TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T01414 XX ID T01414 XX DT 11.12.1994 (created); ewi. DT 01.08.2014 (updated); yre. CO Copyright (C), QIAGEN. XX FA Net XX SY Elk-3; ELK3; ELK3, ETS-domain protein (SRF accessory protein 2); ERP; Net; SAP-2; SAP2; SRF accessory protein 2. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G003953 ELK3; HGNC: ELK3. XX CL C0016; ETS; XX SF member of the elk/TCF subfamily of ETS factors [1]; SF C-terminal 185 AA strongly inhibit interaction with SRF [3]; XX CP abundantly expressed in fibroblasts cell lines. XX FF repressor, turned into an activator by ras; FF activated in vitro and, probably, in vivo by phosphorylation by the MAP kinase ERK2 [3]; FF ternary complex formation with SRF and c-fos SRE [1] [2]; FF DNA-binding characteristics are similar to those of Elk-1 [2]; XX IN T00671 p53; human, Homo sapiens. IN T00764 SRF; human, Homo sapiens. XX MX M03972 V$ELK3_01. MX M00971 V$ETS_Q6. MX M02060 V$NET_02. MX M03832 V$NET_Q6. MX M08824 V$NET_Q6_01. XX BS R61370. BS R61371. BS R26852. BS R02097. XX DR TRANSPATH: MO000041641. DR UniProtKB: P41970; XX RN [1]; RE0000802. RX PUBMED: 7958835. RA Giovane A., Pintzas A., Maira S.-M., Sobieszczuk P., Wasylyk B. RT Net, a new ets transcription factor that is activated by Ras RL Genes Dev. 8:1502-1513 (1994). RN [2]; RE0004468. RX PUBMED: 8668149. RA Shore P., Whitmarsh A. J., Bhaskaran R., Davis R. J., Waltho J. P., Sharrocks A. D. RT Determinants of DNA-binding specificity of ets-domain transcription factors RL Mol. Cell. Biol. 16:3338-3349 (1996). RN [3]; RE0005332. RX PUBMED: 7540136. RA Price M. A., Rogers A. E., Treisman R. RT Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET) RL EMBO J. 14:2589-2601 (1995). XX //