AC T03612
XX
ID T03612
XX
DT 19.07.2000 (created); dkl.
DT 21.01.2016 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA NK-4
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SY Msh-2; NK-4; Tin; Tinman.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
GE G018856 tin.
XX
CL C0053; NK-2/Nkx.
XX
SZ 416 AA; 46.1 kDa (cDNA) (calc.).
XX
SQ MLQHHQQQAQSGGYYDHYTQSPSPGSLTNADALNTTPFSVKDILNMVNQTEAYEGSYGHI
SQ DGAATASALFAAGEYQNPHQYLNHQQHQQSELPIPQQQLHHQHLDDGATTSSSLSPLLPP
SQ PPHQLYGGYQDYGMPAHMFQHHHGHPHQSFQHSASAYNMSASQFYAGASATAYQTPATYN
SQ YNYAGSGEVYGGATPSAVDIKSEYIPTPYVTPSPTLDLNSSAEVDSLQAPTQKLCVNPLS
SQ QRLMETASNSSSLRSIYGSDEGAKKKDNSQVTSSRSELRKNSISGNSNPGSNSGSTKPRM
SQ KRKPRVLFSQAQVLELECRFRLKKYLTGAEREIIAQKLNLSATQVKIWFQNRRYKSKRGD
SQ IDCEGIAKHLKLKSEPLDSPTSLPPPIPNHVMWPPTMQQSQQQQQHHAQQQQMQHM
XX
SC translated from EMBL #X55192
XX
FT 1 110 
activation domain [2].
FT 111 188 
repression domain [2].
FT 299 359 
PS50071; HOMEOBOX_2.
FT 301 363 
SM00389; HOX_1.
FT 302 358 
PF00046; Homeobox domain.
XX
SF NK-2 T04258, NK-3/Bagpipe T02665 and NK-4/Tinman comprise a cluster of homeobox genes and are more closely related to one another (59-66% homology) than to other Drosophila homeo domain factors [1];
SF homeodomain acts as an inhibitory domain [2];
XX
FF acts as either an activator or repressor [2];
FF required for the development of dorsal mesoderm, including heart;
FF interacts with p300 co-activator and Groucho co-repressor [2];
FF synergistic activation with Gata4 T02716 on cardiac-specific promoters [3];
XX
MX M02365 I$TIN_01.
MX M07239 I$TIN_02.
MX M07833 I$TIN_03.
XX
BS R17263.
BS R17264.
BS R17508.
BS R17689.
BS R17690.
BS R17368.
BS R17370.
BS R17372.
BS R17376.
XX
DR TRANSPATH: MO000027545.
DR EMBL: M27292;
DR EMBL: X55192;
DR UniProtKB: P22711;
DR FLYBASE: FBgn0004110; tin.
XX
RN [1]; RE0013335.
RX PUBMED: 2573058.
RA Kim Y., Nirenberg M.
RT Drosophila NK-homeobox genes
RL Proc. Natl. Acad. Sci. USA 86:7716-7720 (1989).
RN [2]; RE0024318.
RX PUBMED: 10531357.
RA Choi C. Y., Lee Y. M., Kim Y. H., Park T., Jeon B. H., Schulz R. A., Kim Y.
RT The homeodomain transcription factor NK-4 acts as either a transcriptional activator or repressor and interacts with the p300 coactivator and the Groucho corepressor.
RL J. Biol. Chem. 274:31543-31552 (1999).
RN [3]; RE0025027.
RX PUBMED: 9584181.
RA Sepulveda J. L., Belaguli N., Nigam V., Chen C. Y., Nemer M., Schwartz R. J.
RT GATA-4 and Nkx-2.5 coactivate Nkx-2 DNA binding targets: role for regulating early cardiac gene expression.
RL Mol. Cell. Biol. 18:3405-3415 (1998).
XX
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