AC T01414
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ID T01414
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DT 11.12.1994 (created); ewi.
DT 01.08.2014 (updated); yre.
CO Copyright (C), QIAGEN.
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FA Net
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SY Elk-3; ELK3; ELK3, ETS-domain protein (SRF accessory protein 2); ERP; Net; SAP-2; SAP2; SRF accessory protein 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G003953 ELK3; HGNC: ELK3.
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CL C0016; ETS; 3.5.2.2.2.
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SF member of the elk/TCF subfamily of ETS factors [1];
SF C-terminal 185 AA strongly inhibit interaction with SRF [3];
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CP abundantly expressed in fibroblasts cell lines.
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FF repressor, turned into an activator by ras;
FF activated in vitro and, probably, in vivo by phosphorylation by the MAP kinase ERK2 [3];
FF ternary complex formation with SRF and c-fos SRE [1] [2];
FF DNA-binding characteristics are similar to those of Elk-1 [2];
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IN T00671 p53; human, Homo sapiens.
IN T00764 SRF; human, Homo sapiens.
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MX M03972 V$ELK3_01.
MX M00971 V$ETS_Q6.
MX M02060 V$NET_02.
MX M03832 V$NET_Q6.
MX M08824 V$NET_Q6_01.
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BS R61370.
BS R61371.
BS R26852.
BS R02097.
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DR TRANSPATH: MO000041641.
DR UniProtKB: P41970;
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RN [1]; RE0000802.
RX PUBMED: 7958835.
RA Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B.
RT Net, a new ets transcription factor that is activated by Ras
RL Genes Dev. 8:1502-1513 (1994).
RN [2]; RE0004468.
RX PUBMED: 8668149.
RA Shore P., Whitmarsh A. J., Bhaskaran R., Davis R. J., Waltho J. P., Sharrocks A. D.
RT Determinants of DNA-binding specificity of ets-domain transcription factors
RL Mol. Cell. Biol. 16:3338-3349 (1996).
RN [3]; RE0005332.
RX PUBMED: 7540136.
RA Price M. A., Rogers A. E., Treisman R.
RT Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)
RL EMBO J. 14:2589-2601 (1995).
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