AC T02214
XX
ID T02214
XX
DT 17.10.1997 (created); ewi.
CO Copyright (C), QIAGEN.
XX
FA CBP-isoform1
XX
SY CBP; CBP/p300; CREB-binding protein; CREBBP.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G004619 CREBBP; HGNC: CREBBP.
XX
SZ 2442 AA; 265.3 kDa (cDNA) (calc.).
XX
SQ MAENLLDGPPNPKRAKLSSPGFSANDSTDFGSLFDLENDLPDELIPNGGELGLLNSGNLV
SQ PDAASKHKQLSELLRGGSGSSINPGIGNVSASSPVQQGLGGQAQGQPNSANMASLSAMGK
SQ SPLSQGDSSAPSLPKQAASTSGPTPAASQALNPQAQKQVGLATSSPATSQTGPGICMNAN
SQ FNQTHPGLLNSNSGHSLINQASQGQAQVMNGSLGAAGRGRGAGMPYPTPAMQGASSSVLA
SQ ETLTQVSPQMTGHAGLNTAQAGGMAKMGITGNTSPFGQPFSQAGGQPMGATGVNPQLASK
SQ QSMVNSLPTFPTDIKNTSVTNVPNMSQMQTSVGIVPTQAIATGPTADPEKRKLIQQQLVL
SQ LLHAHKCQRREQANGEVRACSLPHCRTMKNVLNHMTHCQAGKACQVAHCASSRQIISHWK
SQ NCTRHDCPVCLPLKNASDKRNQQTILGSPASGIQNTIGSVGTGQQNATSLSNPNPIDPSS
SQ MQRAYAALGLPYMNQPQTQLQPQVPGQQPAQPQTHQQMRTLNPLGNNPMNIPAGGITTDQ
SQ QPPNLISESALPTSLGATNPLMNDGSNSGNIGTLSTIPTAAPPSSTGVRKGWHEHVTQDL
SQ RSHLVHKLVQAIFPTPDPAALKDRRMENLVAYAKKVEGDMYESANSRDEYYHLLAEKIYK
SQ IQKELEEKRRSRLHKQGILGNQPALPAPGAQPPVIPQAQPVRPPNGPLSLPVNRMQVSQG
SQ MNSFNPMSLGNVQLPQAPMGPRAASPMNHSVQMNSMGSVPGMAISPSRMPQPPNMMGAHT
SQ NNMMAQAPAQSQFLPQNQFPSSSGAMSVGMGQPPAQTGVSQGQVPGAALPNPLNMLGPQA
SQ SQLPCPPVTQSPLHPTPPPASTAAGMPSLQHTTPPGMTPPQPAAPTQPSTPVSSSGQTPT
SQ PTPGSVPSATQTQSTPTVQAAAQAQVTPQPQTPVQPPSVATPQSSQQQPTPVHAQPPGTP
SQ LSQAAASIDNRVPTPSSVASAETNSQQPGPDVPVLEMKTETQAEDTEPDPGESKGEPRSE
SQ MMEEDLQGASQVKEETDIAEQKSEPMEVDEKKPEVKVEVKEEEESSSNGTASQSTSPSQP
SQ RKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIVKNPMDLSTIKR
SQ KLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCSKLAEVFEQEIDPVMQSLGYCC
SQ GRKYEFSPQTLCCYGKQLCTIPRDAAYYSYQNRYHFCEKCFTEIQGENVTLGDDPSQPQT
SQ TISKDQFEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDIIWPSGFVCDNCLKKTGRPRK
SQ ENKFSAKRLQTTRLGNHLEDRVNKFLRRQNHPEAGEVFVRVVASSDKTVEVKPGMKSRFV
SQ DSGEMSESFPYRTKALFAFEEIDGVDVCFFGMHVQEYGSDCPPPNTRRVYISYLDSIHFF
SQ RPRCLRTAVYHEILIGYLEYVKKLGYVTGHIWACPPSEGDDYIFHCHPPDQKIPKPKRLQ
SQ EWYKKMLDKAFAERIIHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEE
SQ EERKKEESTAASETTEGSQGDSKNAKKKNNKKTNKNKSSISRANKKKPSMPNVSNDLSQK
SQ LYATMEKHKEVFFVIHLHAGPVINTLPPIVDPDPLLSCDLMDGRDAFLTLARDKHWEFSS
SQ LRRSKWSTLCMLVELHTQGQDRFVYTCNECKHHVETRWHCTVCEDYDLCINCYNTKSHAH
SQ KMVKWGLGLDDEGSSQGEPQSKSPQESRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKR
SQ VVQHTKGCKRKTNGGCPVCKQLIALCCYHAKHCQENKCPVPFCLNIKHKLRQQQIQHRLQ
SQ QAQLMRRRMATMNTRNVPQQSLPSPTSAPPGTPTQQPSTPQTPQPPAQPQPSPVSMSPAG
SQ FPSVARTQPPTTVSTGKPTSQVPAPPPPAQPPPAAVEAARQIEREAQQQQHLYRVNINNS
SQ MPPGRTGMGTPGSQMAPVSLNVPRPNQVSGPVMPSMPPGQWQQAPLPQQQPMPGLPRPVI
SQ SMQAQAAVAGPRMPSVQPPRSISPSALQDLLRTLKSPSSPQQQQQVLNILKSNPQLMAAF
SQ IKQRTAKYVANQPGMQPQPGLQSQPGMQPQPGMHQQPSLQNLNAMQAGVPRPGVPPQQQA
SQ MGGLNPQGQALNIMNPGHNPNMASMNPQYREMLRRQLLQQQQQQQQQQQQQQQQQQGSAG
SQ MAGGMAGHGQFQQPQGPGGYPPAMQQQQRMQQHLPLQGSSMGQMAAQMGQLGQMGQPGLG
SQ ADSTPNIQQALQQRILQQQQMKQQIGSPGQPNPMSPQQHMLSGQPQASHLPGQQIATSLS
SQ NQVRSPAPVQSPRPQSQPPHSSPSPRIQPQPSPHHVSPQTGSPHPGLAVTMASSIDQGHL
SQ GNPEQSAMLPQLNTPSRSALSSELSLVGDTTGDTLEKFVEGL
XX
SC Swiss-Prot#Q92793
XX
FT 1 771 
binding of RelA [8].
FT 117 737 
binding of NF-ATp [11].
FT 347 433 
PS50134; ZF_TAZ.
FT 348 432 
PF02135; TAZ zinc finger.
FT 348 433 
SM00551; ZnF_TAZ.
FT 363 430 
Cys/His-rich region (17/68), binding of STAT2 [4].
FT 587 666 
PS50952; KIX.
FT 587 667 
PF02172; KIX domain.
FT 1084 1194 
SM00297; bromo_6.
FT 1090 1180 
PF00439; Bromodomain.
FT 1103 1170 bromo domain [7].
FT 1103 1175 PS50014; BROMODOMAIN_2.
FT 1181 1241 PF06001; Domain of Unknown Function (DUF902).
FT 1316 1553 PF06010; Domain of Unknown Function (DUF906).
FT 1680 1891 binding of NF-ATp [11].
FT 1701 1742 PF00569; Zinc finger, ZZ type.
FT 1701 1742 SM00291; zz_5.
FT 1701 1744 PS50135; ZF_ZZ_2.
FT 1764 1843 PF02135; TAZ zinc finger.
FT 1765 1846 PS50134; ZF_TAZ.
FT 1766 1844 SM00551; ZnF_TAZ.
FT 1892 2441 binding of RelA [8].
XX
SF related to p300 [5];
SF two regions of CBP-isoform1 are required for interactions with NF-ATp [11];
XX
FF coactivator [1];
FF coactivator of STAT2 [4];
FF coactivator of bHLH proteins [2];
FF of c-Jun and JunB [9];
FF coactivator of NF-kappaB p65 [8];
FF coactivator of NF-ATp [11];
FF coactivator of IRF-3 [12];
FF creates a physical bridge between various transcription factors and the basal transcriptional machinery [5];
FF potent histone acetyltransferase [5];
FF mutations can lead to Rubinstein-Taybi syndrome (RTS) [6];
XX
IN T03026 beta-catenin; clawed frog, Xenopus laevis.
IN T00113 c-Ets-2; human, Homo sapiens.
IN T00133 c-Jun; human, Homo sapiens.
IN T00163 CREB-A; human, Homo sapiens.
IN T08994 HIF-1alpha-isoform1; human, Homo sapiens.
IN T09015 HNF-1alpha; human, Homo sapiens.
IN T02758 HNF-4; human, Homo sapiens.
IN T25621 huntingtin; human, Homo sapiens.
IN T27548 IRF-3; human, Homo sapiens.
IN T01977 JunB; human, Homo sapiens.
IN T01948 NFATc2; human, Homo sapiens.
IN T06006 p73alpha; monkey, Cercopithecus aethiops.
IN T06014 p73beta; monkey, Cercopithecus aethiops.
IN T02745 PPARdelta; human, Homo sapiens.
IN T02736 PPARgamma1; human, Homo sapiens.
IN T05351 PPARgamma; human, Homo sapiens.
IN T00594 RelA-p65-isoform1; human, Homo sapiens.
IN T01494 STAT2; human, Homo sapiens.
IN T02483 TIF2; human, Homo sapiens.
IN T05150 ZAC-1b; mouse, Mus musculus.
XX
DR TRANSPATH: MO000019107.
DR PATHODB: MT010911.
DR PATHODB: MT010912.
DR PATHODB: MT010913.
DR PATHODB: MT010914.
DR PATHODB: MT010915.
DR PATHODB: MT010916.
DR PATHODB: MT010917.
DR EMBL: U47741;
DR EMBL: U85962;
DR EMBL: U89354;
DR EMBL: U89355;
DR UniProtKB: Q92793;
XX
RN [1]; RE0001914.
RX PUBMED: 8413673.
RA Chrivia J. C., Kwok R. P. S., Lamb N., Hagiwara M., Montminy M. R., Goodman R. H.
RT Phosphorylated CREB binds specifically to the nuclear protein CBP
RL Nature 365:855-859 (1993).
RN [2]; RE0005904.
RX PUBMED: 8843199.
RA Eckner R., Yao T.-P., Oldread E., Livingston D. M.
RT Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation
RL Genes Dev. 10:2478-2490 (1997).
RN [3]; RE0006091.
RX PUBMED: 8782817.
RA Borrow J., Stanton jr V. P., Andresen J. M., Becher R., Behm F. G., Chaganti R. S. K., Civin C. I., Disteche C., Dube I., Frischauf A. M., Horsman D., Mitelman F., Volinia S., Watmore A. E., Housman D. E.
RT The translocation t (8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetytransferase to the CREB-binding protein
RL Nat. Genet. 14:33-41 (1996).
RN [4]; RE0006163.
RX PUBMED: 8848048.
RA Bhattacharya S., Eckner R., Grossman S., Oldread E., Arany Z., D Andrea A., Livingston D. M.
RT Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha
RL Nature 383:344-347 (1996).
RN [5]; RE0006865.
RX PUBMED: 9613201.
RA Giles R. H., Peters D. J. M., Breuning M. H.
RT Conjunction dysfunction: CBP/p300 in human disease
RL Trends Genet. 14:178-183 (1998).
RN [6]; RE0016487.
RX PUBMED: 11331617.
RA Murata T., Kurokawa R., Krones A., Tatsumi K., Ishii M., Taki T., Masuno M., Ohashi H., Yanagisawa M., Rosenfeld M. G., Glass C. K., Hayashi Y.
RT Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndrome.
RL Hum. Mol. Genet. 10:1071-1076 (2001).
RN [7]; RE0016490.
RX PUBMED: 9177780.
RA Giles R. H., Petrij F., Dauwerse H. G., den Hollander A. I., Lushnikova T., van Ommen G. J., Goodman R. H., Deaven L. L., Doggett N. A., Peters D. J., Breuning M. H.
RT Construction of a 1.2-Mb contig surrounding, and molecular analysis of, the human CREB-binding protein (CBP/CREBBP) gene on chromosome 16p13.3.
RL Genomics 42:96-114 (1997).
RN [8]; RE0018223.
RX PUBMED: 9096323.
RA Gerritsen M. E., Williams A. J., Neish A. S., Moore S., Shi Y., Collins T.
RT CREB-binding protein/p300 are transcriptional coactivators of p65.
RL Proc. Natl. Acad. Sci. USA 94:2927-2932 (1997).
RN [9]; RE0018232.
RX PUBMED: 8754832.
RA Lee J. S., See R. H., Deng T., Shi Y.
RT Adenovirus E1A downregulates cJun- and JunB-mediated transcription by targeting their coactivator p300.
RL Mol. Cell. Biol. 16:4312-4326 (1996).
RN [10]; RE0020259.
RX PUBMED: 9238046.
RA SOBULO O.M., BORROW J., TOMEK R., RESHIMI S., HARDEN A., SCHLEGELBERGER B., HOUSMAN D., DOGGETT N.A., ROWLEY J.D., ZELEZNIK-LE N.J.
RT MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).
RL Proc. Natl. Acad. Sci. USA 94:8732-8737 (1997).
RN [11]; RE0024038.
RX PUBMED: 9625762.
RA Garcia-Rodriguez C., Rao A.
RT Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP).
RL J. Exp. Med. 187:2031-2036 (1998).
RN [12]; RE0024081.
RX PUBMED: 12473110.
RA Yang H., Lin C. H., Ma G., Orr M., Baffi M. O., Wathelet M. G.
RT Transcriptional activity of interferon regulatory factor (IRF)-3 depends on multiple protein-protein interactions.
RL Eur. J. Biochem. 269:6142-6151 (2002).
RN [13]; RE0027648.
RX PUBMED: 10777539.
RA Soutoglou E., Papafotiou G., Katrakili N., Talianidis I.
RT Transcriptional activation by hepatocyte nuclear factor-1 requires synergism between multiple coactivator proteins.
RL J. Biol. Chem. 275:12515-20 (2000).
RN [14]; RE0049828.
RX PUBMED: 16204234.
RA Hassa P. O., Haenni S. S., Buerki C., Meier N. I., Lane W. S., Owen H., Gersbach M., Imhof R., Hottiger M. O.
RT Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription.
RL J. Biol. Chem. 280:40450-40464 (2005).
RN [15]; RE0068793.
RX PUBMED: 17382325.
RA Cho H., Ahn D. R., Park H., Yang E. G.
RT Modulation of p300 binding by posttranslational modifications of the C-terminal activation domain of hypoxia-inducible factor-1alpha.
RL FEBS Lett. 581:1542-1548 (2007).
XX
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