AC T10236
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ID T10236
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DT 18.01.2006 (created); anu.
DT 04.02.2014 (updated); jmh.
CO Copyright (C), QIAGEN.
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FA ATF-2
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SY activating transcription factor 2; ATF-2; ATF2; CRE-BP; CREB2.
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OS Mammalia
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia
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IN T15204 brca1; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T08664 C/EBPalpha; Mammalia.
IN T10639 HMGIY; Mammalia.
IN T15389 NF-IX; Mammalia.
IN T01427 p300; human, Homo sapiens.
IN T08628 POU2F1; Mammalia.
XX
MX M01862 V$ATF2_Q5.
MX M07312 V$ATF2_Q6.
MX M00981 V$CREBATF_Q6.
MX M00041 V$CREBP1CJUN_01.
MX M00040 V$CREBP1_01.
MX M00179 V$CREBP1_Q2.
MX M00801 V$CREB_Q3.
XX
BS R20509.
BS R21737.
BS R37244.
BS R37245.
BS R37246.
BS R24814.
BS R60086.
BS R39266.
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DR TRANSPATH: MO000057404.
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RN [1]; RE0024011.
RX PUBMED: 10357819.
RA Yie J., Merika M., Munshi N., Chen G., Thanos D.
RT The role of HMG I(Y) in the assembly and function of the IFN-beta enhanceosome.
RL EMBO J. 18:3074-3089 (1999).
RN [2]; RE0031925.
RX PUBMED: 12377781.
RA Yoshida K., Miki Y., Kufe D.
RT Activation of SAPK/JNK signaling by protein kinase Cdelta in response to DNA damage.
RL J. Biol. Chem. 277:48372-8 (2002).
RN [3]; RE0033960.
RX PUBMED: 15078890.
RA Nishihara H., Hwang M., Kizaka-Kondoh S., Eckmann L., Insel P. A.
RT Cyclic AMP promotes cAMP-responsive element-binding protein-dependent induction of cellular inhibitor of apoptosis protein-2 and suppresses apoptosis of colon cancer cells through ERK1/2 and p38 MAPK.
RL J. Biol. Chem. 279:26176-83 (2004).
RN [4]; RE0035756.
RX PUBMED: 15192015.
RA Zhu F., Zhang Y., Bode A. M., Dong Z.
RT Involvement of ERKs and mitogen- and stress-activated protein kinase in UVC-induced phosphorylation of ATF2 in JB6 cells.
RL Carcinogenesis 25:1847-1852 (2004).
RN [5]; RE0035810.
RX PUBMED: 9155018.
RA Fukunaga R., Hunter T.
RT MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates.
RL EMBO J. 16:1921-1933 (1997).
RN [6]; RE0035922.
RX PUBMED: 10900165.
RA Kuwahara K., Saito Y., Kishimoto I., Miyamoto Y., Harada M., Ogawa E., Hamanaka I., Kajiyama N., Takahashi N., Izumi T., Kawakami R., Nakao K.
RT Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes.
RL J. Mol. Cell. Cardiol. 32:1385-1394 (2000).
RN [7]; RE0036810.
RX PUBMED: 12874243.
RA Jensen L. E., Whitehead A. S.
RT Pellino3, a novel member of the Pellino protein family, promotes activation of c-Jun and Elk-1 and may act as a scaffolding protein
RL J. Immunol. 171:1500-6 (2003).
RN [8]; RE0048083.
RX PUBMED: 15601262.
RA Halfter U. M., Derbyshire Z. E., Vaillancourt R. R.
RT Interferon-gamma-dependent tyrosine phosphorylation of MEKK4 via Pyk2 is regulated by annexin II and SHP2 in keratinocytes.
RL Biochem. J. 388:17-28 (2005).
RN [9]; RE0048349.
RX PUBMED: 11356826.
RA Hong S., Park S. J., Kong H. J., Shuman J. D., Cheong J.
RT Functional interaction of bZIP proteins and the large subunit of replication factor C in liver and adipose cells.
RL J. Biol. Chem. 276:28098-28105 (2001).
RN [10]; RE0049981.
RX PUBMED: 17251187.
RA Kumar N., Robidoux J., Daniel K. W., Guzman G., Floering L. M., Collins S.
RT Requirement of vimentin filament assembly for beta3-adrenergic receptor activation of ERK MAP kinase and lipolysis.
RL J. Biol. Chem. 282:9244-9250 (2007).
RN [11]; RE0053035.
RX PUBMED: 17442668.
RA Yaghini F. A., Li F., Malik K. U.
RT Expression and mechanism of spleen tyrosine kinase activation by angiotensin II and its implication in protein synthesis in rat vascular smooth muscle cells.
RL J. Biol. Chem. 282:16878-16890 (2007).
RN [12]; RE0053627.
RX PUBMED: 11075819.
RA Lee H., Jiang F., Wang Q., Nicosia S. V., Yang J., Su B., Bai W.
RT MEKK1 activation of human estrogen receptor alpha and stimulation of the agonistic activity of 4-hydroxytamoxifen in endometrial and ovarian cancer cells.
RL Mol. Endocrinol. 14:1882-1896 (2000).
RN [13]; RE0054543.
RX PUBMED: 17317104.
RA Jamaluddin M., Wang S., Boldogh I., Tian B., Brasier A. R.
RT TNF-alpha-induced NF-kappaB/RelA Ser(276) phosphorylation and enhanceosome formation is mediated by an ROS-dependent PKAc pathway.
RL Cell. Signal. 19:1419-1433 (2007).
RN [14]; RE0054772.
RX PUBMED: 17689131.
RA Humar M., Loop T., Schmidt R., Hoetzel A., Roesslein M., Andriopoulos N., Pahl H. L., Geiger K. K., Pannen B. H.
RT The mitogen-activated protein kinase p38 regulates activator protein 1 by direct phosphorylation of c-Jun.
RL Int. J. Biochem. Cell Biol. 39:2278-2288 (2007).
RN [15]; RE0055097.
RX PUBMED: 11533064.
RA Wilson M. P., Sun Y., Cao L., Majerus P. W.
RT Inositol 1,3,4-trisphosphate 5/6-kinase is a protein kinase that phosphorylates the transcription factors c-Jun and ATF-2.
RL J. Biol. Chem. 276:40998-41004 (2001).
RN [16]; RE0055116.
RX PUBMED: 9436983.
RA Kawasaki H., Song J., Eckner R., Ugai H., Chiu R., Taira K., Shi Y., Jones N., Yokoyama K. K.
RT p300 and ATF-2 are components of the DRF complex, which regulates retinoic acid- and E1A-mediated transcription of the c-jun gene in F9 cells.
RL Genes Dev. 12:233-245 (1998).
RN [17]; RE0063474.
RX PUBMED: 19592489.
RA Liu W., Ouyang X., Yang J., Liu J., Li Q., Gu Y., Fukata M., Lin T., He C., Abreu M., Unkeless J. C., Mayer L., Xiong H.
RT AP-1 activated by Toll-like receptors regulates expression of IL-23 p19.
RL J. Biol. Chem. 284:24006-16 (2009).
RN [18]; RE0064558.
RX PUBMED: 17724032.
RA Qi X., Pohl N. M., Loesch M., Hou S., Li R., Qin J. Z., Cuenda A., Chen G.
RT p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response.
RL J. Biol. Chem. 282:31398-31408 (2007).
RN [19]; RE0065835.
RX PUBMED: 10700460.
RA Labuda T., Sundstedt A., Dohlsten M.
RT Selective induction of p38 mitogen-activated protein kinase activity following A6H co-stimulation in primary human CD4(+) T cells.
RL Int. Immunol. 12:253-261 (2000).
RN [20]; RE0066287.
RX PUBMED: 11839738.
RA Uddin S., Sassano A., Deb D. K., Verma A., Majchrzak B., Rahman A., Malik A. B., Fish E. N., Platanias L. C.
RT Protein kinase C-delta (PKC-delta ) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727.
RL J. Biol. Chem. 277:14408-14416 (2002).
RN [21]; RE0067161.
RX PUBMED: 19805025.
RA Yoon K. W., Cho J. H., Lee J. K., Kang Y. H., Chae J. S., Kim Y. M., Kim J., Kim E. K., Kim S. E., Baik J. H., Naik U. P., Cho S. G., Choi E. J.
RT CIB1 functions as a Ca(2+)-sensitive modulator of stress-induced signaling by targeting ASK1.
RL Proc. Natl. Acad. Sci. USA 106:17389-17394 (2009).
RN [22]; RE0067230.
RX PUBMED: 15713638.
RA Mandl M., Slack D. N., Keyse S. M.
RT Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5.
RL Mol. Cell. Biol. 25:1830-1845 (2005).
RN [23]; RE0068114.
RX PUBMED: 12110590.
RA Ouwens D. M., de Ruiter N. D., Van der Zon G. C., Carter A. P., Schouten J., van der Burgt C., Kooistra K., Bos J. L., Maassen J. A., van Dam H.
RT Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.
RL EMBO J. 21:3782-3793 (2002).
RN [24]; RE0070572.
RX PUBMED: 15192708.
RA Matsuda S., Miwa Y., Hirata Y., Minowa A., Tanaka J., Nishida E., Koyasu S.
RT Negative feedback loop in T-cell activation through MAPK-catalyzed threonine phosphorylation of LAT.
RL EMBO J. 23:2577-2585 (2004).
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