TRANSFAC FACTOR TABLE, Release 2017.2 - public - 2017-06-30, (C) QIAGEN

AC T04632 XX ID T04632 XX DT 24.07.2001 (created); mas. DT 15.05.2014 (updated); ili. CO Copyright (C), QIAGEN. XX FA SRC-1 XX SY NCOA-1; NCOA1; nuclear receptor coactivator 1; steroid receptor coactivator-1. XX OS human, Homo sapiens OC eukaryota; animalia; metazoa; chordata; vertebrata; tetrapoda; mammalia; eutheria; primates XX GE G002755 NCOA1; HGNC: NCOA1. XX CL C0010; bHLH; XX SF the C-terminal portion of SRC-1 has strong intrinsic HAT activity [44]; SF conflict in protein sequence between EMBL entries #59302 and #90661; SF coactivator for members of the steroid hormone receptor superfamily [2] [3]; SF contains several NR box motifs within the nuclear receptor interacting domain: important for interaction with cognate nuclear receptors in ligand-bound status (via AF-2 domain) [2] [1]; XX FF co-activator; FF binds directly to several nuclear receptors, for example CAR [7]; FF co-activator for FXR [8]; XX IN T01795 AhR; human, Homo sapiens. IN T08487 AR-isoform1; human, Homo sapiens. IN T00040 AR; human, Homo sapiens. IN T01797 arnt; mouse, Mus musculus. IN T08495 c-Ets-1; human, Homo sapiens. IN T10523 c-Ets-2; human, Homo sapiens. IN T10346 c-Fos; Mammalia. IN T09446 c-Jun; Mammalia. IN T02261 CAR; human, Homo sapiens. IN T05687 CAR; mouse, Mus musculus. IN T08300 ER-alpha-L; human, Homo sapiens. IN T00259 ER-alpha; mouse, Mus musculus. IN T00261 ER-alpha; human, Homo sapiens. IN T04649 ER-beta6; mouse, Mus musculus. IN T08515 ER-beta; human, Homo sapiens. IN T09602 ER; Mammalia. IN T02765 ERR1; human, Homo sapiens. IN T04644 ERR3-isoform1; mouse, Mus musculus. IN T06121 ERR3; human, Homo sapiens. IN T04498 FXR-isoform4; human, Homo sapiens. IN T17931 FXR:RXR-alpha; human, Homo sapiens IN T09632 FXR; human, Homo sapiens. IN T05076 GR; human, Homo sapiens. IN T01610 HIF-1alpha; human, Homo sapiens. IN T02430 HNF-4gamma; human, Homo sapiens. IN T02770 LRH-1; human, Homo sapiens. IN T02752 LXR-alpha; human, Homo sapiens. IN T04453 LXR-beta; human, Homo sapiens. IN T09029 LXR-beta; human, Homo sapiens. IN T08888 LXRalpha-isoform1; human, Homo sapiens. IN T00513 MR; human, Homo sapiens. IN T05300 NR1B1:RXR-alpha; human, Homo sapiens. IN T05299 NR1B1; human, Homo sapiens. IN T00721 NR1B2; human, Homo sapiens. IN T08991 PPARalpha; rat, Rattus norvegicus. IN T02745 PPARdelta; human, Homo sapiens. IN T29293 PPARgamma2; Mammalia. IN T08829 PPARgamma:RXR-alpha; human, Homo sapiens IN T05329 PPARgamma; rat, Rattus norvegicus. IN T05351 PPARgamma; human, Homo sapiens. IN T04618 PXR-isoform1; mouse, Mus musculus. IN T08949 PXR; human, Homo sapiens. IN T00720 RAR-gamma; human, Homo sapiens. IN T09566 RORalpha; human, Homo sapiens. IN T02748 RORbeta; human, Homo sapiens. IN T02749 RORgamma; human, Homo sapiens. IN T01345 RXR-alpha; human, Homo sapiens. IN T09964 RXR-alpha; Mammalia. IN T01334 RXR-beta; human, Homo sapiens. IN T01493 STAT3; human, Homo sapiens. IN T01579 STAT5A; mouse, Mus musculus. IN T15588 T3R-beta1; Mammalia. IN T08264 T3R-beta; human, Homo sapiens. IN T08482 VDR-isoform1; human, Homo sapiens. IN T00882 VDR; rat, Rattus norvegicus. IN T00885 VDR; human, Homo sapiens. XX BS R18539. BS R18813. XX DR TRANSPATH: MO000028465. DR UniProtKB: Q15788; XX RN [1]; RE0006908. RX PUBMED: 9430642. RA Voegel J. J., Heine M. J., Tini M., Vivat V., Chambon P., Gronemeyer H. RT The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways RL EMBO J. 17:507-519 (1998). RN [2]; RE0016476. RX PUBMED: 10713439. RA Leo C., Chen J. D. RT The SRC family of nuclear receptor coactivators RL Gene 245:1-11 (2000). RN [3]; RE0016494. RX PUBMED: 7481822. RA Onate S. A., Tsai S. Y., Tsai M. J., O'Malley B. W. RT Sequence and characterization of a coactivator for the steroid hormone receptor superfamily RL Science 270:1354-1357 (1995). RN [4]; RE0018127. RX PUBMED: 10360171. RA Wang H., Chen J., Hollister K., Sowers L. C., Forman B. M. RT Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. RL Mol. Cell 3:543-553 (1999). RN [5]; RE0018271. RX PUBMED: 10617585. RA Naltner A., Ghaffari M., Whitsett J. A., Yan C. RT Retinoic acid stimulation of the human surfactant protein B promoter is thyroid transcription factor 1 site-dependent. RL J. Biol. Chem. 275:56-62 (2000). RN [6]; RE0022248. RX PUBMED: 9744281. RA Westin S., Kurokawa R., Nolte R. T., Wisely G. B., McInerney E. M., Rose D. W., Milburn M. V., Rosenfeld M. G., Glass C. K. RT Interactions controlling the assembly of nuclear-receptor heterodimers and co-activators. RL Nature 395:199-202 (1998). RN [7]; RE0023337. RX PUBMED: 10757780. RA Tzameli I., Pissios P., Schuetz E. G., Moore D. D. RT The xenobiotic compound 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene is an agonist ligand for the nuclear receptor CAR. RL Mol. Cell. Biol. 20:2951-2958 (2000). RN [8]; RE0023349. RX PUBMED: 10334992. RA Makishima M., Okamoto A. Y., Repa J. J., Tu H., Learned R. M., Luk A., Hull M. V., Lustig K. D., Mangelsdorf D. J., Shan B. RT Identification of a nuclear receptor for bile acids. RL Science 284:1362-1365 (1999). RN [9]; RE0027683. RX PUBMED: 10517671. RA Monden T., Kishi M., Hosoya T., Satoh T., Wondisford F. E., Hollenberg A. N., Yamada M., Mori M. RT p120 acts as a specific coactivator for 9-cis-retinoic acid receptor (RXR) on peroxisome proliferator-activated receptor-gamma/RXR heterodimers. RL Mol. Endocrinol. 13:1695-703 (1999). RN [10]; RE0029151. RX PUBMED: 11773079. RA Giraud S., Bienvenu F., Avril S., Gascan H., Heery D. M., Coqueret O. RT Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a. RL J. Biol. Chem. 277:8004-11 (2002). RN [11]; RE0029979. RX PUBMED: 12163482. RA Ueda T., Mawji N. R., Bruchovsky N., Sadar M. D. RT Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells. RL J. Biol. Chem. 277:38087-94 (2002). RN [12]; RE0031743. RX PUBMED: 11792709. RA Yang F., Li X., Sharma M., Sasaki C. Y., Longo D. L., Lim B., Sun Z. RT Linking beta-catenin to androgen-signaling pathway. RL J. Biol. Chem. 277:11336-44 (2002). RN [13]; RE0032717. RX PUBMED: 14684751. RA Lew J. L., Zhao A., Yu J., Huang L., de Pedro N., Pelaez F., Wright S. D., Cui J. RT The farnesoid X receptor controls gene expression in a ligand- and promoter-selective fashion. RL J. Biol. Chem. 279:8856-61 (2004). RN [14]; RE0033105. RX PUBMED: 15001550. RA Lim H. J., Moon I., Han K. RT Transcriptional cofactors exhibit differential preference toward peroxisome proliferator-activated receptors alpha and delta in uterine cells. RL Endocrinology 145:2886-95 (2004). RN [15]; RE0034422. RX PUBMED: 12529333. RA Chauchereau A., Amazit L., Quesne M., Guiochon-Mantel A., Milgrom E. RT Sumoylation of the progesterone receptor and of the steroid receptor coactivator SRC-1. RL J. Biol. Chem. 278:12335-43 (2003). RN [16]; RE0041230. RX PUBMED: 10747867. RA Kobayashi Y., Kitamoto T., Masuhiro Y., Watanabe M., Kase T., Metzger D., Yanagisawa J., Kato S. RT p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domains RL J. Biol. Chem. 275:15645-51 (2000). RN [17]; RE0042378. RX PUBMED: 14722092. RA Matsuda S., Harries J. C., Viskaduraki M., Troke P. J., Kindle K. B., Ryan C., Heery D. M. RT A Conserved alpha-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP RL J. Biol. Chem. 279:14055-64 (2004). RN [18]; RE0047209. RX PUBMED: 11864604. RA Greschik H., Wurtz J. M., Sanglier S., Bourguet W., van Dorsselaer A., Moras D., Renaud J. P. RT Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3 RL Mol. Cell 9:303-13 (2002). RN [19]; RE0047363. RX PUBMED: 9642216. RA Lee S. K., Kim H. J., Na S. Y., Kim T. S., Choi H. S., Im S. Y., Lee J. W. RT Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits. RL J. Biol. Chem. 273:16651-16654 (1998). RN [20]; RE0047375. RX PUBMED: 11891224. RA Gonzalez M. M., Carlberg C. RT Cross-repression, a functional consequence of the physical interaction of non-liganded nuclear receptors and POU domain transcription factors. RL J. Biol. Chem. 277:18501-18509 (2002). RN [21]; RE0047433. RX PUBMED: 9878542. RA Tagami T., Lutz W. H., Kumar R., Jameson J. L. RT The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators. RL Biochem. Biophys. Res. Commun. 253:358-363 (1998). RN [22]; RE0047490. RX PUBMED: 9891040. RA Takeyama K., Masuhiro Y., Fuse H., Endoh H., Murayama A., Kitanaka S., Suzawa M., Yanagisawa J., Kato S. RT Selective interaction of vitamin D receptor with transcriptional coactivators by a vitamin D analog. RL Mol. Cell. Biol. 19:1049-1055 (1999). RN [23]; RE0047548. RX PUBMED: 10733574. RA Rachez C., Gamble M., Chang C. P., Atkins G. B., Lazar M. A., Freedman L. P. RT The DRIP complex and SRC-1/p160 coactivators share similar nuclear receptor binding determinants but constitute functionally distinct complexes. RL Mol. Cell. Biol. 20:2718-2726 (2000). RN [24]; RE0047584. RX PUBMED: 10823961. RA Ko L., Cardona G. R., Chin W. W. RT Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator. RL Proc. Natl. Acad. Sci. USA 97:6212-6217 (2000). RN [25]; RE0047600. RX PUBMED: 9717844. RA Lee S. K., Choi H. S., Song M. R., Lee M. O., Lee J. W. RT Estrogen receptor, a common interaction partner for a subset of nuclear receptors. RL Mol. Endocrinol. 12:1184-1192 (1998). RN [26]; RE0047715. RX PUBMED: 11266503. RA Zilliacus J., Holter E., Wakui H., Tazawa H., Treuter E., Gustafsson J. A. RT Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140. RL Mol. Endocrinol. 15:501-511 (2001). RN [27]; RE0048002. RX PUBMED: 15788656. RA Myers E., Hill A. D., Kelly G., McDermott E. W., O'Higgins N. J., Buggy Y., Young L. S. RT Associations and interactions between Ets-1 and Ets-2 and coregulatory proteins, SRC-1, AIB1, and NCoR in breast cancer. RL Clin. Cancer Res. 11:2111-2122 (2005). RN [28]; RE0048217. RX PUBMED: 11971985. RA Wu R. C., Qin J., Hashimoto Y., Wong J., Xu J., Tsai S. Y., Tsai M. J., O'Malley B. W. RT Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. RL Mol. Cell. Biol. 22:3549-3561 (2002). RN [29]; RE0048366. RX PUBMED: 16373397. RA Li J., Fu J., Toumazou C., Yoon H. G., Wong J. RT A role of the amino-terminal (N) and carboxyl-terminal (C) interaction in binding of androgen receptor to chromatin. RL Mol. Endocrinol. 20:776-785 (2006). RN [30]; RE0050623. RX PUBMED: 9626662. RA Treuter E., Albrektsen T., Johansson L., Leers J., Gustafsson J. A. RT A regulatory role for RIP140 in nuclear receptor activation. RL Mol. Endocrinol. 12:864-881 (1998). RN [31]; RE0050893. RX PUBMED: 15145977. RA Nishimaki-Mogami T., Une M., Fujino T., Sato Y., Tamehiro N., Kawahara Y., Shudo K., Inoue K. RT Identification of intermediates in the bile acid synthetic pathway as ligands for the farnesoid X receptor. RL J. Lipid Res. 45:1538-1545 (2004). RN [32]; RE0051015. RX PUBMED: 12004058. RA Cui J., Heard T. S., Yu J., Lo J. L., Huang L., Li Y., Schaeffer J. M., Wright S. D. RT The amino acid residues asparagine 354 and isoleucine 372 of human farnesoid X receptor confer the receptor with high sensitivity to chenodeoxycholate. RL J. Biol. Chem. 277:25963-25969 (2002). RN [33]; RE0051017. RX PUBMED: 16857673. RA Yang C., McDonald J. G., Patel A., Zhang Y., Umetani M., Xu F., Westover E. J., Covey D. F., Mangelsdorf D. J., Cohen J. C., Hobbs H. H. RT Sterol intermediates from cholesterol biosynthetic pathway as liver X receptor ligands. RL J. Biol. Chem. 281:27816-27826 (2006). RN [34]; RE0051114. RX PUBMED: 12016314. RA Makishima M., Lu T. T., Xie W., Whitfield G. K., Domoto H., Evans R. M., Haussler M. R., Mangelsdorf D. J. RT Vitamin D receptor as an intestinal bile acid sensor. RL Science 296:1313-1316 (2002). RN [35]; RE0051160. RX PUBMED: 12847102. RA Kaneko E., Matsuda M., Yamada Y., Tachibana Y., Shimomura I., Makishima M. RT Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist. RL J. Biol. Chem. 278:36091-36098 (2003). RN [36]; RE0051308. RX PUBMED: 13130122. RA Fujino T., Une M., Imanaka T., Inoue K., Nishimaki-Mogami T. RT Structure-activity relationship of bile acids and bile acid analogs in regard to FXR activation. RL J. Lipid Res. 45:132-138 (2004). RN [37]; RE0051780. RX PUBMED: 9440810. RA Gill R. K., Atkins L. M., Hollis B. W., Bell N. H. RT Mapping the domains of the interaction of the vitamin D receptor and steroid receptor coactivator-1. RL Mol. Endocrinol. 12:57-65 (1998). RN [38]; RE0051786. RX PUBMED: 10224118. RA Jimenez-Lara A. M., Aranda A. RT Lysine 246 of the vitamin D receptor is crucial for ligand-dependent interaction with coactivators and transcriptional activity. RL J. Biol. Chem. 274:13503-13510 (1999). RN [39]; RE0051975. RX PUBMED: 11075811. RA Liu Y. Y., Nguyen C., Peleg S. RT Regulation of ligand-induced heterodimerization and coactivator interaction by the activation function-2 domain of the vitamin D receptor. RL Mol. Endocrinol. 14:1776-1787 (2000). RN [40]; RE0053029. RX PUBMED: 12796488. RA Yamamoto H., Shevde N. K., Warrier A., Plum L. A., DeLuca H. F., Pike J. W. RT 2-Methylene-19-nor-(20S)-1,25-dihydroxyvitamin D3 potently stimulates gene-specific DNA binding of the vitamin D receptor in osteoblasts. RL J. Biol. Chem. 278:31756-31765 (2003). RN [41]; RE0053695. RX PUBMED: 17395984. RA Galluzzo P., Caiazza F., Moreno S., Marino M. RT Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation. RL Endocr. Relat. Cancer 14:153-167 (2007). RN [42]; RE0054989. RX PUBMED: 15604093. RA Albers M., Kranz H., Kober I., Kaiser C., Klink M., Suckow J., Kern R., Koegl M. RT Automated yeast two-hybrid screening for nuclear receptor-interacting proteins. RL Mol. Cell. Proteomics 4:205-213 (2005). RN [43]; RE0062855. RX PUBMED: 19117054. RA Karmakar S., Foster E. A., Smith C. L. RT Estradiol downregulation of the tumor suppressor gene BTG2 requires estrogen receptor-alpha and the REA corepressor. RL Int. J. Cancer 124:1841-1851 (2009). RN [44]; RE0006142. RX PUBMED: 9296499. RA Spencer T. E., Jenster G., Burcin M. M., Allis C. D., Zhou J., Mizzen C. A., McKenna N. J., Onate S. A., Tsai S. Y., Tsai M. J., O'Malley B. W. RT Steroid receptor coactivator-1 is a histone acetyltransferase RL Nature 389:194-198 (1997). XX //