AC T02116
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ID T02116
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DT 21.05.1997 (created); hiwi.
DT 07.01.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA TAF2J
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SY TAF-20; TAF12; TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa; TAF2J; TAFII20; TBP-associated factor 20.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003981 TAF12; HGNC: TAF12.
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HO TAF(II)30-alpha/p22 (Drosophila).
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SF no interaction with either TAF(II)28 or TAF(II)18 in vitro, but appears to be associated with TAF(II)28 in vivo [2];
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FF part of TFIID complex [2] [4];
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IN T14184 Cdx-1; mouse, Mus musculus.
IN T00784 TAFII100; human, Homo sapiens.
IN T17974 TAFII105; human, Homo sapiens.
IN T02328 TAFII135; human, Homo sapiens.
IN T02114 TAFII28; human, Homo sapiens.
IN T02118 TAFII30; human, Homo sapiens.
IN T00782 TAFII55; human, Homo sapiens.
IN T00783 TAFII70-alpha; human, Homo sapiens.
IN T02208 TAFII70-gamma; human, Homo sapiens.
IN T08520 TBP-isoform1; human, Homo sapiens.
IN T00794 TBP; human, Homo sapiens.
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DR TRANSPATH: MO000026176.
DR UniProtKB: Q16514;
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RN [1]; RE0005507.
RX PUBMED: 8758937.
RA Dubrovskaya V., Lavigne A.-C., Davidson I., Acker J., Staub A., Tora L.
RT Distinct domains of hTAFII100 are requireed for functional interactions with transcription factor TFIIbeta (RAP30) and incorporation into the TFIID complex
RL EMBO J. 15:3702-3712 (1996).
RN [2]; RE0005528.
RX PUBMED: 7729427.
RA Mengus G., May M., Jacq X., Staub A., Tora L., Chambon P., Davidson I.
RT Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID
RL EMBO J. 14:1520-1531 (1995).
RN [3]; RE0005529.
RX PUBMED: 8598932.
RA Hoffmann A., Chiang C.-M., Oelgeschlaeger T., Xie X., Burley S. K., Nakatani Y., Roeder R. G.
RT A histone octamer-like structure within TFIID
RL Nature 380:356-359 (1996).
RN [4]; RE0005591.
RX PUBMED: 7667268.
RA Hisatake K., Ohta T., Takada R., Guermah M., Horikoshi M., Nakatani Y., Roeder R. G.
RT Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors
RL Proc. Natl. Acad. Sci. USA 92:8195-8199 (1995).
RN [5]; RE0005594.
RX PUBMED: 8663456.
RA Hoffmann A., Roeder R. G.
RT Cloning and characterization of human TAF20/15: Multiple interactions suggest a central role in TFIID complex formation
RL J. Biol. Chem. 271:18194-18202 (1996).
RN [6]; RE0005595.
RX PUBMED: 8647459.
RA Choi B., Bando M., Hasegawa S., Horikoshi M.
RT Isolation and characterization of a cDNA encoding a novel human transcription factor TFIID subunit containing similarities with histone H2B and H3
RL Gene 169:263-267 (1996).
RN [7]; RE0049459.
RX PUBMED: 15637059.
RA Boyer-Guittaut M., Birsoy K., Potel C., Elliott G., Jaffray E., Desterro J. M., Hay R. T., Oelgeschlager T.
RT SUMO-1 modification of human transcription factor (TF) IID complex subunits: inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5.
RL J. Biol. Chem. 280:9937-9945 (2005).
RN [8]; RE0052321.
RX PUBMED: 17158164.
RA Calon A., Gross I., Davidson I., Kedinger M., Duluc I., Domon-Dell C., Freund J. N.
RT Functional interaction between the homeoprotein CDX1 and the transcriptional machinery containing the TATA-binding protein.
RL Nucleic Acids Res. 35:175-185 (2007).
RN [9]; RE0064710.
RX PUBMED: 15932940.
RA Palhan V. B., Chen S., Peng G. H., Tjernberg A., Gamper A. M., Fan Y., Chait B. T., La Spada A. R., Roeder R. G.
RT Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration.
RL Proc. Natl. Acad. Sci. USA 102:8472-8477 (2005).
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