AC T04632
XX
ID T04632
XX
DT 24.07.2001 (created); mas.
DT 15.05.2014 (updated); ili.
CO Copyright (C), QIAGEN.
XX
FA SRC-1
XX
SY NCOA-1; NCOA1; nuclear receptor coactivator 1; steroid receptor coactivator-1.
XX
OS human, Homo sapiens
OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates
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GE G002755 NCOA1; HGNC: NCOA1.
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CL C0010; bHLH; 1.2.5.3.1.
XX
SF the C-terminal portion of SRC-1 has strong intrinsic HAT activity [44];
SF conflict in protein sequence between EMBL entries #59302 and #90661;
SF coactivator for members of the steroid hormone receptor superfamily [2] [3];
SF contains several NR box motifs within the nuclear receptor interacting domain: important for interaction with cognate nuclear receptors in ligand-bound status (via AF-2 domain) [2] [1];
XX
FF co-activator;
FF binds directly to several nuclear receptors, for example CAR [7];
FF co-activator for FXR [8];
XX
IN T01795 AhR; human, Homo sapiens.
IN T08487 AR-isoform1; human, Homo sapiens.
IN T00040 AR; human, Homo sapiens.
IN T01797 arnt; mouse, Mus musculus.
IN T08495 c-Ets-1; human, Homo sapiens.
IN T10523 c-Ets-2; human, Homo sapiens.
IN T10346 c-Fos; Mammalia.
IN T09446 c-Jun; Mammalia.
IN T02261 CAR; human, Homo sapiens.
IN T05687 CAR; mouse, Mus musculus.
IN T08300 ER-alpha-L; human, Homo sapiens.
IN T00259 ER-alpha; mouse, Mus musculus.
IN T00261 ER-alpha; human, Homo sapiens.
IN T04649 ER-beta6; mouse, Mus musculus.
IN T08515 ER-beta; human, Homo sapiens.
IN T09602 ER; Mammalia.
IN T02765 ERR1; human, Homo sapiens.
IN T04644 ERR3-isoform1; mouse, Mus musculus.
IN T06121 ERR3; human, Homo sapiens.
IN T04498 FXR-isoform4; human, Homo sapiens.
IN T17931 FXR:RXR-alpha; human, Homo sapiens
IN T09632 FXR; human, Homo sapiens.
IN T05076 GR; human, Homo sapiens.
IN T01610 HIF-1alpha; human, Homo sapiens.
IN T02430 HNF-4gamma; human, Homo sapiens.
IN T02770 LRH-1; human, Homo sapiens.
IN T02752 LXR-alpha; human, Homo sapiens.
IN T04453 LXR-beta; human, Homo sapiens.
IN T09029 LXR-beta; human, Homo sapiens.
IN T08888 LXRalpha-isoform1; human, Homo sapiens.
IN T00513 MR; human, Homo sapiens.
IN T05300 NR1B1:RXR-alpha; human, Homo sapiens.
IN T05299 NR1B1; human, Homo sapiens.
IN T00721 NR1B2; human, Homo sapiens.
IN T08991 PPARalpha; rat, Rattus norvegicus.
IN T02745 PPARdelta; human, Homo sapiens.
IN T29293 PPARgamma2; Mammalia.
IN T08829 PPARgamma:RXR-alpha; human, Homo sapiens
IN T05329 PPARgamma; rat, Rattus norvegicus.
IN T05351 PPARgamma; human, Homo sapiens.
IN T04618 PXR-isoform1; mouse, Mus musculus.
IN T08949 PXR; human, Homo sapiens.
IN T00720 RAR-gamma; human, Homo sapiens.
IN T09566 RORalpha; human, Homo sapiens.
IN T02748 RORbeta; human, Homo sapiens.
IN T02749 RORgamma; human, Homo sapiens.
IN T01345 RXR-alpha; human, Homo sapiens.
IN T09964 RXR-alpha; Mammalia.
IN T01334 RXR-beta; human, Homo sapiens.
IN T01493 STAT3; human, Homo sapiens.
IN T01579 STAT5A; mouse, Mus musculus.
IN T15588 T3R-beta1; Mammalia.
IN T08264 T3R-beta; human, Homo sapiens.
IN T08482 VDR-isoform1; human, Homo sapiens.
IN T00882 VDR; rat, Rattus norvegicus.
IN T00885 VDR; human, Homo sapiens.
XX
BS R18539.
BS R18813.
XX
DR TRANSPATH: MO000028465.
DR UniProtKB: Q15788;
XX
RN [1]; RE0006908.
RX PUBMED: 9430642.
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RT The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways
RL EMBO J. 17:507-519 (1998).
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RA Leo C., Chen J. D.
RT The SRC family of nuclear receptor coactivators
RL Gene 245:1-11 (2000).
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RT Sequence and characterization of a coactivator for the steroid hormone receptor superfamily
RL Science 270:1354-1357 (1995).
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RT Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent.
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RT Identification of a nuclear receptor for bile acids.
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RT Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells.
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RT Linking beta-catenin to androgen-signaling pathway.
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RT Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells.
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RA Chauchereau A., Amazit L., Quesne M., Guiochon-Mantel A., Milgrom E.
RT Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1.
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RA Kobayashi Y., Kitamoto T., Masuhiro Y., Watanabe M., Kase T., Metzger D., Yanagisawa J., Kato S.
RT p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domains
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RA Matsuda S., Harries J. C., Viskaduraki M., Troke P. J., Kindle K. B., Ryan C., Heery D. M.
RT A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP
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RX PUBMED: 11864604.
RA Greschik H., Wurtz J. M., Sanglier S., Bourguet W., van Dorsselaer A., Moras D., Renaud J. P.
RT Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3
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RX PUBMED: 9642216.
RA Lee S. K., Kim H. J., Na S. Y., Kim T. S., Choi H. S., Im S. Y., Lee J. W.
RT Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits.
RL J. Biol. Chem. 273:16651-16654 (1998).
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RT Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors.
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RT The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators.
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RT Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog.
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RA Rachez C., Gamble M., Chang C. P., Atkins G. B., Lazar M. A., Freedman L. P.
RT The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes.
RL Mol. Cell. Biol. 20:2718-2726 (2000).
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RA Ko L., Cardona G. R., Chin W. W.
RT Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator.
RL Proc. Natl. Acad. Sci. USA 97:6212-6217 (2000).
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RA Lee S. K., Choi H. S., Song M. R., Lee M. O., Lee J. W.
RT Estrogen receptor, a common interaction partner for a subset of nuclear receptors.
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RT Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140.
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RA Myers E., Hill A. D., Kelly G., McDermott E. W., O'Higgins N. J., Buggy Y., Young L. S.
RT Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer.
RL Clin. Cancer Res. 11:2111-2122 (2005).
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RT Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase.
RL Mol. Cell. Biol. 22:3549-3561 (2002).
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RT A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin.
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RT A regulatory role for RIP140 in nuclear receptor activation.
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RT Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor.
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RT Vitamin D receptor as an intestinal bile acid sensor.
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RT Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity.
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RT Regulation of ligand-induced heterodimerization and coactivator interaction by the activation function-2 domain of the vitamin D receptor.
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RT 2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts.
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RT Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation.
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RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins.
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RT Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor.
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RT Steroid receptor coactivator-1 is a histone acetyltransferase
RL Nature 389:194-198 (1997).
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