TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T02169 XX ID T02169 XX DT 02.06.1997 (created); hiwi. DT 29.11.2006 (updated); din. CO Copyright (C), QIAGEN. XX FA TFIIF-beta XX SY RAP30. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003986 GTF2F2; HGNC: GTF2F2. XX HO F5b (Drosophila). XX SF some sequence homology with bacterial initiation factors, in particular with region 4 of sigmaK of B. subtilis [4] [10]; SF like sigma factors, TFIIF-beta contains a cryptic DNA-binding activity in its C-terminal region [10]; SF immediately N-terminally adjacent region is involved in interactions with RNA polymerase II and plays a role in transcription elongation [4]; SF either Ser-135, 136, or -142 is protected from phosphorylation by binding to polymerase II [4]; SF the beta-subunit also interacts with E. coli polymerase in a manner that is competitive with sigma70 [4]; XX CP (HeLa). XX FF responsible for polymerase recruitment [5] [7]; FF responsible for the transcription initiation function of the holo-TFIIF [8]; XX IN T02734 DSIF-p160; human, Homo sapiens. IN T16713 MEF-2C; human, Homo sapiens. IN T00784 TAFII100; human, Homo sapiens. IN T00818 TFIIB; human, Homo sapiens. IN T02168 TFIIF-alpha; human, Homo sapiens. XX BS R00996. BS R01002. BS R03170. XX DR TRANSPATH: MO000026208. DR UniProtKB: P13984; XX RN [1]; RE0005507. RX PUBMED: 8758937. RA Dubrovskaya V., Lavigne A.-C., Davidson I., Acker J., Staub A., Tora L. RT Distinct domains of hTAFII100 are requireed for functional interactions with transcription factor TFIIbeta (RAP30) and incorporation into the TFIID complex RL EMBO J. 15:3702-3712 (1996). RN [2]; RE0005742. RX PUBMED: 2477704. RA Sopta M., Burton Z. F., Greenblatt J. RT Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II RL Nature 341:410-414 (1989). RN [3]; RE0005743. RX PUBMED: 1840667. RA Horikoshi M., Fujita H., Wang J., Takada R., Roeder R. G. RT Nucleotide and amino acid sequences of RAP30 RL Nucleic Acids Res. 19:5436-5436 (1991). RN [4]; RE0005748. RX PUBMED: 1652156. RA McCracken S., Greenblatt J. RT Related RNA polymerase-binding regions in human RAP30/74 and Escherichia coli sigma70 RL Science 253:900-902 (1991). RN [5]; RE0005749. RX PUBMED: 1946469. RA Flores O., Lu H., Killeen M., Greenblatt J., Burton Z. F., Reinberg D. RT The small subunit of transcription factor IIF recruits RNA polymerase II into the preinitiation complex RL Proc. Natl. Acad. Sci. USA 88:9999-10003 (1991). RN [6]; RE0005750. RX PUBMED: 2180931. RA Flores O., Ha I., Reinberg D. RT Factors involved in specific transcription by mammalian RNA polymerase II. Purification and subunit composition of transcription factor IIE RL J. Biol. Chem. 265:5629-5634 (1990). RN [7]; RE0005752. RX PUBMED: 1729606. RA Killeen M. T., Greenblatt J. F. RT The general transcription factor RAP30 binds to RNA polymerase II and prevents it from binding nonspecifically to DNA RL Mol. Cell. Biol. 12:30-37 (1992). RN [8]; RE0005753. RX PUBMED: 8376403. RA Chang C.-H., Kostrub C. F., Burton Z. F. RT RAP30/74 (transcription factor IIF) is required for promoter escape by RNA polymerase II RL J. Biol. Chem. 268:20482-20489 (1993). RN [9]; RE0005754. RX PUBMED: 8441635. RA Yonaha M., Aso T., Kobayashi Y., Vasavada H., Yasukochi Y., Weissman S. M., Kitajima S. RT Domain structure of a human general transcription initiation factor, TFIIF RL Nucleic Acids Res. 21:273-279 (1993). RN [10]; RE0005755. RX PUBMED: 7937895. RA Tan S., Garrett K. P., Conaway R. C., Conaway J. W. RT Cryptic DNA-binding domain in the C terminus of RNA polymerase II general transcription factor RAP30 RL Proc. Natl. Acad. Sci. USA 91:9808-9812 (1994). XX //