AC T00784
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ID T00784
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DT 14.04.1993 (created); ewi.
DT 08.01.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA TAFII100
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SY TAF(II)100; TAF(II)95; TAF-100; TAF-95; TAF2D; TAF5; TBP-associated factor 250.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006781 TAF5; HGNC: TAF5.
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HO TAF(II)80 (Drosophila), TAF(II)90 (yeast).
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SF TAFII250-isoform2, TAFII100 and TAFII28 are human coreTAF(II)s common to both TFIIDalpha and TFIIDbeta complexes [7];
SF 44% identical, 65% similar with Drosophila TAF(II)80, 39% identical, 57% similar with yeast TAF(II)90 [3];
SF interacts with several other TAFs and, weakly, with TBP [3];
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FF part of TFIID (D-TFIID) complex [2];
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IN T02116 TAF2J; human, Homo sapiens.
IN T02328 TAFII135; human, Homo sapiens.
IN T02117 TAFII18; human, Homo sapiens.
IN T00781 TAFII250-isoform2; human, Homo sapiens.
IN T08956 TAFII250; human, Homo sapiens.
IN T02114 TAFII28; human, Homo sapiens.
IN T02118 TAFII30; human, Homo sapiens.
IN T02113 TAFII31; human, Homo sapiens.
IN T00782 TAFII55; human, Homo sapiens.
IN T09103 TAFII70; human, Homo sapiens.
IN T00794 TBP; human, Homo sapiens.
IN T00797 TBP; fruit fly, Drosophila melanogaster.
IN T02169 TFIIF-beta; human, Homo sapiens.
IN T01038 TFIIF; human, Homo sapiens.
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DR TRANSPATH: MO000025170.
DR UniProtKB: Q15542;
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RN [1]; RE0000746.
RX PUBMED: 1398073.
RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J.
RT Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter
RL Genes Dev. 6:1964-1974 (1992).
RN [2]; RE0002495.
RX PUBMED: 1387711.
RA Timmers H. T. M., Meyers R. E., Sharp P. A.
RT Composition of transcription factor B-TFIID
RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992).
RN [3]; RE0005507.
RX PUBMED: 8758937.
RA Dubrovskaya V., Lavigne A.-C., Davidson I., Acker J., Staub A., Tora L.
RT Distinct domains of hTAFII100 are requireed for functional interactions with transcription factor TFIIbeta (RAP30) and incorporation into the TFIID complex
RL EMBO J. 15:3702-3712 (1996).
RN [4]; RE0005559.
RX PUBMED: 8436290.
RA Zhou Q., Boyer T. G., Berk A. J.
RT Factors (TAFs) required for activated transcription interact with TATA box-binding protein conserved core domain
RL Genes Dev. 7:180-187 (1993).
RN [5]; RE0048322.
RX PUBMED: 15899866.
RA Frontini M., Soutoglou E., Argentini M., Bole-Feysot C., Jost B., Scheer E., Tora L.
RT TAF9b (formerly TAF9L) is a bona fide TAF that has unique and overlapping roles with TAF9.
RL Mol. Cell. Biol. 25:4638-4649 (2005).
RN [6]; RE0049459.
RX PUBMED: 15637059.
RA Boyer-Guittaut M., Birsoy K., Potel C., Elliott G., Jaffray E., Desterro J. M., Hay R. T., Oelgeschlager T.
RT SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5.
RL J. Biol. Chem. 280:9937-9945 (2005).
RN [7]; RE0005528.
RX PUBMED: 7729427.
RA Mengus G., May M., Jacq X., Staub A., Tora L., Chambon P., Davidson I.
RT Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID
RL EMBO J. 14:1520-1531 (1995).
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