AC T08475
XX
ID T08475
XX
DT 24.01.2006 (created); rad.
DT 31.12.2014 (updated); ros.
CO Copyright (C), QIAGEN.
XX
FA GR-alpha
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SY GCR; glucocorticoid receptor; NR3C1.
XX
OS rat, Rattus norvegicus
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; rodentia; myomorpha; muridae; murinae
XX
GE G000742 Nr3c1.
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CL C0002; CC (rec).
XX
SZ 795 AA; 87.5 kDa (cDNA) (calc.), 89 kDa (SDS) [1], 90 kDa (SDS) [2], 94 kDa (SDS) [1], [3] [3] [2] [1]
XX
SQ MDSKESLAPPGRDEVPGSLLGQGRGSVMDFYKSLRGGATVKVSASSPSVAAASQADSKQQ
SQ RILLDFSKGSTSNVQQRQQQQQQQQQQQQQQQQQQQPGLSKAVSLSMGLYMGETETKVMG
SQ NDLGYPQQGQLGLSSGETDFRLLEESIANLNRSTSVPENPKSSTSATGCATPTEKEFPKT
SQ HSDASSEQQNRKSQTGTNGGSVKLYPTDQSTFDLLKDLEFSAGSPSKDTNESPWRSDLLI
SQ DENLLSPLAGEDDPFLLEGNTNEDCKPLILPDTKPKIKDTGDTILSSPSSVALPQVKTEK
SQ DDFIELCTPGVIKQEKLGPVYCQASFSGTNIIGNKMSAISVHGVSTSGGQMYHYDMNTAS
SQ LSQQQDQKPVFNVIPPIPVGSENWNRCQGSGEDSLTSLGALNFPGRSVFSNGYSSPGMRP
SQ DVSSPPSSSSAATGPPPKLCLVCSDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRN
SQ DCIIDKIRRKNCPACRYRKCLQAGMNLEARKTKKKIKGIQQATAGVSQDTSENPNKTIVP
SQ AALPQLTPTLVSLLEVIEPEVLYAGYDSSVPDSAWRIMTTLNMLGGRQVIAAVKWAKAIL
SQ GLRNLHLDDQMTLLQYSWMFLMAFALGWRSYRQSSGNLLCFAPDLIINEQRMSLPCMYDQ
SQ CKHMLFVSSELQRLQVSYEEYLCMKTLLLLSSVPKEGLKSQELFDEIRMTYIKELGKAIV
SQ KREGNSSQNWQRFYQLTKLLDSMHEVVENLLTYCFQTFLDKTMSIEFPEMLAEIITNQIP
SQ KYSNGNIKKLLFHQK
XX
SC translated from EMBL:M14053
XX
FT 27 421 
PF02155; Glucocorticoid receptor.
FT 106 318 
trans-activating domain 1 (enh 2) [9].
FT 208 305 
amino-terminal activation function AF-1 [8].
FT 208 305 
functional cooperation with STAT5 [8].
FT 258 613 
PF00478; IMP dehydrogenase / GMP reductase domai.
FT 407 556 
interaction with c-Ets-2 [10].
FT 437 508 
SM00399; c4gold.
FT 437 512 
PS51030; NUCLEAR_REC_DBD_2.
FT 438 513 
PF00105; Zinc finger, C4 type (two domains).
FT 583 747 
SM00430; holi.
FT 586 770 PF00104; Ligand-binding domain of nuclear hormon.
XX
IN T08664 C/EBPalpha; Mammalia.
IN T09410 C/EBPbeta; Mammalia.
IN T10398 C/EBPdelta; Mammalia.
IN T08562 CREB1; human, Homo sapiens.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T05490 Hic-5; human, Homo sapiens.
IN T27173 Rbp2-isoform1; human, Homo sapiens.
XX
MX M00205 V$GRE_C.
MX M07355 V$GR_Q4.
MX M00192 V$GR_Q6.
MX M00921 V$GR_Q6_01.
MX M00960 V$PR_Q2.
XX
BS R03531.
BS R03544.
BS R03545.
BS R03546.
BS R03547.
BS R03548.
BS R03549.
BS R00973.
BS R00974.
BS R00975.
BS R00977.
BS R00979.
BS R00980.
BS R00982.
BS R00984.
BS R00985.
BS R03543.
BS R00737.
BS R12420.
BS R12421.
BS R12422.
BS R03558.
BS R00613.
BS R00591.
BS R01030.
BS R14295.
BS R14296.
BS R14297.
BS R01099.
BS R01100.
BS R01101.
BS R01102.
BS R01103.
BS R01104.
BS R01109.
BS R01114.
BS R01115.
BS R01117.
BS R01119.
BS R01121.
BS R01130.
BS R01131.
BS R01132.
BS R01133.
BS R02961.
BS R02043.
BS R14272.
BS R14278.
BS R12367.
BS R01285.
BS R01547.
BS R01549.
BS R01550.
BS R01554.
BS R00579.
BS R03534.
BS R03535.
BS R03536.
BS R03537.
BS R03538.
BS R03539.
BS R00425.
BS R00426.
BS R00427.
BS R00428.
BS R00429.
BS R00433.
BS R14392.
BS R00584.
BS R12371.
BS R23291.
BS R23292.
BS R03890.
BS R03891.
BS R35841.
BS R02793.
BS R01811.
BS R01812.
BS R01813.
BS R01814.
BS R01815.
BS R12377.
BS R01480.
BS R01481.
BS R01482.
BS R01484.
BS R01473.
BS R01475.
BS R12372.
BS R12353.
XX
DR TRANSPATH: MO000058588.
DR EMBL: M14053; RNGCR.
DR EMBL: Y00489; RNGRP.
DR UniProtKB: P06536-1;
DR PDB: 1gdc.
DR PDB: 2gda.
XX
RN [1]; RE0003698.
RX PUBMED: 479195.
RA Wrange O., Carlstedt-Duke J., Gustafsson J.-A.
RT Purification of the glucocorticoid receptor from the rat liver cytosol
RL J. Biol. Chem. 254:9284-9289 (1979).
RN [2]; RE0003699.
RX PUBMED: 7188251.
RA Westphal H. M., Moldenhauer G., Beato M.
RT Monoclonal antibodies to the rat liver glucocorticoid receptor
RL EMBO J. 1:1467-1471 (1982).
RN [3]; RE0013603.
RX PUBMED: 3474612.
RA Carlstedt-Duke J., Stromstedt P. E., Wrange O., Bergman T., Gustafsson J. A., Jornvall H.
RT Domain structure of the glucocorticoid receptor protein
RL Proc. Natl. Acad. Sci. USA 84:4437-4440 (1987).
RN [4]; RE0030660.
RX PUBMED: 9817600.
RA Boruk M., Savory J. G., Hache R. J.
RT AF-2-dependent potentiation of CCAAT enhancer binding protein beta-mediated transcriptional activation by glucocorticoid receptor.
RL Mol. Endocrinol. 12:1749-63 (1998).
RN [5]; RE0046545.
RX PUBMED: 11358960.
RA Chan S. W., Hong W.
RT Retinoblastoma-binding protein 2 (Rbp2) potentiates nuclear hormone receptor-mediated transcription
RL J. Biol. Chem. 276:28402-12 (2001).
RN [6]; RE0047660.
RX PUBMED: 12727880.
RA Wiper-Bergeron N., Wu D., Pope L., Schild-Poulter C., Hache R. J.
RT Stimulation of preadipocyte differentiation by steroid through targeting of an HDAC1 complex.
RL EMBO J. 22:2135-2145 (2003).
RN [7]; RE0047768.
RX PUBMED: 15004228.
RA Freedman N. D., Yamamoto K. R.
RT Importin 7 and importin alpha/importin beta are nuclear import receptors for the glucocorticoid receptor.
RL Mol. Biol. Cell 15:2276-2286 (2004).
RN [8]; RE0023558.
RX PUBMED: 9343435.
RA Stoecklin E., Wissler M., Moriggl R., Groner B.
RT Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription.
RL Mol. Cell. Biol. 17:6708-6716 (1997).
RN [9]; RE0002622.
RX PUBMED: 2473529.
RA Freedman L. P., Yoshinaga S. K., Vanderbilt J. N., Yamamoto K.
RT In vitro transcription enhancement by purified derivates of the glucocorticoid receptor
RL Science 245:298-301 (1989).
RN [10]; RE0023549.
RX PUBMED: 11279115.
RA Mullick J., Anandatheerthavarada H. K., Amuthan G., Bhagwat S. V., Biswas G., Camasamudram V., Bhat N. K., Reddy S. E., Rao V., Avadhani N. G.
RT Physical interaction and functional synergy between glucocorticoid receptor and Ets2 proteins for transcription activation of the rat cytochrome P-450c27 promoter.
RL J. Biol. Chem. 276:18007-18017 (2001).
XX
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