AC T06124
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ID T06124
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DT 08.09.2004 (created); asili.
DT 06.09.2015 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA REST
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SY neural-restrictive silencer factor; NRSF; RE1-silencing transcription factor; REST; XBR.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G009401 REST; HGNC: REST.
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CL C0001; CH; 2.3.4.0.27.
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SF there are two alternative products known, REST form 2 T01973 and REST form 1T01974;
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CP HB1.F3, SHSY5Y, C17.2, C6 and HEK293 [3]; Keratinocytes, epidermis [4]; HeLa, PTA, C5, P19, P19 (RA), PC12 [5].
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FF repressor of neural and non-neural genes [1];
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IN T28743 Hp1-gamma; human, Homo sapiens.
IN T25621 huntingtin; human, Homo sapiens.
IN T02338 Sp3; human, Homo sapiens.
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MX M00325 V$NRSE_B.
MX M00256 V$NRSF_01.
MX M01028 V$NRSF_Q4.
MX M01256 V$REST_01.
MX M04695 V$REST_04.
MX M04702 V$REST_05.
MX M04726 V$REST_06.
MX M04853 V$REST_10.
MX M04926 V$REST_12.
MX M03883 V$REST_Q5.
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BS R07754.
BS R15658.
BS R15657.
BS R40970.
BS R15673.
BS R56891.
BS R40692.
BS R40693.
BS R56888.
BS R15656.
BS R15625.
BS R15666.
BS R71688.
BS R65114.
BS R40968.
BS R40972.
BS R40973.
BS R15660.
BS R15609.
BS R69538.
BS R21266.
BS R21250.
BS R21282.
BS R63840.
BS R38384.
BS R62628.
BS R57891.
BS R15652.
BS R29222.
BS R21149.
BS R21152.
BS R21153.
BS R62636.
BS R15662.
BS R34870.
BS R15610.
BS R21318.
BS R40966.
BS R15627.
BS R15665.
BS R15664.
BS R14827.
BS R15635.
BS R22156.
BS R15605.
BS R22157.
BS R21270.
BS R21269.
BS R21271.
BS R21268.
BS R22646.
BS R15663.
BS R15655.
BS R40971.
BS R15661.
BS R15654.
BS R15608.
BS R15659.
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DR TRANSPATH: MO000041817.
DR UniProtKB: Q13127;
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RN [1]; RE0024698.
RX PUBMED: 9756936.
RA Thiel G., Lietz M., Cramer M.
RT Biological activity and modular structure of RE-1-silencing transcription factor (REST), a repressor of neuronal genes.
RL J. Biol. Chem. 273:26891-26899 (1998).
RN [2]; RE0047003.
RX PUBMED: 15200951.
RA Roopra A., Qazi R., Schoenike B., Daley T. J., Morrison J. F.
RT Localized domains of G9a-mediated histone methylation are required for silencing of neuronal genes
RL Mol. Cell 14:727-38 (2004).
RN [3]; RE0049879.
RX PUBMED: 16764822.
RA Kim S. M., Yang J. W., Park M. J., Lee J. K., Kim S. U., Lee Y. S., Lee M. A.
RT Regulation of human tyrosine hydroxylase gene by neuron-restrictive silencer factor.
RL Biochem. Biophys. Res. Commun. 346:426-435 (2006).
RN [4]; RE0050015.
RX PUBMED: 16330548.
RA Kurschat P., Bielenberg D., Rossignol-Tallandier M., Stahl A., Klagsbrun M.
RT Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration.
RL J. Biol. Chem. 281:2721-2729 (2006).
RN [5]; RE0032729.
RX PUBMED: 10640675.
RA Okamoto S., Sherman K., Lipton S. A.
RT Absence of binding activity of neuron-restrictive silencer factor is necessary, but not sufficient for transcription of NMDA receptor subunit type 1 in neuronal cells.
RL Brain Res. Mol. Brain Res. 74:44-54 (1999).
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