AC T01839
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ID T01839
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DT 05.06.1996 (created); ewi.
DT 20.08.2014 (updated); msr.
CO Copyright (C), QIAGEN.
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FA WT1 -KTS
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SY Swiss-Prot isoform-4; Wilms tumor zinc finger protein; WT II; WT-ZFP; WT1(+/-); WT33.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004120 WT1; HGNC: WT1.
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CL C0001; CH; 2.3.3.0.21.4.
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SZ 446 AA; 48.9 kDa (cDNA) (calc.).
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SQ MGSDVRDLNALLPAVPSLGGGGGCALPVSGAAQWAPVLDFAPPGASAYGSLGGPAPPPAP
SQ PPPPPPPPHSFIKQEPSWGGAEPHEEQCLSAFTVHFSGQFTGTAGACRYGPFGPPPPSQA
SQ SSGQARMFPNAPYLPSCLESQPAIRNQGYSTVTFDGTPSYGHTPSHHAAQFPNHSFKHED
SQ PMGQQGSLGEQQYSVPPPVYGCHTPTDSCTGSQALLLRTPYSSDNLYQMTSQLECMTWNQ
SQ MNLGATLKGVAAGSSSSVKWTEGQSNHSTGYESDNHTTPILCGAQYRIHTHGVFRGIQDV
SQ RRVPGVAPTLVRSASETSEKRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDC
SQ ERRFSRSDQLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSCQK
SQ KFARSDELVRHHNMHQRNMTKLQLAL
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SC edited from Swiss-Prot #P19544
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FT 1 321 
PF02165; Wilm's tumour protein.
FT 323 347 
PF00096; zf-C2H2.
FT 323 347 
SM00355; c2h2final6.
FT 323 352 
PS50157; ZINC_FINGER_C2H2_2.
FT 353 377 
PF00096; zf-C2H2.
FT 353 377 
SM00355; c2h2final6.
FT 353 382 
PS50157; ZINC_FINGER_C2H2_2.
FT 383 405 
PF00096; zf-C2H2.
FT 383 405 
SM00355; c2h2final6.
FT 383 410 
PS50157; ZINC_FINGER_C2H2_2.
FT 411 435 PF00096; zf-C2H2.
FT 411 435 SM00355; c2h2final6.
FT 411 440 PS50157; ZINC_FINGER_C2H2_2.
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SF 4 zinc finger motifs;
SF alternative splice variant lacking AA 408-410 (K-T-S) of full-length WT1;
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FF represses the activity of insulin-like growth factor II and platelet-derived growth factor A chain promoters [2];
FF KTS lacking isoforms show a nuclear distribution that parallels that of Sp1 and TFIIB [3];
FF binding to RNA via zinc finger [3];
FF comprises about 15 per cent of the WT1 transcripts [4];
FF four-fold transcriptional repression of EGF receptor promoter [4];
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IN T06006 p73alpha; monkey, Cercopithecus aethiops.
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MX M07436 V$WT1_Q4.
MX M01118 V$WT1_Q6.
MX M02036 V$WT1_Q6_01.
MX M03893 V$WT1_Q6_02.
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BS R04924.
BS R02307.
BS R02308.
BS R02309.
BS R02310.
BS R02311.
BS R02312.
BS R60220.
BS R63451.
BS R31233.
BS R63448.
BS R04858.
BS R04859.
BS R04860.
BS R04861.
BS R04862.
BS R04863.
BS R04864.
BS R04865.
BS R04866.
BS R04867.
BS R04868.
BS R04925.
BS R02262.
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DR TRANSPATH: MO000025969.
DR UniProtKB: P19544-4;
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RN [1]; RE0002675.
RX PUBMED: 1321494.
RA Bickmore W. A., Oghene K., Little M. H., Seawright A., van Heyningen V., Hastie N. D.
RT Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript
RL Science 257:235-237 (1992).
RN [2]; RE0006497.
RX PUBMED: 7753836.
RA Kudoh T., Ishidate T., Moriyama M., Toyoshima K., Akiyama T.
RT G1 phase arrest induced by Wilms tumor protein WT1 is abrogated by cyclin/CDK complexes
RL Proc. Natl. Acad. Sci. USA 92:4517-4521 (1995).
RN [3]; RE0006498.
RX PUBMED: 7736591.
RA Larsson S. H., Charlieu J.-P., Miyagawa K., Engelkamp D., Rassoulzadegan M., Ross A., Cuzin F., van Heyningen V., Hastie N. D.
RT Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing
RL Cell 81:391-401 (1995).
RN [4]; RE0006727.
RX PUBMED: 7588596.
RA Englert C., Hou X., Maheswaran S., Bennett P., Ngwu C., Re G. G., Garvin A. J., Rosner M. R., Haber D. A.
RT WT1 suppresses synthesis of the epidermal growth factor receptor and induces apoptosis
RL EMBO J. 14:4662-4676 (1995).
RN [5]; RE0049501.
RX PUBMED: 16087727.
RA Reizner N., Maor S., Sarfstein R., Abramovitch S., Welshons W. V., Curran E. M., Lee A. V., Werner H.
RT The WT1 Wilms' tumor suppressor gene product interacts with estrogen receptor-alpha and regulates IGF-I receptor gene transcription in breast cancer cells.
RL J. Mol. Endocrinol. 35:135-144 (2005).
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