TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T00764 AS T00672. XX ID T00764 XX DT 15.10.1992 (created); ewi. DT 07.04.2015 (updated); pro. CO Copyright (C), QIAGEN. XX FA SRF XX SY CArG-binding factor; p67; p67SRF; serum response factor; Serum Responsive Factor; SRF. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003938 SRF; HGNC: SRF. XX HO EBF, factor 1 (mouse). XX CL C0014; MADS; XX SF binds DNA as a homodimer [4]; SF crystal structure of DNA-binding domain (132-223) and DNA (SRE): two antiparallel amphipathic alpha-helices (alpha-I), arranged as coiled coil, approximately parallel on the minor groove of the A/T-rich center [37]; SF helices make minor and major groove contacts, N-terminal extension form minor groove contacts [37]; SF bound DNA is bent, wrapped around the protein [63]; SF upon SRF binding to its DNA sites, minor groove is compressed in the center, widened minor groove in the flanks [37]; SF DNA-binding specificity is located N-terminally to the MADS box [25]; SF truncation of these sequences plus point mutation K154E imprints same binding specificity as for RSRFC4 [25]; SF G142E imprints MCM1-like DNA-binding specificity [27]; SF X-ray structure of the Sap1-SRF-SRE ternary complex is determined [68]; SF cooperation with ternary complex factor (TCF) enhances DNA-binding 50-fold [4]; SF flexible orientation and spacing of both SRF- and TCF-contact sites [7]; SF crucial for TCF-binding: AA 198, 200, 203 [8]; SF N-terminal modification by N-acetylglucosamine [4]; SF phosphorylation enhances DNA-binding up to 13-fold due to an altered conformation of the DBD [17]; SF additional multiple phosphorylation at Ser-77, -79, -83, -85, -103 [31]; SF main impact of phosphorylation at 77-85 is enhanced association/dissociation kinetics of DNA-binding [30]; SF phosphorylation of Ser-103 affects thermodynamic features of DNA-binding [31]; SF phosphorylation may be done by a growth factor-inducible ribosomal S6 kinase pp90rsk [42]; SF Ser-253 phosphorylation by CKII affects transcriptional repression by SRF [32]; SF activation domain required in 3T3 cells (414-508) is smaller than that for HeLa cells (339-508) [34]; SF possibly two inhibitory domains [34]; SF a 4.5 kb transcript was observed in Ramos, BL2, E418, IARC-EW17, Saos, HeLa, Jurkat, K562 cell lines [56]; SF Barx2b T04452 interacts with dimerization domain and increases the affinity for a CArG box binding site [59]; SF residue in beta loop of the MADS-box (K53) determine the DNA binding specificity [60]; SF Elk-1 and Fli-1 bind to overlapping surfaces on SRF [67]; SF MADS box region is necessary and sufficient for physical interactions and functional cooperation with GATA-4 [58] [70]; SF DBD is important for direct interactions and functional cooperation with p35-C/EBPbeta upon stimulation with activated Ras [73]; XX CP (HeLa); chicken embryo protein (Immunoperoxidase staining): HH stage-12: abundant in myocardium and myotomal portion of anterior somites [50]. XX FF activator and repressor; FF specifically binds to CArG boxes; FF binding to serum response elements (SRE) is enhanced by p62TCF/Elk-1 T00250, SAP-1a T00737, SAP-2 T01414, EWS-FLI-1 [52] [55] [63] [64] [66] [72] [74] [39] [40] [4]; FF binding to SREs can be enhanced by Fli-1 T06078 [67]; FF binding to the c-fos SRE can be enhanced by HMG-I(Y) [62]; FF SRF and Nkx3-1 T04256 cooperatively bind to their closely situated sites in the promoter of the SMGA gene, and Nkx3-1 facilitates SRF binding to the CArG-box [57]; FF competition for DNA binding with YY1 [18]; FF YY1 binding to the serum response element (SRE) is essential to enhance SRF binding [41]; FF induces an optimal TFIID conformation for recruitment of the transcription preinitiation complex [29]; FF phosphorylation by casein kinase II most likely involves a phospholipase C-pathway [10] [28]; FF gene activation by SRF in response to serum is mediated by two pathways, only one depends on the cooperation with TCF [35]; FF both are sensitive to mutations in the DNA-binding domain that do not affect DNA-binding [36]; FF nuclear localization is influenced by a protein kinase A-dependent mechanism which does not involve direct SRF phosphorylation [38]; FF can be recruited to SRE via interactions with homeodomain factor Phox1 T02059 [43]; FF physical interaction between mitogen-responsive SRF and myogenic bHLH proteins exists, e.g. heterodimers of myogenin and E12 physically interact with SRF in vivo and vitro [47]; FF R157 and R164 are essential for DNA binding [49]; FF protein-protein interaction with 30 AA peptide encompassing the B-box of Elk-1 is essential for formation of the ternary complex with c-fos SRE [51] [52]; FF Elk-1 B-box adopts an alpha-helical structure for interaction with SRF [52]; FF it is proposed that phosphorylation of Thr-160 introduces a negative charge, what results in a disturbance of interaction of SRF with SRE and of dimerization [53]; FF functional cooperation with GATA-4 for induction of muscle-specific promoters [58] [70]; FF ternary complex formation with myocardin T05970 provides one of the mechanisms by which SRF regulates muscle-specific genes [65]; FF interactions with myocardin and Elk-1 are mutually exclusive [64]; FF interaction of SRF with Elk-1 (via its B-box) is required for inhibition of RhoA-actin signaling to SRF [61]; FF functionally cooperates and physically interacts with TEA-domain factor TEF-1 [69]; FF together with Nkx2.5 T01675 provided strong transcriptional activation of the avian cardiac alpha actin promoter [71]; FF SRF and Nkx2.5 overcome YY1 T00915 repression on the alpha cardiac actin promoter [71]; FF direct interactions with C/EBPbeta are important for the c-fos promoter activation [73]; XX IN T00043 Arg80p; yeast, Saccharomyces cerevisiae. IN T04452 Barx2b; mouse, Mus musculus. IN T00459 C/EBPbeta-FL; rat, Rattus norvegicus. IN T00250 Elk-1; human, Homo sapiens. IN T02066 Fli-1; human, Homo sapiens. IN T06078 Fli-1; zebra fish, Brachydanio rerio. IN T02716 GATA-4; rat, Rattus norvegicus. IN T01852 HMGIY; mouse, Mus musculus. IN T05970 myocardin-isoform1; mouse, Mus musculus. IN T01414 Net; human, Homo sapiens. IN T08563 NF-YA; Mammalia. IN T04256 NKX3A; mouse, Mus musculus. IN T02059 PMX1; human, Homo sapiens. IN T00737 SAP-1a; human, Homo sapiens. IN T02128 SAP-1b; human, Homo sapiens. IN T04217 Smad7; human, Homo sapiens. IN T00764 SRF; human, Homo sapiens. IN T00801 TCF; human, Homo sapiens. IN T01399 TCF; mouse, Mus musculus. IN T01124 TEF-1; mouse, Mus musculus. IN T17039 TEF-1; Mammalia. IN T00824 TFII-I; human, Homo sapiens. IN T02168 TFIIF-alpha; human, Homo sapiens. IN T01038 TFIIF; human, Homo sapiens. XX MX M00152 V$SRF_01. MX M01257 V$SRF_02. MX M01304 V$SRF_03. MX M04680 V$SRF_09. MX M07227 V$SRF_11. MX M00215 V$SRF_C. MX M07618 V$SRF_Q3. MX M00810 V$SRF_Q4. MX M00922 V$SRF_Q5_01. MX M01007 V$SRF_Q5_02. MX M00186 V$SRF_Q6. XX BS R03592. BS R03593. BS R03594. BS R03595. BS R03596. BS R03597. BS R03598. BS R03599. BS R03600. BS R03601. BS R03602. BS R03603. BS R03604. BS R03606. BS R03605. BS R03608. BS R16076. BS R16072. BS R39319. BS R31636. BS R67017. BS R00142. BS R00038. BS R00039. BS R00040. BS R25980. BS R66501. BS R09707. BS R26621. BS R28261. BS R14637. BS R60094. BS R36278. BS R00460. BS R36326. BS R32710. BS R31635. BS R60773. BS R66334. BS R31618. BS R27592. BS R16778. BS R00961. BS R09691. BS R73924. BS R14842. BS R31568. BS R33433. BS R00037. BS R55838. BS R20619. BS R14956. BS R16105. BS R16070. XX DR TRANSPATH: MO000013015. DR TRANSCOMPEL: C00022. DR TRANSCOMPEL: C00127. DR TRANSCOMPEL: C00270. DR TRANSCOMPEL: C00423. DR TRANSCOMPEL: C00429. DR TRANSCOMPEL: C00430. DR TRANSCOMPEL: C00431. DR TRANSCOMPEL: C00432. DR TRANSCOMPEL: C00433. DR TRANSCOMPEL: C00434. DR TRANSCOMPEL: C00436. DR TRANSCOMPEL: C00437. DR TRANSCOMPEL: C00560. DR UniProtKB: P11831; DR PDB: 1SRS. XX RN [1]; RE0000067. RX PUBMED: 3524858. RA Treisman R. RT Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors RL Cell 46:567-574 (1986). RN [2]; RE0000068. RX PUBMED: 2492906. RA Shaw P. E., Schroeter H., Nordheim A. RT The Ability of a Ternary Complex to Form Over the Serum Response Element Correlates with Serum Inducibility of the Human c-fos Promoter RL Cell 56:563-572 (1989). RN [3]; RE0000311. RX PUBMED: 3582369. RA Mohun T., Garrett N., Treisman R. RT Xenopus cytoskeletal actin and human c-fos gene promoters share a conserved protein-binding site RL EMBO J. 6:667-673 (1987). RN [4]; RE0000343. RX PUBMED: 2108863. RA Schroeter H., Mueller C. G. F., Meese K., Nordheim A. RT Synergism in ternary complex formation between the dimeric glycoprotein p67SRF, polypeptide p62TCF and the c-fos serum response element RL EMBO J. 9:1123-1130 (1990). RN [5]; RE0000418. RX PUBMED: 3119326. RA Treisman R. RT Identification and purification of a polypeptide that binds to the c-fos serum response element RL EMBO J. 6:2711-2717 (1987). RN [6]; RE0000426. RX PUBMED: 2511007. RA Shaw P. E., Frasch S., Nordheim A. RT Repression of c-fos transcription is mediated through p6SRF bound to the SRE RL EMBO J. 8:2567-2574 (1989). RN [7]; RE0000531. RX PUBMED: 1425594. RA Treisman R., Marais R., Wynne J. RT Spatial flexibility in ternary complexes between SRF and its accessory proteins RL EMBO J. 11:4631-4640 (1992). RN [8]; RE0000532. RX PUBMED: 1756729. RA Mueller C. G. F., Nordheim A. RT A protein domain conserved between yeast MCM1 and human SRF directs ternary complex formation RL EMBO J. 10:4219-4229 (1991). RN [9]; RE0000639. RX PUBMED: 3071491. RA Hayes T. E., Sengupta P., Cochran B. H. RT The human c-fos serum response factor and the yeast factors GRM/PRTF have related DNA-binding specificities RL Genes Dev. 2:1713-1722 (1988). RN [10]; RE0000770. RX PUBMED: 2200737. RA Manak J. R., de Bisschop N., Kris R. M., Prywes R. RT Casein kinase II enhances the DNA binding activity of serum response factor RL Genes Dev. 4:955-967 (1990). RN [11]; RE0000817. RX PUBMED: 3372525. RA Smith J. D., Melian A., Leff T., Breslow J. L. RT Expression of the Human Apolipoprotein E Gene is Regulated by Multiple Positive and Negative Elements RL J. Biol. Chem. 263:8300-8308 (1988). RN [12]; RE0001200. RX PUBMED: 2710114. RA Boxer L. M., Prywes R., Roeder R. G., Kedes L. RT The Sarcomeric Actin CArG-Binding Factor Is Indistinguishable from the c-fos Serum Response Factor RL Mol. Cell. Biol. 9:515-522 (1989). RN [13]; RE0001203. RX PUBMED: 2501661. RA Walsh K. RT Cross-Binding of Factors to Functionally Different Promoter Elements in c-fos and Skeletal Actin Genes RL Mol. Cell. Biol. 9:2191-2201 (1989). RN [14]; RE0001205. RX PUBMED: 3561415. RA Greenberg M. E., Siegfried Z., Ziff E. B. RT Mutation of the c-fos gene dyad symmetry element inhibits serum inducibility of transcription in vivo and the nuclear regulatory factor binding in vitro RL Mol. Cell. Biol. 7:1217-1225 (1987). RN [15]; RE0001303. RX PUBMED: 2496302. RA Chavrier P., Janssen-Timmen U., Mattei M.-G., Zerial M., Bravo R., Charnay P. RT Structure, Chromosome Location and Expression of the Mouse Zinc Finger Gene Krox-20: Multiple Gene Products and Coregulation with the Proto-Oncogene c-fos RL Mol. Cell. Biol. 9:787-797 (1989). RN [16]; RE0001393. RX PUBMED: 2513479. RA Christy B., Nathans D. RT Functional Serum Response Elements Upstream of the Growth Factor-Inducible Gene zif268 RL Mol. Cell. Biol. 9:4889-4895 (1989). RN [17]; RE0001496. RX PUBMED: 2046671. RA Manak J. R., Prywes R. RT Mutation of serum response factor phosphorylation sites and the mechanism by which its DNA-binding activity is increased by casein kinase II RL Mol. Cell. Biol. 11:3652-3659 (1991). RN [18]; RE0001687. RX PUBMED: 1508214. RA Gualberto A., LePage D., Pons G., Mader S. L., Park K., Atchison M. L., Walsh K. RT Functional antagonism between YY1 and the serum response factor RL Mol. Cell. Biol. 12:4209-4214 (1992). RN [19]; RE0001688. RX PUBMED: 8417320. RA Sharrocks A. D., Gille H., Shaw P. E. RT Identification of amino acids essential for DNA binding and dimerization in p67SRF: implications for a novel DNA-binding motif RL Mol. Cell. Biol. 13:123-132 (1993). RN [20]; RE0001867. RX PUBMED: 1722028. RA Hipskind R. A., Rao V. N., Mueller C. G. F., Reddy E. S. P., Nordheim A. RT Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF RL Nature 354:531-534 (1991). RN [21]; RE0001949. RX PUBMED: 2911466. RA Frederickson R. M., Micheau M. R., Iwamoto A., Miyamoto N. G. RT 5' flanking and first intron sequences of the human beta-actin gene required for efficient promoter activity RL Nucleic Acids Res. 17:253-270 (1989). RN [22]; RE0001974. RX PUBMED: 3320962. RA Schroeter H., Shaw P. E., Nordheim A. RT Purification of intercalator-released p67, a polypeptide that interacts specifically with the c-fos serum response element RL Nucleic Acids Res. 15:10145-10158 (1987). RN [23]; RE0001975. RX PUBMED: 2493627. RA Leung S., Miyamoto N. G. RT Point mutational analysis of the human c-fos serum response factor binding site RL Nucleic Acids Res. 17:1177 (1989). RN [24]; RE0002166. RX PUBMED: 2062642. RA Latinkic B. V., O'Brien T. P., Lau L. F. RT Promoter function and structure of the growth factor-inducible immediate early gene cyr61 RL Nucleic Acids Res. 19:3261 (1991). RN [25]; RE0002185. RX PUBMED: 8095095. RA Sharrocks A. D., von Hesler F., Shaw P. E. RT The identification of elements determining the different DNA binding specificities of the MADS box proteins p67SRF and RSRFC4 RL Nucleic Acids Res. 21:215-221 (1993). RN [26]; RE0002364. RX PUBMED: 2845402. RA Prywes R., Dutta A., Cromlish J. A., Roeder R. G. RT Phosphorylation of serum response factor, a factor that binds to the serum response element of the c-FOS enhancer RL Proc. Natl. Acad. Sci. USA 85:7206-7210 (1988). RN [27]; RE0004114. RX PUBMED: 7623803. RA Nurrish S. J., Treisman R. RT DNA binding specificity determinants in MADS-box transcription factors RL Mol. Cell. Biol. 15:4076-4085 (1995). RN [28]; RE0004128. RX PUBMED: 2169025. RA Schalasta G., Doppler C. RT Inhibition of c-fos transcription and phosphorylation of the serum response factor by an inhibitor of phospholipase C-type reactions RL Mol. Cell. Biol. 10:5558-5561 (1990). RN [29]; RE0004129. RX PUBMED: 1909174. RA Zhu H., Roy A. L., Roeder R. G., Prywes R. RT Serum response factor affects preinitiation complex formation by TFIID in vitro RL New Biol. 3:455-464 (1991). RN [30]; RE0004130. RX PUBMED: 1740119. RA Marais R. M., Hsuan J. J., McGuigan C., Wynne J., Treisman R. RT Casein kinase II phosphorylation increases the rate of serum response factor-binding site exchange RL EMBO J. 11:97-105 (1992). RN [31]; RE0004131. RX PUBMED: 1547771. RA Janknecht R., Hipskind R. A., Houthaeve T., Nordheim A., Stunnenberg H. G. RT Identification of multiple SRF N-terminal phosphorylation sites affecting DNA binding properties RL EMBO J. 11:1045-1054 (1992). RN [32]; RE0004132. RX PUBMED: 8375385. RA Janknecht R., Ernst W. H., Houthaeve T., Nordheim A. RT C-terminal phosphorylation of the serum-response factor RL Eur. J. Biochem. 216:469-475 (1993). RN [33]; RE0004133. RX PUBMED: 1531519. RA Prywes R., Zhu H. RT In vitro squelching of activated transcription by serum response factor: evidence for a common coactivator used by multiple transcriptional activators RL Nucleic Acids Res. 20:513-520 (1992). RN [34]; RE0004134. RX PUBMED: 8336707. RA Johansen F.-E., Prywes R. RT Identification of transcriptional activation and inhibitory domains in serum response factor (SRF) by using GAL4-SRF constructs RL Mol. Cell. Biol. 13:4640-4647 (1993). RN [35]; RE0004135. RX PUBMED: 8065325. RA Johansen F.-E., Prywes R. RT Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor RL Mol. Cell. Biol. 14:5920-5928 (1994). RN [36]; RE0004136. RX PUBMED: 7957108. RA Hill C. S., Wynne J., Treisman R. RT Serum-regulated transcription by Serum Response Factor (SRF): a novel role for the DNA binding domain RL EMBO J. 13:5421-5432 (1994). RN [37]; RE0004137. RX PUBMED: 7637780. RA Pellegrini L., Tan S., Richmond T. J. RT Structure of serum response factor core bound to DNA RL Nature 376:490-498 (1995). RN [38]; RE0004138. RX PUBMED: 7799952. RA Gauthier-Rouviere C., Vandromme M., Lautredou N., Cai Q. Q., Girard F., Fernandez A., Lamb N. RT The serum response factor nuclear localization signal: general implications for cyclic AMP-dependent protein kinase activity in control of nuclear tanslocation RL Mol. Cell. Biol. 15:433-444 (1995). RN [39]; RE0004468. RX PUBMED: 8668149. RA Shore P., Whitmarsh A. J., Bhaskaran R., Davis R. J., Waltho J. P., Sharrocks A. D. RT Determinants of DNA-binding specificity of ets-domain transcription factors RL Mol. Cell. Biol. 16:3338-3349 (1996). RN [40]; RE0005331. RX PUBMED: 8164681. RA Shore P., Sharrocks A. D. RT The transcriptional factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1 RL Mol. Cell. Biol. 14:3283-3291 (1994). RN [41]; RE0006768. RX PUBMED: 7565750. RA Natesan S., Gilman M. RT YY1 facilitates the association of serum response factor with the c-fos serum response element RL Mol. Cell. Biol. 15:5975-5982 (1995). RN [42]; RE0008678. RX PUBMED: 8413226. RA Rivera V. M., Miranti C. K., Misra R. P., Ginty D. D., Chen R. H., Blenis J., Greenberg M. E. RT A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA binding activity RL Mol. Cell. Biol. 13:6260-6273 (1993). RN [43]; RE0010523. RX PUBMED: 7760827. RA Grueneberg D. A., Simon K. J., Brennan K., Gilman M. RT Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins. RL Mol. Cell. Biol. 15:3318-3326 (1995). RN [44]; RE0015081. RX PUBMED: 10960789. RA Casero M., Sastre L. RT A serum response factor homologue is expressed in ectodermal tissues during development of the crustacean Artemia franciscana RL Mech. Dev. 96:229-232 (2000). RN [45]; RE0015088. RX PUBMED: 10318869. RA Heidenreich O., Neininger A., Schratt G., Zinck R., Cahill M.A., Engel K., Kotlyarov A., Kraft R., Kostka S., Gaestel M., Nordheim A. RT MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo RL J. Biol. Chem. 274:14434-14443 (1999). RN [46]; RE0015279. RX PUBMED: 3203386. RA Norman C., Runswick M., Pollock R., Treisman R. RT Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element RL Cell 55:989-1003 (1988). RN [47]; RE0015298. RX PUBMED: 8617811. RA Groisman R., Masutani H., Leibovitch M. P., Robin P., Soudant I., Trouche D., Harel-Bellan A. RT Physical interaction between the mitogen-responsive serum response factor and myogenic basic-helix-loop-helix proteins RL J. Biol. Chem. 271:5258-5264 (1996). RN [48]; RE0015299. RX PUBMED: 9553110. RA Ling Y., West A. G., Roberts E. C., Lakey J. H., Sharrocks A. D. RT Interaction of transcription factors with serum response factor. Identification of the Elk-1 binding surface RL J. Biol. Chem. 273:10506-10514 (1998). RN [49]; RE0015302. RX PUBMED: 9111360. RA West A. G., Shore P., Sharrocks A. D. RT DNA binding by MADS-box transcription factors: a molecular mechanism for differential DNA bending RL Mol. Cell. Biol. 17:2876-2887 (1997). RN [50]; RE0015323. RX PUBMED: 8900044. RA Chen C. Y., Croissant J., Majesky M., Topouzis S., McQuinn T., Frankovsky M. J., Schwartz R. J. RT Activation of the cardiac alpha-actin promoter depends upon serum response factor, Tinman homologue, Nkx-2.5, and intact serum response elements RL Dev. Genet. 19:119-130 (1996). RN [51]; RE0015342. RX PUBMED: 8193547. RA Treisman R. RT Ternary complex factors: growth factor regulated transcriptional activators RL Curr. Opin. Gen. Dev. 4:96-101 (1994). RN [52]; RE0015343. RX PUBMED: 9171356. RA Ling Y., Lakey J. H., Roberts C. E., Sharrocks A.D. RT Molecular characterization of the B-box protein-protein interaction motif of the ETS-domain transcription factor Elk-1 RL EMBO J. 16:2431-2440 (1997). RN [53]; RE0015389. RX PUBMED: 10753652. RA Fluck M., Booth F. W., Waxham M. N. RT Skeletal muscle CaMKII enriches in nuclei and phosphorylates myogenic factor SRF at multiple sites RL Biochem. Biophys. Res. Commun. 270:488-494 (2000). RN [54]; RE0015398. RX PUBMED: 1512232. RA Reason A. J., Morris H. R., Panico M., Marais R., Treisman R. H., Haltiwanger R. S., Hart G. W., Kelly W. G., Dell A. RT Localization of O-GlcNAc modification on the serum response transcription factor RL J. Biol. Chem. 267:16911-16921 (1992). RN [55]; RE0015489. RX PUBMED: 8604338. RA Magnaghi-Jaulin L., Masutani H., Robin P., Lipinski M., Harel-Bellan A. RT SRE elements are binding sites for the fusion protein EWS-FLI-1 RL Nucleic Acids Res. 24:1052-1058 (1996). RN [56]; RE0015517. RX PUBMED: 8764983. RA Magnaghi-Jaulin L., Masutani H., Lipinski M., Harel-Bellan A. RT Analysis of SRF, SAP-1 and ELK-1 transcripts and proteins in human cell lines RL FEBS Lett. 391:247-251 (1996). RN [57]; RE0015521. RX PUBMED: 10993896. RA Carson J. A., Fillmore R. A., Schwartz R. J., Zimmer W. E. RT The smooth muscle gamma -actin gene promoter is a molecular target for the mouse bagpipe homologue, mNkx3-1, and serum response factor RL J. Biol. Chem. 275:39061-39072 (2000). RN [58]; RE0015523. RX PUBMED: 11003651. RA Belaguli N. S., Sepulveda J. L., Nigam V., Charron F., Nemer M., Schwartz R. J. RT Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators RL Mol. Cell. Biol. 20:7550-7558 (2000). RN [59]; RE0016089. RX PUBMED: 11278942. RA Herring B. P., Kriegel A. M., Hoggatt A. M. RT Identification of Barx2b, a serum response factor-associated homeodomain protein. RL J. Biol. Chem. 276:14482-14489 (2001). RN [60]; RE0022791. RX PUBMED: 10064699. RA West A. G., Sharrocks A. D. RT MADS-box transcription factors adopt alternative mechanisms for bending DNA. RL J. Mol. Biol. 286:1311-1323 (1999). RN [61]; RE0024084. RX PUBMED: 12242287. RA Murai K., Treisman R. RT Interaction of serum response factor (SRF) with the Elk-1 B box inhibits RhoA-actin signaling to SRF and potentiates transcriptional activation by Elk-1. RL Mol. Cell. Biol. 22:7083-7092 (2002). RN [62]; RE0024126. RX PUBMED: 9545312. RA Chin M. T., Pellacani A., Wang H., Lin S. S., Jain M. K., Perrella M. A., Lee M. E. RT Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y). RL J. Biol. Chem. 273:9755-9760 (1998). RN [63]; RE0024136. RX PUBMED: 7630721. RA Sharrocks A. D., Shore P. RT DNA bending in the ternary nucleoprotein complex at the c-fos promoter. RL Nucleic Acids Res. 23:2442-2449 (1995). RN [64]; RE0024249. RX PUBMED: 15014501. RA Wang Z., Wang D. Z., Hockemeyer D., McAnally J., Nordheim A., Olson E. N. RT Myocardin and ternary complex factors compete for SRF to control smooth muscle gene expression. RL Nature 428:185-189 (2004). RN [65]; RE0024258. RX PUBMED: 11439182. RA Wang D., Chang P. S., Wang Z., Sutherland L., Richardson J. A., Small E., Krieg P. A., Olson E. N. RT Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor. RL Cell 105:851-862 (2001). RN [66]; RE0024298. RX PUBMED: 9880555. RA Lehmann U., Brocke P., Dittmer J., Nordheim A. RT Characterization of the human elk-1 promoter. Potential role of a downstream intronic sequence for elk-1 gene expression in monocytes. RL J. Biol. Chem. 274:1736-1744 (1999). RN [67]; RE0024587. RX PUBMED: 10606656. RA Dalgleish P., Sharrocks A. D. RT The mechanism of complex formation between Fli-1 and SRF transcription factors. RL Nucleic Acids Res. 28:560-569 (2000). RN [68]; RE0024594. RX PUBMED: 11406578. RA Hassler M., Richmond T. J. RT The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex. RL EMBO J. 20:3018-3028 (2001). RN [69]; RE0025059. RX PUBMED: 11136726. RA Gupta M., Kogut P., Davis F. J., Belaguli N. S., Schwartz R. J., Gupta M. P. RT Physical interaction between the MADS box of serum response factor and the TEA/ATTS DNA-binding domain of transcription enhancer factor-1. RL J. Biol. Chem. 276:10413-10422 (2001). RN [70]; RE0025060. RX PUBMED: 11158291. RA Morin S., Paradis P., Aries A., Nemer M. RT Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor. RL Mol. Cell. Biol. 21:1036-1044 (2001). RN [71]; RE0025100. RX PUBMED: 9171244. RA Chen C. Y., Schwartz R. J. RT Competition between negative acting YY1 versus positive acting serum response factor and tinman homologue Nkx-2.5 regulates cardiac alpha-actin promoter activity. RL Mol. Endocrinol. 11:812-822 (1997). RN [72]; RE0025147. RX PUBMED: 8970984. RA Chan Y. J., Chiou C. J., Huang Q., Hayward G. S. RT Synergistic interactions between overlapping binding sites for the serum response factor and ELK-1 proteins mediate both basal enhancement and phorbol ester responsiveness of primate cytomegalovirus major immediate-early promoters in monocyte and T-lymphocyte cell types. RL J. Virol. 70:8590-8605 (1996). RN [73]; RE0025209. RX PUBMED: 10318842. RA Hanlon M., Sealy L. RT Ras regulates the association of serum response factor and CCAAT/enhancer-binding protein beta. RL J. Biol. Chem. 274:14224-14228 (1999). RN [74]; RE0025229. RX PUBMED: 8614640. RA Latinkic B. V., Zeremski M., Lau L. F. RT Elk-1 can recruit SRF to form a ternary complex upon the serum response element. RL Nucleic Acids Res. 24:1345-1351 (1996). RN [75]; RE0027715. RX PUBMED: 10571058. RA Yamada K., Osawa H., Granner D. K. RT Identification of proteins that interact with NF-YA. RL FEBS Lett. 460:41-5 (1999). RN [76]; RE0047857. RX PUBMED: 15492011. RA Zhang X., Azhar G., Zhong Y., Wei J. Y. RT Identification of a novel serum response factor cofactor in cardiac gene regulation. RL J. Biol. Chem. 279:55626-55632 (2004). RN [77]; RE0047866. RX PUBMED: 16135793. RA Kawai-Kowase K., Kumar M. S., Hoofnagle M. H., Yoshida T., Owens G. K. RT PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins. RL Mol. Cell. Biol. 25:8009-8023 (2005). RN [78]; RE0060832. RX PUBMED: 16690609. RA Camoretti-Mercado B., Fernandes D. J., Dewundara S., Churchill J., Ma L., Kogut P. C., McConville J. F., Parmacek M. S., Solway J. RT Inhibition of transforming growth factor beta-enhanced serum response factor-dependent transcription by SMAD7. RL J. Biol. Chem. 281:20383-20392 (2006). XX //