AC T02059
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ID T02059
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DT 28.01.1997 (created); ewi.
DT 28.01.2011 (updated); mkl.
CO Copyright (C), QIAGEN.
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FA PMX1
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SY K-2b (mouse); MHox; Paired-like homeobox; Phox-1; PHOX1; Pmx.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G006570 PRRX1; HGNC: PRRX1.
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HO Drosophila Paired T00699.
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CL C0006; homeo; 3.1.3.21.1.
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SF belongs to the paired class of homeodomain factors;
SF recruitment of SRF to SRE requires homeodomain function [2];
SF asparagine at position 51 is absolutely required for the recruitment of SRF to SRE [2];
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FF weak binding to serum response elements (SRE) by its own and in a cooperative manner with SRF [1];
FF significantly accelerates formation as well as dissociation of (unphosphorylated) SRF-SRE complexes, most likely by formation of transient ternary complexes through direct contacts with SRF [1];
FF may help to determine cell-specific responses to external signals acting through MADS domain factors [2] [1];
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IN T00764 SRF; human, Homo sapiens.
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MX M01348 V$K2B_01.
MX M03560 V$PMX1_Q6.
MX M04431 V$PRRX1_02.
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DR TRANSPATH: MO000026128.
DR UniProtKB: P54821; PMX1_HUMAN.
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RN [1]; RE0005124.
RX PUBMED: 1509260.
RA Grueneberg D. A., Natesan S., Alexandre C., Gilman M. Z.
RT Human and Drosophila homeodomain proteins that enhance the DNA binding activity of serum response factor
RL Science 257:1089-1095 (1992).
RN [2]; RE0010523.
RX PUBMED: 7760827.
RA Grueneberg D. A., Simon K. J., Brennan K., Gilman M.
RT Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins.
RL Mol. Cell. Biol. 15:3318-3326 (1995).
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