AC T08664
XX
ID T08664
XX
DT 10.03.2005 (created); nvo.
DT 15.04.2016 (updated); hna.
CO Copyright (C), QIAGEN.
XX
FA C/EBPalpha
XX
SY CCAAT Enhancer Binding Protein alpha; CEBPalpha.
XX
OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
XX
IN T14315 AML1; Mammalia.
IN T00041 AR; mouse, Mus musculus.
IN T15601 AR; Mammalia.
IN T09335 ATF-2-isoform2; rat, Rattus norvegicus.
IN T01382 ATF-2; rat, Rattus norvegicus.
IN T10236 ATF-2; Mammalia.
IN T30879 BRD4-isoform1; human, Homo sapiens.
IN T05451 BRG1; human, Homo sapiens.
IN T16150 BRG1; mouse, Mus musculus.
IN T09410 C/EBPbeta; Mammalia.
IN T14188 C/EBPgamma; Mammalia.
IN T23077 CHOP-10; Mammalia.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T00308 GATA-2; human, Homo sapiens.
IN T00310 GATA-3; mouse, Mus musculus.
IN T08475 GR-alpha; rat, Rattus norvegicus.
IN T09344 Msx-2; mouse, Mus musculus.
IN T01626 NeuroD; mouse, Mus musculus.
IN T09280 NeuroD; mouse, Mus musculus.
IN T10399 NF-kappaB1-p50; Mammalia.
IN T00154 NF-YB; human, Homo sapiens.
IN T15891 NR1B2; Mammalia.
IN T10037 PU.1; Mammalia.
IN T10397 RelA-p65; Mammalia.
IN T08947 SHP; mouse, Mus musculus.
IN T10594 SHP; human, Homo sapiens.
IN T14175 TBP; Mammalia.
IN T00818 TFIIB; human, Homo sapiens.
XX
MX M00116 V$CEBPA_01.
MX M07412 V$CEBPA_04.
MX M07037 V$CEBPA_Q4.
MX M01866 V$CEBPA_Q6.
MX M00159 V$CEBP_01.
MX M00201 V$CEBP_C.
MX M00190 V$CEBP_Q2.
MX M00912 V$CEBP_Q2_01.
MX M00770 V$CEBP_Q3.
MX M00249 V$CHOP_01.
XX
BS R31191.
BS R08477.
BS R40964.
BS R57365.
BS R57366.
BS R22254.
BS R22256.
BS R22257.
BS R22258.
BS R22259.
BS R22260.
BS R22263.
BS R25363.
BS R25369.
BS R73673.
BS R30671.
BS R72226.
BS R72228.
BS R21124.
BS R20354.
BS R20356.
BS R33581.
BS R56681.
BS R34357.
BS R69930.
BS R69931.
BS R36307.
BS R21707.
BS R30407.
BS R72621.
BS R72622.
BS R72623.
BS R72624.
BS R31971.
BS R65782.
BS R13179.
BS R24144.
BS R27058.
BS R27059.
BS R26713.
BS R23185.
BS R28354.
BS R32348.
BS R41835.
BS R67542.
BS R67544.
BS R26031.
BS R73947.
BS R39166.
BS R20515.
BS R66700.
BS R29474.
BS R62242.
BS R61574.
BS R13310.
BS R13311.
BS R20179.
BS R26162.
BS R26163.
BS R26164.
BS R66205.
BS R66209.
BS R30034.
BS R30030.
BS R00097.
BS R20485.
BS R20488.
BS R34549.
BS R34550.
BS R34563.
BS R34560.
BS R34558.
BS R31189.
BS R31190.
BS R34581.
BS R65360.
BS R68560.
BS R41901.
BS R41902.
BS R37816.
BS R29376.
BS R19079.
XX
DR TRANSPATH: MO000046422.
DR TRANSCOMPEL: C00069.
DR TRANSCOMPEL: C00122.
DR TRANSCOMPEL: C00175.
DR TRANSCOMPEL: C00176.
DR TRANSCOMPEL: C00177.
DR TRANSCOMPEL: C00246.
DR TRANSCOMPEL: C00360.
DR TRANSCOMPEL: C00529.
DR TRANSCOMPEL: C00630.
XX
RN [1]; RE0006251.
RX PUBMED: 7556073.
RA Nerlov C., Ziff E. B.
RT CCAAT/enhancer binding protein-alpha amino acid motifs with dual TBP and TFIIB binding ability co-operate to activate transcription in both yeast and mammalian cells
RL EMBO J. 14:4318-4328 (1995).
RN [2]; RE0007500.
RX PUBMED: 8340393.
RA Alam T., An M. R., Mifflin R. C., Hsieh C., Ge X., Papaconstantinou J.
RT trans-activation of the alpha1-acid glycoprotein gene acute phase responsive element by multiple isoforms of C/EBP and glucocorticoid receptor
RL J. Biol. Chem. 268:15681- 15688 (1993).
RN [3]; RE0016671.
RX PUBMED: 9632776.
RA Petrovick M. S., Hiebert S. W., Friedman A. D., Hetherington C. J., Tenen D. G., Zhang D.-E.
RT Multiple functional domains of AML1: PU.1 and C/EBPalpha synergize with different regions of AML1.
RL Mol. Cell. Biol. 18:3915-3925 (1998).
RN [4]; RE0025710.
RX PUBMED: 11867521.
RA Wang H., Goode T., Iakova P., Albrecht J. H., Timchenko N. A.
RT C/EBPalpha triggers proteasome-dependent degradation of cdk4 during growth arrest.
RL EMBO J. 21:930-41 (2002).
RN [5]; RE0028650.
RX PUBMED: 11012671.
RA Jung N., Yi Y. W., Kim D., Shong M., Hong S. S., Lee H. S., Bae I.
RT Regulation of Gadd45gamma expression by C/EBP.
RL Eur. J. Biochem. 267:6180-7 (2000).
RN [6]; RE0030566.
RX PUBMED: 12947119.
RA Zhang F., Lin M., Abidi P., Thiel G., Liu J.
RT Specific interaction of Egr1 and c/EBPbeta leads to the transcriptional activation of the human low density lipoprotein receptor gene.
RL J. Biol. Chem. 278:44246-54 (2003).
RN [7]; RE0030660.
RX PUBMED: 9817600.
RA Boruk M., Savory J. G., Hache R. J.
RT AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor.
RL Mol. Endocrinol. 12:1749-63 (1998).
RN [8]; RE0032033.
RX PUBMED: 12757710.
RA Iakova P., Awad S. S., Timchenko N. A.
RT Aging reduces proliferative capacities of liver by switching pathways of C/EBPalpha growth arrest.
RL Cell 113:495-506 (2003).
RN [9]; RE0032279.
RX PUBMED: 14684614.
RA Pereira R. C., Delany A. M., Canalis E.
RT CCAAT/enhancer binding protein homologous protein (DDIT3) induces osteoblastic cell differentiation.
RL Endocrinology 145:1952-60 (2004).
RN [10]; RE0035887.
RX PUBMED: 14701740.
RA Ross S. E., Radomska H. S., Wu B., Zhang P., Winnay J. N., Bajnok L., Wright W. S., Schaufele F., Tenen D. G., MacDougald O. A.
RT Phosphorylation of C/EBPalpha inhibits granulopoiesis.
RL Mol. Cell. Biol. 24:675-686 (2004).
RN [11]; RE0036169.
RX PUBMED: 15632071.
RA Tong Q., Tsai J., Tan G., Dalgin G., Hotamisligil G. S.
RT Interaction between GATA and the C/EBP family of transcription factors is critical in GATA-mediated suppression of adipocyte differentiation.
RL Mol. Cell. Biol. 25:706-715 (2005).
RN [12]; RE0037534.
RX PUBMED: 10082561.
RA Timchenko N. A., Wilde M., Darlington G. J.
RT C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice
RL Mol. Cell. Biol. 19:2936-45 (1999).
RN [13]; RE0038791.
RX PUBMED: 14697342.
RA Kurash J. K., Shen C. N., Tosh D.
RT Induction and regulation of acute phase proteins in transdifferentiated hepatocytes
RL Exp. Cell Res. 292:342-58 (2004).
RN [14]; RE0038827.
RX PUBMED: 9756925.
RA Diarra-Mehrpour M., Sarafan N., Bourguignon J., Bonnet F., Bost F., Martin J. P.
RT Human inter-alpha-trypsin inhibitor heavy chain H3 gene. Genomic organization, promoter analysis, and gene linkage
RL J. Biol. Chem. 273:26809-19 (1998).
RN [15]; RE0040282.
RX PUBMED: 11493644.
RA Spinella-Jaegle S., Rawadi G., Kawai S., Gallea S., Faucheu C., Mollat P., Courtois B., Bergaud B., Ramez V., Blanchet A. M., Adelmant G., Baron R., Roman-Roman S.
RT Sonic hedgehog increases the commitment of pluripotent mesenchymal cells into the osteoblastic lineage and abolishes adipocytic differentiation
RL J. Cell Sci. 114:2085-94 (2001).
RN [16]; RE0041178.
RX PUBMED: 12511558.
RA Subramanian L., Benson M. D., Iniguez-Lluhi J. A.
RT A synergy control motif within the attenuator domain of CCAAT/enhancer-binding protein alpha inhibits transcriptional synergy through its PIASy-enhanced modification by SUMO-1 or SUMO-3
RL J. Biol. Chem. 278:9134-41 (2003).
RN [17]; RE0041442.
RX PUBMED: 10510303.
RA Vasseur S., Mallo G. V., Garcia-Montero A., Ortiz E. M., Fiedler F., Canepa E., Moreno S., Iovanna J. L.
RT Structural and functional characterization of the mouse p8 gene: promotion of transcription by the CAAT-enhancer binding protein alpha (C/EBPalpha) and C/EBPbeta trans-acting factors involves a C/EBP cis-acting element and other regions of the promoter
RL Biochem. J. 343:377-83 (1999).
RN [18]; RE0042688.
RX PUBMED: 11684017.
RA Wang H., Iakova P., Wilde M., Welm A., Goode T., Roesler W. J., Timchenko N. A.
RT C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4
RL Mol. Cell 8:817-28 (2001).
RN [19]; RE0043357.
RX PUBMED: 12594283.
RA Shimokawa T., Ra C.
RT C/EBP alpha and Ets protein family members regulate the human myeloid IgA Fc receptor (Fc alpha R, CD89) promoter
RL J. Immunol. 170:2564-72 (2003).
RN [20]; RE0044497.
RX PUBMED: 12074569.
RA Lee I. H., Lee J. H., Lee M. J., Lee S. Y., Kim I. S.
RT Involvement of CCAAT/enhancer-binding protein alpha in haptoglobin gene expression by all-trans-retinoic acid
RL Biochem. Biophys. Res. Commun. 294:956-61 (2002).
RN [21]; RE0045092.
RX PUBMED: 12437985.
RA Song H., Shojima N., Sakoda H., Ogihara T., Fujishiro M., Katagiri H., Anai M., Onishi Y., Ono H., Inukai K., Fukushima Y., Kikuchi M., Shimano H., Yamada N., Oka Y., Asano T.
RT Resistin is regulated by C/EBPs, PPARs, and signal-transducing molecules
RL Biochem. Biophys. Res. Commun. 299:291-8 (2002).
RN [22]; RE0045093.
RX PUBMED: 15191360.
RA Gong H., Ni Y., Guo X., Fei L., Pan X., Guo M., Chen R.
RT Resistin promotes 3T3-L1 preadipocyte differentiation
RL Eur. J. Endocrinol. 150:885-92 (2004).
RN [23]; RE0045643.
RX PUBMED: 15123608.
RA Phan J., Peterfy M., Reue K.
RT Lipin expression preceding peroxisome proliferator-activated receptor-gamma is critical for adipogenesis in vivo and in vitro
RL J. Biol. Chem. 279:29558-64 (2004).
RN [24]; RE0045707.
RX PUBMED: 10037704.
RA Agarwal C., Efimova T., Welter J. F., Crish J. F., Eckert R. L.
RT CCAAT/enhancer-binding proteins. A role in regulation of human involucrin promoter response to phorbol ester
RL J. Biol. Chem. 274:6190-4 (1999).
RN [25]; RE0047831.
RX PUBMED: 11302752.
RA Hong S., Lee M. Y., Cheong J.
RT Functional interaction of transcriptional coactivator ASC-2 and C/EBPalpha in granulocyte differentiation of HL-60 promyelocytic cell.
RL Biochem. Biophys. Res. Commun. 282:1257-1262 (2001).
RN [26]; RE0048242.
RX PUBMED: 15644333.
RA Bezy O., Elabd C., Cochet O., Petersen R. K., Kristiansen K., Dani C., Ailhaud G., Amri E. Z.
RT Delta-interacting protein A, a new inhibitory partner of CCAAT/enhancer-binding protein beta, implicated in adipocyte differentiation.
RL J. Biol. Chem. 280:11432-11438 (2005).
RN [27]; RE0048324.
RX PUBMED: 9139739.
RA Shuman J. D., Cheong J., Coligan J. E.
RT ATF-2 and C/EBPalpha can form a heterodimeric DNA binding complex in vitro. Functional implications for transcriptional regulation.
RL J. Biol. Chem. 272:12793-12800 (1997).
RN [28]; RE0048341.
RX PUBMED: 10859305.
RA Zhou Y. L., Lei Y., Snead M. l.
RT Functional antagonism between Msx2 and CCAAT/enhancer-binding protein alpha in regulating the mouse amelogenin gene expression is mediated by protein-protein interaction.
RL J. Biol. Chem. 275:29066-29075 (2000).
RN [29]; RE0048349.
RX PUBMED: 11356826.
RA Hong S., Park S. J., Kong H. J., Shuman J. D., Cheong J.
RT Functional interaction of bZIP proteins and the large subunit of replication factor C in liver and adipose cells.
RL J. Biol. Chem. 276:28098-28105 (2001).
RN [30]; RE0048356.
RX PUBMED: 16455820.
RA Chattopadhyay S., Gong E. Y., Hwang M., Park E., Lee H. J., Hong C. Y., Choi H. S., Cheong J. H., Kwon H. B., Lee K.
RT The CCAAT enhancer-binding protein-alpha negatively regulates the transactivation of androgen receptor in prostate cancer cells.
RL Mol. Endocrinol. 20:984-995 (2006).
RN [31]; RE0048459.
RX PUBMED: 12091339.
RA Reddy V. A., Iwama A., Iotzova G., Schulz M., Elsasser A., Vangala R. K., Tenen D. G., Hiddemann W., Behre G.
RT Granulocyte inducer C/EBPalpha inactivates the myeloid master regulator PU.1: possible role in lineage commitment decisions.
RL Blood 100:483-490 (2002).
RN [32]; RE0048515.
RX PUBMED: 16644732.
RA McFie P. J., Wang G. L., Timchenko N. A., Wilson H. L., Hu X., Roesler W. J.
RT Identification of a co-repressor that inhibits the transcriptional and growth-arrest activities of CCAAT/enhancer-binding protein alpha.
RL J. Biol. Chem. 281:18069-18080 (2006).
RN [33]; RE0048551.
RX PUBMED: 16254192.
RA Paz-Priel I., Cai D. H., Wang D., Kowalski J., Blackford A., Liu H., Heckman C. A., Gombart A. F., Koeffler H. P., Boxer L. M., Friedman A. D.
RT CCAAT/enhancer binding protein alpha (C/EBPalpha) and C/EBPalpha myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-kappaB p50.
RL Mol. Cancer Res. 3:585-596 (2005).
RN [34]; RE0048565.
RX PUBMED: 16735515.
RA Sato Y., Miyake K., Kaneoka H., Iijima S.
RT Sumoylation of CCAAT/enhancer-binding protein alpha and its functional roles in hepatocyte differentiation.
RL J. Biol. Chem. 281:21629-21639 (2006).
RN [35]; RE0050079.
RX PUBMED: 17254333.
RA Calella A. M., Nerlov C., Lopez R. G., Sciarretta C., von Bohlen Und Halbach O., Bereshchenko O., Minichiello L.
RT Neurotrophin/Trk receptor signaling mediates C/EBPalpha, -beta and NeuroD recruitment to immediate-early gene promoters in neuronal cells and requires C/EBPs to induce immediate-early gene transcription.
RL Neural Develop. 2:4 (2007).
RN [36]; RE0053527.
RX PUBMED: 17094771.
RA Park M. J., Kong H. J., Kim H. Y., Kim H. H., Kim J. H., Cheong J. H.
RT Transcriptional repression of the gluconeogenic gene PEPCK by the orphan nuclear receptor SHP through inhibitory interaction with C/EBPalpha.
RL Biochem. J. 402:567-574 (2007).
RN [37]; RE0053554.
RX PUBMED: 16807249.
RA Qiao L., MacDougald O. A., Shao J.
RT CCAAT/enhancer-binding protein alpha mediates induction of hepatic phosphoenolpyruvate carboxykinase by p38 mitogen-activated protein kinase.
RL J. Biol. Chem. 281:24390-24397 (2006).
RN [38]; RE0055471.
RX PUBMED: 19054766.
RA Dhawan P., Weider R., Christakos S.
RT CCAAT Enhancer-binding Protein {alpha} Is a Molecular Target of 1,25-Dihydroxyvitamin D3 in MCF-7 Breast Cancer Cells.
RL J. Biol. Chem. 284:3086-3095 (2009).
RN [39]; RE0065122.
RX PUBMED: 15467009.
RA Mura C., Le Gac G., Jacolot S., Ferec C.
RT Transcriptional regulation of the human HFE gene indicates high liver expression and erythropoiesis coregulation.
RL FASEB J. 18:1922-1924 (2004).
RN [40]; RE0066024.
RX PUBMED: 15308577.
RA Gery S., Park D. J., Vuong P. T., Chih D. Y., Lemp N., Koeffler H. P.
RT Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes.
RL Blood 104:3911-3917 (2004).
RN [41]; RE0070563.
RX PUBMED: 21689417.
RA Shackleford T. J., Zhang Q., Tian L., Vu T. T., Korapati A. L., Baumgartner A., Le X. F., Liao W. S., Claret F. X.
RT Stat3 and CCAAT/enhancer binding protein beta (C/EBP-beta) regulate Jab1/CSN5 expression in mammary carcinoma cells.
RL Breast Cancer Res. 13:R65 (2011).
RN [42]; RE0072582.
RX PUBMED: 21856370.
RA Wu Y. L., Peng X. E., Wang D., Chen W. N., Lin X.
RT Human liver fatty acid binding protein (hFABP1) gene is regulated by liver-enriched transcription factors HNF3beta and C/EBPalpha.
RL Biochimie 94:384-392 (2012).
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