AC T08947
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ID T08947
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DT 18.05.2006 (created); jag.
DT 03.10.2012 (updated); spk.
CO Copyright (C), QIAGEN.
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FA SHP
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SY NR0B2; short heterodimer partner; SHP-1; small heterodimer partner.
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OS mouse, Mus musculus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
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GE G002555 Nr0b2.
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CL C0002; CC (rec).
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SZ 260 AA; 28.8 kDa (cDNA) (calc.).
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SQ MSSGQSGVCPCQGSAGRPTILYALLSPSPRTRPVAPASHSHCLCQQQRPVRLCAPHRTCR
SQ EALDVLAKTVAFLRNLPSFCHLPHEDQRRLLECCWGPLFLLGLAQDAVTFEVAEAPVPSI
SQ LKKILLEEASSGTQGAQPSDRPQPSLAAVQWLQRCLESFWSLELGPKEYAYLKGTILFNP
SQ DVPGLRASCHIAHLQQEAHWALCEVLEPWYPASQGRLARILLMASTLKNIPGTLLVDLFF
SQ RPIMGDVDITELLEDMLLLR
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SC translated from EMBL #BC019540
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FT 60 231 
SM00430; holi.
FT 63 256 
PF00104; Ligand-binding domain of nuclear hormon.
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IN T08664 C/EBPalpha; Mammalia.
IN T05687 CAR; mouse, Mus musculus.
IN T02770 LRH-1; human, Homo sapiens.
IN T02752 LXR-alpha; human, Homo sapiens.
IN T01327 NR1B1; mouse, Mus musculus.
IN T08433 RXR-alpha; human, Homo sapiens.
IN T00853 T3R-beta1; rat, Rattus norvegicus.
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DR TRANSPATH: MO000081684.
DR EMBL: BC019540;
DR UniProtKB: Q62227;
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RN [1]; RE0016208.
RX PUBMED: 11030331.
RA Lu T. T., Makishima M., Repa J. J., Schoonjans K., Kerr T. A., Auwerx J., Mangelsdorf D. J.
RT Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
RL Mol. Cell 6:507-515 (2000).
RN [2]; RE0028212.
RX PUBMED: 9372944.
RA Seol W., Chung M., Moore D. D.
RT Novel receptor interaction and repression domains in the orphan receptor SHP.
RL Mol. Cell. Biol. 17:7126-31 (1997).
RN [3]; RE0042891.
RX PUBMED: 12198243.
RA Brendel C., Schoonjans K., Botrugno O. A., Treuter E., Auwerx J.
RT The Small Heterodimer Partner Interacts with the Liver X Receptor alpha and Represses Its Transcriptional Activity
RL Mol. Endocrinol. 16:2065-76 (2002).
RN [4]; RE0053527.
RX PUBMED: 17094771.
RA Park M. J., Kong H. J., Kim H. Y., Kim H. H., Kim J. H., Cheong J. H.
RT Transcriptional repression of the gluconeogenic gene PEPCK by the orphan nuclear receptor SHP through inhibitory interaction with C/EBPalpha.
RL Biochem. J. 402:567-574 (2007).
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