AC T04258
XX
ID T04258
XX
DT 29.01.2001 (created); rio.
DT 15.07.2005 (updated); ili.
CO Copyright (C), QIAGEN.
XX
FA NK-2
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SY ventral nervous system defective protein; VND.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
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CL C0053; NK-2/Nkx.
XX
SZ 722 AA; 76.5 kDa (cDNA) (calc.).
XX
SQ MTTSASLERTPSKRDRDRERDNSSGLGSAGSLPASPQSAITVSPSSPATPKRPLRTSTPS
SQ LERKREREDREDREDRKERQERHERDREHERFAAVFSTASTTVPTNTSSSSGLAPEQLRI
SQ PTGAAAFSGFPGLHSMSSLMLPSSAAVARAAAPFLPWSPILLPPWNHALLPAAFYPAALR
SQ NALPGLFDAKVPSSQRSGFHISDILNLEGSELKNAAAAAAAAAHHGSDLSHHSASESTSG
SQ HRGQGSHTSPSALSPTPAGVSADEHHNGSGTGGGAGEADHHSTTEHHAPPSHPQQQHPHH
SQ QQHHHPHLLLPQQHHQQAVAPLPLAHHQSGEAQSHAHANAAAAHLLASHNAAAAAAVAAG
SQ KYLPNLPKNFPGSFGDEMSSYHHMAQTMLQHSGRSAWMKENELYGTQQPASPDSTSPVTS
SQ EVSYTYIGSNCQTSPALSGDYKSYSRSADSDALSVGDALHTLHGSSGNGSAGGAPTAHAL
SQ HNNNNNTTNNNNHSLKAEGINGAGSGHDDSLNEDGIEEDIDDVDDADGSGGGDANGSDGL
SQ PNKKRKRRVLFTKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKTK
SQ RAQNEKGYEGHPGLLHGHATHPHHPSALPSPRRVAVPVLVRNGKPCLGDSSKLGADCVSV
SQ SSATATAMQNAAAHHLVALNGAAAYQHAAAAAAGLHAHAHAHAHAHGHGHPHAHAQRAAW
SQ WP
XX
SC translated from EMBL #X87141
XX
FT 307 700 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 542 602 
PS50071; HOMEOBOX_2.
FT 544 606 
SM00389; HOX_1.
FT 545 601 
PF00046; Homeobox domain.
XX
SF homeo domain is most closely related to msh T03551, zen-1 T00917, NK-3/Bagpipe T02665 and Dll T02005 [1];
SF structure of NK2-DNA complex has been resolved, helix III of the homeodomain binds in the major groove of the DNA and the N-terminal arm binds in the minor groove [2];
SF contact of Y54 with DNA contributes to the unusual DNA binding specificity [2];
XX
FF unusual DNA consensus CAAGTG [2];
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MX M02371 I$VND_01.
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BS R17533.
BS R17534.
BS R17535.
XX
DR TRANSPATH: MO000028124.
DR EMBL: M27290;
DR EMBL: X87141;
DR UniProtKB: P22808;
DR FLYBASE: FBgn0003986; vnd.
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RN [1]; RE0013335.
RX PUBMED: 2573058.
RA Kim Y., Nirenberg M.
RT Drosophila NK-homeobox genes
RL Proc. Natl. Acad. Sci. USA 86:7716-7720 (1989).
RN [2]; RE0024312.
RX PUBMED: 9154919.
RA Gruschus J. M., Tsao D. H., Wang L. H., Nirenberg M., Ferretti J. A.
RT Interactions of the vnd/NK-2 homeodomain with DNA by nuclear magnetic resonance spectroscopy: basis of binding specificity.
RL Biochemistry 36:5372-5380 (1997).
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