AC T00783
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ID T00783
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DT 14.04.1993 (created); ewi.
DT 06.08.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA TAFII70-alpha
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SY TAF(II)78; TAF(II)80; TAF-70; TAF-80; TBP-associated factor 70 alpha.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G004667 TAF6; HGNC: TAF6.
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HO TAF(II)60 (Drosophila).
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SZ 677 AA; 72.7 kDa (cDNA) (calc.), 70 kDa (SDS) [3] [2], 80 kDa (SDS) [4] [4] [3] [2]
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SQ MAEEKKLKLSNTVLPSESMKVVAESMGIAQIQEETCQLLTDEVSYRIKEIAQDALKFMHM
SQ GKRQKLTTSDIDYALKLKNVEPLYGFHAQEFIPFRFASGGGRELYFYEEKEVDLSDIINT
SQ PLPRVPLDVCLKAHWLSIEGCQPAIPENPPPAPKEQQKAEATEPLKSAKPGQEEDGPLKG
SQ KGQGATTADGKGKEKKAPPLLEGAPLRLKPRSIHELSVEQQLYYKEITEACVGSCEAKRA
SQ EALQSIATDPGLYQMLPRFSTFISEGVRVNVVQNNLALLIYLMRMVKALMDNPTLYLEKY
SQ VHELIPAVMTCIVSRQLCLRPDVDNHWALRDFAARLVAQICKHFSTTTNNIQSRITKTFT
SQ KSWVDEKTPWTTRYGSIAGLAELGHDVIKTLILPRLQQEGERIRSVLDGPVLSNIDRIGA
SQ DHVQSLLLKHCAPVLAKLRPPPDNQDAYRAEFGSLGPLLCSQVVKARAQAALQAQQVNRT
SQ TLTITQPRPTLTLSQAPQPGPRTPGLLKVPGSIALPVQTLVSARAAAPPQPSPPPTKFIV
SQ MSSSSSAPSTQQVLSLSTSAPGSGSTTTSPVTTTVPSVQPIVKLVSTATTAPPSTAPSGP
SQ GSVQKYIVVSLPPTGEGKGGPTSHPSPVPPPASSPSPLSGSALCGGKQEAGDSPPPAPGT
SQ PKANGSQPNSGSPQPAP
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SC Swiss-Prot#P49848-1
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FT 1 100 
binding to TAF(II)31 and TAF(II)20 [4].
FT 12 78 
PF02969; TATA box binding protein associated factor (.
FT 15 78 
PS50028; HIST_TAF.
FT 82 458 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 203 276 
binding to TAF(II)250 and TFIIF-alpha [4].
FT 304 402 
PF07571; Protein of unknown function (DUF1546).
FT 377 505 
binding to TBP and TFIIE-alpha [4].
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SF splice variants are TAF(II)-beta T02209 and -gamma T02208 [3];
SF calculated pI = 9.1 [3];
SF weak interaction with TBP, strong interaction with TAF(II)250 [3];
SF no interaction with TFIIB, TFIIE-beta, TFIIF-beta [4];
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FF part of TFIID complex D-TFIID [3] [2];
FF interacts with the acidic activation domain of CIITA T05450 thus mediating CIITA interactions with the basal transcription complex [5];
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IN T05450 C2TA; human, Homo sapiens.
IN T02116 TAF2J; human, Homo sapiens.
IN T00781 TAFII250-isoform2; human, Homo sapiens.
IN T02118 TAFII30; human, Homo sapiens.
IN T02113 TAFII31; human, Homo sapiens.
IN T02125 TAFII40; fruit fly, Drosophila melanogaster.
IN T00794 TBP; human, Homo sapiens.
IN T02162 TFIIE-alpha; human, Homo sapiens.
IN T02168 TFIIF-alpha; human, Homo sapiens.
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DR TRANSPATH: MO000025169.
DR EMBL: L25444;
DR EMBL: U31659;
DR UniProtKB: P49848-1;
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RN [1]; RE0000746.
RX PUBMED: 1398073.
RA Zhou Q., Lieberman P. M., Boyer T. G., Berk A. J.
RT Holo-TFIID supports transcriptional stimulation by diverse activators and from a TATA-less promoter
RL Genes Dev. 6:1964-1974 (1992).
RN [2]; RE0002495.
RX PUBMED: 1387711.
RA Timmers H. T. M., Meyers R. E., Sharp P. A.
RT Composition of transcription factor B-TFIID
RL Proc. Natl. Acad. Sci. USA 89:8140-8144 (1992).
RN [3]; RE0005560.
RX PUBMED: 8262073.
RA Weinzierl R. O. J., Ruppert S., Dynlacht B. D., Tanese N., Tjian R.
RT Cloning and expression of Drosophila TAFII60 and human TAFII70 reveal conserved interactions with other subunits of TFIID
RL EMBO J. 12:5303-5309 (1993).
RN [4]; RE0005591.
RX PUBMED: 7667268.
RA Hisatake K., Ohta T., Takada R., Guermah M., Horikoshi M., Nakatani Y., Roeder R. G.
RT Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors
RL Proc. Natl. Acad. Sci. USA 92:8195-8199 (1995).
RN [5]; RE0022568.
RX PUBMED: 9177216.
RA Mahanta S. K., Scholl T., Yang F. C., Strominger J. L.
RT Transactivation by CIITA, the type II bare lymphocyte syndrome-associated factor, requires participation of multiple regions of the TATA box binding protein.
RL Proc. Natl. Acad. Sci. USA 94:6324-6329 (1997).
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