AC T06078
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ID T06078
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DT 05.08.2004 (created); oke.
DT 15.11.2007 (updated); sba.
CO Copyright (C), QIAGEN.
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FA Fli-1
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OS zebra fish, Brachydanio rerio
OC eukaryota; animalia; metazoa; chordata; vertebrata; osteichthyes; actinopterygii; cypriniformes; cyprinoidei; cyprinidae
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GE G009819 fli1a.
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HO human, mouse, frog Fli-1 factors.
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CL C0016; ETS; 3.5.2.1.5.
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SF structure and most likely function is conserved between different vertebrate species [2];
SF in experimental systems, can be used instead of the human Fli-1 [1];
SF N-part of the protein (aa 1-219) contains potential inhibitory domain that prevents ternary complex formation with SRF [1];
SF mechanism of interactions with SRF is different from that of Elk-1, Fli-1 contains two SRF-binding domains located on both flanks of DBD [1];
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CP in embryo, sites of vasculogenesis [2].
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FF activator [1];
FF one of the earliest indicators of hemangioblast formation [2];
FF forms ternary complexes with SRF on the c-fos SRE [1];
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IN T00764 SRF; human, Homo sapiens.
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MX M08881 V$ETSLIKE_Q4.
MX M00771 V$ETS_Q4.
MX M00971 V$ETS_Q6.
MX M07382 V$FLI1_Q5.
MX M01208 V$FLI1_Q6.
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BS R00460.
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DR TRANSPATH: MO000043215.
DR TRANSCOMPEL: C00022.
DR UniProtKB: Q9PU61; Q9PU61.
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RN [1]; RE0024587.
RX PUBMED: 10606656.
RA Dalgleish P., Sharrocks A. D.
RT The mechanism of complex formation between Fli-1 and SRF transcription factors.
RL Nucleic Acids Res. 28:560-569 (2000).
RN [2]; RE0024589.
RX PUBMED: 10640707.
RA Brown L. A., Rodaway A. R., Schilling T. F., Jowett T., Ingham P. W., Patient R. K., Sharrocks A. D.
RT Insights into early vasculogenesis revealed by expression of the ETS-domain transcription factor Fli-1 in wild-type and mutant zebrafish embryos.
RL Mech. Dev. 90:237-252 (2000).
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