AC T02169
XX
ID T02169
XX
DT 02.06.1997 (created); hiwi.
DT 29.11.2006 (updated); din.
CO Copyright (C), QIAGEN.
XX
FA TFIIF-beta
XX
SY RAP30.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
XX
GE G003986 GTF2F2; HGNC: GTF2F2.
XX
HO F5b (Drosophila).
XX
SF some sequence homology with bacterial initiation factors, in particular with region 4 of sigmaK of B. subtilis [4] [10];
SF like sigma factors, TFIIF-beta contains a cryptic DNA-binding activity in its C-terminal region [10];
SF immediately N-terminally adjacent region is involved in interactions with RNA polymerase II and plays a role in transcription elongation [4];
SF either Ser-135, 136, or -142 is protected from phosphorylation by binding to polymerase II [4];
SF the beta-subunit also interacts with E. coli polymerase in a manner that is competitive with sigma70 [4];
XX
CP (HeLa).
XX
FF responsible for polymerase recruitment [5] [7];
FF responsible for the transcription initiation function of the holo-TFIIF [8];
XX
IN T02734 DSIF-p160; human, Homo sapiens.
IN T16713 MEF-2C; human, Homo sapiens.
IN T00784 TAFII100; human, Homo sapiens.
IN T00818 TFIIB; human, Homo sapiens.
IN T02168 TFIIF-alpha; human, Homo sapiens.
XX
BS R00996.
BS R01002.
BS R03170.
XX
DR TRANSPATH: MO000026208.
DR UniProtKB: P13984;
XX
RN [1]; RE0005507.
RX PUBMED: 8758937.
RA Dubrovskaya V., Lavigne A.-C., Davidson I., Acker J., Staub A., Tora L.
RT Distinct domains of hTAFII100 are requireed for functional interactions with transcription factor TFIIbeta (RAP30) and incorporation into the TFIID complex
RL EMBO J. 15:3702-3712 (1996).
RN [2]; RE0005742.
RX PUBMED: 2477704.
RA Sopta M., Burton Z. F., Greenblatt J.
RT Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II
RL Nature 341:410-414 (1989).
RN [3]; RE0005743.
RX PUBMED: 1840667.
RA Horikoshi M., Fujita H., Wang J., Takada R., Roeder R. G.
RT Nucleotide and amino acid sequences of RAP30
RL Nucleic Acids Res. 19:5436-5436 (1991).
RN [4]; RE0005748.
RX PUBMED: 1652156.
RA McCracken S., Greenblatt J.
RT Related RNA polymerase-binding regions in human RAP30/74 and Escherichia coli sigma70
RL Science 253:900-902 (1991).
RN [5]; RE0005749.
RX PUBMED: 1946469.
RA Flores O., Lu H., Killeen M., Greenblatt J., Burton Z. F., Reinberg D.
RT The small subunit of transcription factor IIF recruits RNA polymerase II into the preinitiation complex
RL Proc. Natl. Acad. Sci. USA 88:9999-10003 (1991).
RN [6]; RE0005750.
RX PUBMED: 2180931.
RA Flores O., Ha I., Reinberg D.
RT Factors involved in specific transcription by mammalian RNA polymerase II. Purification and subunit composition of transcription factor IIE
RL J. Biol. Chem. 265:5629-5634 (1990).
RN [7]; RE0005752.
RX PUBMED: 1729606.
RA Killeen M. T., Greenblatt J. F.
RT The general transcription factor RAP30 binds to RNA polymerase II and prevents it from binding nonspecifically to DNA
RL Mol. Cell. Biol. 12:30-37 (1992).
RN [8]; RE0005753.
RX PUBMED: 8376403.
RA Chang C.-H., Kostrub C. F., Burton Z. F.
RT RAP30/74 (transcription factor IIF) is required for promoter escape by RNA polymerase II
RL J. Biol. Chem. 268:20482-20489 (1993).
RN [9]; RE0005754.
RX PUBMED: 8441635.
RA Yonaha M., Aso T., Kobayashi Y., Vasavada H., Yasukochi Y., Weissman S. M., Kitajima S.
RT Domain structure of a human general transcription initiation factor, TFIIF
RL Nucleic Acids Res. 21:273-279 (1993).
RN [10]; RE0005755.
RX PUBMED: 7937895.
RA Tan S., Garrett K. P., Conaway R. C., Conaway J. W.
RT Cryptic DNA-binding domain in the C terminus of RNA polymerase II general transcription factor RAP30
RL Proc. Natl. Acad. Sci. USA 91:9808-9812 (1994).
XX
//