AC T02716
XX
ID T02716
XX
DT 30.04.1999 (created); vma.
DT 14.06.2016 (updated); vis.
CO Copyright (C), QIAGEN.
XX
FA GATA-4
XX
SY GATA-GT2.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G013505 Gata4.
XX
CL C0004; CC; 2.2.1.1.4.
XX
SF two different sequences published [5] [2];
SF the second zinc finger and the immediate C-terminal basic extension are necessary and sufficient for interaction with SRF [8] [10];
XX
CP heart (cardiomyocytes), testis, ovary [2] [4]; testis, Sertoli cells [11].
CN brain, lung, liver, kidney, skeletal muscle, hypothalamus, pituitary gland, adrenal gland, submaxillary gland, parotid gland [2].
XX
FF activator;
FF as a cell type-specific factor regulates gene transcription in cardiomyocytes;
FF up-regulated in cardiomyocytes after treatment with triidothyronine or retinoic acid [3];
FF functionally cooperates, forms a ternary complex on DNA and directly interacts with SRF upon regulation of cardiomyocyte-specific genes [7] [10];
FF may work as a tissue-specific coactivator for SRF [8];
FF synergistic activation with Nkx2.5 T01675, Nkx2.1 T00859and Tinman T03612 on cardiac-specific promoters, like rat ANF promoter and rat BNP promoter [9] [1];
FF transcriptional cooperativity (synergistic activation) was observed with the members of the Antp superfamily Nkx2.5, TTF-1 and HoxB3 [1];
XX
IN T09410 C/EBPbeta; Mammalia.
IN T02770 LRH-1; human, Homo sapiens.
IN T16712 NFATc4; rat, Rattus norvegicus.
IN T00764 SRF; human, Homo sapiens.
XX
MX M00632 V$GATA4_Q3.
MX M03549 V$GATA4_Q5_01.
MX M00789 V$GATA_Q6.
XX
BS R14852.
BS R16058.
BS R28015.
BS R64196.
BS R64197.
BS R31905.
BS R34947.
BS R29588.
BS R21182.
BS R27949.
BS R27950.
BS R21210.
BS R66537.
BS R66538.
BS R73976.
BS R42371.
BS R42372.
BS R42373.
BS R42374.
BS R34948.
BS R34949.
BS R34950.
BS R21242.
BS R73616.
BS R61093.
BS R23089.
BS R20177.
BS R08290.
BS R20942.
BS R20943.
BS R31120.
BS R15857.
BS R26989.
BS R27447.
BS R27448.
BS R27450.
BS R65486.
BS R08289.
BS R32187.
BS R08287.
BS R42375.
BS R32087.
BS R32088.
BS R27797.
BS R27798.
BS R30697.
XX
DR TRANSPATH: MO000026692.
DR TRANSCOMPEL: C00220.
DR TRANSCOMPEL: C00428.
DR TRANSCOMPEL: C00429.
DR UniProtKB: P46152;
XX
RN [1]; RE0005960.
RX PUBMED: 9312027.
RA Durocher D., Charron F., Warren R., Schwartz R. J., Nemer M.
RT The cardiac transcription factors Nkx2-5 and GATA-4 are mutual cofactors
RL EMBO J. 16:5687-5696 (1997).
RN [2]; RE0009018.
RX PUBMED: 8164667.
RA Grepin C., Dagnino L., Robitaille L., Haberstroh L., Antakly T., Nemer M.
RT A hormone-encoding gene identifies a pathway for cardiac but not skeletal muscle gene transcription
RL Mol. Cell. Biol. 14:3115-3129 (1994).
RN [3]; RE0009636.
RX PUBMED: 8007990.
RA Molkentin J. D., Kalvakolanu D. V., Markham B. E.
RT Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene
RL Mol. Cell. Biol. 14:4947-4957 (1994).
RN [4]; RE0009877.
RX PUBMED: 7935467.
RA Ip H. S., Wilson D. B., Heikinheimo M., Tang Z., Ting C.-N., Simon M. C., Leiden J. M., Parmacek M. S.
RT The GATA-4 transcription factor transactivates the cardiac muscle-specific troponin C promoter-enhancer in nonmuscle cells
RL Mol. Cell. Biol. 14:7517-7526 (1994).
RN [5]; RE0013588.
RX PUBMED: 8248184.
RA Tamura S., Wang X. H., Maeda M., Futai M.
RT Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes.
RL Proc. Natl. Acad. Sci. USA 90:10876-10880 (1993).
RN [6]; RE0013589.
RX PUBMED: 8183957.
RA Tamura S., Wang X. H., Maeda M., Futai M.
RT Gastric DNA-binding proteins recognize upstream sequence motifs of parietal cell-specific genes. (Erratum)
RL Proc. Natl. Acad. Sci. USA 91:4609 (1994).
RN [7]; RE0015397.
RX PUBMED: 11038368.
RA Moore M. L., Wang G. L., Belaguli N. S., Schwartz R. J., McMillin J. B.
RT GATA-4 and Serum Response Factor Regulate Transcription of the Muscle-Specific Carnitine Palmitoyltransferase I {beta} in Rat Heart
RL J. Biol. Chem. 276:1026-1033 (2001).
RN [8]; RE0015523.
RX PUBMED: 11003651.
RA Belaguli N. S., Sepulveda J. L., Nigam V., Charron F., Nemer M., Schwartz R. J.
RT Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators
RL Mol. Cell. Biol. 20:7550-7558 (2000).
RN [9]; RE0025027.
RX PUBMED: 9584181.
RA Sepulveda J. L., Belaguli N., Nigam V., Chen C. Y., Nemer M., Schwartz R. J.
RT GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression.
RL Mol. Cell. Biol. 18:3405-3415 (1998).
RN [10]; RE0025060.
RX PUBMED: 11158291.
RA Morin S., Paradis P., Aries A., Nemer M.
RT Serum response factor-GATA ternary complex required for nuclear signaling by a G-protein-coupled receptor.
RL Mol. Cell. Biol. 21:1036-1044 (2001).
RN [11]; RE0027116.
RX PUBMED: 9514155.
RA Feng Z. M., Wu A. Z., Chen C. L.
RT Testicular GATA-1 factor up-regulates the promoter activity of rat inhibin alpha-subunit gene in MA-10 Leydig tumor cells.
RL Mol. Endocrinol. 12:378-90 (1998).
RN [12]; RE0036087.
RX PUBMED: 12239105.
RA Tremblay J. J., Hamel F., Viger R. S.
RT Protein kinase A-dependent cooperation between GATA and CCAAT/enhancer-binding protein transcription factors regulates steroidogenic acute regulatory protein promoter activity.
RL Endocrinology 143:3935-3945 (2002).
RN [13]; RE0036094.
RX PUBMED: 15928316.
RA Martin L. J., Taniguchi H., Robert N. M., Simard J., Tremblay J. J., Viger R. S.
RT GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter.
RL Mol. Endocrinol. 19:2358-2370 (2005).
RN [14]; RE0036097.
RX PUBMED: 15337742.
RA Wang J., Feng X. H., Schwartz R. J.
RT SUMO-1 modification activated GATA4-dependent cardiogenic gene activity.
RL J. Biol. Chem. 279:49091-49098 (2004).
XX
//