AC T02328
XX
ID T02328
XX
DT 15.01.1998 (created); ewi.
DT 06.08.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA TAFII135
XX
SY FLJ41943; hTAF(II)130; RP5-1107C24.1; TAF(II)135; TAF-135; TAF130; TAF2C; TAF2C1; TAF4; TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa; TAF4A; TAFII130; TAFII135; TBP-associated factor 130; TBP-associated factor 135; TBP-associated factor 4.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006780 TAF4; HGNC: TAF4.
XX
HO dTAF(II)110 (Drosophila).
XX
SZ 1083 AA; 109.9 kDa (cDNA) (calc.).
XX
SQ MAAGSDLLDEVFFNSEVDEKVVSDLVGSLESQLAASAAHHHHLAPRTPEVRAAAAGALGN
SQ HVVSGSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPA
SQ PPAAKLRPPPEGSAGACAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGPGPGPGPGP
SQ GPGPGKPAGPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPP
SQ FVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAVPPPAA
SQ AQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLA
SQ ASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGLPKGAAGAVTQSLSRTPTATTSG
SQ IRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVRSENGQLLMIPQQALAQMQAQAHA
SQ QPQTTMAPRPATPTSAPPVQISTVQAPGTPIIARQVTPTTIIKQVSQAQTTVQPSATLQR
SQ SPGVQPQLVLGGAAQTASLGTATAVQTGTPQRTVPGATTTSSAATETMENVKKCKNFLST
SQ LIKLASSGKQSTETAANVKELVQNLLDGKIEAEDFTSRLYRELNSSPQPYLVPFLKRSLP
SQ ALRQLTPDSAAFIQQSQQQPPPPTSQATTALTAVVLSSSVQRTAGKTAATVTSALQPPVL
SQ SLTQPTQVGVGKQGQPTPLVIQQPPKPGALIRPPQVTLTQTPMVALRQPHNRIMLTTPQQ
SQ IQLNPLQPVPVVKPAVLPGTKALSAVSAQAAAAQKNKLKEPGGGSFRDDDDINDVASMAG
SQ VNLSEESARILATNSELVGTLTRSCKDETFLLQAPLQRRILEIGKKHGITELHPDVVSYV
SQ SHATQQRLQNLVEKISETAQQKNFSYKDDDRYEQASDVRAQLKFFEQLDQIEKQRKDEQE
SQ REILMRAAKSRSRQEDPEQLRLKQKAKEMQQQELAQMRQRDANLTALAAIGPRKKRKVDC
SQ PGPGSGAEGSGPGSVVPGSSGVGTPRQFTRQRITRVNLRDLIFCLENERETSHSLLLYKA
SQ FLK
XX
SC SPTREMBL #O00268
XX
FT 2 911 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 588 685 
PF07531; NHR1 homology to TAF.
FT 588 685 
PS51119; TAFH.
FT 590 682 
SM00549; nervy_1.
FT 713 804 
required for coactivator activity [1].
FT 832 1083 
PF05236; Transcription initiation factor TFIID compon.
XX
SF two conserved regions among TAFII135, TAF(II)110 and TAF(II)105 [1];
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FF component of TFIID complex [1];
FF by facilitating recruitment of TFIID, it mediates trans-activation by AF-2 function of RAR, T3R, and VDR, but not of ER or RXR [1];
FF co-activator for NFATp [2];
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IN T25621 huntingtin; human, Homo sapiens.
IN T01948 NFATc2; human, Homo sapiens.
IN T00759 Sp1; human, Homo sapiens.
IN T02116 TAF2J; human, Homo sapiens.
IN T00784 TAFII100; human, Homo sapiens.
IN T02328 TAFII135; human, Homo sapiens.
IN T00781 TAFII250-isoform2; human, Homo sapiens.
IN T00794 TBP; human, Homo sapiens.
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DR TRANSPATH: MO000033529.
DR EMBL: Y11354;
DR UniProtKB: O00268;
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RN [1]; RE0005875.
RX PUBMED: 9192867.
RA Mengus G., May M., Carre L., Chambon P., Davidson I.
RT Human TAFII135 potentiates transcriptional activation by the AF-2s of the retinoic acid, vitamin D3, and thyroid hormone receptors in mammalian cells
RL Genes Dev. 11:1381-1395 (1997).
RN [2]; RE0024034.
RX PUBMED: 11313476.
RA Kim L. J., Seto A. G., Nguyen T. N., Goodrich J. A.
RT Human Taf(II)130 is a coactivator for NFATp.
RL Mol. Cell. Biol. 21:3503-3513 (2001).
XX
//