AC T00196
XX
ID T00196
XX
DT 15.10.1992 (created); ewi.
DT 31.05.2006 (updated); mkl.
CO Copyright (C), QIAGEN.
XX
FA Dl
XX
SY dl; Dorsal.
XX
OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
XX
CL C0020; Rel.
XX
FF morphogen, establishes dorsal-ventral polarity in embryogenesis;
FF complexed and cytoplasmically retained by Cactus [4];
FF proteolytic degradation of Cactus allows nuclear translocation of DI [4];
FF the responsible signal is mediated by a protein kinase encoded by pelle gene [5];
FF cooperative DNA-binding with Scute T00004 to activate genes in lateral embryonic regions [3];
FF activator and repressor [7];
FF Dri T04679 plays an important role in converting DI from an activator into a repressor [7];
XX
IN T01933 Cactus; fruit fly, Drosophila melanogaster.
IN T02451 groucho; fruit fly, Drosophila melanogaster.
XX
MX M00043 I$DL_01.
MX M00120 I$DL_02.
XX
BS R06806.
BS R06807.
BS R06808.
BS R06809.
BS R06810.
BS R06811.
BS R06812.
BS R06813.
BS R06814.
BS R06815.
BS R06816.
BS R06817.
BS R04551.
BS R04580.
BS R03463.
BS R17555.
BS R17556.
BS R17557.
BS R17558.
BS R17559.
BS R17560.
BS R17561.
BS R17563.
BS R17564.
BS R17565.
BS R17566.
BS R17567.
BS R17568.
BS R17569.
BS R17908.
BS R17909.
BS R17910.
XX
DR TRANSPATH: MO000016638.
DR UniProtKB: P15330;
DR FLYBASE: FBgn0000462; dl.
XX
RN [1]; RE0000232.
RX PUBMED: 1988156.
RA Ip Y. T., Kraut R., Levine M., Rushlow C. A.
RT The dorsal morphogen if a sequence-specific DNA-binding protein that interacts with a long-range repression element in Drosophila
RL Cell 64:439-446 (1991).
RN [2]; RE0000246.
RX PUBMED: 1648449.
RA Thisse C., Perrin-Schmitt F., Stoetzel C., Thisse B.
RT Sequence-specific transactivation of the Drosophila twist gene by the dorsal gene product
RL Cell 65:1191-1201 (1991).
RN [3]; RE0003619.
RX PUBMED: 8453668.
RA Jiang J., Levine M.
RT Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen
RL Cell 72:741-752 (1993).
RN [4]; RE0004586.
RX PUBMED: 7705656.
RA Belvin M. P., Jin Y., Anderson K. V.
RT Cactus protein degradation mediates Drosophila dorsal-ventral signaling
RL Genes Dev. 9:783-793 (1995).
RN [5]; RE0004587.
RX PUBMED: 8440018.
RA Shelton C. A., Wasserman S. A.
RT pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
RL Cell 72:515-525 (1993).
RN [6]; RE0022136.
RX PUBMED: 9597130.
RA Ghosh S., May M. J., Kopp E. B.
RT NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
RL Annu. Rev. Immunol. 16:225-260 (1998).
RN [7]; RE0025509.
RX PUBMED: 9774673.
RA Valentine S. A., Chen G., Shandala T., Fernandez J., Mische S., Saint R., Courey A. J.
RT Dorsal-mediated repression requires the formation of a multiprotein repression complex at the ventral silencer.
RL Mol. Cell. Biol. 18:6584-6594 (1998).
XX
//