AC T01933
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ID T01933
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DT 05.11.1996 (created); ewi.
DT 24.11.2004 (updated); vma.
CO Copyright (C), QIAGEN.
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FA Cactus
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OS fruit fly, Drosophila melanogaster
OC eukaryota; animalia; metazoa; arthropoda; insecta; diptera; drosophiloidea; drosophilidae
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HO IkappaB.
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SZ 500 AA; 53.8 kDa (gene) (calc.).
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SQ MPSPTKAAEAATKATATSDCSCSAASVEQRAPSNAANPSSSLATSGKIGGKTQDQTAAIN
SQ KQKEFAVPNETSDSGFISGPQSSQIFSEEIVPDSEEQDKDQQESAPQKEQPVVLDSGIID
SQ EEEDQEEQEKEEEHQDTTTATADSMRLKHSADTGIPQWTVESHLVSRGEQLNNLGQSSST
SQ QITGRSKVQSSTASTGNANPSGSGATSSAPPSSINIMNAWEQFYQQNDDGDTPLHLACIS
SQ GSVDVVAALIRMAPHPCLLNIQNDVAQTPLHLAALTAQPNIMRILLLAGAEPTVRDRHGN
SQ TALHLSCIAGEKQCVRALTEKFGATEIHEAHRQYGHRSNDKAVSSLSYACLPADLEIRNY
SQ DGERCVHLAAEAGHIDILRILVSHGADINAREGKSGRTPLHIAIEGCNEDLANFLLDECE
SQ KLNLETATYAGLTAYQFACIMNKSRMQNILEKRGAETVTPPDSDYDSSDIEDLDDTKMYD
SQ RFGDPRYFVSYNGGNPMTVA
XX
SC Swiss-Prot#Q03017
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FT 9 460 
PF00478; IMP dehydrogenase / GMP reductase domain.
FT 229 251 
PS50088; ANK_REPEAT.
FT 229 258 
SM00248; ANK_2a.
FT 229 264 
PF00023; Ankyrin repeat.
FT 229 456 
PS50297; ANK_REP_REGION.
FT 265 294 
SM00248; ANK_2a.
FT 265 297 
PF00023; Ankyrin repeat.
FT 265 297 
PS50088; ANK_REPEAT.
FT 298 329 
SM00248; ANK_2a.
FT 298 331 
PF00023; Ankyrin repeat.
FT 361 390 SM00248; ANK_2a.
FT 361 393 PF00023; Ankyrin repeat.
FT 361 393 PS50088; ANK_REPEAT.
FT 395 424 SM00248; ANK_2a.
FT 395 427 PF00023; Ankyrin repeat.
FT 395 427 PS50088; ANK_REPEAT.
XX
FF retains Dorsal T00196 in the cytoplasm [1];
FF rapid degradation of Cactus in response to certain signals releases Dorsal [1];
FF signal-dependent degradation involves the pelle protein kinase and proceeds through N-terminal sequences or through the ankyrin repeats [1] [2];
FF signal-independent degradation occurs at the C-terminal PEST sequence [1];
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IN T00196 Dl; fruit fly, Drosophila melanogaster.
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DR TRANSPATH: MO000000239.
DR EMBL: L04964;
DR UniProtKB: Q03017;
DR FLYBASE: FBgn0000250.
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RN [1]; RE0004586.
RX PUBMED: 7705656.
RA Belvin M. P., Jin Y., Anderson K. V.
RT Cactus protein degradation mediates Drosophila dorsal-ventral signaling
RL Genes Dev. 9:783-793 (1995).
RN [2]; RE0004587.
RX PUBMED: 8440018.
RA Shelton C. A., Wasserman S. A.
RT pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo
RL Cell 72:515-525 (1993).
RN [3]; RE0004623.
RX PUBMED: 1423618.
RA Geisler R., Bergmann A., Hiromi Y., Nuesslein-Volhard C.
RT cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the IkappaB gene family of vertebrates
RL Cell 71:613-621 (1992).
RN [4]; RE0004624.
RX PUBMED: 1423619.
RA Kidd S.
RT Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins
RL Cell 71:623-635 (1992).
RN [5]; RE0018441.
RX PUBMED: 9426183.
RA Piette J., Piret B., Bonizzi G., Schoonbroodt S., Merville M. P., Legrand-Poels S., Bours V.
RT Multiple redox regulation in NF-kappaB transcription factor activation.
RL Biol. Chem. 378:1237-1245 (1997).
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