQVLGRRSFEGRICACPGR
SQ DRKADEDHYREQQALNESSAKNGAASKRAFKQSPPAVPALGPGVKKRRHGDEDTYYLQVR
SQ GRENFEILMKLKESLELMELVPQPLVDSYRQQQQLLQRPSHLQPPSYGPVLSPMNKVHGG
SQ VNKLPSVNQLVGQPPPHSSAATPNLGPVGSGMLNNHGHAVPANSEMTSSHGTQSMVSGSH
SQ CTPPPPYHADPSLVSFLTGLGCPNCIEYFTSQGLQSIYHLQNLTIEDLGALKIPEQYRMT
SQ IWRGLQDLKQGHDYGAAAQQLLRSSNAAAISIGGSGELQRQRVMEAVHFRVRHTITIPNR
SQ GGPGAGPDEWADFGFDLPDCKARKQPIKEEFTEAEIH
XX
SC translated from EMBL #Y11419
XX
FT 24 581 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 113 309 
PF00870; P53 DNA-binding domain.
FT 345 386 
PF07710; P53 tetramerisation motif.
FT 483 487 
interaction with YAP [2].
FT 485 551 
PF07647; SAM domain (Sterile alpha motif).
FT 485 551 
SM00454; SAM.
XX
SF is very similar to the corresponding human factor;
XX
FF activator [4];
FF can recruit co-activator p300/CBP [4] [5];
FF can recruit co-activator YAP [2];
XX
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T01427 p300; human, Homo sapiens.
IN T01839 WT1 -KTS; human, Homo sapiens.
IN T00900 WT1 I -KTS; human, Homo sapiens.
IN T01840 WT1 I; human, Homo sapiens.
IN T00899 WT1; human, Homo sapiens.
IN T22876 YAP; human, Homo sapiens.
XX
MX M00761 V$P53DECAMER_Q2.
MX M03558 V$P73_Q6.
XX
BS R11385.
BS R11386.
XX
DR TRANSPATH: MO000042297.
DR EMBL: Y11419;
DR UniProtKB: Q9XSK8;
XX
RN [1]; RE0006141.
RX PUBMED: 9296498.
RA Jost C. A., Marin M. C., Kaelin WG J. r.
RT P73 is a simian (correction of human) p53- related protein that can induce apoptosis
RL Nature 389:191-194 (1997).
RN [2]; RE0024344.
RX PUBMED: 11278685.
RA Strano S., Munarriz E., Rossi M., Castagnoli L., Shaul Y., Sacchi A., Oren M., Sudol M., Cesareni G., Blandino G.
RT Physical interaction with Yes-associated protein enhances p73 transcriptional activity.
RL J. Biol. Chem. 276:15164-15173 (2001).
RN [3]; RE0024351.
RX PUBMED: 10648616.
RA Zeng X., Li X., Miller A., Yuan Z., Yuan W., Kwok R. P., Goodman R., Lu H.
RT The N-terminal domain of p73 interacts with the CH1 domain of p300/CREB binding protein and mediates transcriptional activation and apoptosis.
RL Mol. Cell. Biol. 20:1299-1310 (2000).
RN [4]; RE0024370.
RX PUBMED: 11076933.
RA Zeng X., Lee H., Zhang Q., Lu H.
RT p300 does not require its acetylase activity to stimulate p73 function.
RL J. Biol. Chem. 276:48-52 (2001).
RN [5]; RE0024378.
RX PUBMED: 10207051.
RA Zeng X., Chen L., Jost C. A., Maya R., Keller D., Wang X., Kaelin WG J. r., Oren M., Chen J., Lu H.
RT MDM2 suppresses p73 function without promoting p73 degradation.
RL Mol. Cell. Biol. 19:3257-3266 (1999).
RN [6]; RE0047316.
RX PUBMED: 10469568.
RA Ongkeko W. M., Wang X. Q., Siu W. Y., Lau A. W., Yamashita K., Harris A. L., Cox L. S., Poon R. Y.
RT MDM2 and MDMX bind and stabilize the p53-related protein p73.
RL Curr. Biol. 9:829-832 (1999).
XX
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