AC T00917
XX
ID T00917
XX
DT 15.10.1992 (created); ewi.
DT 12.11.2007 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Zen-1
XX
SY Z1; Zen; Zerknuellt 1.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
GE G000127 zen.
XX
CL C0006; homeo.
XX
SZ 353 AA; 39.3 kDa (cDNA) (calc.), 49 kDa (SDS)
XX
SQ MSSVMHYYPVHQAKVGSYSADPSEVKYSDLIYGHHHDVNPIGLPPNYNQMNSNPTTLNDH
SQ CSPQHVHQQHVSSDENLPSQPNHDSQRVKLKRSRTAFTSVQLVELENEFKSNMYLYRTRR
SQ IEIAQRLSLCERQVKIWFQNRRMKFKKDIQGHREPKSNAKLAQPQAEQSAHRGIVKRLMS
SQ YSQDPREGTAAAEKRPMMAVAPVNPKPDYQASQKMKTEASTNNGMCSSADLSEILEHLAQ
SQ TTAAPQVSTATSSTGTSTNSASSSSSGHYSYNVDLVLQSIKQDLEAAAQAWSKSKSAPIL
SQ ATQSWHPSSQSQVPTSVHAAPSMNLSWGEPAAKSRKLSVNHMNPCVTSYNYPN
XX
SC Swiss-Prot#P09089
XX
FT 88 148 
PS50071; HOMEOBOX_2.
FT 90 152 
SM00389; HOX_1.
FT 91 147 
PF00046; Homeobox domain.
XX
FF Dorsal T00196 represses zen transcription through several far upstream binding sites [6];
FF probably represses expression of DNA replication-related genes by reducing DREF T04324 [9];
XX
MX M02374 I$ZEN_01.
MX M07841 I$ZEN_02.
MX M00710 I$ZEN_Q6.
XX
BS R01669.
BS R17500.
BS R17501.
BS R17502.
BS R00411.
BS R00412.
BS R00413.
BS R00418.
BS R02801.
BS R01282.
BS R01283.
BS R01284.
BS R09872.
BS R01529.
BS R01888.
BS R01678.
XX
DR TRANSPATH: MO000045965.
DR EMBL: L18923; DMCOREP.
DR EMBL: S78213; S78213.
DR UniProtKB: P09089; HMZ1_DROME.
DR FLYBASE: FBgn0004053.
XX
RN [1]; RE0000066.
RX PUBMED: 2572327.
RA Treisman J., Goenczy P., Vashishta M., Harris E., Desplan C.
RT A single amino acid can determine the DNA binding specificity of homeodomain proteins
RL Cell 59:553-562 (1989).
RN [2]; RE0000149.
RX PUBMED: 2569362.
RA Biggin M. D., Tjian R.
RT A Purified Drosophila Homeodomain Protein Represses Transcription In Vitro
RL Cell 58:433-440 (1989).
RN [3]; RE0001333.
RX PUBMED: 1968224.
RA Yamaguchi M., Nishida Y., Moriuchi T., Hirose F., Hui C.-C., Suzuki Y., Matsugake A.
RT Drosophila proliferating cell nuclear antigen (cyclin) gene: structure, expression during development, and specific binding of homeodomain proteins to its 5'-flanking region
RL Mol. Cell. Biol. 10:872-879 (1990).
RN [4]; RE0002802.
RX PUBMED: 1679407.
RA Morrissey D., Askew D., Raj L., Weir M.
RT Functional dissection of the paired segmentation gene in Drosophila embryos
RL Genes Dev. 5:1684-1696 (1991).
RN [5]; RE0005216.
RX PUBMED: 8344256.
RA Kirov N., Zhelnin L., Shah J., Rushlow C.
RT Conversion of a silencer into an enhancer: evidence for a co-repressor in dorsal-mediated repression in Drosophila
RL EMBO J. 12:3193-3199 (1993).
RN [6]; RE0005217.
RX PUBMED: 1768648.
RA Kamens J., Brent R.
RT A yeast transcription assay defines distinct rel and dorsal DNA recognition sequences
RL New Biol. 3:1005-1013 (1991).
RN [7]; RE0005218.
RX PUBMED: 2612903.
RA Doyle H. J., Kraut R., Levine M.
RT Spatial regulation of zerknuellt: a dorsal-ventral patterning gene in Drosophila
RL Genes Dev. 3:1518-1533 (1989).
RN [8]; RE0005219.
RX PUBMED: 2892759.
RA Rushlow C., Doyle H., Hoey T., Levine M.
RT Molecular characterization of the zerknullt region of the Antennapedia gene complex in Drosophila
RL Genes Dev. 1:1268-1279 (1987).
RN [9]; RE0008468.
RX PUBMED: 7905482.
RA Hirose F., Yamaguchi M., Matsukage A.
RT Repression of regulatory factor for Drosophila DNA replication-related gene promoters by zerknuellt homeodomain protein
RL J. Biol. Chem. 269:2937-2942 (1994).
XX
//