AC T02770
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ID T02770
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DT 08.06.1999 (created); mpr.
DT 01.02.2016 (updated); mom.
CO Copyright (C), QIAGEN.
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FA LRH-1
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SY alpha-1-fetoprotein transcription factor; B1-binding factor; B1F; B1F2; CPF; CYP7A promoter binding factor; fetoprotein transcription factor; FTF; Ftz-F1; FTZ-F1beta; HB1F; hB1F-2; hepatocytic transcription factor; liver receptor homologous protein; LRH-1; LRH1; NR5A2; nuclear receptor subfamily 5, group A, member 2.
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OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002482 NR5A2; HGNC: NR5A2.
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CL C0002; CC (rec); 2.1.5.0.2.
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SF variants are T08492 and T08525;
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EX brain,,,adult; none; Northern blot; RNA (undefined); [3].
EX heart,,,adult; low; Northern blot; RNA (undefined); [3].
EX kidney (right and left),,,adult; none; Northern blot; RNA (undefined); [3].
EX liver,,,adult; high; Northern blot; RNA (undefined); [3].
EX lung (right and left),,,adult; low; Northern blot; RNA (undefined); [3].
EX muscles,,,adult; none; Northern blot; RNA (undefined); [3].
EX pancreas,,,adult; high; Northern blot; RNA (undefined); [3].
EX placenta,,,adult; none; Northern blot; RNA (undefined); [3].
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IN T02872 beta-catenin; human, Homo sapiens.
IN T11171 foxl2; human, Homo sapiens.
IN T02716 GATA-4; rat, Rattus norvegicus.
IN T02717 GATA-6; rat, Rattus norvegicus.
IN T04922 Prox-1; human, Homo sapiens.
IN T02738 SHP; human, Homo sapiens.
IN T08947 SHP; mouse, Mus musculus.
IN T04632 SRC-1; human, Homo sapiens.
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MX M01142 V$LRH1_Q5.
MX M02098 V$LRH1_Q5_01.
MX M07360 V$LRH1_Q6.
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BS R27834.
BS R20900.
BS R20902.
BS R22990.
BS R28957.
BS R28955.
BS R28817.
BS R28910.
BS R23036.
BS R27822.
BS R23905.
BS R24513.
BS R39435.
BS R39436.
BS R39437.
BS R19636.
BS R28701.
BS R28702.
BS R71681.
BS R56046.
BS R67513.
BS R67514.
BS R67515.
BS R29090.
BS R29112.
BS R27897.
BS R39438.
BS R29154.
BS R29120.
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DR TRANSPATH: MO000026742.
DR UniProtKB: O00482;
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RN [1]; RE0013625.
RX PUBMED: 10219237.
RA Nuclear Receptors Nomenclature Committee.
RT A unified nomenclature system for the nuclear receptor superfamily
RL Cell 97:161-163 (1999).
RN [2]; RE0013659.
RX PUBMED: 9858833.
RA Galarneau L., Drouin R., Belanger L.
RT Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization
RL Cytogenet. Cell Genet. 82:269-270 (1998).
RN [3]; RE0016199.
RX PUBMED: 10359768.
RA Nitta M., Ku S., Brown C., Okamoto A. Y., Shan B.
RT CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene
RL Proc. Natl. Acad. Sci. USA 96:6660-6665 (1999).
RN [4]; RE0036094.
RX PUBMED: 15928316.
RA Martin L. J., Taniguchi H., Robert N. M., Simard J., Tremblay J. J., Viger R. S.
RT GATA factors and the nuclear receptors, steroidogenic factor 1/liver receptor homolog 1, are key mutual partners in the regulation of the human 3beta-hydroxysteroid dehydrogenase type 2 promoter.
RL Mol. Endocrinol. 19:2358-2370 (2005).
RN [5]; RE0042891.
RX PUBMED: 12198243.
RA Brendel C., Schoonjans K., Botrugno O. A., Treuter E., Auwerx J.
RT The Small Heterodimer Partner Interacts with the Liver X Receptor alpha and Represses Its Transcriptional Activity
RL Mol. Endocrinol. 16:2065-76 (2002).
RN [6]; RE0047682.
RX PUBMED: 12040021.
RA Brendel C., Gelman L., Auwerx J.
RT Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.
RL Mol. Endocrinol. 16:1367-1377 (2002).
RN [7]; RE0049388.
RX PUBMED: 15923626.
RA Chalkiadaki A., Talianidis I.
RT SUMO-dependent compartmentalization in promyelocytic leukemia protein nuclear bodies prevents the access of LRH-1 to chromatin.
RL Mol. Cell. Biol. 25:5095-5105 (2005).
RN [8]; RE0051247.
RX PUBMED: 11518759.
RA Chen W., Owsley E., Yang Y., Stroup D., Chiang J. Y.
RT Nuclear receptor-mediated repression of human cholesterol 7alpha-hydroxylase gene transcription by bile acids.
RL J. Lipid Res. 42:1402-1412 (2001).
RN [9]; RE0053152.
RX PUBMED: 15205472.
RA Qin J., Gao D. M., Jiang Q. F., Zhou Q., Kong Y. Y., Wang Y., Xie Y. H.
RT Prospero-related homeobox (Prox1) is a corepressor of human liver receptor homolog-1 and suppresses the transcription of the cholesterol 7-alpha-hydroxylase gene.
RL Mol. Endocrinol. 18:2424-2439 (2004).
RN [10]; RE0054989.
RX PUBMED: 15604093.
RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M.
RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
RL Mol. Cell. Proteomics 4:205-213 (2005).
XX
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