AC T01852
XX
ID T01852
XX
DT 12.06.1996 (created); dbo.
DT 07.05.2013 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA HMGIY
XX
SY high mobility group AT-hook 1; high mobility group protein I; High Mobility Group protein I(Y); high mobility group protein Y; HMG-I(Y); Hmgi; HMGI(Y); HMGIY; HMGY.
XX
OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G004784 Hmga1.
XX
CL C0083; AT-hook; 8.2.1.0.1.
XX
SF subject to acetylation and phosphorylation [2];
SF the 3d AT-hook is required for direct interactions with SRF [6];
XX
FF may regulate transcription positively or negatively;
FF binds AT-rich boxes;
FF auxiliary factor for other transcription factors such as NF-kappaB or ATF-2 to optimally assemble into a transcription complex [3] [4] [5];
FF activates transcription synergistically with SRF and directly interacts with it [6];
XX
IN T00764 SRF; human, Homo sapiens.
XX
MX M01653 V$HMGIY_01.
MX M01010 V$HMGIY_Q3.
MX M07320 V$HMGIY_Q3_01.
MX M01879 V$HMGIY_Q4.
MX M00750 V$HMGIY_Q6.
XX
BS R30105.
BS R14727.
BS R24896.
BS R73938.
BS R34630.
BS R05081.
BS R34652.
BS R08132.
BS R24879.
XX
DR TRANSPATH: MO000006711.
DR TRANSCOMPEL: C00146.
DR TRANSCOMPEL: C00436.
DR UniProtKB: P17095;
XX
RN [1]; RE0004348.
RX PUBMED: 3192537.
RA Johnson K. R., Lehn D. A., Elton T. S., Barr P. J., Reeves R.
RT Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I (Y)
RL J. Biol. Chem. 263:18338-18342 (1992).
RN [2]; RE0004349.
RX PUBMED: 1429598.
RA Ferranti P., Malorni A., Marino G., Pucci P., Goodwin G. H., Manfioletti G., Giancotti V.
RT Mass spectrometric analysis of the HMGY protein from Lewis lung carcinoma
RL J. Biol. Chem. 267:22486-22489 (1992).
RN [3]; RE0004376.
RX PUBMED: 1330326.
RA Thanos D., Maniatis T.
RT The high mobility group protein HMG I(Y) is required for NF-kappaB-dependent virus induction of the human IFN-beta gene
RL Cell 71:777-789 (1992).
RN [4]; RE0004383.
RX PUBMED: 7972056.
RA Du W., Maniatis T.
RT The high mobility group protein HMG I (Y) can stimulate or inhibit DNA binding of distinct transcription factor ATF-2 isoforms
RL Proc. Natl. Acad. Sci. USA 91:11318-11322 (1994).
RN [5]; RE0016568.
RX PUBMED: 8374955.
RA Du W., Thanos D., Maniatis T.
RT Mechanism of transcriptional synergism between distinct virus-inducible enhancer elements.
RL Cell 74:887-898 (1993).
RN [6]; RE0024126.
RX PUBMED: 9545312.
RA Chin M. T., Pellacani A., Wang H., Lin S. S., Jain M. K., Perrella M. A., Lee M. E.
RT Enhancement of serum-response factor-dependent transcription and DNA binding by the architectural transcription factor HMG-I(Y).
RL J. Biol. Chem. 273:9755-9760 (1998).
XX
//