AC T02168
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ID T02168
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DT 02.06.1997 (created); hiwi.
DT 14.12.2009 (updated); sla.
CO Copyright (C), QIAGEN.
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FA TFIIF-alpha
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SY GTF2F1; RAP74; TFIIF-alpha; transcription initiation factor IIF, alpha subunit.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006186 GTF2F1; HGNC: GTF2F1.
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HO F5a (Drosophila).
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SF associates with TFIIF-beta/RAP30 to TFIIF heterodimers and, presumably, heterotetramers [7];
SF the central region exhibits alternating acidic and basic clusters which may account for the abnormal migration behavior in electrophoresis [5] [6];
SF mediates interaction of TFIIF with some upstream factors such as SRF for which the charged region is important, in particular the region 291-437 [2] [4];
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CP (HeLa).
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FF important for TFIIF activity during very early transcription elongation [9];
FF phosphorylation of TFIIF-alpha increases its transcription activation capability 5-7-fold [3];
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IN T02725 cdk9; human, Homo sapiens.
IN T28752 RPB1; human, Homo sapiens.
IN T00764 SRF; human, Homo sapiens.
IN T00781 TAFII250-isoform2; human, Homo sapiens.
IN T00783 TAFII70-alpha; human, Homo sapiens.
IN T02208 TAFII70-gamma; human, Homo sapiens.
IN T00818 TFIIB; human, Homo sapiens.
IN T02169 TFIIF-beta; human, Homo sapiens.
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BS R00996.
BS R01002.
BS R03170.
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DR TRANSPATH: MO000013300.
DR EMBL: X64002;
DR EMBL: X64037;
DR UniProtKB: P35269;
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RN [1]; RE0005590.
RX PUBMED: 7590250.
RA Ruppert S., Tjian R.
RT Human TAFII250 interacts with RAP74: implications for RNA polymerase II initiation
RL Genes Dev. 9:2747-2755 (1995).
RN [2]; RE0005736.
RX PUBMED: 8106390.
RA Zhu H., Joliot V., Prywes R.
RT Role of transcription factor TRIIF in serum response factor-activated transcription
RL J. Biol. Chem. 269:3489-3497 (1994).
RN [3]; RE0005737.
RX PUBMED: 7961996.
RA Kitajima S., Chibazakura T., Yonaha M., Yasukochi Y.
RT Regulation of the human general transcription initiation factor TFIIF by phosphorylation
RL J. Biol. Chem. 269:29970-29977 (1994).
RN [4]; RE0005739.
RX PUBMED: 7854423.
RA Joliot V., Demma M., Prywes R.
RT Interaction with RAP74 subunit of TFIIF is required for transcriptional activation by serum response factor
RL Nature 373:632-635 (1995).
RN [5]; RE0005740.
RX PUBMED: 1734283.
RA Aso T., Vasavada H. A., Kawaguchi T., Germino F. J., Ganguly S., Kitajima S., Weissman S. M., Yasukochi Y.
RT Characterization of cDNA for the large subunit of the transcription initiation factor TFIIF
RL Nature 335:461-464 (1992).
RN [6]; RE0005741.
RX PUBMED: 1734284.
RA Finkelstein A., Kostrub C. F., Li J., Chavez D. P., Wang B. Q., Fang S. M., Greenblatt J., Burton Z. F.
RT A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II
RL Nature 355:464-467 (1992).
RN [7]; RE0005750.
RX PUBMED: 2180931.
RA Flores O., Ha I., Reinberg D.
RT Factors involved in specific transcription by mammalian RNA polymerase II. Purification and subunit composition of transcription factor IIE
RL J. Biol. Chem. 265:5629-5634 (1990).
RN [8]; RE0005751.
RX PUBMED: 2395645.
RA Kitajima S., Tanaka Y., Kawagachi T., Nagaoka T., Weissman S. M., Yasukochi Y.
RT A heteromeric transcription factor required for mammalian RNA polymerase II
RL Nucleic Acids Res. 18:4843-4849 (1990).
RN [9]; RE0005753.
RX PUBMED: 8376403.
RA Chang C.-H., Kostrub C. F., Burton Z. F.
RT RAP30/74 (transcription factor IIF) is required for promoter escape by RNA polymerase II
RL J. Biol. Chem. 268:20482-20489 (1993).
RN [10]; RE0005754.
RX PUBMED: 8441635.
RA Yonaha M., Aso T., Kobayashi Y., Vasavada H., Yasukochi Y., Weissman S. M., Kitajima S.
RT Domain structure of a human general transcription initiation factor, TFIIF
RL Nucleic Acids Res. 21:273-279 (1993).
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