AC T25621
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ID T25621
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DT 11.09.2002 (created); cch.
DT 03.05.2013 (updated); yre.
CO Copyright (C), QIAGEN.
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FA huntingtin
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SY HD protein; huntingtin; Huntington disease protein; IT15.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004723 HTT; HGNC: Htt.
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EX brain,,,adult; high; Western blot; protein; [9].
EX brain,,,adult; medium; Western blot; protein; [9].
EX brain,,,adult; very high; Western blot; protein; [9].
EX cerebral cortex,,,adult; very high; Western blot; protein; [10].
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FF huntingtin is able to inhibit constitutive transcription probably by being part of nuclear matrix-bound complexes [3];
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IN T05963 CA150; human, Homo sapiens.
IN T02214 CBP-isoform1; human, Homo sapiens.
IN T05962 NCOR1; rat, Rattus norvegicus.
IN T06148 p/CAF; human, Homo sapiens.
IN T06124 REST; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
IN T02328 TAFII135; human, Homo sapiens.
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DR TRANSPATH: MO000033243.
DR UniProtKB: P42858;
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RN [1]; RE0022222.
RX PUBMED: 9140394.
RA Kalchman M. A., Koide H. B., McCutcheon K., Graham R. K., Nichol K., Nishiyama K., Kazemi-Esfarjani P., Lynn F. C., Wellington C., Metzler M., Goldberg Y. P., Kanazawa I., Gietz R. D., Hayden M. R.
RT HIP1, a human homologue of S. cerevisiae Sla2p, interacts with membrane-associated huntingtin in the brain.
RL Nat. Genet. 16:44-53 (1997).
RN [2]; RE0023030.
RX PUBMED: 10801775.
RA Liu Y. F., Dorow D., Marshall J.
RT Activation of MLK2-mediated signaling cascades by polyglutamine-expanded huntingtin.
RL J. Biol. Chem. 275:19035-19040 (2000).
RN [3]; RE0024221.
RX PUBMED: 11739372.
RA Kegel K. B., Meloni A. R., Yi Y., Kim Y. J., Doyle E., Cuiffo B. G., Sapp E., Wang Y., Qin Z. H., Chen J. D., Nevins J. R., Aronin N., DiFiglia M.
RT Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription.
RL J. Biol. Chem. 277:7466-7476 (2002).
RN [4]; RE0024222.
RX PUBMED: 12888569.
RA Busch A., Engemann S., Lurz R., Okazawa H., Lehrach H., Wanker E. E.
RT Mutant huntingtin promotes the fibrillogenesis of wild-type huntingtin: a potential mechanism for loss of huntingtin function in Huntington's disease.
RL J. Biol. Chem. 278:41452-41461 (2003).
RN [5]; RE0024228.
RX PUBMED: 14557250.
RA Zhou H., Cao F., Wang Z., Yu Z. X., Nguyen H. P., Evans J., Li S. H., Li X. J.
RT Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity.
RL J. Cell Biol. 163:109-118 (2003).
RN [6]; RE0048055.
RX PUBMED: 15383276.
RA Goehler H., Lalowski M., Stelzl U., Waelter S., Stroedicke M., Worm U., Droege A., Lindenberg K. S., Knoblich M., Haenig C., Herbst M., Suopanki J., Scherzinger E., Abraham C., Bauer B., Hasenbank R., Fritzsche A., Ludewig A. H., Bussow K., Coleman S. H., Gutekunst C. A., Landwehrmeyer B. G., Lehrach H., Wanker E. E.
RT A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.
RL Mol. Cell 15:853-865 (2004).
RN [7]; RE0069930.
RX PUBMED: 19345187.
RA Jeong H., Then F., Melia TJ J. r., Mazzulli J. R., Cui L., Savas J. N., Voisine C., Paganetti P., Tanese N., Hart A. C., Yamamoto A., Krainc D.
RT Acetylation targets mutant huntingtin to autophagosomes for degradation.
RL Cell 137:60-72 (2009).
RN [8]; RE0070231.
RX PUBMED: 19566678.
RA Kegel K. B., Sapp E., Alexander J., Valencia A., Reeves P., Li X., Masso N., Sobin L., Aronin N., DiFiglia M.
RT Polyglutamine expansion in huntingtin alters its interaction with phospholipids.
RL J. Neurochem 110:1585-1597 (2009).
RN [9]; RE0024211.
RX PUBMED: 11675509.
RA Kim Y. J., Yi Y., Sapp E., Wang Y., Cuiffo B., Kegel K. B., Qin Z. H., Aronin N., DiFiglia M.
RT Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.
RL Proc. Natl. Acad. Sci. USA 98:12784-12789 (2001).
RN [10]; RE0024246.
RX PUBMED: 11319238.
RA Sun Y., Savanenin A., Reddy P. H., Liu Y. F.
RT Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95.
RL J. Biol. Chem. 276:24713-24718 (2001).
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